ES2196190T3 - Inhibidores de metaloproteinasas matriciales, con hidroxamato bifenlico. - Google Patents
Inhibidores de metaloproteinasas matriciales, con hidroxamato bifenlico.Info
- Publication number
- ES2196190T3 ES2196190T3 ES96940406T ES96940406T ES2196190T3 ES 2196190 T3 ES2196190 T3 ES 2196190T3 ES 96940406 T ES96940406 T ES 96940406T ES 96940406 T ES96940406 T ES 96940406T ES 2196190 T3 ES2196190 T3 ES 2196190T3
- Authority
- ES
- Spain
- Prior art keywords
- metaloproteinasas
- matriciales
- bifenlico
- hydroxamate
- inhibitors
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000003112 inhibitor Substances 0.000 title abstract 2
- 239000011159 matrix material Substances 0.000 abstract 3
- 230000028327 secretion Effects 0.000 abstract 3
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/60—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton with the carbon atom of at least one of the carboxyl groups bound to nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/04—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids
- C07C259/06—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups without replacement of the other oxygen atom of the carboxyl group, e.g. hydroxamic acids having carbon atoms of hydroxamic groups bound to hydrogen atoms or to acyclic carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Rheumatology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pain & Pain Management (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Epidemiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
COMPUESTOS DE FORMULA (I), O SU SAL FARMACEUTICAMENTE ACEPTABLE QUE INHIBEN LA METALOPROTEINASAS DE LA MATRIZ Y LA SECRECION DE TNF AL Y SE UTILIZAN EN EL TRATAMIENTO DE SITUACIONES DE ENFERMEDADES INFECCIOSAS. TAMBIEN SE DESCRIBEN COMPOSICIONES INHIBIDORAS DE LAS METALOPROTEINASAS DE LA MATRIZ Y DE LA SECRECION DE TNF AL Y UN PROCEDIMIENTO PARA INHIBIR LAS METALOPROTEINASAS DE LA MATRIZ Y LA SECRECION DE TNF AL .
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/555,690 US5665777A (en) | 1995-11-14 | 1995-11-14 | Biphenyl hydroxamate inhibitors of matrix metalloproteinases |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2196190T3 true ES2196190T3 (es) | 2003-12-16 |
Family
ID=24218248
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES96940406T Expired - Lifetime ES2196190T3 (es) | 1995-11-14 | 1996-11-13 | Inhibidores de metaloproteinasas matriciales, con hidroxamato bifenlico. |
Country Status (13)
Country | Link |
---|---|
US (1) | US5665777A (es) |
EP (1) | EP0874808B1 (es) |
JP (1) | JP2002504073A (es) |
KR (1) | KR19990067573A (es) |
AT (1) | ATE236873T1 (es) |
AU (1) | AU710666B2 (es) |
DE (1) | DE69627380T2 (es) |
DK (1) | DK0874808T3 (es) |
ES (1) | ES2196190T3 (es) |
IL (1) | IL123502A0 (es) |
MX (1) | MX9803809A (es) |
PT (1) | PT874808E (es) |
WO (1) | WO1997018188A1 (es) |
Families Citing this family (30)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0890114A1 (en) * | 1996-03-29 | 1999-01-13 | Lawrence Berkeley National Laboratory | Enhancement of nmr and mri in the presence of hyperpolarized noble gases |
DE69729007T2 (de) * | 1996-08-07 | 2005-04-07 | Darwin Discovery Ltd., Slough | Hydroxamsäure- und carbonsäure-derivate mit mmp und tnf hemmender wirkung |
US6566384B1 (en) | 1996-08-07 | 2003-05-20 | Darwin Discovery Ltd. | Hydroxamic and carboxylic acid derivatives having MMP and TNF inhibitory activity |
US6172057B1 (en) * | 1997-02-27 | 2001-01-09 | American Cyanamid Company | N-Hydroxy-2-(alkyl, aryl, or heteroaryl sulfanyl, sulfinyl or sulfonyl)-3-substituted alkyl, aryl or heteroarylamides as matrix metalloproteinase inhibitors |
