PT3116891T - Purificação de imunoglobulina utilizando passos de pré-limpeza - Google Patents

Purificação de imunoglobulina utilizando passos de pré-limpeza

Info

Publication number
PT3116891T
PT3116891T PT157085226T PT15708522T PT3116891T PT 3116891 T PT3116891 T PT 3116891T PT 157085226 T PT157085226 T PT 157085226T PT 15708522 T PT15708522 T PT 15708522T PT 3116891 T PT3116891 T PT 3116891T
Authority
PT
Portugal
Prior art keywords
cleaning steps
immunoglobulin purification
immunoglobulin
purification
cleaning
Prior art date
Application number
PT157085226T
Other languages
English (en)
Original Assignee
Richter Gedeon Nyrt
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from HU1400131A external-priority patent/HUP1400131A1/hu
Priority claimed from HU1500053A external-priority patent/HUP1500053A1/hu
Application filed by Richter Gedeon Nyrt filed Critical Richter Gedeon Nyrt
Publication of PT3116891T publication Critical patent/PT3116891T/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
    • B01J39/26—Cation exchangers for chromatographic processes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
    • B01J41/20—Anion exchangers for chromatographic processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/241—Tumor Necrosis Factors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Treatment Of Liquids With Adsorbents In General (AREA)
PT157085226T 2014-03-10 2015-03-09 Purificação de imunoglobulina utilizando passos de pré-limpeza PT3116891T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
HU1400131A HUP1400131A1 (hu) 2014-03-10 2014-03-10 Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával
HU1500053A HUP1500053A1 (hu) 2015-02-09 2015-02-09 Immunglobulin tisztítása elõtisztítási lépések alkalmazásával

Publications (1)

Publication Number Publication Date
PT3116891T true PT3116891T (pt) 2020-05-18

Family

ID=89991731

Family Applications (1)

Application Number Title Priority Date Filing Date
PT157085226T PT3116891T (pt) 2014-03-10 2015-03-09 Purificação de imunoglobulina utilizando passos de pré-limpeza

Country Status (15)

Country Link
US (1) US10487138B2 (pt)
EP (2) EP3116891B1 (pt)
JP (1) JP6293907B2 (pt)
KR (1) KR101921552B1 (pt)
CN (1) CN106103465B (pt)
CA (1) CA2930350C (pt)
DK (1) DK3116891T3 (pt)
ES (1) ES2784749T3 (pt)
HR (1) HRP20200711T1 (pt)
HU (1) HUE048782T2 (pt)
LT (1) LT3116891T (pt)
PL (1) PL3116891T3 (pt)
PT (1) PT3116891T (pt)
SI (1) SI3116891T1 (pt)
WO (1) WO2015135884A1 (pt)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE048782T2 (hu) 2014-03-10 2020-08-28 Richter Gedeon Nyrt Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával
GB2539420B (en) * 2015-06-16 2021-01-13 Cytiva Sweden Ab Determination of chromatography conditions
JP6851109B2 (ja) * 2016-06-16 2021-03-31 Jsr株式会社 抗体を精製する方法及び担体を洗浄する方法
WO2017218977A2 (en) * 2016-06-17 2017-12-21 Genentech, Inc. Purification of multispecific antibodies
EP3512884A4 (en) * 2016-09-14 2020-09-16 Kinbio Ltd. METHODS FOR CLEANING UP AND QUALIFYING ANTIBODIES
CN110582510B (zh) * 2017-03-24 2023-09-15 科学与工业研究委员会 用于纯化重组抗体片段的方法
MA49962A (fr) * 2017-08-22 2020-07-01 Biogen Ma Inc Procédés de purification d'anticorps présentant des agrégats réduits à poids moléculaire élevé
KR20190047376A (ko) 2017-10-27 2019-05-08 주식회사 녹십자 개선된 면역글로불린의 정제방법
EP3762120A4 (en) * 2018-03-08 2021-09-01 Bio-Rad Laboratories, Inc. MIXED MODE ANIONIC-HYDROPHOBIC EXCHANGE CHROMATOGRAPHY RESIN
CN111902720A (zh) 2018-03-21 2020-11-06 沃特世科技公司 基于非抗体高亲和力的样品制备、吸附剂、装置和方法
GB201805142D0 (en) * 2018-03-29 2018-05-16 Ge Healthcare Bioprocess R&D Ab Separation method
WO2020016417A1 (en) * 2018-07-19 2020-01-23 Ichnos Sciences S.A. Liquid antibody formulation
KR102209790B1 (ko) * 2018-12-20 2021-02-01 에이치케이이노엔 주식회사 친화성 크로마토그래피를 이용한 백신용 바이러스 정제방법
CN113227789A (zh) * 2018-12-30 2021-08-06 豪夫迈·罗氏有限公司 基于pH梯度SPR的结合测定
CN113518654B (zh) * 2019-03-21 2023-12-15 新加坡科技研究局 捕获和/或纯化靶标的方法
HU231498B1 (hu) 2019-04-04 2024-05-28 Richter Gedeon Nyrt Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelõzõ flokkulálás alkalmazásával
WO2020252072A1 (en) * 2019-06-10 2020-12-17 Millennium Pharmaceuticals, Inc. Antibody purification methods and compositions thereof
JP2022546901A (ja) 2019-09-05 2022-11-10 バイオ－ラッド・ラボラトリーズ・インコーポレーテッド アニオン交換－疎水性混合モードクロマトグラフィー樹脂
CN117355538A (zh) * 2020-04-10 2024-01-05 等离子体技术有限责任公司 简化高效分离蛋白质的组合物和方法
CN113563469A (zh) * 2020-04-28 2021-10-29 江苏中新医药有限公司 高回收率纯化阿达木单抗的方法
AU2021265591A1 (en) * 2020-05-01 2022-12-22 Kashiv Biosciences, Llc An improved process of purification of protein
WO2023057995A1 (en) * 2021-10-08 2023-04-13 Kashiv Biosciences, Llc Separation of pre-peak and post-peak in fusion protein sample by using size exclusion high performance liquid chromatography
WO2023057994A1 (en) * 2021-10-08 2023-04-13 Kashiv Biosciences, Llc Separation of pre-peak in fusion protein sample by using size exclusion high performance liquid chromatography
CN114133446A (zh) * 2021-12-31 2022-03-04 方坦思(上海)生物医药有限公司 单克隆抗体的纯化方法
CN115304673A (zh) * 2022-06-24 2022-11-08 上海赛伦生物技术股份有限公司 一种马抗破伤风特异性免疫球蛋白F(ab’)2的纯化方法及其应用

