MX370828B - Métodos de purificación de polipéptidos. - Google Patents

Métodos de purificación de polipéptidos.

Info

Publication number
MX370828B
MX370828B MX2016016228A MX2016016228A MX370828B MX 370828 B MX370828 B MX 370828B MX 2016016228 A MX2016016228 A MX 2016016228A MX 2016016228 A MX2016016228 A MX 2016016228A MX 370828 B MX370828 B MX 370828B
Authority
MX
Mexico
Prior art keywords
methods
polypeptide
purifying
purifying polypeptides
polypeptides
Prior art date
Application number
MX2016016228A
Other languages
English (en)
Inventor
Hui F Liu
Brian David Kelley
Deanna E Myers
Beth Mccooey
Krista Marie Petty
Original Assignee
Genentech Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45004368&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX370828(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Genentech Inc filed Critical Genentech Inc
Publication of MX370828B publication Critical patent/MX370828B/es

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/18Ion-exchange chromatography
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361Ion-exchange
    • B01D15/362Cation-exchange
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D15/00Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08Selective adsorption, e.g. chromatography
    • B01D15/26Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3847Multimodal interactions
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/165Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K1/00General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14Extraction; Separation; Purification
    • C07K1/16Extraction; Separation; Purification by chromatography
    • C07K1/22Affinity chromatography or related techniques based upon selective absorption processes
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02Column chromatography
    • G01N30/88Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8831Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

La presente invención se refiere a un método para purificar un anticuerpo o una inmunoadhesina de una composición que comprende el anticuerpo o la inmunoadhesina y al menos un contaminante de proteína de ovario de hámster chico a un pH de 4.5 a 6.5.
MX2016016228A 2010-05-25 2011-05-25 Métodos de purificación de polipéptidos. MX370828B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US34814310P 2010-05-25 2010-05-25
PCT/US2011/037977 WO2011150110A1 (en) 2010-05-25 2011-05-25 Methods of purifying polypeptides

Publications (1)

Publication Number Publication Date
MX370828B true MX370828B (es) 2020-01-08

Family

ID=45004368

Family Applications (2)

Application Number Title Priority Date Filing Date
MX2012013575A MX344248B (es) 2010-05-25 2011-05-25 Metodos de purificacion de polipeptidos.
MX2016016228A MX370828B (es) 2010-05-25 2011-05-25 Métodos de purificación de polipéptidos.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
MX2012013575A MX344248B (es) 2010-05-25 2011-05-25 Metodos de purificacion de polipeptidos.

Country Status (21)

Country Link
US (4) US20130079272A1 (es)
EP (2) EP3299380B1 (es)
JP (3) JP5934190B2 (es)
KR (1) KR101976853B1 (es)
CN (2) CN102905718A (es)
AU (1) AU2011258254B2 (es)
BR (1) BR112012029904A2 (es)
CA (2) CA2799915C (es)
ES (1) ES2637613T5 (es)
HK (1) HK1246328A1 (es)
HR (1) HRP20171095T4 (es)
IL (2) IL223029A0 (es)
MX (2) MX344248B (es)
MY (1) MY161534A (es)
NZ (1) NZ603648A (es)
PL (1) PL2575847T5 (es)
RU (1) RU2594163C2 (es)
SG (2) SG185737A1 (es)
SI (1) SI2575847T2 (es)
WO (1) WO2011150110A1 (es)
ZA (1) ZA201208673B (es)

