MX2022006304A - Composiciones y metodos para inhibir la actividad biologica de biomoleculas solubles. - Google Patents

Composiciones y metodos para inhibir la actividad biologica de biomoleculas solubles.

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Publication number
MX2022006304A
MX2022006304A MX2022006304A MX2022006304A MX2022006304A MX 2022006304 A MX2022006304 A MX 2022006304A MX 2022006304 A MX2022006304 A MX 2022006304A MX 2022006304 A MX2022006304 A MX 2022006304A MX 2022006304 A MX2022006304 A MX 2022006304A
Authority
MX
Mexico
Prior art keywords
compositions
biological activity
inhibiting
methods
soluble biomolecules
Prior art date
Application number
MX2022006304A
Other languages
English (en)
Inventor
Louis Hawthorne
Original Assignee
Nanotics Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nanotics Llc filed Critical Nanotics Llc
Publication of MX2022006304A publication Critical patent/MX2022006304A/es

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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
    • A61K47/6927—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere the form being a solid microparticle having no hollow or gas-filled cores
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Abstract

La descripción provee, entre otras cosas, composiciones que se unen a, e inhiben, la actividad biológica de biomoléculas solubles, así como composiciones farmacéuticas de las mismas. También en este documento se provee una serie de aplicaciones (por ejemplo, aplicaciones terapéuticas) en las cuales las composiciones son útiles.
MX2022006304A 2014-10-03 2017-03-24 Composiciones y metodos para inhibir la actividad biologica de biomoleculas solubles. MX2022006304A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201462059628P 2014-10-03 2014-10-03
US201562198519P 2015-07-29 2015-07-29
US201562198541P 2015-07-29 2015-07-29

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MX2022006304A true MX2022006304A (es) 2022-06-22

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MX2022006304A MX2022006304A (es) 2014-10-03 2017-03-24 Composiciones y metodos para inhibir la actividad biologica de biomoleculas solubles.

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EP (1) EP3215176A4 (es)
JP (3) JP6876608B2 (es)
KR (2) KR102510540B1 (es)
CN (4) CN115957347A (es)
AU (2) AU2015327928A1 (es)
BR (1) BR112017006552A2 (es)
CA (1) CA2962251A1 (es)
EA (1) EA035898B1 (es)
HK (1) HK1252911A1 (es)
IL (1) IL251232B (es)
MX (2) MX2017003903A (es)
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WO (1) WO2016054522A1 (es)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3097420A4 (en) * 2014-01-24 2018-01-17 Ntercept, LLC Methods and compositions for immune dis-inhibition
JP6876608B2 (ja) 2014-10-03 2021-05-26 ナノティックス，エルエルシー 可溶性生体分子の生物学的活性を阻害するための組成物及び方法
AU2016285868B2 (en) * 2015-06-30 2021-11-11 Nanotics, Llc Compositions and methods related to scavenger particles
CN114146056A (zh) * 2015-07-29 2022-03-08 纳米提克斯有限责任公司 用于清除可溶性生物分子的模块化组合物及其相关方法
WO2018129188A1 (en) * 2017-01-04 2018-07-12 Nanotics, Llc Methods for assembling scavenging particles
JP2020504177A (ja) * 2017-01-04 2020-02-06 ナノティックス，エルエルシー 捕捉粒子をアセンブルするための方法
CN109173755B (zh) * 2018-09-19 2020-04-03 苏州大学 超疏水多功能膜及其制备方法与在油水分离中的应用
CN113272320A (zh) * 2018-11-19 2021-08-17 得克萨斯大学体系董事会 自杀基因