Family Cites Families (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR930007430B1 (ko) * 1987-07-16 1993-08-10 쉐링 코포레이션 크로마토그래피 단계에 의한 과립구-대식세포 콜로니-자극 인자의 정제방법
CA1341235C (en) 1987-07-24 2001-05-22 Randy R. Robinson Modular assembly of antibody genes, antibodies prepared thereby and use
US4983722A (en) 1988-06-08 1991-01-08 Miles Inc. Removal of protein A from antibody preparations
AU8001291A (en) * 1990-05-31 1991-12-31 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Method for purifying hiv reverse transcriptase
DK1097945T3 (da) 1991-03-18 2007-11-05 Univ New York Monoklonale og kimære antistoffer, der er specifikke for human tumornekrosefaktor
DK0590058T3 (da) 1991-06-14 2004-03-29 Genentech Inc Humaniseret heregulin-antistof
ATE196606T1 (de) 1992-11-13 2000-10-15 Idec Pharma Corp Therapeutische verwendung von chimerischen und markierten antikörpern, die gegen ein differenzierung-antigen gerichtet sind, dessen expression auf menschliche b lymphozyt beschränkt ist, für die behandlung von b-zell-lymphoma
US5429746A (en) 1994-02-22 1995-07-04 Smith Kline Beecham Corporation Antibody purification
BRPI9715219B8 (pt) 1996-02-09 2015-07-07 Abbvie Biotechnology Ltd Vetor recombinante de expressão, e célula hospedeira procariótica.
AU743758B2 (en) 1997-04-07 2002-02-07 Genentech Inc. Anti-VEGF antibodies
WO2001015011A2 (en) 1999-08-26 2001-03-01 Symtec Limited Methods and devices for selecting data files
JP4212470B2 (ja) 2001-06-26 2009-01-21 アムジェン フレモント インク． Ｏｐｇｌへの抗体
WO2003016909A1 (en) * 2001-08-16 2003-02-27 Ludwig Institute For Cancer Research Method for determining protein component in a biological sample
DE10155984A1 (de) 2001-11-15 2003-05-28 Boehringer Ingelheim Pharma Verfahren zur Reduktion des Liganden-leakage von Affinitätschromatographie-Matrices
JP4319979B2 (ja) 2002-04-26 2009-08-26 ジェネンテック・インコーポレーテッド タンパク質の非アフィニティ精製
AU2004215653B2 (en) 2003-02-28 2011-03-17 Lonza Biologics Plc. Antibody purification by protein A and ion exchange chromatography
EP1614693A4 (en) 2003-03-31 2006-07-19 Kirin Brewery PURIFICATION OF A HUMAN MONOCLONAL ANTIBODY AND A HUMAN POLYCLONAL ANTIBODY
AU2004265253B2 (en) 2003-07-28 2011-09-01 Genentech, Inc. Reducing protein A leaching during protein A affinity chromatography
CA2544146C (en) * 2003-11-05 2012-10-02 Ares Trading S.A. Process for the purification of il-18 binding protein
NZ548126A (en) 2004-02-27 2009-10-30 Ge Healthcare Bio Sciences Ab A process for the purification of antibodies involving addition of a second resin