DK0970046T3 (da) * | 1997-02-27 | 2004-04-13 | Wyeth Corp | N-Hydroxy-2-(alkyl-, aryl- eller heteroarylsulfanyl, -sulfinyl eller -sulfonyl)-3-substituerede alkyl- eller heteroaryl-amider som matrixmetalloproteinaseinhibitorer |
US6300514B1 (en) | 1997-06-25 | 2001-10-09 | Ono Pharmaceutical Co., Ltd. | Aryl (sulfide, sulfoxide and sulfone) derivatives and drugs containing the same as the active ingredient |
ES2189207T3 (es) * | 1997-07-31 | 2003-07-01 | Abbott Lab | Inhibidores de hidroxamatos inversos de metaloproteinasas matriciales. |
US6235786B1 (en) | 1997-08-06 | 2001-05-22 | Abbott Laboratories | Reverse hydroxamate inhibitors of matrix metalloproteinases |
US6294573B1 (en) | 1997-08-06 | 2001-09-25 | Abbott Laboratories | Reverse hydroxamate inhibitors of matrix metalloproteinases |
US6420427B1 (en) | 1997-10-09 | 2002-07-16 | Ono Pharmaceutical Co., Ltd. | Aminobutyric acid derivatives |
US6288063B1 (en) * | 1998-05-27 | 2001-09-11 | Bayer Corporation | Substituted 4-biarylbutyric and 5-biarylpentanoic acid derivatives as matrix metalloprotease inhibitors |
FR2780402B1 (fr) * | 1998-06-30 | 2001-04-27 | Adir | Nouveaux composes acides carboxyliques et hydroxamiques inhibiteurs de metalloproteases, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
US6288261B1 (en) | 1998-12-18 | 2001-09-11 | Abbott Laboratories | Inhibitors of matrix metalloproteinases |
WO2000044712A1 (en) * | 1999-01-27 | 2000-08-03 | Abbott Laboratories | N-hydroxyformamide derivatives as inhibitors of matrix metalloproteinases |
NZ520711A (en) * | 2000-02-10 | 2004-03-26 | Ono Pharmaceutical Co | N-hydroxy-5-ethoxymethyloxy-2(S)-methyl-4(S)-(4- phenoxybenzoyl)aminopentanamide useful for treating osteoarthritis |
US6652833B2 (en) | 2000-07-13 | 2003-11-25 | The Regents Of The University Of California | Functionalized active-nucleus complex sensor |
US20030165431A1 (en) * | 2000-07-13 | 2003-09-04 | The Regents Of The University Of California | Method for detecting macromolecular conformational change and binding information |
US7061237B2 (en) * | 2000-07-13 | 2006-06-13 | The Regents Of The University Of California | Remote NMR/MRI detection of laser polarized gases |
JP2004359546A (ja) * | 2001-03-15 | 2004-12-24 | Ono Pharmaceut Co Ltd | ヒドロキサム酸誘導体、それらの非毒性塩およびそれらのプロドラッグ体を有効成分として含有する、固形癌の予防および/または治療剤 |
JPWO2002074298A1 (ja) * | 2001-03-21 | 2004-07-08 | 小野薬品工業株式会社 | Il−6産生阻害剤 |
PE20030701A1 (es) * | 2001-12-20 | 2003-08-21 | Schering Corp | Compuestos para el tratamiento de trastornos inflamatorios |
ATE457716T1 (de) | 2002-12-30 | 2010-03-15 | Angiotech Int Ag | Wirkstofffreisetzung von schnell gelierender polymerzusammensetzung |
ATE509956T1 (de) * | 2006-06-08 | 2011-06-15 | Helmholtz Zentrum Muenchen | Spezifische proteaseinhibitoren und ihre verwendung in der krebstherapie |
WO2009008905A1 (en) * | 2007-02-01 | 2009-01-15 | Panthera Biopharma, Llc. | Hydroxamic acid derivatives of phenoxy-acetic acids and analogs useful as therapeutic agents for treating anthrax poisoning |
CN102267923B (zh) * | 2010-06-04 | 2015-07-15 | 台北医学大学 | 组蛋白去乙酰化酶抑制剂 |
US20140271465A1 (en) * | 2013-03-15 | 2014-09-18 | Mallinckrodt Llc | Matrix metalloprotease (mmp) targeted agents for imaging and therapy |
EP3628661A1 (en) * | 2013-06-27 | 2020-04-01 | Lg Chem, Ltd. | Biaryl derivatives as gpr120 agonists |
KR101829290B1 (ko) * | 2014-12-24 | 2018-02-19 | 주식회사 엘지화학 | Gpr120 효능제로서의 바이아릴 유도체 |
EP3860608A1 (en) | 2018-10-04 | 2021-08-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Egfr inhibitors for treating keratodermas |
