NZ538726A - N-substituted hydromorphones and the use thereof - Google Patents
N-substituted hydromorphones and the use thereofInfo
- Publication number
- NZ538726A NZ538726A NZ538726A NZ53872603A NZ538726A NZ 538726 A NZ538726 A NZ 538726A NZ 538726 A NZ538726 A NZ 538726A NZ 53872603 A NZ53872603 A NZ 53872603A NZ 538726 A NZ538726 A NZ 538726A
- Authority
- NZ
- New Zealand
- Prior art keywords
- compound
- pain
- compounds
- pharmaceutically acceptable
- human animal
- Prior art date
Links
- WVLOADHCBXTIJK-YNHQPCIGSA-N hydromorphone Chemical class O([C@H]1C(CC[C@H]23)=O)C4=C5[C@@]12CCN(C)[C@@H]3CC5=CC=C4O WVLOADHCBXTIJK-YNHQPCIGSA-N 0.000 title claims description 15
- 150000001875 compounds Chemical class 0.000 claims abstract description 82
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- 230000036407 pain Effects 0.000 claims abstract description 31
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- 238000004519 manufacturing process Methods 0.000 claims abstract description 5
- 238000000034 method Methods 0.000 claims description 25
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- 150000003839 salts Chemical class 0.000 claims description 19
- 210000004556 brain Anatomy 0.000 claims description 11
- 230000000694 effects Effects 0.000 claims description 11
- 208000000094 Chronic Pain Diseases 0.000 claims description 10
- 210000003169 central nervous system Anatomy 0.000 claims description 9
- 229960001410 hydromorphone Drugs 0.000 claims description 9
- 239000008194 pharmaceutical composition Substances 0.000 claims description 9
- 238000012360 testing method Methods 0.000 claims description 9
- 125000000217 alkyl group Chemical group 0.000 claims description 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 8
- 208000035475 disorder Diseases 0.000 claims description 6
- 230000005284 excitation Effects 0.000 claims description 6
- 238000009472 formulation Methods 0.000 claims description 6
- BRUQQQPBMZOVGD-XFKAJCMBSA-N Oxycodone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(OC)C2=C5[C@@]13CCN4C BRUQQQPBMZOVGD-XFKAJCMBSA-N 0.000 claims description 4
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- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical compound IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 claims description 4
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 4
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- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- 239000004408 titanium dioxide Substances 0.000 description 1
- JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
- 235000010487 tragacanth Nutrition 0.000 description 1
- 239000000196 tragacanth Substances 0.000 description 1
- 229940116362 tragacanth Drugs 0.000 description 1
- 230000008733 trauma Effects 0.000 description 1
- 229940078499 tricalcium phosphate Drugs 0.000 description 1
- 235000019731 tricalcium phosphate Nutrition 0.000 description 1
- 229910000391 tricalcium phosphate Inorganic materials 0.000 description 1
- 239000001226 triphosphate Substances 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
- 208000009852 uremia Diseases 0.000 description 1
- 239000011782 vitamin Substances 0.000 description 1
- 229940088594 vitamin Drugs 0.000 description 1
- 229930003231 vitamin Natural products 0.000 description 1
- 235000013343 vitamin Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000005303 weighing Methods 0.000 description 1
- 230000036642 wellbeing Effects 0.000 description 1
