LT3116891T - Imunoglobulino gryninimas, naudojant išankstinio valymo pakopas - Google Patents

Imunoglobulino gryninimas, naudojant išankstinio valymo pakopas

Info

Publication number
LT3116891T
LT3116891T LTEP15708522.6T LT15708522T LT3116891T LT 3116891 T LT3116891 T LT 3116891T LT 15708522 T LT15708522 T LT 15708522T LT 3116891 T LT3116891 T LT 3116891T
Authority
LT
Lithuania
Prior art keywords
cleaning steps
immunoglobulin purification
immunoglobulin
purification
cleaning
Prior art date
Application number
LTEP15708522.6T
Other languages
English (en)
Inventor
Ferenc FELFÖLDI
Zsuzsa BENKÖ
Melinda Gaspar
Original Assignee
Richter Gedeon Nyrt.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU1400131A external-priority patent/HUP1400131A1/hu
Priority claimed from HU1500053A external-priority patent/HUP1500053A1/hu
Application filed by Richter Gedeon Nyrt. filed Critical Richter Gedeon Nyrt.
Publication of LT3116891T publication Critical patent/LT3116891T/lt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26—Cation exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Peptides Or Proteins (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
LTEP15708522.6T 2014-03-10 2015-03-09 Imunoglobulino gryninimas, naudojant išankstinio valymo pakopas LT3116891T (lt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
HU1400131A HUP1400131A1 (hu) 2014-03-10 2014-03-10 Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával
HU1500053A HUP1500053A1 (hu) 2015-02-09 2015-02-09 Immunglobulin tisztítása elõtisztítási lépések alkalmazásával
PCT/EP2015/054862 WO2015135884A1 (en) 2014-03-10 2015-03-09 Immunoglobulin purification using pre-cleaning steps

Publications (1)

Publication Number Publication Date
LT3116891T true LT3116891T (lt) 2020-03-25

Family

ID=89991731

Family Applications (1)

Application Number Title Priority Date Filing Date
LTEP15708522.6T LT3116891T (lt) 2014-03-10 2015-03-09 Imunoglobulino gryninimas, naudojant išankstinio valymo pakopas

Country Status (15)

