MA49775A - Procédés de préparation d'oligomères morpholino de phosphorodiamidate - Google Patents
Procédés de préparation d'oligomères morpholino de phosphorodiamidateInfo
- Publication number
- MA49775A MA49775A MA049775A MA49775A MA49775A MA 49775 A MA49775 A MA 49775A MA 049775 A MA049775 A MA 049775A MA 49775 A MA49775 A MA 49775A MA 49775 A MA49775 A MA 49775A
- Authority
- MA
- Morocco
- Prior art keywords
- phosphorodiamidate
- processes
- preparation
- morpholino oligomers
- morpholino
- Prior art date
Links
- CPEONABTMRSIKA-UHFFFAOYSA-N 1,4$l^{2}-oxazinane Chemical class C1COCC[N]1 CPEONABTMRSIKA-UHFFFAOYSA-N 0.000 title 1
- ANCLJVISBRWUTR-UHFFFAOYSA-N diaminophosphinic acid Chemical compound NP(N)(O)=O ANCLJVISBRWUTR-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Saccharide Compounds (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662341049P | 2016-05-24 | 2016-05-24 | |
| US201662357072P | 2016-06-30 | 2016-06-30 | |
| US201662357166P | 2016-06-30 | 2016-06-30 | |
| US201662356923P | 2016-06-30 | 2016-06-30 | |
| US201662357153P | 2016-06-30 | 2016-06-30 | |
| US201762508256P | 2017-05-18 | 2017-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA49775A true MA49775A (fr) | 2020-06-10 |
Family
ID=59078165
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA045154A MA45154A (fr) | 2016-05-24 | 2017-05-24 | Procédés de préparation d'oligomères |
| MA049775A MA49775A (fr) | 2016-05-24 | 2017-05-24 | Procédés de préparation d'oligomères morpholino de phosphorodiamidate |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA045154A MA45154A (fr) | 2016-05-24 | 2017-05-24 | Procédés de préparation d'oligomères |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10875880B2 (fr) |
| EP (2) | EP3464305B1 (fr) |
| JP (2) | JP7008642B2 (fr) |
| KR (1) | KR102506298B1 (fr) |
| CN (1) | CN109563114B (fr) |
| AU (1) | AU2017269355B2 (fr) |
| BR (2) | BR122022014984B1 (fr) |
| CA (1) | CA3025339A1 (fr) |
| CO (1) | CO2018013838A2 (fr) |
| IL (1) | IL263149B2 (fr) |
| MA (2) | MA45154A (fr) |
| MX (2) | MX2018014472A (fr) |
| SA (1) | SA518400500B1 (fr) |
| SG (1) | SG10202101830WA (fr) |
| TW (2) | TWI801843B (fr) |
| WO (1) | WO2017205496A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI541024B (zh) | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
| KR102506298B1 (ko) | 2016-05-24 | 2023-03-06 | 사렙타 쎄러퓨틱스 인코퍼레이티드 | 올리고머의 제조 방법 |
| US11472824B2 (en) | 2016-05-24 | 2022-10-18 | Sarepta Therapeutics, Inc. | Processes for preparing phosphorodiamidate morpholino oligomers |
| MA45362A (fr) * | 2016-05-24 | 2019-04-10 | Sarepta Therapeutics Inc | Procédés de préparation d'oligomères morpholino de phosphorodiamidate |
| SG11201809499UA (en) | 2016-05-24 | 2018-12-28 | Sarepta Therapeutics Inc | Processes for preparing phosphorodiamidate morpholino oligomers |
| JP7022079B2 (ja) * | 2016-06-30 | 2022-02-17 | サレプタ セラピューティクス， インコーポレイテッド | ホスホロジアミダートモルホリノオリゴマーを調製するためのプロセス |
| JP7022078B2 (ja) * | 2016-06-30 | 2022-02-17 | サレプタ セラピューティクス， インコーポレイテッド | ホスホロジアミダートモルホリノオリゴマーを調製するためのプロセス |
| JP7218361B2 (ja) * | 2017-09-25 | 2023-02-06 | サレプタ セラピューティクス， インコーポレイテッド | 高速流動合成を介してホスホロジアミデートモルホリノオリゴマーを調製するための方法 |
| EP3784248A4 (fr) * | 2018-04-26 | 2022-08-10 | Sarepta Therapeutics, Inc. | Oligomères induisant le saut d'exon et conjugués d'oligomères pour la dystrophie musculaire |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| ATE171185T1 (de) | 1985-03-15 | 1998-10-15 | Antivirals Inc | Immunotestmittel für polynukleotid und verfahren |
| US5217866A (en) | 1985-03-15 | 1993-06-08 | Anti-Gene Development Group | Polynucleotide assay reagent and method |
| US5521063A (en) | 1985-03-15 | 1996-05-28 | Antivirals Inc. | Polynucleotide reagent containing chiral subunits and methods of use |
