PL3299380T3 - Sposoby oczyszczania polipeptydów - Google Patents
Sposoby oczyszczania polipeptydówInfo
- Publication number
- PL3299380T3 PL3299380T3 PL17167800.6T PL17167800T PL3299380T3 PL 3299380 T3 PL3299380 T3 PL 3299380T3 PL 17167800 T PL17167800 T PL 17167800T PL 3299380 T3 PL3299380 T3 PL 3299380T3
- Authority
- PL
- Poland
- Prior art keywords
- methods
- purifying polypeptides
- polypeptides
- purifying
- Prior art date
Links
- 229920001184 polypeptide Polymers 0.000 title 1
- 102000004196 processed proteins & peptides Human genes 0.000 title 1
- 108090000765 processed proteins & peptides Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3847—Multimodal interactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US34814310P | 2010-05-25 | 2010-05-25 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PL3299380T3 true PL3299380T3 (pl) | 2024-12-16 |
Family
ID=45004368
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL17167800.6T PL3299380T3 (pl) | 2010-05-25 | 2011-05-25 | Sposoby oczyszczania polipeptydów |
| PL11787363.8T PL2575847T5 (pl) | 2010-05-25 | 2011-05-25 | Sposoby oczyszczania polipeptydów |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PL11787363.8T PL2575847T5 (pl) | 2010-05-25 | 2011-05-25 | Sposoby oczyszczania polipeptydów |
Country Status (21)
| Country | Link |
|---|---|
| US (5) | US20130079272A1 (pl) |
| EP (3) | EP3299380B1 (pl) |
| JP (3) | JP5934190B2 (pl) |
| KR (1) | KR101976853B1 (pl) |
| CN (2) | CN102905718A (pl) |
| AU (1) | AU2011258254B2 (pl) |
| CA (2) | CA2799915C (pl) |
| ES (2) | ES2637613T5 (pl) |
| HK (1) | HK1246328A1 (pl) |
| HR (2) | HRP20171095T4 (pl) |
| HU (1) | HUE068857T2 (pl) |
| IL (2) | IL223029A0 (pl) |
| MX (2) | MX344248B (pl) |
| MY (1) | MY161534A (pl) |
| NZ (1) | NZ603648A (pl) |
| PL (2) | PL3299380T3 (pl) |
| RU (1) | RU2594163C2 (pl) |
| SG (2) | SG10201710439UA (pl) |
| SI (1) | SI2575847T2 (pl) |
| WO (1) | WO2011150110A1 (pl) |
| ZA (1) | ZA201208673B (pl) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SG10201710439UA (en) | 2010-05-25 | 2018-01-30 | Genentech Inc | Methods of purifying polypeptides |
| WO2013088259A2 (en) * | 2011-10-19 | 2013-06-20 | Novimmune S.A. | Methods of purifying antibodies |
| HRP20181846T1 (hr) | 2011-12-22 | 2018-12-28 | Genentech, Inc. | Kromatografija membranom za ionsku izmjenu |
| CN102911250B (zh) * | 2012-09-29 | 2014-04-16 | 浙江海正药业股份有限公司 | 酸性重组蛋白药物的纯化方法 |
| CN103880947B (zh) * | 2012-12-21 | 2016-01-13 | 武汉禾元生物科技股份有限公司 | 一种分离纯化高纯度重组人血清白蛋白的层析方法 |
| WO2014118685A2 (en) * | 2013-01-29 | 2014-08-07 | Dr. Reddy's Laboratories Limited | Method of altering the acidic variant content of antibody |
| WO2014143616A1 (en) | 2013-03-14 | 2014-09-18 | Qiagen Sciences Llc | Assessing dna quality using real-time pcr and ct values |
| CN104236983A (zh) * | 2013-06-14 | 2014-12-24 | 中国科学院大连化学物理研究所 | 溶液样品中含长烷基链的离子液体的去除方法 |
| CN105848746B (zh) * | 2013-09-05 | 2019-07-09 | 豪夫迈·罗氏有限公司 | 用于层析重复利用的方法 |
| SG10201802525QA (en) | 2013-09-13 | 2018-04-27 | Genentech Inc | Methods and compositions comprising purified recombinant polypeptides |
| KR102332302B1 (ko) | 2013-09-13 | 2021-12-01 | 제넨테크, 인크. | 세포주에서 숙주 세포 단백질 및 재조합 폴리펩티드 생성물을 검출 및 정량화하기 위한 조성물 및 방법 |
| WO2015057910A1 (en) | 2013-10-16 | 2015-04-23 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
| US8859252B1 (en) | 2014-01-02 | 2014-10-14 | Aerial Biopharma, Llc | Prostatic acid phosphatase, compositions comprising the same, and methods for producing and/or purifying the same |
