AU2017213775A1

AU2017213775A1 - Buffer formulations for enhanced antibody stability

Buffer formulations for enhanced antibody stability Download PDF

Info

Publication number: AU2017213775A1
Authority: AU; Australia
Prior art keywords: ser; val; leu; thr; lys
Prior art date: 2016-02-03
Legal status : Abandoned

Application number

AU2017213775A

Other languages

English (en)

Inventor

Jessica CHEUNG

Hiten GUTKA

Maria TADDEI

Current Assignee

Outlook Therapeutics Inc

Original Assignee

Outlook Therapeutics Inc

Priority date

2016-02-03

Filing date

2017-02-01

Publication date

2018-08-16

2017-02-01 Application filed by Outlook Therapeutics Inc filed Critical Outlook Therapeutics Inc

2018-08-16 Publication of AU2017213775A1 publication Critical patent/AU2017213775A1/en

2019-07-04 Assigned to OUTLOOK THERAPEUTICS, INC. reassignment OUTLOOK THERAPEUTICS, INC. Amend patent request/document other than specification (104) Assignors: ONCOBIOLOGICS, INC.

Status Abandoned legal-status Critical Current

Links

239000000203 mixture Substances 0.000 title claims abstract description 300
238000009472 formulation Methods 0.000 title claims abstract description 288
239000000872 buffer Substances 0.000 title claims abstract description 152
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229960002964 adalimumab Drugs 0.000 claims abstract description 75
HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims abstract description 63
FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims abstract description 58
239000000600 sorbitol Substances 0.000 claims abstract description 58
159000000021 acetate salts Chemical class 0.000 claims abstract description 55
239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims abstract description 50
235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims abstract description 50
229920000053 polysorbate 80 Polymers 0.000 claims abstract description 50
229940068968 polysorbate 80 Drugs 0.000 claims abstract description 50
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230000002378 acidificating effect Effects 0.000 claims abstract description 23
238000000034 method Methods 0.000 claims description 79
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108090000623 proteins and genes Proteins 0.000 claims description 29
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BDKLKNJTMLIAFE-UHFFFAOYSA-N 2-(3-fluorophenyl)-1,3-oxazole-4-carbaldehyde Chemical compound FC1=CC=CC(C=2OC=C(C=O)N=2)=C1 BDKLKNJTMLIAFE-UHFFFAOYSA-N 0.000 claims description 21
229940087562 sodium acetate trihydrate Drugs 0.000 claims description 21
FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims description 19
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FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims description 16
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KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims description 4
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NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims description 3
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150000002410 histidine derivatives Chemical class 0.000 claims 3
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MDNAVFBZPROEHO-DCAQKATOSA-N Ala-Lys-Val Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(O)=O MDNAVFBZPROEHO-DCAQKATOSA-N 0.000 claims 2
MAEQBGQTDWDSJQ-LSJOCFKGSA-N Ala-Met-His Chemical compound C[C@@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC1=CN=CN1)C(=O)O)N MAEQBGQTDWDSJQ-LSJOCFKGSA-N 0.000 claims 2
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101100505161 Caenorhabditis elegans mel-32 gene Proteins 0.000 claims 2
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IULKWYSYZSURJK-AVGNSLFASA-N Gln-Leu-Lys Chemical compound NC(=O)CC[C@H](N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(O)=O IULKWYSYZSURJK-AVGNSLFASA-N 0.000 claims 1
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