Family Cites Families (77)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3710795A (en) 1970-09-29 1973-01-16 Alza Corp Drug-delivery device with stretched, rate-controlling membrane
US4863457A (en) 1986-11-24 1989-09-05 Lee David A Drug delivery device
US5164188A (en) 1989-11-22 1992-11-17 Visionex, Inc. Biodegradable ocular implants
KR0185215B1 (ko) 1990-11-30 1999-05-01 요시다 쇼오지 서방성 안구삽입용 약제
US6005079A (en) 1992-08-21 1999-12-21 Vrije Universiteit Brussels Immunoglobulins devoid of light chains
PT1498427E (pt) 1992-08-21 2010-03-22 Univ Bruxelles Imunoglobulinas desprovidas de cadeias leves
DK0698097T3 (da) 1993-04-29 2001-10-08 Unilever Nv Produktion af antistoffer eller (funktionaliserede) fragmenter deraf afledt af Camelidae-immunoglobuliner med tung kæde
US5814272A (en) 1996-02-21 1998-09-29 Millipore Corporation Method for forming dendritic metal particles
US7070590B1 (en) 1996-07-02 2006-07-04 Massachusetts Institute Of Technology Microchip drug delivery devices
US6620382B1 (en) 1998-05-22 2003-09-16 Biopheresis Technologies, Llc. Method and compositions for treatment of cancers
US8197430B1 (en) 1998-05-22 2012-06-12 Biopheresis Technologies, Inc. Method and system to remove cytokine inhibitor in patients
AU783238B2 (en) 1999-11-10 2005-10-06 Innatus Corporation Method and system to remove cytokine inhibitor in patients
EP1174129A1 (en) 2000-07-17 2002-01-23 Zenner, Hans Peter, Prof. Dr. med. Use of a matrix-metalloprotease inhibitor for the treatment of cancer
JP2002248682A (ja) * 2001-02-26 2002-09-03 Neoex Lab Inc 表皮装着用の型、及び表皮装着方法
DE10144252A1 (de) * 2001-08-31 2003-03-27 Fraunhofer Ges Forschung Nanopartikel mit daran immobilisiertem biologisch aktivem TNF
DE10144251A1 (de) * 2001-08-31 2003-03-27 Fraunhofer Ges Forschung Vorrichtung für die gerichtete Immobilisierung von Proteinen
ES2425013T3 (es) 2002-06-12 2013-10-10 Symphony Evolution, Inc. Inhibidores de ADAM-10 humana
AU2003279070A1 (en) 2002-09-30 2004-04-23 Acusphere Inc Sustained release porous microparticles for inhalation
AU2003295471B2 (en) 2002-11-15 2011-08-25 Genmab A/S Human monoclonal antibodies against CD25
US7297298B2 (en) 2002-12-25 2007-11-20 Fujifilm Corporation Nano-particles and process for producing nano-particles
WO2004071641A2 (en) * 2003-02-10 2004-08-26 Pointilliste, Inc. Self-assembling arrays and uses thereof
US8685435B2 (en) 2004-04-30 2014-04-01 Allergan, Inc. Extended release biodegradable ocular implants
SI1949915T1 (sl) 2004-04-30 2012-12-31 Biopheresis Technologies, Inc. Postopek in sistem za odstranitev topnih TNFR1, TNFR2 in IL2R pri pacientih
JP2008507529A (ja) 2004-07-22 2008-03-13 アーリー ディテクション， エルエルシー 抗サイトカインレセプター抗体を用いる診断のための方法
CN101123990A (zh) 2004-10-01 2008-02-13 Mida科技有限公司 包含抗原和佐剂的纳米颗粒，和免疫原性结构
WO2006086428A2 (en) * 2005-02-08 2006-08-17 Board Of Regents, The University Of Texas System Particles for inactivating toxins
US20110097277A1 (en) 2005-08-25 2011-04-28 University Of Washington Particles coated with zwitterionic polymers
FR2895289B1 (fr) 2005-12-23 2009-08-21 Centre Nat Rech Scient Synthese de particules dans des structures dendritiques en milieux fluides supercritiques