| US10214747B2 (en) | 2014-01-09 | 2019-02-26 | Kentucky Bioprocessing, Inc. | Method of purifying monoclonal antibodies |
| JP6293907B2 (ja) | 2014-03-10 | 2018-03-14 | リヒター ゲデオン エヌワイアールティー. | プレクリーニング工程を用いた免疫グロブリンの精製 |
| JP6647220B2 (ja) * | 2014-05-23 | 2020-02-14 | インスティトゥート・マッソーネ・エセ・ア | Hmg−up(超高純度グレードのヒト閉経期ゴナドトロピン)を得るための方法及び夾雑物を含まない組成物 |
| EP3145951A1 (en) * | 2014-06-24 | 2017-03-29 | InSight Biopharmaceuticals Ltd. | Methods of purifying antibodies |
| GB201411802D0 (en) | 2014-07-02 | 2014-08-13 | Univ Bradford | Effervescent compositions |
| US10696735B2 (en) * | 2015-01-21 | 2020-06-30 | Outlook Therapeutics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
| EP3411401A1 (en) | 2016-02-03 | 2018-12-12 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
| ES2988363T3 (es) | 2016-06-17 | 2024-11-20 | Hoffmann La Roche | Purificación de anticuerpos multiespecíficos |
| SG11201901228QA (en) | 2016-08-15 | 2019-03-28 | Genentech Inc | Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide |
| JP6564539B1 (ja) | 2018-09-14 | 2019-08-21 | 長瀬産業株式会社 | スルホン酸化合物によるペプチド精製方法 |
| EP3898689A1 (en) * | 2018-12-20 | 2021-10-27 | Armagen, Inc. | Purification of iduronate-2-sulfatase immunoglobulin fusion protein |
| CN109765307B (zh) * | 2018-12-24 | 2021-06-29 | 山东省科学院海洋仪器仪表研究所 | 一种水体中六氯环己烷的测量方法 |
| CN111366547A (zh) * | 2018-12-26 | 2020-07-03 | 贵州中烟工业有限责任公司 | 一种用连续流动法测定烟草或烟草制品中α-氨基氮的检测方法 |
| SG11202107192VA (en) | 2019-01-23 | 2021-07-29 | Daiichi Sankyo Co Ltd | Methods for purifying antibodies comprising of a process by using activated carbon materials |
| EP3962924A1 (en) | 2019-05-03 | 2022-03-09 | Genentech, Inc. | Methods of reducing the enzymatic hydrolysis activity rate in a composition obtained from a purification platform |
| TWI870412B (zh) * | 2019-06-05 | 2025-01-21 | 美商建南德克公司 | 過載層析管柱之再生方法 |
| US20220396598A1 (en) * | 2019-10-14 | 2022-12-15 | Pierce Biotechnology, Inc. | Peptide purification formulations and methods |
| WO2021240458A2 (en) * | 2020-05-28 | 2021-12-02 | Kashiv Biosciences, Llc | An improved process of storing and preparing the protein |
| US20230251269A1 (en) * | 2020-07-15 | 2023-08-10 | The Johns Hopkins University | Comprehensive analysis of anti-allergen antibodies using phage display |
| EP4237116A1 (en) * | 2020-10-30 | 2023-09-06 | Genentech, Inc. | Purification platforms for obtaining pharmaceutical compositions having a reduced hydrolytic enzyme activity rate |
| CN112852876B (zh) * | 2021-03-04 | 2022-11-29 | 西南大学 | 一种表达人表皮生长因子的家蚕丝腺重组表达载体及其制备方法和应用 |
| EP4314009A1 (en) | 2021-03-31 | 2024-02-07 | F. Hoffmann-La Roche AG | Purification of antibodies by mixed mode chromatography |
Family Cites Families (70)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| US4399216A (en) | 1980-02-25 | 1983-08-16 | The Trustees Of Columbia University | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
| US4419446A (en) | 1980-12-31 | 1983-12-06 | The United States Of America As Represented By The Department Of Health And Human Services | Recombinant DNA process utilizing a papilloma virus DNA as a vector |
| NZ201705A (en) | 1981-08-31 | 1986-03-14 | Genentech Inc | Recombinant dna method for production of hepatitis b surface antigen in yeast |