Country Link
US (1) US10487138B2 (lt)
EP (2) EP3116891B1 (lt)
JP (1) JP6293907B2 (lt)
KR (1) KR101921552B1 (lt)
CN (1) CN106103465B (lt)
CA (1) CA2930350C (lt)
DK (1) DK3116891T3 (lt)
ES (1) ES2784749T3 (lt)
HR (1) HRP20200711T1 (lt)
HU (1) HUE048782T2 (lt)
LT (1) LT3116891T (lt)
PL (1) PL3116891T3 (lt)
PT (1) PT3116891T (lt)
SI (1) SI3116891T1 (lt)
WO (1) WO2015135884A1 (lt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE048782T2 (hu) 2014-03-10 2020-08-28 Richter Gedeon Nyrt Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával
GB2539420B (en) * 2015-06-16 2021-01-13 Cytiva Sweden Ab Determination of chromatography conditions
JP6851109B2 (ja) * 2016-06-16 2021-03-31 Jsr株式会社 抗体を精製する方法及び担体を洗浄する方法
EP3472177B1 (en) * 2016-06-17 2024-08-14 F. Hoffmann-La Roche AG Purification of multispecific antibodies
WO2018051348A1 (en) * 2016-09-14 2018-03-22 Insight Biopharmaceutical Ltd. Methods of purifying and qualifying antibodies
JP2020511516A (ja) * 2017-03-24 2020-04-16 カウンスィル オブ サイエンティフィック アンド インダストリアル リサーチＣｏｕｎｃｉｌ Ｏｆ Ｓｃｉｅｎｔｉｆｉｃ ＆ Ｉｎｄｕｓｔｒｉａｌ Ｒｅｓｅａｒｃｈ 組換え抗体断片の精製方法
US11697670B2 (en) 2017-08-22 2023-07-11 Biogen Ma Inc. Methods for purifying antibodies having reduced high molecular weight aggregates
KR20190047376A (ko) 2017-10-27 2019-05-08 주식회사 녹십자 개선된 면역글로불린의 정제방법
US20200406232A1 (en) * 2018-03-08 2020-12-31 Bio-Rad Laboratories, Inc. Anionic exchange-hydrophobic mixed mode chromatography resin
EP3769083A1 (en) 2018-03-21 2021-01-27 Waters Technologies Corporation Non-antibody high-affinity-based sample preparation, sorbents, devices and methods
GB201805142D0 (en) * 2018-03-29 2018-05-16 Ge Healthcare Bioprocess R&D Ab Separation method
WO2020016417A1 (en) * 2018-07-19 2020-01-23 Ichnos Sciences S.A. Liquid antibody formulation
KR102209790B1 (ko) * 2018-12-20 2021-02-01 에이치케이이노엔 주식회사 친화성 크로마토그래피를 이용한 백신용 바이러스 정제방법
JP7241888B2 (ja) * 2018-12-30 2023-03-17 エフ． ホフマン－ラ ロシュ アーゲー ｐＨ勾配ＳＰＲに基づく結合アッセイ
CN113518654B (zh) * 2019-03-21 2023-12-15 新加坡科技研究局 捕获和/或纯化靶标的方法
HU231498B1 (hu) * 2019-04-04 2024-05-28 Richter Gedeon Nyrt Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelőző flokkulálás alkalmazásával
CN114025843A (zh) * 2019-06-10 2022-02-08 武田药品工业株式会社 抗体纯化方法及其组合物
CN114040815B (zh) 2019-09-05 2024-06-28 生物辐射实验室股份有限公司 阴离子交换-疏水混合模式色谱树脂
US11732004B2 (en) 2020-04-10 2023-08-22 Plasma Technologies, Llc Compositions and methods for simplified high efficiency isolation of proteins
CN113563469A (zh) * 2020-04-28 2021-10-29 江苏中新医药有限公司 高回收率纯化阿达木单抗的方法
AU2021265591A1 (en) * 2020-05-01 2022-12-22 Kashiv Biosciences, Llc An improved process of purification of protein
EP4412747A1 (en) * 2021-10-08 2024-08-14 Kashiv Biosciences, LLC Separation of pre-peak in fusion protein sample by using size exclusion high performance liquid chromatography
EP4392156A1 (en) * 2021-10-08 2024-07-03 Kashiv Biosciences, LLC Separation of pre-peak and post-peak in fusion protein sample by using size exclusion high performance liquid chromatography
CN114133446A (zh) * 2021-12-31 2022-03-04 方坦思(上海)生物医药有限公司 单克隆抗体的纯化方法
CN115304673A (zh) * 2022-06-24 2022-11-08 上海赛伦生物技术股份有限公司 一种马抗破伤风特异性免疫球蛋白F(ab’)2的纯化方法及其应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH0779709B2 (ja) * 1987-07-16 1995-08-30 シェリング・コーポレーション Ｇｍ‐ｃｓｆの精製
CA1341235C (en) 1987-07-24 2001-05-22 Randy R. Robinson Modular assembly of antibody genes, antibodies prepared thereby and use
US4983722A (en) 1988-06-08 1991-01-08 Miles Inc. Removal of protein A from antibody preparations
WO1991018975A1 (en) 1990-05-31 1991-12-12 The United States Of America, Represented By The Secretary, United States Department Of Commerce Method for purifying hiv reverse transcriptase
DE07012625T1 (de) 1991-03-18 2010-01-21 New York University Monoklonale und chimäre Antikörper gegen humanen Tumornekrosefaktor
AU675916B2 (en) 1991-06-14 1997-02-27 Genentech Inc. Method for making humanized antibodies
NZ258392A (en) 1992-11-13 1997-09-22 Idec Pharma Corp Chimeric and radiolabelled antibodies to the b lymphocyte cellsurface antigen bp35 (cd-20) and their use in the treatment of b cell lymphona
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
BRPI9715219B8 (pt) 1996-02-09 2015-07-07 Abbvie Biotechnology Ltd Vetor recombinante de expressão, e célula hospedeira procariótica.
DE122007000021I1 (de) 1997-04-07 2007-05-24 Genentech Inc Anti-vefg Antibodies
EP1222572A2 (en) 1999-08-26 2002-07-17 Symtec Limited Methods and devices for selecting data files
MXPA04000134A (es) 2001-06-26 2005-06-06 Abgenix Inc Anticuerpos para ligandos de osteoprotegerina.
US20030040027A1 (en) * 2001-08-16 2003-02-27 Gerd Ritter Method for determining protein component in a biological sample
DE10155984A1 (de) 2001-11-15 2003-05-28 Boehringer Ingelheim Pharma Verfahren zur Reduktion des Liganden-leakage von Affinitätschromatographie-Matrices
WO2003102132A2 (en) 2002-04-26 2003-12-11 Genetech, Inc. Non-affinity purification of proteins
AU2004215653B2 (en) 2003-02-28 2011-03-17 Lonza Biologics Plc. Antibody purification by protein A and ion exchange chromatography
JPWO2004087761A1 (ja) 2003-03-31 2006-07-27 麒麟麦酒株式会社 ヒトモノクローナル抗体およびヒトポリクローナル抗体の精製
SI1648940T1 (sl) * 2003-07-28 2016-08-31 Genentech, Inc. Zmanjševanje izluževanja proteina A med afinitetno kromatografijo proteina A
SI1689777T1 (sl) * 2003-11-05 2007-08-31 Ares Trading Sa Postopek za äśiĺ äśenje il-18 vezavnega proteina
US7750129B2 (en) * 2004-02-27 2010-07-06 Ge Healthcare Bio-Sciences Ab Process for the purification of antibodies
AU2005279347A1 (en) 2004-08-30 2006-03-09 Lonza Biologics Plc. Affinity- plus ion exchange- chromatography for purifying antibodies
HUE037409T2 (hu) 2007-10-30 2018-08-28 Genentech Inc Antitest-tisztítás kationcserés kromatográfiával
US20110105725A1 (en) 2008-05-15 2011-05-05 Novo Nordisk A/S Antibody purification process
AU2009347206C1 (en) 2008-10-20 2016-12-08 Abbvie Inc. Isolation and purification of antibodies using Protein A affinity chromatography
WO2010071208A1 (ja) * 2008-12-19 2010-06-24 武田薬品工業株式会社 抗体の精製方法
WO2011009623A1 (en) * 2009-07-24 2011-01-27 F. Hoffmann-La Roche Ag Optimizing the production of antibodies
WO2011017514A1 (en) 2009-08-07 2011-02-10 Millipore Corporation Methods for purifying a target protein from one or more impurities in a sample
MX2012002565A (es) * 2009-09-01 2012-05-29 Genentech Inc Purificacion de proteina mejorada a traves de una elucion de proteina a modificada.
US20120208986A1 (en) 2009-10-20 2012-08-16 Wenger Marc D Use of mixed mode chromatography for the capture and purification of basic antibody products
WO2011090720A2 (en) 2009-12-29 2011-07-28 Dr. Reddy's Laboratories Ltd Purification of proteins
MY161534A (en) 2010-05-25 2017-04-28 Genentech Inc Methods of purifying polypeptides
WO2012051147A1 (en) * 2010-10-11 2012-04-19 Abbott Laboratories Processes for purification of proteins
PE20142243A1 (es) * 2011-07-11 2015-01-11 Glenmark Pharmaceuticals Sa Anticuerpos que se unen a ox40 y sus usos
EP2773439A4 (en) 2011-10-31 2015-07-01 Merck Sharp & Dohme CHROMATOGRAPHY METHOD FOR DECOMPOSING HETEROGENEOUS ANTIBODY AGGREGATES
DK2773438T4 (da) 2011-11-02 2022-01-03 Hoffmann La Roche Overladnings- og elueringskromatografi
EP2855504B1 (en) * 2012-05-31 2018-10-24 Agency For Science, Technology And Research Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities
HUE048782T2 (hu) 2014-03-10 2020-08-28 Richter Gedeon Nyrt Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával

