JP2019504086A5 - - Google Patents

Info

Publication number

JP2019504086A5

JP2019504086A5 JP2018540113A JP2018540113A JP2019504086A5 JP 2019504086 A5 JP2019504086 A5 JP 2019504086A5 JP 2018540113 A JP2018540113 A JP 2018540113A JP 2018540113 A JP2018540113 A JP 2018540113A JP 2019504086 A5 JP2019504086 A5 JP 2019504086A5

Authority

JP

Japan

Prior art keywords

antibody

buffered

formulation

buffer

arginine

Prior art date

2017-02-01

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 238000009472 formulation Methods 0.000 claims 18
• 239000000203 mixture Substances 0.000 claims 18
• 239000000872 buffer Substances 0.000 claims 12
• 238000002360 preparation method Methods 0.000 claims 7
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 6
• 239000004475 Arginine Substances 0.000 claims 4
• ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 4
• 150000001484 arginines Chemical class 0.000 claims 4
• FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 3
• HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 3
• 150000002411 histidines Chemical class 0.000 claims 3
• 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 3
• 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 3
• 229920000053 polysorbate 80 Polymers 0.000 claims 3
• 229940068968 polysorbate 80 Drugs 0.000 claims 3
• 239000000600 sorbitol Substances 0.000 claims 3
• 206010002556 Ankylosing Spondylitis Diseases 0.000 claims 2
• 206010009900 Colitis ulcerative Diseases 0.000 claims 2
• 208000011231 Crohn disease Diseases 0.000 claims 2
• 208000003456 Juvenile Arthritis Diseases 0.000 claims 2
• 206010059176 Juvenile idiopathic arthritis Diseases 0.000 claims 2
• 201000004681 Psoriasis Diseases 0.000 claims 2
• 201000001263 Psoriatic Arthritis Diseases 0.000 claims 2
• 208000036824 Psoriatic arthropathy Diseases 0.000 claims 2
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
• 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
• 150000001413 amino acids Chemical group 0.000 claims 2
• 201000002215 juvenile rheumatoid arthritis Diseases 0.000 claims 2
• 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
• BDKLKNJTMLIAFE-UHFFFAOYSA-N 2-(3-fluorophenyl)-1,3-oxazole-4-carbaldehyde Chemical compound FC1=CC=CC(C=2OC=C(C=O)N=2)=C1 BDKLKNJTMLIAFE-UHFFFAOYSA-N 0.000 claims 1
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 1
• 229910019142 PO4 Inorganic materials 0.000 claims 1
• 239000007853 buffer solution Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 1
• 239000010452 phosphate Substances 0.000 claims 1
• 235000017281 sodium acetate Nutrition 0.000 claims 1
• 229940087562 sodium acetate trihydrate Drugs 0.000 claims 1
• 239000011780 sodium chloride Substances 0.000 claims 1