MA49775A - Procédés de préparation d'oligomères morpholino de phosphorodiamidate - Google Patents
Procédés de préparation d'oligomères morpholino de phosphorodiamidateInfo
- Publication number
- MA49775A MA49775A MA049775A MA49775A MA49775A MA 49775 A MA49775 A MA 49775A MA 049775 A MA049775 A MA 049775A MA 49775 A MA49775 A MA 49775A MA 49775 A MA49775 A MA 49775A
- Authority
- MA
- Morocco
- Prior art keywords
- phosphorodiamidate
- processes
- preparation
- morpholino oligomers
- morpholino
- Prior art date
Links
- CPEONABTMRSIKA-UHFFFAOYSA-N 1,4$l^{2}-oxazinane Chemical class C1COCC[N]1 CPEONABTMRSIKA-UHFFFAOYSA-N 0.000 title 1
- ANCLJVISBRWUTR-UHFFFAOYSA-N diaminophosphinic acid Chemical compound NP(N)(O)=O ANCLJVISBRWUTR-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
- C07F9/65616—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings containing the ring system having three or more than three double bonds between ring members or between ring members and non-ring members, e.g. purine or analogs
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
- C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
- Polymers With Sulfur, Phosphorus Or Metals In The Main Chain (AREA)
- Saccharide Compounds (AREA)
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662341049P | 2016-05-24 | 2016-05-24 | |
| US201662357166P | 2016-06-30 | 2016-06-30 | |
| US201662356923P | 2016-06-30 | 2016-06-30 | |
| US201662357153P | 2016-06-30 | 2016-06-30 | |
| US201662357072P | 2016-06-30 | 2016-06-30 | |
| US201762508256P | 2017-05-18 | 2017-05-18 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA49775A true MA49775A (fr) | 2020-06-10 |
Family
ID=59078165
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA045154A MA45154A (fr) | 2016-05-24 | 2017-05-24 | Procédés de préparation d'oligomères |
| MA049775A MA49775A (fr) | 2016-05-24 | 2017-05-24 | Procédés de préparation d'oligomères morpholino de phosphorodiamidate |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA045154A MA45154A (fr) | 2016-05-24 | 2017-05-24 | Procédés de préparation d'oligomères |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US10875880B2 (fr) |
| EP (2) | EP3464305B1 (fr) |
| JP (2) | JP7008642B2 (fr) |
| KR (1) | KR102506298B1 (fr) |
| CN (1) | CN109563114B (fr) |
| AU (1) | AU2017269355B2 (fr) |
| BR (2) | BR112018074346B1 (fr) |
| CA (1) | CA3025339A1 (fr) |
| CO (1) | CO2018013838A2 (fr) |
| IL (1) | IL263149B2 (fr) |
| MA (2) | MA45154A (fr) |
| MX (2) | MX2021008539A (fr) |
| SA (1) | SA518400500B1 (fr) |
| SG (1) | SG10202101830WA (fr) |
| TW (2) | TWI801843B (fr) |
| WO (1) | WO2017205496A1 (fr) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI541024B (zh) | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
| MA45154A (fr) | 2016-05-24 | 2019-04-10 | Sarepta Therapeutics Inc | Procédés de préparation d'oligomères |
| AU2017270598B2 (en) * | 2016-05-24 | 2022-12-01 | Sarepta Therapeutics, Inc. | Processes for preparing phosphorodiamidate morpholino oligomers |