| US4601978A (en) | 1982-11-24 | 1986-07-22 | The Regents Of The University Of California | Mammalian metallothionein promoter system |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4965199A (en) | 1984-04-20 | 1990-10-23 | Genentech, Inc. | Preparation of functional human factor VIII in mammalian cells using methotrexate based selection |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5567610A (en) | 1986-09-04 | 1996-10-22 | Bioinvent International Ab | Method of producing human monoclonal antibodies and kit therefor |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| ES2058199T3 (es) | 1987-09-23 | 1994-11-01 | Bristol Myers Squibb Co | Heteroconjugados de anticuerpos para la eliminacion de celulas infectadas por el vih. |
| ATE105585T1 (de) | 1987-12-21 | 1994-05-15 | Univ Toledo | Transformation von keimenden pflanzensamen mit hilfe von agrobacterium. |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5175384A (en) | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| FR2646437B1 (fr) | 1989-04-28 | 1991-08-30 | Transgene Sa | Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| ES2096590T3 (es) | 1989-06-29 | 1997-03-16 | Medarex Inc | Reactivos biespecificos para la terapia del sida. |
| US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
| US5229275A (en) | 1990-04-26 | 1993-07-20 | Akzo N.V. | In-vitro method for producing antigen-specific human monoclonal antibodies |
| US5571894A (en) | 1991-02-05 | 1996-11-05 | Ciba-Geigy Corporation | Recombinant antibodies specific for a growth factor receptor |
| JPH06507398A (ja) | 1991-05-14 | 1994-08-25 | リプリジェン コーポレーション | Hiv感染治療のための異種複合抗体 |
| EP0940468A1 (en) | 1991-06-14 | 1999-09-08 | Genentech, Inc. | Humanized antibody variable domain |
| MX9204374A (es) | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
| ES2136092T3 (es) | 1991-09-23 | 1999-11-16 | Medical Res Council | Procedimientos para la produccion de anticuerpos humanizados. |
| FI941572L (fi) | 1991-10-07 | 1994-05-27 | Oncologix Inc | Anti-erbB-2-monoklonaalisten vasta-aineiden yhdistelmä ja käyttömenetelmä |
| WO1993008829A1 (en) | 1991-11-04 | 1993-05-13 | The Regents Of The University Of California | Compositions that mediate killing of hiv-infected cells |
| JPH07501451A (ja) | 1991-11-25 | 1995-02-16 | エンゾン・インコーポレイテッド | 多価抗原結合タンパク質 |
| DE69333807T2 (de) | 1992-02-06 | 2006-02-02 | Chiron Corp., Emeryville | Marker für krebs und biosynthetisches bindeprotein dafür |
| JP3571337B2 (ja) | 1992-02-11 | 2004-09-29 | セル ジェネシス,インコーポレーテッド | 遺伝子標的現象による同型遺伝子接合 |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| DE69308573T2 (de) | 1992-08-17 | 1997-08-07 | Genentech Inc | Bispezifische immunoadhesine |
| US5736137A (en) | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| EP1005870B1 (en) | 1992-11-13 | 2009-01-21 | Biogen Idec Inc. | Therapeutic application of chimeric antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
| US5545328A (en) * | 1993-09-21 | 1996-08-13 | Hemosol Inc. | Purification of hemoglobin by displacement chromatography |
| CA2106612C (en) * | 1993-09-21 | 2001-02-06 | Diana Pliura | Displacement chromatography process |
| US5534615A (en) | 1994-04-25 | 1996-07-09 | Genentech, Inc. | Cardiac hypertrophy factor and uses therefor |
| US5840523A (en) | 1995-03-01 | 1998-11-24 | Genetech, Inc. | Methods and compositions for secretion of heterologous polypeptides |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| US5641870A (en) | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
| CA2242931A1 (en) | 1996-01-31 | 1997-08-07 | David Francis Elgar | Production of an immunoglobulin enriched fraction from whey protein solutions |