Families Citing this family (31)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2013088259A2 (en) * 2011-10-19 2013-06-20 Novimmune S.A. Methods of purifying antibodies
MX360453B (es) 2011-12-22 2018-11-01 Genentech Inc Cromatografia de membrana de intercambio ionico.
CN102911250B (zh) * 2012-09-29 2014-04-16 浙江海正药业股份有限公司 酸性重组蛋白药物的纯化方法
CN103880947B (zh) * 2012-12-21 2016-01-13 武汉禾元生物科技股份有限公司 一种分离纯化高纯度重组人血清白蛋白的层析方法
WO2014118685A2 (en) * 2013-01-29 2014-08-07 Dr. Reddy's Laboratories Limited Method of altering the acidic variant content of antibody
WO2014143616A1 (en) * 2013-03-14 2014-09-18 Qiagen Sciences Llc Assessing dna quality using real-time pcr and ct values
CN104236983A (zh) * 2013-06-14 2014-12-24 中国科学院大连化学物理研究所 溶液样品中含长烷基链的离子液体的去除方法
US20150093800A1 (en) * 2013-09-05 2015-04-02 Genentech, Inc. Method for chromatography reuse
SG10201802525QA (en) 2013-09-13 2018-04-27 Genentech Inc Methods and compositions comprising purified recombinant polypeptides
BR112016004437A2 (pt) 2013-09-13 2017-10-17 Genentech Inc métodos de imunoteste e de seleção de linhagem de células, anticorpos e kit
CA2926588C (en) 2013-10-16 2020-07-21 Oncobiologics, Inc. Buffer formulations for enhanced antibody stability
US8859252B1 (en) 2014-01-02 2014-10-14 Aerial Biopharma, Llc Prostatic acid phosphatase, compositions comprising the same, and methods for producing and/or purifying the same
WO2015105551A1 (en) * 2014-01-09 2015-07-16 Kentucky Bioprocessing, Inc. Method of purifying monoclonal antibodies
HUE048782T2 (hu) 2014-03-10 2020-08-28 Richter Gedeon Nyrt Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával
US9920107B2 (en) 2014-05-23 2018-03-20 Instituto Massone S.A. Process for obtaining HMG-UP (human menopausal gonadotropin with ultra-purity grade) and a composition free of contaminants
WO2015198320A1 (en) * 2014-06-24 2015-12-30 Insight Biopharmaceuticals Ltd. Methods of purifying antibodies
GB201411802D0 (en) 2014-07-02 2014-08-13 Univ Bradford Effervescent compositions
EP3247718B1 (en) * 2015-01-21 2021-09-01 Outlook Therapeutics, Inc. Modulation of charge variants in a monoclonal antibody composition
AU2017213775A1 (en) 2016-02-03 2018-08-16 Outlook Therapeutics, Inc. Buffer formulations for enhanced antibody stability
EP3472177B1 (en) 2016-06-17 2024-08-14 F. Hoffmann-La Roche AG Purification of multispecific antibodies
CN109716127B (zh) * 2016-08-15 2022-06-14 豪夫迈·罗氏有限公司 定量包含非离子表面活性剂和多肽的组合物中非离子表面活性剂的层析方法
JP6564539B1 (ja) 2018-09-14 2019-08-21 長瀬産業株式会社 スルホン酸化合物によるペプチド精製方法
JP7458404B2 (ja) * 2018-12-20 2024-03-29 アーマジェン・インコーポレイテッド イズロン酸-2-スルファターゼ免疫グロブリン融合タンパク質の精製
CN109765307B (zh) * 2018-12-24 2021-06-29 山东省科学院海洋仪器仪表研究所 一种水体中六氯环己烷的测量方法
CN111366547A (zh) * 2018-12-26 2020-07-03 贵州中烟工业有限责任公司 一种用连续流动法测定烟草或烟草制品中α-氨基氮的检测方法
US20220098235A1 (en) 2019-01-23 2022-03-31 Daiichi Sankyo Company, Limited Methods for purifying antibodies comprising of a process by using activated carbon materials
TW202112799A (zh) * 2019-06-05 2021-04-01 美商建南德克公司 過載層析管柱之再生方法
WO2021076489A1 (en) * 2019-10-14 2021-04-22 Pierce Biotechnology, Inc. Peptide purification formulations and methods
US20230251269A1 (en) * 2020-07-15 2023-08-10 The Johns Hopkins University Comprehensive analysis of anti-allergen antibodies using phage display
CN112852876B (zh) * 2021-03-04 2022-11-29 西南大学 一种表达人表皮生长因子的家蚕丝腺重组表达载体及其制备方法和应用
WO2022207615A1 (en) 2021-03-31 2022-10-06 F. Hoffmann-La Roche Ag Purification of antibodies by mixed mode chromatography