| MD3464306T2 (ro) * | 2016-05-24 | 2024-08-31 | Sarepta Therapeutics Inc | Procedee de preparare a oligomerilor morfolino fosforodiamidați |
| MA45362A (fr) | 2016-05-24 | 2019-04-10 | Sarepta Therapeutics Inc | Procédés de préparation d'oligomères morpholino de phosphorodiamidate |
| US11472824B2 (en) | 2016-05-24 | 2022-10-18 | Sarepta Therapeutics, Inc. | Processes for preparing phosphorodiamidate morpholino oligomers |
| CN109152775B (zh) * | 2016-06-30 | 2022-04-26 | 萨勒普塔医疗公司 | 制备磷酸二酰胺吗啉代寡聚物的方法 |
| ES2963336T3 (es) * | 2017-09-25 | 2024-03-26 | Sarepta Therapeutics Inc | Procesos para preparar oligómeros de fosforodiamidato morfolino mediante síntesis de flujo rápido |
| EP3784248A4 (fr) * | 2018-04-26 | 2022-08-10 | Sarepta Therapeutics, Inc. | Oligomères induisant le saut d'exon et conjugués d'oligomères pour la dystrophie musculaire |
Family Cites Families (53)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5185444A (en) | 1985-03-15 | 1993-02-09 | Anti-Gene Deveopment Group | Uncharged morpolino-based polymers having phosphorous containing chiral intersubunit linkages |
| US5217866A (en) | 1985-03-15 | 1993-06-08 | Anti-Gene Development Group | Polynucleotide assay reagent and method |
| EP0639582B1 (fr) | 1985-03-15 | 1998-09-16 | Antivirals Inc. | Réactif et procédé d'analyse de polynucléotides |
| US5506337A (en) | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| US5166315A (en) | 1989-12-20 | 1992-11-24 | Anti-Gene Development Group | Sequence-specific binding polymers for duplex nucleic acids |
| US5034506A (en) | 1985-03-15 | 1991-07-23 | Anti-Gene Development Group | Uncharged morpholino-based polymers having achiral intersubunit linkages |
| US5521063A (en) | 1985-03-15 | 1996-05-28 | Antivirals Inc. | Polynucleotide reagent containing chiral subunits and methods of use |
| WO1990002749A1 (fr) | 1988-09-01 | 1990-03-22 | Forskningscenter Risø | Procede de synthese de peptides et support solide de realisation dudit procede |
| CA2180253A1 (fr) | 1993-12-29 | 1995-07-06 | Atsushi Akahane | Compose pyrazolopyridine antagoniste de l'adenosine |
| US7572582B2 (en) | 1997-09-12 | 2009-08-11 | Exiqon A/S | Oligonucleotide analogues |
| US6794499B2 (en) | 1997-09-12 | 2004-09-21 | Exiqon A/S | Oligonucleotide analogues |
| US7084125B2 (en) | 1999-03-18 | 2006-08-01 | Exiqon A/S | Xylo-LNA analogues |
| US7053207B2 (en) | 1999-05-04 | 2006-05-30 | Exiqon A/S | L-ribo-LNA analogues |
| US6784291B2 (en) | 2000-05-04 | 2004-08-31 | Avi Biopharma, Inc. | Splice-region antisense composition and method |
| EP1446412B1 (fr) | 2001-09-04 | 2012-03-07 | Exiqon A/S | Compositions d'acides nucleiques verrouilles et utilisations |
| US7569575B2 (en) | 2002-05-08 | 2009-08-04 | Santaris Pharma A/S | Synthesis of locked nucleic acid derivatives |
| WO2004043978A2 (fr) | 2002-11-05 | 2004-05-27 | Isis Pharmaceuticals, Inc. | Composes oligomeres substitues par methoxy en position 2' et compositions a utiliser dans des modulations geniques |