| US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| EP0433345B1 (fr) | 1988-09-01 | 1994-04-20 | Forskningscenter Riso | Procede de synthese de peptides et support solide de realisation dudit procede |
| AU694157B2 (en) | 1993-12-29 | 1998-07-16 | Fujisawa Pharmaceutical Co., Ltd. | Pyrazolopyridine adenosine antagonists |
| US7572582B2 (en) | 1997-09-12 | 2009-08-11 | Exiqon A/S | Oligonucleotide analogues |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US7084125B2 (en) | 1999-03-18 | 2006-08-01 | Exiqon A/S | Xylo-LNA analogues |
| ES2283298T3 (es) | 1999-05-04 | 2007-11-01 | Santaris Pharma A/S | Analogos de l-ribo-lna. |
| US6784291B2 (en) | 2000-05-04 | 2004-08-31 | Avi Biopharma, Inc. | Splice-region antisense composition and method |
| US7060809B2 (en) | 2001-09-04 | 2006-06-13 | Exiqon A/S | LNA compositions and uses thereof |
| US7569575B2 (en) | 2002-05-08 | 2009-08-04 | Santaris Pharma A/S | Synthesis of locked nucleic acid derivatives |
| AU2003287464A1 (en) | 2002-11-05 | 2004-06-03 | Isis Pharmaceuticals, Inc. | 2'-fluoro substituted oligomeric compounds and compositions for use in gene modulations |
| US7759513B2 (en) | 2003-02-21 | 2010-07-20 | Nigu Chemie Gmbh | Photolabile protective groups for improved processes to prepare oligonucleotide arrays |
| ATE498685T1 (de) | 2004-06-28 | 2011-03-15 | Univ Western Australia | Antisense-oligonukleotide zur induktion von exon- skipping sowie verfahren zur verwendung davon |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| LT2735568T (lt) * | 2006-05-10 | 2017-11-27 | Sarepta Therapeutics, Inc. | Oligonukleotido analogai, turintys katijonines jungtis tarp subvienetų |
| US9371348B2 (en) | 2006-11-27 | 2016-06-21 | The Trustees Of The University Of Pennsylvania | Photocleavable oligonucleotide and uses thereof |
| US8299206B2 (en) | 2007-11-15 | 2012-10-30 | Avi Biopharma, Inc. | Method of synthesis of morpholino oligomers |
| US8076476B2 (en) | 2007-11-15 | 2011-12-13 | Avi Biopharma, Inc. | Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits |
| WO2009064471A1 (fr) * | 2007-11-15 | 2009-05-22 | Avi Biopharma, Inc. | Procédé de synthèse d'oligomères morpholino |
| CN102203253B (zh) | 2008-10-24 | 2016-04-06 | 萨雷普塔治疗公司 | 用于dmd的多外显子跳跃组合物 |
| ES2573981T3 (es) | 2009-04-10 | 2016-06-13 | Association Institut De Myologie | Oligonucleótidos antisentido de triciclo-ADN, composiciones, y métodos para el tratamiento de enfermedades |
| CN105838714B (zh) | 2009-11-12 | 2020-07-17 | 西澳大利亚大学 | 反义分子和治疗疾病的方法 |
| TWI463423B (zh) | 2010-05-28 | 2014-12-01 | Poynt Corp | 用以針對基於三維形狀之廣告系統使用位置資訊的方法 |
| KR101981705B1 (ko) * | 2010-05-28 | 2019-05-24 | 사렙타 쎄러퓨틱스, 인코퍼레이티드 | 변형된 서브유니트간 결합 및/또는 말단 그룹을 갖는 올리고뉴클레오타이드 유사체 |
| TWI541024B (zh) * | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
| PL2623507T3 (pl) | 2010-09-30 | 2017-03-31 | Nippon Shinyaku Co., Ltd. | Pochodna kwasu morfolinonukleinowego |
| EP2672977A1 (fr) * | 2011-02-08 | 2013-12-18 | The Charlotte-Mecklenburg Hospital Authority d/b/a Carolina Healthcare System | Oligonucléotides antisens |
| US9920084B2 (en) | 2011-08-23 | 2018-03-20 | The Royal Institution For The Advancement Of Learning/Mcgill University | Ionic tags for synthesis of oligoribonucleotides |
| ES2535654T3 (es) | 2011-10-13 | 2015-05-13 | Association Institut De Myologie | ADN triciclo-fosforotioato |
| MX354940B (es) | 2011-11-18 | 2018-03-27 | Sarepta Therapeutics Inc | Oligonucleotidos funcionalmente modificados y subunidades de los mismos. |
| US9944926B2 (en) * | 2011-11-30 | 2018-04-17 | Sarepta Therapeutics, Inc. | Induced exon inclusion in spinal muscle atrophy |
| CN117721110A (zh) * | 2011-12-28 | 2024-03-19 | 日本新药株式会社 | 反义核酸 |