Family Cites Families (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4704362A (en) 1977-11-08 1987-11-03 Genentech, Inc. Recombinant cloning vehicle microbial polypeptide expression
FR2413974A1 (fr) 1978-01-06 1979-08-03 David Bernard Sechoir pour feuilles imprimees par serigraphie
US4399216A (en) 1980-02-25 1983-08-16 The Trustees Of Columbia University Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials
US4419446A (en) 1980-12-31 1983-12-06 The United States Of America As Represented By The Department Of Health And Human Services Recombinant DNA process utilizing a papilloma virus DNA as a vector
NZ201705A (en) 1981-08-31 1986-03-14 Genentech Inc Recombinant dna method for production of hepatitis b surface antigen in yeast
US4601978A (en) 1982-11-24 1986-07-22 The Regents Of The University Of California Mammalian metallothionein promoter system
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
US4965199A (en) 1984-04-20 1990-10-23 Genentech, Inc. Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
US4676980A (en) 1985-09-23 1987-06-30 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Target specific cross-linked heteroantibodies
US5567610A (en) 1986-09-04 1996-10-22 Bioinvent International Ab Method of producing human monoclonal antibodies and kit therefor
IL85035A0 (en) 1987-01-08 1988-06-30 Int Genetic Eng Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same
EP0397687B1 (en) 1987-12-21 1994-05-11 The University Of Toledo Agrobacterium mediated transformation of germinating plant seeds
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5175384A (en) 1988-12-05 1992-12-29 Genpharm International Transgenic mice depleted in mature t-cells and methods for making transgenic mice
FR2646437B1 (fr) 1989-04-28 1991-08-30 Transgene Sa Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
EP0402226A1 (en) 1989-06-06 1990-12-12 Institut National De La Recherche Agronomique Transformation vectors for yeast yarrowia
DE3920358A1 (de) 1989-06-22 1991-01-17 Behringwerke Ag Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung
WO1991000360A1 (en) 1989-06-29 1991-01-10 Medarex, Inc. Bispecific reagents for aids therapy
US5208020A (en) 1989-10-25 1993-05-04 Immunogen Inc. Cytotoxic agents comprising maytansinoids and their therapeutic use
US5229275A (en) 1990-04-26 1993-07-20 Akzo N.V. In-vitro method for producing antigen-specific human monoclonal antibodies
US5571894A (en) 1991-02-05 1996-11-05 Ciba-Geigy Corporation Recombinant antibodies specific for a growth factor receptor
WO1992020373A1 (en) 1991-05-14 1992-11-26 Repligen Corporation Heteroconjugate antibodies for treatment of hiv infection
AU675916B2 (en) 1991-06-14 1997-02-27 Genentech Inc. Method for making humanized antibodies
IE922437A1 (en) 1991-07-25 1993-01-27 Idec Pharma Corp Recombinant antibodies for human therapy
ES2136092T3 (es) 1991-09-23 1999-11-16 Medical Res Council Procedimientos para la produccion de anticuerpos humanizados.
US5587458A (en) 1991-10-07 1996-12-24 Aronex Pharmaceuticals, Inc. Anti-erbB-2 antibodies, combinations thereof, and therapeutic and diagnostic uses thereof
WO1993008829A1 (en) 1991-11-04 1993-05-13 The Regents Of The University Of California Compositions that mediate killing of hiv-infected cells
EP1136556B1 (en) 1991-11-25 2005-06-08 Enzon, Inc. Method of producing multivalent antigen-binding proteins
DE69333807T2 (de) 1992-02-06 2006-02-02 Chiron Corp., Emeryville Marker für krebs und biosynthetisches bindeprotein dafür
JP3571337B2 (ja) 1992-02-11 2004-09-29 セル ジェネシス,インコーポレーテッド 遺伝子標的現象による同型遺伝子接合
US5573905A (en) 1992-03-30 1996-11-12 The Scripps Research Institute Encoded combinatorial chemical libraries
ATE149570T1 (de) 1992-08-17 1997-03-15 Genentech Inc Bispezifische immunoadhesine
US5736137A (en) 1992-11-13 1998-04-07 Idec Pharmaceuticals Corporation Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
NZ258392A (en) 1992-11-13 1997-09-22 Idec Pharma Corp Chimeric and radiolabelled antibodies to the b lymphocyte cellsurface antigen bp35 (cd-20) and their use in the treatment of b cell lymphona
US5545328A (en) * 1993-09-21 1996-08-13 Hemosol Inc. Purification of hemoglobin by displacement chromatography
CA2106612C (en) * 1993-09-21 2001-02-06 Diana Pliura Displacement chromatography process
US5534615A (en) 1994-04-25 1996-07-09 Genentech, Inc. Cardiac hypertrophy factor and uses therefor
US5840523A (en) 1995-03-01 1998-11-24 Genetech, Inc. Methods and compositions for secretion of heterologous polypeptides
US5731168A (en) 1995-03-01 1998-03-24 Genentech, Inc. Method for making heteromultimeric polypeptides
US5641870A (en) 1995-04-20 1997-06-24 Genentech, Inc. Low pH hydrophobic interaction chromatography for antibody purification
US5712374A (en) 1995-06-07 1998-01-27 American Cyanamid Company Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates
AU1458497A (en) * 1996-01-31 1997-08-22 John Stephen Ayers Production of an immunoglobulin enriched fraction from whey protein solutions
US6037454A (en) 1996-11-27 2000-03-14 Genentech, Inc. Humanized anti-CD11a antibodies
US20020032315A1 (en) 1997-08-06 2002-03-14 Manuel Baca Anti-vegf antibodies
ATE370961T1 (de) * 1998-05-06 2007-09-15 Genentech Inc Reinigung von antikörpern durch ionenaustauschchromatographie
SE526227C2 (sv) * 2002-05-15 2005-08-02 North China Pharmaceutical Group Metod för rening av rekombinant humant serumalbumin
AU2005285347A1 (en) 2004-08-19 2006-03-23 Genentech, Inc. Polypeptide variants with altered effector function
AU2005286607B2 (en) 2004-09-23 2011-01-27 Genentech, Inc. Cysteine engineered antibodies and conjugates
DK1827691T3 (en) 2004-10-21 2017-02-13 Ge Healthcare Bioprocess R&D Ab chromatography matrix
DK1869065T3 (da) 2005-03-11 2020-06-08 Wyeth Llc Fremgangsmåde til kromatografi med svag opdeling
CA2604877A1 (en) * 2005-04-11 2006-10-19 J.P. Sercel Associates Inc. Protein purification
US7691980B2 (en) 2007-01-09 2010-04-06 Bio-Rad Laboratories, Inc. Enhanced capacity and purification of antibodies by mixed mode chromatography in the presence of aqueous-soluble nonionic organic polymers
US9433922B2 (en) * 2007-08-14 2016-09-06 Emd Millipore Corporation Media for membrane ion exchange chromatography based on polymeric primary amines, sorption device containing that media, and chromatography scheme and purification method using the same
HUE037409T2 (hu) * 2007-10-30 2018-08-28 Genentech Inc Antitest-tisztítás kationcserés kromatográfiával
US8188242B2 (en) 2008-04-08 2012-05-29 Bio-Rad Laboratories, Inc. Chromatography purification of antibodies
WO2010019148A1 (en) 2008-08-14 2010-02-18 Genentech, Inc. Methods for removing a contaminant using indigenous protein displacement ion exchange membrane chromatography
WO2010071208A1 (ja) 2008-12-19 2010-06-24 武田薬品工業株式会社 抗体の精製方法
WO2010102276A2 (en) * 2009-03-06 2010-09-10 Medimmune, Llc Humanized anti-cd19 antibody formulations
US20120178910A1 (en) * 2009-09-23 2012-07-12 Medarex, Inc. Cation exchange chromatography (methods)