| US7759513B2 (en) | 2003-02-21 | 2010-07-20 | Nigu Chemie Gmbh | Photolabile protective groups for improved processes to prepare oligonucleotide arrays |
| EP3808845A1 (fr) | 2004-06-28 | 2021-04-21 | The University Of Western Australia | Oligonucléotides antisens pour induire l'omission de l'exon et leurs procédés d'utilisation |
| US8067571B2 (en) | 2005-07-13 | 2011-11-29 | Avi Biopharma, Inc. | Antibacterial antisense oligonucleotide and method |
| AU2007297861A1 (en) * | 2006-05-10 | 2008-03-27 | Avi Biopharma, Inc. | Oligonucleotide analogs having cationic intersubunit linkages |
| US9371348B2 (en) | 2006-11-27 | 2016-06-21 | The Trustees Of The University Of Pennsylvania | Photocleavable oligonucleotide and uses thereof |
| US8076476B2 (en) | 2007-11-15 | 2011-12-13 | Avi Biopharma, Inc. | Synthesis of morpholino oligomers using doubly protected guanine morpholino subunits |
| US8299206B2 (en) | 2007-11-15 | 2012-10-30 | Avi Biopharma, Inc. | Method of synthesis of morpholino oligomers |
| CN101861318A (zh) * | 2007-11-15 | 2010-10-13 | Avi生物制药公司 | 合成吗啉代低聚物的方法 |
| US8871918B2 (en) | 2008-10-24 | 2014-10-28 | Sarepta Therapeutics, Inc. | Multiple exon skipping compositions for DMD |
| WO2010115993A1 (fr) | 2009-04-10 | 2010-10-14 | Association Institut De Myologie | Oligonucléotides antisens tricyclo-adn, compositions, et méthodes de traitement de maladies |
| KR102581868B1 (ko) | 2009-11-12 | 2023-10-04 | 더 유니버시티 오브 웨스턴 오스트레일리아 | 안티센스 분자 및 이를 이용한 질환 치료방법 |
| JP2013530154A (ja) * | 2010-05-28 | 2013-07-25 | サレプタ セラピューティクス， インコーポレイテッド | 修飾されたサブユニット間結合および／または末端基を有するオリゴヌクレオチドアナログ |
| TWI463423B (zh) * | 2010-05-28 | 2014-12-01 | Poynt Corp | 用以針對基於三維形狀之廣告系統使用位置資訊的方法 |
| TWI541024B (zh) | 2010-09-01 | 2016-07-11 | 日本新藥股份有限公司 | 反義核酸 |
| RS55610B1 (sr) | 2010-09-30 | 2017-06-30 | Nippon Shinyaku Co Ltd | Derivat morfolino nukleinske kiseline |
| CN103501793A (zh) * | 2011-02-08 | 2014-01-08 | 夏洛特-梅克伦堡医院(商业用名:卡罗来纳保健系统) | 反义寡核苷酸 |
| EP2748176B1 (fr) | 2011-08-23 | 2019-04-17 | The Royal Institution for the Advancement of Learning / McGill University | Marqueurs ioniques pour la synthèse d'oligoribonucléotides |
| EP2581448B1 (fr) | 2011-10-13 | 2015-01-28 | Association Institut de Myologie | ADN tricyclo-phosphorothioate |
| BR112014011875B1 (pt) | 2011-11-18 | 2022-01-04 | Sarepta Therapeutics, Inc | Oligonucleotídeos funcionalmente modificados e subunidades dos mesmos |
| ES2727481T3 (es) | 2011-11-30 | 2019-10-16 | Sarepta Therapeutics Inc | Inclusión inducida de exón en atrofia muscular espinal |
| CN110055243B (zh) * | 2011-12-28 | 2024-03-26 | 日本新药株式会社 | 反义核酸 |
| US9670529B2 (en) | 2012-02-28 | 2017-06-06 | Population Genetics Technologies Ltd. | Method for attaching a counter sequence to a nucleic acid sample |
| CN102702265A (zh) * | 2012-05-14 | 2012-10-03 | 天津特安化学科技有限公司 | 一种固相合成磷酰二胺吗啉代寡核苷酸及方法 |
| CA2906209A1 (fr) * | 2013-03-14 | 2014-09-25 | Sarepta Therapeutics, Inc. | Compositions de saut d'exon pour le traitement de dystrophie musculaire ciblant le site d'annelage h44a (-07+15) |
| CN110066793A (zh) * | 2013-03-14 | 2019-07-30 | 萨勒普塔医疗公司 | 用于治疗肌肉萎缩的外显子跳跃组合物 |