- 229940100445 wheat starch Drugs 0.000 description 1
- 239000009637 wintergreen oil Substances 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
- C07D489/04—Salts; Organic complexes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/14—Antitussive agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/02—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with oxygen atoms attached in positions 3 and 6, e.g. morphine, morphinone
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Physical Education & Sports Medicine (AREA)
- Biomedical Technology (AREA)
- Rheumatology (AREA)
- Neurosurgery (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41325402P | 2002-09-25 | 2002-09-25 | |
| PCT/US2003/029876 WO2004029059A1 (en) | 2002-09-25 | 2003-09-24 | N-substituted hydromorphones and the use thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| NZ538726A true NZ538726A (en) | 2006-11-30 |
Family
ID=32043224
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| NZ538726A NZ538726A (en) | 2002-09-25 | 2003-09-24 | N-substituted hydromorphones and the use thereof |
Country Status (18)
| Country | Link |
|---|---|
| US (1) | US6825205B2 (enExample) |
| EP (2) | EP1543010B1 (enExample) |
| JP (2) | JP4806190B2 (enExample) |
| KR (1) | KR20050074462A (enExample) |
| CN (1) | CN100387600C (enExample) |
| AT (1) | ATE360633T1 (enExample) |
| AU (1) | AU2003272642B2 (enExample) |
| BR (1) | BR0314488A (enExample) |
| CA (1) | CA2500118C (enExample) |
| CY (1) | CY1106697T1 (enExample) |
| DE (1) | DE60313478T2 (enExample) |
| DK (1) | DK1543010T3 (enExample) |
| ES (1) | ES2286461T3 (enExample) |
| MX (1) | MXPA05003104A (enExample) |
| NZ (1) | NZ538726A (enExample) |
| PT (1) | PT1543010E (enExample) |
| WO (1) | WO2004029059A1 (enExample) |
| ZA (1) | ZA200502174B (enExample) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040202717A1 (en) | 2003-04-08 | 2004-10-14 | Mehta Atul M. | Abuse-resistant oral dosage forms and method of use thereof |
| US20070185145A1 (en) * | 2006-02-03 | 2007-08-09 | Royds Robert B | Pharmaceutical composition containing a central opioid agonist, a central opioid antagonist, and a peripheral opioid antagonist, and method for making the same |
| CA2663909A1 (en) | 2006-09-20 | 2008-03-27 | Mallinckrodt Inc. | Preparation of substituted morphinan-6-ones and salts and intermediates thereof |
| BRPI0719305A2 (pt) * | 2006-11-22 | 2014-02-04 | Progenics Pharm Inc | (r)-n-estereoisômeros de análogos de 7,8-saturados-4,5-epóxi-morfinano |
| EP2099456A2 (en) * | 2006-11-22 | 2009-09-16 | Progenics Pharmaceuticals, Inc. | N-oxides of 4,5-epoxy-morphinanium analogs |
| ES2598140T3 (es) * | 2007-03-06 | 2017-01-25 | Mallinckrodt Llc | Procedimiento para la preparación de sales cuaternarias de alcaloides de N-alquil morfinano |
| US9040726B2 (en) | 2007-03-06 | 2015-05-26 | Mallinckrodt Llc | Process for the preparation of quaternary N-alkyl morphinan alkaloid salts |
| EP2190819B1 (en) * | 2007-08-09 | 2016-05-25 | Rensselaer Polytechnic Institute | Quaternary opioid carboxamides |
| US8748448B2 (en) | 2007-10-18 | 2014-06-10 | Aiko Biotechnology | Combination analgesic employing opioid agonist and neutral antagonist |
| WO2009051824A2 (en) * | 2007-10-18 | 2009-04-23 | Aiko Biotechnology | Combination analgesic employing opioid and neutral antagonist |
| US20110112129A2 (en) * | 2007-11-26 | 2011-05-12 | Pharmacofore, Inc. | Peripheral Phenolic Opioid Antagonist |
| NZ589496A (en) | 2008-05-27 | 2013-02-22 | Mallinckrodt Llc | Processes and compounds for the preparation of normorphinans |
| US9458109B2 (en) | 2008-09-03 | 2016-10-04 | Mallinckrodt Llc | Substituted berbines and processes for their synthesis |
| ES2566828T3 (es) | 2010-09-21 | 2016-04-15 | Purdue Pharma L.P. | Análogos de buprenorfina como agonistas y/o antagonistas del receptor opioide |
| EP2917182B1 (en) | 2012-11-09 | 2018-01-03 | Purdue Pharma LP | Benzomorphan analogs and the use thereof |
| EP2951160B1 (en) | 2013-01-31 | 2019-04-24 | Purdue Pharma LP | Benzomorphan analogs and the use thereof |
| US8969358B2 (en) | 2013-03-15 | 2015-03-03 | Purdue Pharma L.P. | Buprenorphine analogs |
| WO2015097545A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | Opioid receptor modulating oxabicyclo[2.2.2]octane morphinans |
| WO2015097548A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | 7-beta-alkyl analogs of orvinols |
| WO2015100174A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | Ring-contracted morphinans and the use thereof |
| WO2015097547A1 (en) | 2013-12-26 | 2015-07-02 | Purdue Pharma L.P. | 10-substituted morphinan hydantoins |
| WO2015099863A1 (en) | 2013-12-27 | 2015-07-02 | Purdue Pharma L.P. | 6-substituted and 7-substituted morphinan analogs and the use thereof |
| CA2950567A1 (en) | 2014-05-27 | 2015-12-03 | Purdue Pharma L.P. | Spirocyclic morphinans and use thereof |
| JP6360915B2 (ja) | 2014-06-13 | 2018-07-18 | パーデュー、ファーマ、リミテッド、パートナーシップ | アザモルフィナン誘導体及びその使用 |
| MA41125A (fr) | 2014-12-05 | 2017-10-10 | Purdue Pharma Lp | Dérivés de 6.7-cyclomorphinane et leur utilisation |
| WO2018125716A1 (en) | 2017-01-02 | 2018-07-05 | Purdue Pharma L.P. | Morphinan derivatives and use thereof |
| CN117567477A (zh) * | 2023-11-15 | 2024-02-20 | 宜昌人福药业有限责任公司 | 一种氢吗啡酮和二氢吗啡类药物低分子聚乙二醇化物及其制备方法和应用 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3536809A (en) | 1969-02-17 | 1970-10-27 | Alza Corp | Medication method |
| US3598123A (en) | 1969-04-01 | 1971-08-10 | Alza Corp | Bandage for administering drugs |
| US3845770A (en) | 1972-06-05 | 1974-11-05 | Alza Corp | Osmatic dispensing device for releasing beneficial agent |
| US3916899A (en) | 1973-04-25 | 1975-11-04 | Alza Corp | Osmotic dispensing device with maximum and minimum sizes for the passageway |
| US4008719A (en) | 1976-02-02 | 1977-02-22 | Alza Corporation | Osmotic system having laminar arrangement for programming delivery of active agent |
| US4176186A (en) * | 1978-07-28 | 1979-11-27 | Boehringer Ingelheim Gmbh | Quaternary derivatives of noroxymorphone which relieve intestinal immobility |
| IE58110B1 (en) | 1984-10-30 | 1993-07-14 | Elan Corp Plc | Controlled release powder and process for its preparation |
| ES2051742T3 (es) * | 1987-09-10 | 1994-07-01 | Univ Chicago | Derivados cuaternarios de noroxi-morfina que mitigan las nauseas y la emesis. |
| US5073543A (en) | 1988-07-21 | 1991-12-17 | G. D. Searle & Co. | Controlled release formulations of trophic factors in ganglioside-lipsome vehicle |
| IT1229203B (it) | 1989-03-22 | 1991-07-25 | Bioresearch Spa | Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative. |
| US5120548A (en) | 1989-11-07 | 1992-06-09 | Merck & Co., Inc. | Swelling modulated polymeric drug delivery device |
| US5733566A (en) | 1990-05-15 | 1998-03-31 | Alkermes Controlled Therapeutics Inc. Ii | Controlled release of antiparasitic agents in animals |
| US5698155A (en) | 1991-05-31 | 1997-12-16 | Gs Technologies, Inc. | Method for the manufacture of pharmaceutical cellulose capsules |