| EP2820155B1 (fr) | 2012-02-28 | 2017-07-26 | Population Genetics Technologies Ltd. | Procédé de fixation d'une contre-séquence à un échantillon d'acides nucléiques |
| CN102702265A (zh) * | 2012-05-14 | 2012-10-03 | 天津特安化学科技有限公司 | 一种固相合成磷酰二胺吗啉代寡核苷酸及方法 |
| EP3760720A1 (fr) | 2013-03-14 | 2021-01-06 | Sarepta Therapeutics, Inc. | Compositions de saut d'exons pour le traitement de la dystrophie musculaire |
| BR122020016865B1 (pt) * | 2013-03-14 | 2022-12-27 | Sarepta Therapeutics, Inc. | Oligonucleotídeo antisenso, composição farmacêutica compreendendo o mesmo e uso da dita composição para o tratamento de distrofia muscular de duchenne (dmd) |
| CA2906812A1 (fr) | 2013-03-15 | 2014-09-18 | Sarepta Therapeutics, Inc. | Compositions ameliorees pour le traitement de la dystrophie musculaire |
| CN105228999B (zh) * | 2013-05-24 | 2021-03-02 | 味之素株式会社 | 吗啉代寡核苷酸的制备方法 |
| MA45362A (fr) | 2016-05-24 | 2019-04-10 | Sarepta Therapeutics Inc | Procédés de préparation d'oligomères morpholino de phosphorodiamidate |
| MX2018014123A (es) | 2016-05-24 | 2019-04-29 | Sarepta Therapeutics Inc | Procesos para preparar oligomeros de morfolino fosforodiamidato. |
| US11472824B2 (en) | 2016-05-24 | 2022-10-18 | Sarepta Therapeutics, Inc. | Processes for preparing phosphorodiamidate morpholino oligomers |
| SG11201809499UA (en) | 2016-05-24 | 2018-12-28 | Sarepta Therapeutics Inc | Processes for preparing phosphorodiamidate morpholino oligomers |
| KR102506298B1 (ko) | 2016-05-24 | 2023-03-06 | 사렙타 쎄러퓨틱스 인코퍼레이티드 | 올리고머의 제조 방법 |
| CA3046801A1 (fr) | 2016-12-19 | 2018-06-28 | Sarepta Therapeutics, Inc. | Conjugues oligomeres de sauts d'exons pour la dystrophie musculaire |
| PT3554553T (pt) | 2016-12-19 | 2022-08-04 | Sarepta Therapeutics Inc | Conjugados oligoméricos de salto de exão para a distrofia muscular |
| EP3554552B1 (fr) | 2016-12-19 | 2022-08-17 | Sarepta Therapeutics, Inc. | Conjugués oligomères de sauts d'exons pour la dystrophie musculaire |
| EA201991450A1 (ru) | 2017-09-22 | 2019-12-30 | Сарепта Терапьютикс, Инк. | Конъюгаты олигомеров для пропуска экзона при мышечной дистрофии |
-
2017
- 2017-05-24 KR KR1020187036117A patent/KR102506298B1/ko active IP Right Grant
- 2017-05-24 CA CA3025339A patent/CA3025339A1/fr active Pending
- 2017-05-24 MA MA045154A patent/MA45154A/fr unknown
- 2017-05-24 AU AU2017269355A patent/AU2017269355B2/en active Active
- 2017-05-24 CN CN201780037531.XA patent/CN109563114B/zh active Active
- 2017-05-24 TW TW110113938A patent/TWI801843B/zh active
- 2017-05-24 TW TW106117189A patent/TWI738784B/zh active
- 2017-05-24 JP JP2018562078A patent/JP7008642B2/ja active Active
- 2017-05-24 MX MX2018014472A patent/MX2018014472A/es unknown
- 2017-05-24 US US16/303,356 patent/US10875880B2/en active Active
- 2017-05-24 MX MX2021008539A patent/MX2021008539A/es unknown
- 2017-05-24 BR BR122022014984-7A patent/BR122022014984B1/pt active IP Right Grant
- 2017-05-24 BR BR112018074346-1A patent/BR112018074346B1/pt active IP Right Grant
- 2017-05-24 MA MA049775A patent/MA49775A/fr unknown
- 2017-05-24 EP EP17731336.8A patent/EP3464305B1/fr active Active
- 2017-05-24 EP EP19174995.1A patent/EP3564248A1/fr active Pending
- 2017-05-24 WO PCT/US2017/034235 patent/WO2017205496A1/fr active Application Filing
- 2017-05-24 SG SG10202101830WA patent/SG10202101830WA/en unknown
-
2018
- 2018-11-20 IL IL263149A patent/IL263149B2/en unknown
- 2018-11-24 SA SA518400500A patent/SA518400500B1/ar unknown
- 2018-12-19 CO CONC2018/0013838A patent/CO2018013838A2/es unknown
-
2020
- 2020-11-16 US US17/098,935 patent/US11384105B2/en active Active
-
2021
- 2021-07-15 JP JP2021117392A patent/JP2021176967A/ja active Pending
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