| JP2016516066A (ja) | 2013-03-15 | 2016-06-02 | サレプタ セラピューティクス， インコーポレイテッド | 筋ジストロフィを処置するための改善された組成物 |
| JP6477464B2 (ja) | 2013-05-24 | 2019-03-06 | 味の素株式会社 | モルフォリノオリゴヌクレオチドの製造方法 |
| MD3464306T2 (ro) | 2016-05-24 | 2024-08-31 | Sarepta Therapeutics Inc | Procedee de preparare a oligomerilor morfolino fosforodiamidați |
| MA45362A (fr) | 2016-05-24 | 2019-04-10 | Sarepta Therapeutics Inc | Procédés de préparation d'oligomères morpholino de phosphorodiamidate |
| MA45154A (fr) | 2016-05-24 | 2019-04-10 | Sarepta Therapeutics Inc | Procédés de préparation d'oligomères |
| CA3024456A1 (fr) | 2016-05-24 | 2017-11-30 | Sarepta Therapeutics, Inc. | Procedes de preparation d'oligomeres morpholino de phosphorodiamidate |
| US11472824B2 (en) | 2016-05-24 | 2022-10-18 | Sarepta Therapeutics, Inc. | Processes for preparing phosphorodiamidate morpholino oligomers |
| ES2980686T3 (es) | 2016-12-19 | 2024-10-02 | Sarepta Therapeutics Inc | Conjugados de oligómero de omisión de exones para distrofia muscular |
| KR20240006057A (ko) | 2016-12-19 | 2024-01-12 | 사렙타 쎄러퓨틱스 인코퍼레이티드 | 근육 이상증에 대한 엑손 스킵핑 올리고머 결합체 |
| EP3554553B1 (fr) | 2016-12-19 | 2022-07-20 | Sarepta Therapeutics, Inc. | Conjugués oligomère de sauts d'exons pour la dystrophie musculaire |
| EA201991450A1 (ru) | 2017-09-22 | 2019-12-30 | Сарепта Терапьютикс, Инк. | Конъюгаты олигомеров для пропуска экзона при мышечной дистрофии |
-
2017
- 2017-05-24 MA MA045154A patent/MA45154A/fr unknown
- 2017-05-24 AU AU2017269355A patent/AU2017269355B2/en active Active
- 2017-05-24 MA MA049775A patent/MA49775A/fr unknown
- 2017-05-24 EP EP17731336.8A patent/EP3464305B1/fr active Active
- 2017-05-24 US US16/303,356 patent/US10875880B2/en active Active
- 2017-05-24 KR KR1020187036117A patent/KR102506298B1/ko active IP Right Grant
- 2017-05-24 BR BR112018074346-1A patent/BR112018074346B1/pt active IP Right Grant
- 2017-05-24 TW TW110113938A patent/TWI801843B/zh active
- 2017-05-24 BR BR122022014984-7A patent/BR122022014984B1/pt active IP Right Grant
- 2017-05-24 WO PCT/US2017/034235 patent/WO2017205496A1/fr active Application Filing
- 2017-05-24 MX MX2021008539A patent/MX2021008539A/es unknown
- 2017-05-24 CA CA3025339A patent/CA3025339A1/fr active Pending
- 2017-05-24 CN CN201780037531.XA patent/CN109563114B/zh active Active
- 2017-05-24 EP EP19174995.1A patent/EP3564248A1/fr active Pending
- 2017-05-24 SG SG10202101830WA patent/SG10202101830WA/en unknown
- 2017-05-24 JP JP2018562078A patent/JP7008642B2/ja active Active
- 2017-05-24 TW TW106117189A patent/TWI738784B/zh active
- 2017-05-24 MX MX2018014472A patent/MX2018014472A/es unknown
-
2018
- 2018-11-20 IL IL263149A patent/IL263149B2/en unknown
- 2018-11-24 SA SA518400500A patent/SA518400500B1/ar unknown
- 2018-12-19 CO CONC2018/0013838A patent/CO2018013838A2/es unknown
-
2020
- 2020-11-16 US US17/098,935 patent/US11384105B2/en active Active
-
2021
- 2021-07-15 JP JP2021117392A patent/JP2021176967A/ja active Pending
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