| US6037454A (en) | 1996-11-27 | 2000-03-14 | Genentech, Inc. | Humanized anti-CD11a antibodies |
| US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
| ES2292682T3 (es) | 1998-05-06 | 2008-03-16 | Genentech, Inc. | Purificacion de anticuerpos mediante cromatografia de intercambio ionico. |
| AU2003265235A1 (en) | 2002-04-26 | 2003-12-19 | Genetech, Inc. | Non-affinity purification of proteins |
| SE526227C2 (sv) | 2002-05-15 | 2005-08-02 | North China Pharmaceutical Group | Metod för rening av rekombinant humant serumalbumin |
| BRPI0510915A (pt) | 2004-06-04 | 2007-11-13 | Genentech Inc | método para o tratamento da esclerose múltipla e artigo manufaturado |
| US20060067930A1 (en) | 2004-08-19 | 2006-03-30 | Genentech, Inc. | Polypeptide variants with altered effector function |
| KR101270829B1 (ko) | 2004-09-23 | 2013-06-07 | 제넨테크, 인크. | 시스테인 유전자조작 항체 및 접합체 |
| WO2006043895A1 (en) † | 2004-10-21 | 2006-04-27 | Ge Healthcare Bio-Sciences Ab | A method of antibody purification |
| WO2006099308A2 (en) † | 2005-03-11 | 2006-09-21 | Wyeth | A method of weak partitioning chromatography |
| EP1869067A1 (en) | 2005-04-11 | 2007-12-26 | Medarex, Inc. | Protein purification using hcic amd ion exchange chromatography |
| DE112006001012B4 (de) | 2005-04-22 | 2017-05-18 | Waters Technologies Corp. (N.D.Ges.D. Staates Delaware) | Verfahren für eine auf Massenspektrometrie gerichtete Aufbereitung von Biopolymeren |
| US7691980B2 (en) * | 2007-01-09 | 2010-04-06 | Bio-Rad Laboratories, Inc. | Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers |
| MX2009007632A (es) | 2007-01-22 | 2009-07-24 | Genentech Inc | Precipitacion de polielectrolito y purificacion de proteinas. |
| RU2009148891A (ru) | 2007-06-01 | 2011-07-20 | Ф.Хоффманн-Ля Рош Аг (Ch) | Очистка иммуноглобулина |
| US9433922B2 (en) * | 2007-08-14 | 2016-09-06 | Emd Millipore Corporation | Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same |
| BRPI0817182A2 (pt) † | 2007-10-30 | 2015-03-17 | Genentech Inc | Método para purificar um anticorpo e composições |
| JP5999899B2 (ja) † | 2008-04-08 | 2016-09-28 | バイオ−ラッド ラボラトリーズ インコーポレーティッド | 抗体のクロマトグラフィー精製法 |
| US20110105725A1 (en) | 2008-05-15 | 2011-05-05 | Novo Nordisk A/S | Antibody purification process |
| CN102149724B (zh) | 2008-08-14 | 2014-04-09 | 健泰科生物技术公司 | 使用原地蛋白质置换离子交换膜层析清除污染物的方法 |
| EP2360183B1 (en) | 2008-12-19 | 2016-07-27 | Takeda Pharmaceutical Company Limited | Antibody purification method by mixed mode chromatography utilizing an arginine-containing loading solution |
| CN102413839A (zh) * | 2009-03-06 | 2012-04-11 | 医学免疫有限责任公司 | 人源化抗cd19抗体制剂 |
| CN102574911B (zh) | 2009-08-07 | 2017-06-06 | Emd密理博公司 | 从样品的一或多种杂质中纯化靶蛋白的方法 |
| WO2011035282A1 (en) | 2009-09-21 | 2011-03-24 | Ge Healthcare Bio-Sciences Ab | Dual capture separation |
| EP2480561B1 (en) * | 2009-09-23 | 2016-07-13 | E. R. Squibb & Sons, L.L.C. | Cation exchange chromatography |
| SG10201710439UA (en) | 2010-05-25 | 2018-01-30 | Genentech Inc | Methods of purifying polypeptides |
| WO2012068134A1 (en) | 2010-11-15 | 2012-05-24 | Biogen Idec Inc. | Enrichment and concentration of select product isoforms by overloaded bind and elute chromatography |
-
2011
- 2011-05-25 SG SG10201710439UA patent/SG10201710439UA/en unknown
- 2011-05-25 CN CN2011800254040A patent/CN102905718A/zh active Pending
- 2011-05-25 ES ES11787363T patent/ES2637613T5/es active Active
- 2011-05-25 HR HRP20171095TT patent/HRP20171095T4/hr unknown
- 2011-05-25 PL PL17167800.6T patent/PL3299380T3/pl unknown