EP1685161A1 (en) * 2004-08-30 2006-08-02 Lonza Biologics plc Affinity- plus ion exchange-chromatography for purifying antibodies
PL2840090T3 (pl) 2007-10-30 2018-07-31 Genentech, Inc. Oczyszczanie przeciwciał za pomocą chromatografii kationowymiennej
JP2011523408A (ja) 2008-05-15 2011-08-11 ノボ・ノルデイスク・エー／エス 抗体精製方法
EP2921501A1 (en) 2008-10-20 2015-09-23 Abbvie Inc. Isolation and purification of antibodies using Protein A affinity chromatography
JPWO2010071208A1 (ja) 2008-12-19 2012-05-31 武田薬品工業株式会社 抗体の精製方法
AU2010275774B2 (en) * 2009-07-24 2016-03-31 F. Hoffmann-La Roche Ag Optimizing the production of antibodies
ES2817802T3 (es) * 2009-08-07 2021-04-08 Emd Millipore Corp Métodos para purificar una proteína objetivo de una o más impurezas en una muestra
WO2011028753A1 (en) * 2009-09-01 2011-03-10 Genentech, Inc. Enhanced protein purification through a modified protein a elution
WO2011049798A1 (en) 2009-10-20 2011-04-28 Merck Sharp & Dohme Corp. Use of mixed mode chromatography for the capture and purification of basic antibody products
US20130116413A1 (en) 2009-12-29 2013-05-09 Dr. Reddy's Laboratories, Inc. Purification of proteins
SG10201710439UA (en) 2010-05-25 2018-01-30 Genentech Inc Methods of purifying polypeptides
TW201221641A (en) * 2010-10-11 2012-06-01 Abbott Lab Processes for purification of proteins
CA2840460C (en) * 2011-07-11 2022-08-16 Glenmark Pharmaceuticals S.A. Antibodies that bind to ox40 and their uses
EP2773439A4 (en) 2011-10-31 2015-07-01 Merck Sharp & Dohme CHROMATOGRAPHY METHOD FOR DECOMPOSING HETEROGENEOUS ANTIBODY AGGREGATES
ES2717536T3 (es) 2011-11-02 2019-06-21 Hoffmann La Roche Cromatografía de sobrecarga y elución
EP2855504B1 (en) * 2012-05-31 2018-10-24 Agency For Science, Technology And Research Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities
HUE048782T2 (hu) 2014-03-10 2020-08-28 Richter Gedeon Nyrt Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával

Also Published As

Publication number Publication date
PL3116891T3 (pl) 2020-07-27
HUE048782T2 (hu) 2020-08-28
CN106103465B (zh) 2021-01-08
KR20160124107A (ko) 2016-10-26
CN106103465A (zh) 2016-11-09
EP3116891A1 (en) 2017-01-18
JP6293907B2 (ja) 2018-03-14
CA2930350A1 (en) 2015-09-17
HRP20200711T1 (hr) 2020-07-24
US10487138B2 (en) 2019-11-26
DK3116891T3 (da) 2020-05-04
US20170058019A1 (en) 2017-03-02
ES2784749T3 (es) 2020-09-30
SI3116891T1 (sl) 2020-07-31
JP2017507907A (ja) 2017-03-23
EP3116891B1 (en) 2020-02-12
EP3674310A1 (en) 2020-07-01
LT3116891T (lt) 2020-03-25
WO2015135884A1 (en) 2015-09-17
CA2930350C (en) 2021-04-06
KR101921552B1 (ko) 2018-11-23

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