MA51510A - Procédés de préparation de dérivés d'indolinobenzodiazépine - Google Patents
Procédés de préparation de dérivés d'indolinobenzodiazépineInfo
- Publication number
- MA51510A MA51510A MA051510A MA51510A MA51510A MA 51510 A MA51510 A MA 51510A MA 051510 A MA051510 A MA 051510A MA 51510 A MA51510 A MA 51510A MA 51510 A MA51510 A MA 51510A
- Authority
- MA
- Morocco
- Prior art keywords
- processes
- preparation
- indolinobenzodiazepine
- derivatives
- indolinobenzodiazepine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
- C07D209/12—Radicals substituted by oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762487695P | 2017-04-20 | 2017-04-20 |
Publications (1)
Publication Number | Publication Date |
---|---|
MA51510A true MA51510A (fr) | 2020-11-11 |
Family
ID=62117004
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MA051510A MA51510A (fr) | 2017-04-20 | 2018-04-19 | Procédés de préparation de dérivés d'indolinobenzodiazépine |
Country Status (12)
Country | Link |
---|---|
US (4) | US10442809B2 (fr) |
EP (1) | EP3612533A1 (fr) |
JP (2) | JP7170663B2 (fr) |
KR (2) | KR20230154089A (fr) |
CN (2) | CN115448926A (fr) |
AU (2) | AU2018254463B2 (fr) |
CA (1) | CA3060086A1 (fr) |
IL (4) | IL311609A (fr) |
MA (1) | MA51510A (fr) |
SG (1) | SG11201909564XA (fr) |
TW (1) | TWI790228B (fr) |
WO (1) | WO2018195245A1 (fr) |
Families Citing this family (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL311609A (en) | 2017-04-20 | 2024-05-01 | Immunogen Inc | Methods for the preparation of indolinobenzodiazepine derivatives |
CA3228268A1 (fr) * | 2021-08-13 | 2023-02-16 | Andrew Brian Hague | Procedes ameliores de preparation de derives de benzodiazepine cytotoxiques |
Family Cites Families (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3453266A (en) | 1966-03-14 | 1969-07-01 | American Home Prod | 1,2,5-benzothiadiazepine 1,1-dioxides |
US3506646A (en) | 1966-06-27 | 1970-04-14 | American Home Prod | Process for the preparation of 7h-pyrido (1,2-b)(1,2,5)benzothiadiazepine 5,5 - dioxides and pyrrolo(1,2-b)(1,2,5)benzothiadiazepine 5,5-dioxides |
US3875162A (en) | 1973-07-26 | 1975-04-01 | Squibb & Sons Inc | Certain 6H-pyrimido{8 1,2-c{9 {8 1,3,5{9 benzothiadiaza compounds |
US4003905A (en) | 1974-12-11 | 1977-01-18 | E. R. Squibb & Sons, Inc. | Diels-alder adducts of benzdiazepines |
US4444688A (en) | 1981-05-11 | 1984-04-24 | Ciba-Geigy Corporation | Imidazobenzothiadiazepines |
JP2920385B2 (ja) | 1988-08-18 | 1999-07-19 | 武田薬品工業株式会社 | 1,2,5‐ベンゾチアジアゼピン誘導体,その製造法および用途 |
JP3006615B2 (ja) * | 1989-02-08 | 2000-02-07 | 電気化学工業株式会社 | D―β―ヒドロキシアミノ酸の製造法 |
US6660856B2 (en) * | 2002-03-08 | 2003-12-09 | Kaohsiung Medical University | Synthesis of pyrrolo[2,1-c][1,4]benzodiazepine analogues |
GB0209467D0 (en) | 2002-04-25 | 2002-06-05 | Astrazeneca Ab | Chemical compounds |
RU2338747C2 (ru) | 2003-03-31 | 2008-11-20 | Каунсил Оф Сайентифик Энд Индастриал Рисерч | ДИМЕРЫ ПИРРОЛО [2, 1-c][1, 4] БЕНЗОДИАЗЕПИНА В КАЧЕСТВЕ ПРОТИВООПУХОЛЕВЫХ СРЕДСТВ И СПОСОБ ИХ ПОЛУЧЕНИЯ |
RU2314309C2 (ru) | 2003-03-31 | 2008-01-10 | Каунсил Оф Сайентифик Энд Индастриал Рисерч | Пирроло [2.1-c][1.4] бензодиазепины, способ их получения и фармацевтическая композиция на их основе |
AU2010210646B2 (en) * | 2009-02-05 | 2015-10-29 | Immunogen, Inc. | Novel benzodiazepine derivatives |
SI2675479T1 (sl) * | 2011-02-15 | 2016-04-29 | Immunogen, Inc. | Citotoksični derivati benzodiazepina |
GB201201100D0 (en) | 2012-01-20 | 2012-03-07 | Medical Res Council | Polypeptides and methods |
CN116514903A (zh) | 2014-09-03 | 2023-08-01 | 伊缪诺金公司 | 细胞毒性苯并二氮杂䓬衍生物 |
US9381256B2 (en) | 2014-09-03 | 2016-07-05 | Immunogen, Inc. | Cytotoxic benzodiazepine derivatives |
WO2016115201A1 (fr) | 2015-01-14 | 2016-07-21 | Bristol-Myers Squibb Company | Dimères de benzodiazépines à ponts hétéroarylène, leurs conjugués, et procédés de production et d'utilisation |
IL311609A (en) | 2017-04-20 | 2024-05-01 | Immunogen Inc | