JP2020518599A5 - - Google Patents

Info

Publication number

JP2020518599A5

JP2020518599A5 JP2019559834A JP2019559834A JP2020518599A5 JP 2020518599 A5 JP2020518599 A5 JP 2020518599A5 JP 2019559834 A JP2019559834 A JP 2019559834A JP 2019559834 A JP2019559834 A JP 2019559834A JP 2020518599 A5 JP2020518599 A5 JP 2020518599A5

Authority

JP

Japan

Prior art keywords

human

approximately

antibody

seq

antibody preparation

Prior art date

2018-05-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 102100023990 60S ribosomal protein L17 Human genes 0.000 claims 37
• 101710089372 Programmed cell death protein 1 Proteins 0.000 claims 37
• 150000003839 salts Chemical class 0.000 claims 13
• 150000001413 amino acids Chemical group 0.000 claims 12
• 229930006000 Sucrose Natural products 0.000 claims 9
• 239000005720 sucrose Substances 0.000 claims 9
• FFEARJCKVFRZRR-UHFFFAOYSA-N L-Methionine Natural products CSCCC(N)C(O)=O FFEARJCKVFRZRR-UHFFFAOYSA-N 0.000 claims 8
• 229930195722 L-methionine Natural products 0.000 claims 8
• 229960004452 methionine Drugs 0.000 claims 8
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 7
• 239000000427 antigen Substances 0.000 claims 7
• 102000036639 antigens Human genes 0.000 claims 7
• 108091007433 antigens Proteins 0.000 claims 7
• 239000012634 fragment Substances 0.000 claims 7
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 7
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 7
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 7
• 229920000053 polysorbate 80 Polymers 0.000 claims 7
• 229940068968 polysorbate 80 Drugs 0.000 claims 7
• FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims 5
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
• ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical class OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims 4
• 239000003963 antioxidant agent Substances 0.000 claims 4
• 230000003078 antioxidant effect Effects 0.000 claims 4
• 239000003381 stabilizer Substances 0.000 claims 4
• ODKSFYDXXFIFQN-BYPYZUCNSA-N L-arginine Chemical compound OC(=O)[C@@H](N)CCCN=C(N)N ODKSFYDXXFIFQN-BYPYZUCNSA-N 0.000 claims 3
• 229930064664 L-arginine Natural products 0.000 claims 3
• 235000014852 L-arginine Nutrition 0.000 claims 3
• 125000000393 L-methionino group Chemical group [H]OC(=O)[C@@]([H])(N([H])[*])C([H])([H])C(SC([H])([H])[H])([H])[H] 0.000 claims 3
• 238000009472 formulation Methods 0.000 claims 3
• 239000000203 mixture Substances 0.000 claims 3
• 239000002736 nonionic surfactant Substances 0.000 claims 3
• 229960002621 pembrolizumab Drugs 0.000 claims 3
• HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 2
• -1 2-hydroxypropyl Chemical group 0.000 claims 2
• 229920000858 Cyclodextrin Polymers 0.000 claims 2
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 2
• FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 2
• 239000001116 FEMA 4028 Substances 0.000 claims 2
• 239000004471 Glycine Substances 0.000 claims 2
• 229930182821 L-proline Natural products 0.000 claims 2
• 229930195725 Mannitol Natural products 0.000 claims 2
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 2
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 2
• 229960004853 betadex Drugs 0.000 claims 2
• 239000003814 drug Substances 0.000 claims 2
• 125000000487 histidyl group Chemical group [H]N([H])C(C(=O)O*)C([H])([H])C1=C([H])N([H])C([H])=N1 0.000 claims 2
• 239000000594 mannitol Substances 0.000 claims 2
• 235000010355 mannitol Nutrition 0.000 claims 2
• 238000004519 manufacturing process Methods 0.000 claims 2
• 229960002429 proline Drugs 0.000 claims 2
• 239000000600 sorbitol Substances 0.000 claims 2
• 235000010356 sorbitol Nutrition 0.000 claims 2
• 125000000185 sucrose group Chemical group 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 208000035473 Communicable disease Diseases 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 230000001684 chronic effect Effects 0.000 claims 1
• 238000007920 subcutaneous administration Methods 0.000 claims 1