CN109820861B (zh) * | 2019-03-13 | 2021-02-26 | 湖北科技学院 | 一种具有抗肿瘤活性的吩噻嗪类衍生物的应用 |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1548641A (es) * | 1967-10-26 | 1968-12-06 | ||
US3755603A (en) * | 1970-07-01 | 1973-08-28 | Syntex Corp | Biphenylyloxyacetic acids in pharmaceutical compositions |
JPS525730A (en) * | 1975-07-03 | 1977-01-17 | Nippon Shinyaku Co Ltd | Process for preparation of 1,3,5-tri-substituted derivatives |
JPS5762239A (en) * | 1980-08-26 | 1982-04-15 | Hisamitsu Pharmaceut Co Inc | Novel phenylacetic acid derivative |
US4599361A (en) * | 1985-09-10 | 1986-07-08 | G. D. Searle & Co. | Hydroxamic acid based collagenase inhibitors |
US5036157A (en) * | 1986-03-11 | 1991-07-30 | Burroughs Wellcome Co. | Aryl derivatives |
CA2073513A1 (en) * | 1990-12-03 | 1992-06-04 | John Robert Porter | Peptidyl derivatives |
GB9102635D0 (en) * | 1991-02-07 | 1991-03-27 | British Bio Technology | Compounds |
JPH05205730A (ja) * | 1992-01-29 | 1993-08-13 | Shin Kobe Electric Mach Co Ltd | 薄形鉛蓄電池 |
EP0634998B1 (en) * | 1992-04-07 | 1997-03-19 | British Biotech Pharmaceuticals Limited | Hydroxamic acid based collagenase and cytokine inhibitors |
US5318964A (en) * | 1992-06-11 | 1994-06-07 | Hoffmann-La Roche Inc. | Hydroxamic derivatives and pharmaceutical compositions |
JPH07509178A (ja) * | 1992-07-16 | 1995-10-12 | シェブロン ケミカル カンパニー | コークスで不活性化された改質触媒の低温再生法 |
US5310121A (en) * | 1992-07-24 | 1994-05-10 | Consilium Bulk Babcock Atlanta, Inc. | Cold weather bulk stacker/reclaimer apparatus and method |
GB9223904D0 (en) * | 1992-11-13 | 1993-01-06 | British Bio Technology | Inhibition of cytokine production |
CA2158352A1 (en) * | 1993-03-16 | 1994-09-29 | Michael John Crimmin | Hydroxamic acid derivatives as metalloproteinase inhibitors |
EP0715619A4 (en) * | 1993-08-23 | 1997-03-19 | Immunex Corp | INHIBITORS OF TNF-ALPHA SECRETION |
GB9320660D0 (en) * | 1993-10-07 | 1993-11-24 | British Bio Technology | Inhibition of cytokine production |
-
1995
- 1995-11-14 US US08/555,690 patent/US5665777A/en not_active Expired - Fee Related
-
1996
- 1996-11-13 WO PCT/US1996/018172 patent/WO1997018188A1/en not_active Application Discontinuation
- 1996-11-13 AU AU77296/96A patent/AU710666B2/en not_active Ceased
- 1996-11-13 JP JP51903097A patent/JP2002504073A/ja not_active Ceased
- 1996-11-13 ES ES96940406T patent/ES2196190T3/es not_active Expired - Lifetime
- 1996-11-13 AT AT96940406T patent/ATE236873T1/de not_active IP Right Cessation
- 1996-11-13 IL IL12350296A patent/IL123502A0/xx unknown
- 1996-11-13 PT PT96940406T patent/PT874808E/pt unknown
- 1996-11-13 DE DE69627380T patent/DE69627380T2/de not_active Expired - Fee Related
- 1996-11-13 KR KR1019980703596A patent/KR19990067573A/ko not_active Application Discontinuation
- 1996-11-13 EP EP96940406A patent/EP0874808B1/en not_active Expired - Lifetime
- 1996-11-13 DK DK96940406T patent/DK0874808T3/da active
-
1998
- 1998-05-13 MX MX9803809A patent/MX9803809A/es unknown
Also Published As
Publication number | Publication date |
---|---|
AU7729696A (en) | 1997-06-05 |
KR19990067573A (ko) | 1999-08-25 |
US5665777A (en) | 1997-09-09 |
DK0874808T3 (da) | 2003-08-04 |
ATE236873T1 (de) | 2003-04-15 |
JP2002504073A (ja) | 2002-02-05 |
EP0874808A1 (en) | 1998-11-04 |
AU710666B2 (en) | 1999-09-23 |
DE69627380D1 (en) | 2003-05-15 |
WO1997018188A1 (en) | 1997-05-22 |
IL123502A0 (en) | 1998-09-24 |
EP0874808B1 (en) | 2003-04-09 |
MX9803809A (es) | 1998-09-30 |
DE69627380T2 (de) | 2004-03-25 |
PT874808E (pt) | 2003-08-29 |
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