WO2007095162A2 (en) 2006-02-13 2007-08-23 Advanced Materials Technology, Inc. Porous microparticles solid cores
WO2008021908A2 (en) 2006-08-08 2008-02-21 Board Of Regents Of The University Of Texas Multistage delivery of active agents
US20080075690A1 (en) 2006-09-22 2008-03-27 Mark Douglas Howell Method for enhancing immune responses in mammals
WO2008041774A1 (fr) * 2006-10-02 2008-04-10 National Institute For Materials Science Préparation à libération prolongée capable de conduction osseuse
WO2008127515A1 (en) * 2007-03-01 2008-10-23 Cytologic, Inc. Compositions and method for enhancing immune responses in mammals
CN101903290B (zh) 2007-08-31 2013-01-09 混合硅晶科技公司 Peg包覆的核-壳二氧化硅纳米颗粒及其制备方法和应用
EP2033660A1 (en) 2007-09-05 2009-03-11 Freie Universität Berlin Functionalized nanoparticles for the inhibition of selectin-mediated cell adhesion
US8586096B2 (en) 2007-10-01 2013-11-19 The Curators Of The University Of Missouri Soy or lentil stabilized gold nanoparticles and method for making same
US8906356B2 (en) 2007-11-05 2014-12-09 Massachusetts Institute Of Technology Mutant interleukin-2 (IL-2) polypeptides
WO2010042555A2 (en) 2008-10-06 2010-04-15 The Brigham And Women's Hospital, Inc. Particles with multiple functionalized surface domains
US8574549B2 (en) 2008-12-29 2013-11-05 General Electric Company Nanoparticle contrast agents for diagnostic imaging
US9399075B2 (en) 2008-12-29 2016-07-26 General Electric Company Nanoparticle contrast agents for diagnostic imaging
WO2010084088A2 (en) 2009-01-21 2010-07-29 Basf Se Starch nanoparticles for drug delivery systems
US20120108787A1 (en) * 2009-02-26 2012-05-03 Nubiome, Inc. Immobilization Particles for Removal of Microorganisms and/or Chemicals
WO2010111517A1 (en) 2009-03-25 2010-09-30 Northeastern University Stable polyelectrolyte coated nanoparticles
RU2624506C2 (ru) 2009-04-29 2017-07-04 АМАРИН КОРПОРЕЙШН ПиЭлСи Фармацевтические композиции, содержащие ера и сердечно-сосудистое средство, и способы их применения
DK2449379T3 (en) 2009-07-02 2017-08-28 Sloan-Kettering Inst For Cancer Res FLUORESCING SILICA-BASED NANOPARTICLES
EA201290506A1 (ru) 2009-12-16 2013-03-29 Брихэм Энд Уимен'З Хоспитал, Инк. Частицы для доставки множества агентов
US20120141797A1 (en) 2010-04-21 2012-06-07 Brookhaven Science Associates, Llc Zwitterion-Linker Coatings for Nano-objects in Solutions of Multivalent Counterions
CN103124725B (zh) 2010-05-14 2014-11-12 香港大学 固体负载金纳米粒子、其使用方法及其制备方法
ES2628351T3 (es) 2010-10-13 2017-08-02 Pharma Diagnostics Nv Método para recubrir nanopartículas
EP2468764A1 (en) 2010-12-24 2012-06-27 Rijksuniversiteit te Groningen TNF family ligand variants
KR101642903B1 (ko) 2011-02-09 2016-07-27 한화케미칼 주식회사 친수성 물질이 코팅된 산화철 나노입자의 제조방법 및 이를 이용하는 자기공명영상 조영제
WO2012163544A1 (en) 2011-06-01 2012-12-06 Biopheresis Technologies, Inc. Removal of soluble tumor necrosis factor receptor 2 (stnfr2)
WO2013052167A2 (en) 2011-06-02 2013-04-11 The Regents Of The University Of California Membrane encapsulated nanoparticles and method of use
