MA49962A - Procédés de purification d'anticorps présentant des agrégats réduits à poids moléculaire élevé - Google Patents

Procédés de purification d'anticorps présentant des agrégats réduits à poids moléculaire élevé

Info

Publication number
MA49962A
MA49962A MA049962A MA49962A MA49962A MA 49962 A MA49962 A MA 49962A MA 049962 A MA049962 A MA 049962A MA 49962 A MA49962 A MA 49962A MA 49962 A MA49962 A MA 49962A
Authority
MA
Morocco
Prior art keywords
processes
molecular weight
high molecular
purifying antibodies
presenting reduced
Prior art date
Application number
MA049962A
Other languages
English (en)
Inventor
Greg Evangelist
Matthew Westoby
Original Assignee
Biogen Ma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biogen Ma Inc filed Critical Biogen Ma Inc
Publication of MA49962A publication Critical patent/MA49962A/fr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/20—Partition-, reverse-phase or hydrophobic interaction chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
MA049962A 2017-08-22 2018-08-22 Procédés de purification d'anticorps présentant des agrégats réduits à poids moléculaire élevé MA49962A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762548962P 2017-08-22 2017-08-22

Publications (1)

Publication Number Publication Date
MA49962A true MA49962A (fr) 2020-07-01

Family

ID=65439585

Family Applications (1)

Application Number Title Priority Date Filing Date
MA049962A MA49962A (fr) 2017-08-22 2018-08-22 Procédés de purification d'anticorps présentant des agrégats réduits à poids moléculaire élevé

Country Status (4)

Country Link
US (1) US11697670B2 (fr)
EP (1) EP3672981A4 (fr)
MA (1) MA49962A (fr)
WO (1) WO2019040671A1 (fr)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102511050B1 (ko) 2016-08-16 2023-03-17 리제너론 파아마슈티컬스, 인크. 혼합물로부터 개별 항체들을 정량하는 방법
CA3039788A1 (fr) 2016-10-25 2018-05-03 Regeneron Pharmaceuticals, Inc. Procedes et systemes d'analyse de donnees de chromatographie
TW202005694A (zh) 2018-07-02 2020-02-01 美商里珍納龍藥品有限公司 自混合物製備多肽之系統及方法

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2418830T3 (es) 2003-10-27 2013-08-16 Wyeth Llc Retirada de agregados de alto peso molecular usando cromatografía de hidroxiapatita
US20060134694A1 (en) * 2004-12-22 2006-06-22 Intel Corporation Methods of protein profiling by thiolation
CA2604877A1 (fr) 2005-04-11 2006-10-19 J.P. Sercel Associates Inc. Purification des proteines
PL3327026T3 (pl) * 2007-07-09 2020-02-28 Genentech, Inc. Zapobieganie redukcji wiązań disiarczkowych podczas rekombinacyjnego wytwarzania polipeptydów
US20090016301A1 (en) 2007-07-11 2009-01-15 Interdigital Technology Corporation Packet data convergence protocol operations
WO2010151688A2 (fr) 2009-06-25 2010-12-29 Amgen Inc. Procédés de purification par capture de protéines exprimées dans un système non mammifère
DK2483289T3 (da) 2009-10-02 2019-06-11 Biogen Ma Inc Fremgangsmåder til forebyggelse og fjernelse af trisulfidbindinger
US9096648B2 (en) 2011-08-19 2015-08-04 Emd Millipore Corporation Methods of reducing level of one or more impurities in a sample during protein purification
EP2970865B1 (fr) * 2013-03-15 2020-09-02 Alder Biopharmaceuticals, Inc. Purification d'anticorps et contrôle de pureté
SI3116891T1 (sl) 2014-03-10 2020-07-31 Richter Gedeon Nyrt. Čiščenje imunoglobulina z uporabo predčistilnih stopenj
KR102366547B1 (ko) * 2016-04-28 2022-02-23 바이오젠 엠에이 인코포레이티드 항-혈액 수지상 세포 항원 2 항체의 임상적 사용을 위한 약제학적 조성물 및 투약 요법

Also Published As

Publication number Publication date
EP3672981A4 (fr) 2021-09-15
WO2019040671A1 (fr) 2019-02-28
US20210130397A1 (en) 2021-05-06
EP3672981A1 (fr) 2020-07-01
US11697670B2 (en) 2023-07-11

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