TR201903707T4 - Aşırı yükleme ve elüsyon kromatografisi. - Google Patents

Aşırı yükleme ve elüsyon kromatografisi. Download PDF

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Publication number
TR201903707T4
TR201903707T4 TR2019/03707T TR201903707T TR201903707T4 TR 201903707 T4 TR201903707 T4 TR 201903707T4 TR 2019/03707 T TR2019/03707 T TR 2019/03707T TR 201903707 T TR201903707 T TR 201903707T TR 201903707 T4 TR201903707 T4 TR 201903707T4
Authority
TR
Turkey
Prior art keywords
overloading
elution chromatography
elution
polypeptide
chromatography
Prior art date
Application number
TR2019/03707T
Other languages
English (en)
Inventor
Nadarajah Deepa
Mehta Amit
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48192803&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR201903707(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of TR201903707T4 publication Critical patent/TR201903707T4/tr

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/10—Selective adsorption, e.g. chromatography characterised by constructional or operational features
    • B01D15/14—Selective adsorption, e.g. chromatography characterised by constructional or operational features relating to the introduction of the feed to the apparatus
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/42—Selective adsorption, e.g. chromatography characterised by the development mode, e.g. by displacement or by elution
    • B01D15/424—Elution mode
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/32—Bonded phase chromatography
    • B01D15/325—Reversed phase
    • B01D15/327—Reversed phase with hydrophobic interaction
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction
    • B01D15/361—Ion-exchange
    • B01D15/363—Anion-exchange
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3804—Affinity chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
    • B01D15/08—Selective adsorption, e.g. chromatography
    • B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
    • B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 - B01D15/36
    • B01D15/3847—Multimodal interactions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)

Abstract

Mevcut buluş, bir polipeptit ve en az bir kirletici içeren bir bileşimden bu polipeptidin, bir kromatografi materyalinin aşırı yüklenmesi ve ürünün elüsyonu yoluyla saflaştırılmasına yönelik metotlar sağlar.
TR2019/03707T 2011-11-02 2012-11-02 Aşırı yükleme ve elüsyon kromatografisi. TR201903707T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161554898P 2011-11-02 2011-11-02

Publications (1)

Publication Number Publication Date
TR201903707T4 true TR201903707T4 (tr) 2019-04-22

Family

ID=48192803

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/03707T TR201903707T4 (tr) 2011-11-02 2012-11-02 Aşırı yükleme ve elüsyon kromatografisi.

Country Status (25)

Country Link
US (3) US20140301977A1 (tr)
EP (3) EP3257564B2 (tr)
JP (4) JP6356607B2 (tr)
KR (1) KR20140091721A (tr)
CN (2) CN107163101B (tr)
AU (1) AU2012323995B2 (tr)
BR (1) BR112014010406A2 (tr)
CA (1) CA2854330A1 (tr)
DK (2) DK3257564T3 (tr)
ES (2) ES2717536T3 (tr)
HK (1) HK1201489A1 (tr)
HR (1) HRP20190485T1 (tr)
HU (2) HUE043755T2 (tr)
IL (1) IL232146A0 (tr)
LT (1) LT3257564T (tr)
MX (1) MX2014005330A (tr)
PL (2) PL3257564T3 (tr)
PT (1) PT3257564T (tr)
RS (1) RS58472B1 (tr)
RU (1) RU2014121884A (tr)
SG (1) SG11201402019TA (tr)
SI (2) SI3257564T1 (tr)
TR (1) TR201903707T4 (tr)
WO (1) WO2013067301A1 (tr)
ZA (1) ZA201402932B (tr)

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US20140301977A1 (en) 2014-10-09
CN104023804B (zh) 2017-05-24
LT3257564T (lt) 2019-04-10
US20190023768A1 (en) 2019-01-24
JP2022033774A (ja) 2022-03-02
CN104023804A (zh) 2014-09-03
EP2773438A4 (en) 2015-06-03
EP3527274A1 (en) 2019-08-21
SI3257564T1 (sl) 2019-04-30
JP2020059718A (ja) 2020-04-16
HK1201489A1 (en) 2015-09-04
IL232146A0 (en) 2014-05-28
ZA201402932B (en) 2016-08-31
US20210206836A1 (en) 2021-07-08
HUE043755T2 (hu) 2019-09-30
PL2773438T5 (pl) 2022-01-17
SI2773438T2 (sl) 2022-05-31
NZ624317A (en) 2016-06-24
JP2014532718A (ja) 2014-12-08
AU2012323995A1 (en) 2013-05-16
CN107163101B (zh) 2021-08-17
EP3257564B2 (en) 2024-05-29
HRP20190485T1 (hr) 2019-04-19
JP6979442B2 (ja) 2021-12-15
EP2773438B1 (en) 2017-06-14
EP2773438B2 (en) 2021-10-20
EP3257564B1 (en) 2019-01-23
ES2717536T3 (es) 2019-06-21
BR112014010406A2 (pt) 2017-04-25
SG11201402019TA (en) 2014-09-26
PL2773438T3 (pl) 2017-11-30
JP6356607B2 (ja) 2018-07-11
EP2773438A1 (en) 2014-09-10
RS58472B1 (sr) 2019-04-30
CA2854330A1 (en) 2013-05-10
EP3257564A1 (en) 2017-12-20
MX2014005330A (es) 2014-09-08
CN107163101A (zh) 2017-09-15
DK2773438T4 (da) 2022-01-03
AU2012323995B2 (en) 2016-06-09
PL3257564T3 (pl) 2019-06-28
PT3257564T (pt) 2019-03-22
WO2013067301A1 (en) 2013-05-10
HUE035685T2 (en) 2018-05-28
DK2773438T3 (en) 2017-08-21
ES2637423T3 (es) 2017-10-13
SI2773438T1 (sl) 2017-10-30
DK3257564T3 (en) 2019-04-15
ES2637423T5 (es) 2022-03-17
JP2018184405A (ja) 2018-11-22
KR20140091721A (ko) 2014-07-22
RU2014121884A (ru) 2015-12-10
JP7203928B2 (ja) 2023-01-13

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