WO2013011764A1 (ja) 2011-07-15 2013-01-24 国立大学法人 東京大学 シリコンマイクロ粒子及びその合成方法
JP6209517B2 (ja) 2011-08-26 2017-10-04 ベコイ ナノメディシンズ リミテッドＶｅｃｏｙ Ｎａｎｏｍｅｄｉｃｉｎｅｓ Ｌｔｄ． 病原体を捕獲するための合成物および薬学的組成物
WO2013029278A1 (en) 2011-09-02 2013-03-07 National Center For Nanoscience And Technology A method for preparing functionalized silicon nanoparticles
WO2013095736A2 (en) 2011-09-27 2013-06-27 The Methodist Hospital Research Institute Gold-in-silicon nanoassembly for thermal therapy and methods of use
US8926994B2 (en) 2011-12-07 2015-01-06 The Methodist Hospital Research Institute Mesoporous silicon particles for the presentation of tumor antigens and adjuvant for anti-cancer immunity
US20130337070A1 (en) 2012-05-25 2013-12-19 University Of Central Florida Research Foundation Inc. Coated Nanoparticle Therapy for Skin Cancer
WO2013179143A2 (en) 2012-06-01 2013-12-05 Biopheresis Technologies, Inc. Sensitization of cancer cells by the removal of soluble tumor necrosis factor receptors
US10842749B2 (en) 2012-06-12 2020-11-24 The Methodist Hospital Research Institute Compositions and methods of treating therapy resistant cancer and uses thereof
EP2895197B1 (en) 2012-09-12 2020-02-26 Ramot at Tel-Aviv University Ltd. Immunoparticles and methods of generating and using same
WO2014109842A2 (en) * 2012-11-28 2014-07-17 Cytimmune Sciences, Inc. Nanotechnology based medicine for biodefense
US9309114B2 (en) 2013-01-14 2016-04-12 Xerox Corporation Porous nanoparticles produced by solvent-free emulsification
EP2968571A4 (en) 2013-03-15 2016-09-07 Psivida Inc BIODEGRADABLE SILICONE BASED COMPOSITIONS FOR THE DELIVERY OF THERAPEUTIC AGENTS
RU2015132626A (ru) 2013-03-15 2017-04-25 Слоун-Кеттеринг Инститьют Фо Кэнсэ Рисерч Мультимодальные наночастицы на основе диоксида кремния
WO2014170899A1 (en) 2013-04-18 2014-10-23 Bar-Ilan University Systems comprising non-immunogenic and nuclease resistant nucleic acid origami devices for molecular computation
ITMI20130631A1 (it) * 2013-04-18 2014-10-19 Consiglio Nazionale Ricerche Metodo di realizzazione di una guida d'onda in un substrato tramite laser a femtosecondi
US20150112842A1 (en) 2013-10-21 2015-04-23 Insurance Auto Auctions, Inc. Parts exchange method and apparatus
EP3097420A4 (en) * 2014-01-24 2018-01-17 Ntercept, LLC Methods and compositions for immune dis-inhibition
JP6876608B2 (ja) * 2014-10-03 2021-05-26 ナノティックス，エルエルシー 可溶性生体分子の生物学的活性を阻害するための組成物及び方法
AU2016285868B2 (en) 2015-06-30 2021-11-11 Nanotics, Llc Compositions and methods related to scavenger particles
CN114146056A (zh) 2015-07-29 2022-03-08 纳米提克斯有限责任公司 用于清除可溶性生物分子的模块化组合物及其相关方法
US20170056327A1 (en) 2015-08-25 2017-03-02 The Methodist Hospital Micro/nano composite drug delivery formulations and uses thereof
WO2017176762A1 (en) 2016-04-06 2017-10-12 Nanotics, Llc Particles comprising subparticles or nucleic acid scaffolds
JP2020504177A (ja) 2017-01-04 2020-02-06 ナノティックス，エルエルシー 捕捉粒子をアセンブルするための方法
WO2018129188A1 (en) 2017-01-04 2018-07-12 Nanotics, Llc Methods for assembling scavenging particles

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