| US5580578A (en) | 1992-01-27 | 1996-12-03 | Euro-Celtique, S.A. | Controlled release formulations coated with aqueous dispersions of acrylic polymers |
| US5968551A (en) | 1991-12-24 | 1999-10-19 | Purdue Pharma L.P. | Orally administrable opioid formulations having extended duration of effect |
| US5591767A (en) | 1993-01-25 | 1997-01-07 | Pharmetrix Corporation | Liquid reservoir transdermal patch for the administration of ketorolac |
| IT1270594B (it) | 1994-07-07 | 1997-05-07 | Recordati Chem Pharm | Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida |
| ES2285733T3 (es) * | 1996-11-25 | 2007-11-16 | Toray Industries, Inc. | Agente antipruritico. |
| WO2001014382A1 (en) * | 1999-08-23 | 2001-03-01 | Toray Industries, Inc. | Analgesics containing as the active ingredient quaternary ammonium salt derivatives of morphinan |
-
2003
- 2003-09-24 AU AU2003272642A patent/AU2003272642B2/en not_active Ceased
- 2003-09-24 US US10/668,326 patent/US6825205B2/en not_active Expired - Lifetime
- 2003-09-24 EP EP03754837A patent/EP1543010B1/en not_active Expired - Lifetime
- 2003-09-24 AT AT03754837T patent/ATE360633T1/de active
- 2003-09-24 BR BR0314488-7A patent/BR0314488A/pt not_active IP Right Cessation
- 2003-09-24 ES ES03754837T patent/ES2286461T3/es not_active Expired - Lifetime
- 2003-09-24 KR KR1020057005255A patent/KR20050074462A/ko not_active Ceased
- 2003-09-24 NZ NZ538726A patent/NZ538726A/en not_active IP Right Cessation
- 2003-09-24 JP JP2004540164A patent/JP4806190B2/ja not_active Expired - Fee Related
- 2003-09-24 CN CNB038229587A patent/CN100387600C/zh not_active Expired - Fee Related
- 2003-09-24 EP EP07007240A patent/EP1803724A1/en not_active Withdrawn
- 2003-09-24 PT PT03754837T patent/PT1543010E/pt unknown
- 2003-09-24 CA CA2500118A patent/CA2500118C/en not_active Expired - Fee Related
- 2003-09-24 WO PCT/US2003/029876 patent/WO2004029059A1/en not_active Ceased
- 2003-09-24 MX MXPA05003104A patent/MXPA05003104A/es active IP Right Grant
- 2003-09-24 DE DE60313478T patent/DE60313478T2/de not_active Expired - Lifetime
- 2003-09-24 DK DK03754837T patent/DK1543010T3/da active
-
2005
- 2005-03-15 ZA ZA200502174A patent/ZA200502174B/en unknown
-
2007
- 2007-07-03 CY CY20071100881T patent/CY1106697T1/el unknown
-
2010
- 2010-10-28 JP JP2010242645A patent/JP2011042681A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| DE60313478T2 (de) | 2008-01-03 |
| US20040067973A1 (en) | 2004-04-08 |
| AU2003272642B2 (en) | 2009-07-09 |
| US6825205B2 (en) | 2004-11-30 |
| CA2500118A1 (en) | 2004-04-08 |
| JP2011042681A (ja) | 2011-03-03 |
| ES2286461T3 (es) | 2007-12-01 |
| KR20050074462A (ko) | 2005-07-18 |
| MXPA05003104A (es) | 2005-05-27 |
| PT1543010E (pt) | 2007-07-26 |
| CY1106697T1 (el) | 2012-05-23 |
| HK1080456A1 (en) | 2006-04-28 |
| AU2003272642A1 (en) | 2004-04-19 |
| CA2500118C (en) | 2011-04-12 |
| DE60313478D1 (de) | 2007-06-06 |
| JP2006503850A (ja) | 2006-02-02 |
| EP1803724A1 (en) | 2007-07-04 |
| EP1543010B1 (en) | 2007-04-25 |
| ATE360633T1 (de) | 2007-05-15 |
| EP1543010A1 (en) | 2005-06-22 |
| JP4806190B2 (ja) | 2011-11-02 |
| WO2004029059A1 (en) | 2004-04-08 |
| CN1684967A (zh) | 2005-10-19 |
| ZA200502174B (en) | 2006-05-31 |
| CN100387600C (zh) | 2008-05-14 |
| DK1543010T3 (da) | 2007-09-17 |
| BR0314488A (pt) | 2005-08-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PSEA | Patent sealed | ||
| RENW | Renewal (renewal fees accepted) | ||
| RENW | Renewal (renewal fees accepted) | ||
| LAPS | Patent lapsed |