Also Published As

Publication number Publication date
RU2012156271A (ru) 2014-06-27
NZ603648A (en) 2014-12-24
JP2016190851A (ja) 2016-11-10
ES2637613T5 (es) 2022-07-20
KR20130086544A (ko) 2013-08-02
AU2011258254B2 (en) 2016-01-07
JP6272941B2 (ja) 2018-01-31
CN107365346A (zh) 2017-11-21
JP2018087192A (ja) 2018-06-07
CA2799915C (en) 2023-09-26
SG10201710439UA (en) 2018-01-30
SG185737A1 (en) 2013-01-30
US20130079272A1 (en) 2013-03-28
EP3299380B1 (en) 2024-08-28
CN102905718A (zh) 2013-01-30
US20190300566A1 (en) 2019-10-03
JP5934190B2 (ja) 2016-06-15
PL2575847T5 (pl) 2022-07-18
SI2575847T1 (sl) 2017-09-29
MX344248B (es) 2016-12-09
HRP20171095T4 (hr) 2022-07-22
ES2637613T3 (es) 2017-10-13
CA2799915A1 (en) 2011-12-01
HK1246328A1 (zh) 2018-09-07
EP2575847A4 (en) 2014-10-08
WO2011150110A1 (en) 2011-12-01
US20220064209A1 (en) 2022-03-03
CA3209878A1 (en) 2011-12-01
SI2575847T2 (sl) 2022-08-31
AU2011258254A1 (en) 2013-01-10
IL261147A (en) 2018-10-31
KR101976853B1 (ko) 2019-05-09
JP2013530156A (ja) 2013-07-25
BR112012029904A2 (pt) 2017-08-08
EP3299380A1 (en) 2018-03-28
IL223029A0 (en) 2013-02-03
EP2575847B2 (en) 2022-04-27
EP2575847B1 (en) 2017-06-14
RU2594163C2 (ru) 2016-08-10
ZA201208673B (en) 2016-02-24
EP2575847A1 (en) 2013-04-10
PL2575847T3 (pl) 2017-10-31
MX2012013575A (es) 2013-03-21
HRP20171095T1 (hr) 2017-10-06
US20200399307A1 (en) 2020-12-24
MY161534A (en) 2017-04-28

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