Also Published As

Publication number Publication date
JP2017507907A (ja) 2017-03-23
HRP20200711T1 (hr) 2020-07-24
SI3116891T1 (sl) 2020-07-31
PL3116891T3 (pl) 2020-07-27
CN106103465A (zh) 2016-11-09
DK3116891T3 (da) 2020-05-04
EP3116891A1 (en) 2017-01-18
EP3116891B1 (en) 2020-02-12
US20170058019A1 (en) 2017-03-02
CA2930350C (en) 2021-04-06
CN106103465B (zh) 2021-01-08
US10487138B2 (en) 2019-11-26
EP3674310A1 (en) 2020-07-01
JP6293907B2 (ja) 2018-03-14
PT3116891T (pt) 2020-05-18
WO2015135884A1 (en) 2015-09-17
HUE048782T2 (hu) 2020-08-28
KR101921552B1 (ko) 2018-11-23
KR20160124107A (ko) 2016-10-26
ES2784749T3 (es) 2020-09-30
CA2930350A1 (en) 2015-09-17

Similar Documents

Publication Publication Date Title
SI3116891T1 (sl) Čiščenje imunoglobulina z uporabo predčistilnih stopenj
ZA201606906B (en) Modified j-chain
IL251508A0 (en) Anti-TNF compounds
PL3127502T3 (pl) Układ czyszczący
GB201410262D0 (en) Novel method
SI3113858T1 (sl) Metoda čiščenja konjugatov na osnovi IL-15/IL-15Ralfa
GB201419859D0 (en) No title listed
EP3118210A4 (en) Method for purifying immunoglobulin
EP3118209A4 (en) Method for purifying immunoglobulin
SG11201607098SA (en) Antibody purification process
SG11201606811VA (en) Fractionation method
SG11201607341SA (en) Robust antibody purification
EP3168225A4 (en) Fidaxomicin purification method
GB201413225D0 (en) Solder cleaning system
GB201600158D0 (en) Purification method
GB201504280D0 (en) Ancillary additive manufacturing system
GB201421962D0 (en) Filtration method
GB201405591D0 (en) Heatseal
HUP1400131A1 (hu) Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával
HUP1500053A1 (hu) Immunglobulin tisztítása elõtisztítási lépések alkalmazásával
GB201520903D0 (en) Purification method
GB201617240D0 (en) Purification process
GB201512073D0 (en) Vehicle cleaning method
GB201512950D0 (en) Vehicle cleaning method
GB2523168B (en) Vehicle cleaning apparatus