- 2011-05-25 CA CA2799915A patent/CA2799915C/en active Active
- 2011-05-25 PL PL11787363.8T patent/PL2575847T5/pl unknown
- 2011-05-25 RU RU2012156271/04A patent/RU2594163C2/ru active
- 2011-05-25 WO PCT/US2011/037977 patent/WO2011150110A1/en not_active Ceased
- 2011-05-25 MX MX2012013575A patent/MX344248B/es active IP Right Grant
- 2011-05-25 NZ NZ603648A patent/NZ603648A/en unknown
- 2011-05-25 EP EP17167800.6A patent/EP3299380B1/en active Active
- 2011-05-25 SG SG2012086419A patent/SG185737A1/en unknown
- 2011-05-25 CA CA3209878A patent/CA3209878A1/en active Pending
- 2011-05-25 AU AU2011258254A patent/AU2011258254B2/en active Active
- 2011-05-25 MX MX2016016228A patent/MX370828B/es unknown
- 2011-05-25 ES ES17167800T patent/ES2991883T3/es active Active
- 2011-05-25 JP JP2013512218A patent/JP5934190B2/ja active Active
- 2011-05-25 EP EP11787363.8A patent/EP2575847B2/en active Active
- 2011-05-25 HU HUE17167800A patent/HUE068857T2/hu unknown
- 2011-05-25 SI SI201131267T patent/SI2575847T2/sl unknown
- 2011-05-25 HR HRP20241463TT patent/HRP20241463T1/hr unknown
- 2011-05-25 KR KR1020127033600A patent/KR101976853B1/ko active Active
- 2011-05-25 MY MYPI2012005025A patent/MY161534A/en unknown
- 2011-05-25 EP EP24189611.7A patent/EP4492053A3/en active Pending
- 2011-05-25 CN CN201710269454.2A patent/CN107365346A/zh active Pending
-
2012
- 2012-11-14 IL IL223029A patent/IL223029A0/en active IP Right Grant
- 2012-11-19 ZA ZA2012/08673A patent/ZA201208673B/en unknown
- 2012-11-20 US US13/682,620 patent/US20130079272A1/en not_active Abandoned
-
2016
- 2016-05-06 JP JP2016093347A patent/JP6272941B2/ja active Active
-
2018
- 2018-01-04 JP JP2018000140A patent/JP2018087192A/ja active Pending
- 2018-05-08 HK HK18105945.5A patent/HK1246328A1/zh unknown
- 2018-08-14 IL IL261147A patent/IL261147A/en unknown
- 2018-10-22 US US16/167,364 patent/US20190300566A1/en not_active Abandoned
-
2020
- 2020-01-22 US US16/749,888 patent/US20200399307A1/en not_active Abandoned
-
2021
- 2021-07-07 US US17/369,765 patent/US12152054B2/en active Active
-
2024
- 2024-10-16 US US18/917,874 patent/US20250034204A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PL3299380T3 (pl) | Sposoby oczyszczania polipeptydów | |
| DK2625295T3 (da) | High-throughput-immunsekvensering | |
| LT3703369T (lt) | Ėminių srities sujungimas | |
| DK2598514T3 (da) | Proteinoprensning | |
| DK2536830T3 (da) | Polypeptider | |
| IL225897A0 (en) | Cxcr2 binding polypeptides | |
| DK3459564T3 (da) | Plasmakallikreinbindende proteiner | |
| EP2609148A4 (en) | PHTHALIC ACID-FREE SOFT MAKER | |
| EP2622818A4 (en) | EXPANSION OF ATTENTION COMMANDS | |
| EP2641343A4 (en) | CONFIGURATION OF A BUILDING | |
| DK2598516T3 (da) | Fremgangsmåde til proteinoprensning | |
| BR112013024521A2 (pt) | métodos de purificação de proteínas | |
| PL3299356T3 (pl) | Sposób wytwarzania pleuromutylin | |
| ME02224B (me) | Antikancerski fuzioni protein | |
| DK2568821T3 (da) | Æggeskal-membran-separationsfremgangsmåde | |
| HRP20190030T1 (hr) | Postupak pročišćavanja protutijela | |
| EP2553017A4 (en) | POLYSTYRENE MIXTURES | |
| FR2968671B1 (fr) | Sequencage maspet | |
| BR112013009679A2 (pt) | peptídeo | |
| FR2956419B1 (fr) | Elements de construction calorifuges | |
| BR112013014731A2 (pt) | tamavidina modificada | |
| FR2955136B1 (fr) | Arret de vantail | |
| EP2714717A4 (en) | PHOENIXINPEPTIDE | |
| UA21042S (uk) | Комплект бланків | |
| FI9590U1 (fi) | Laituri |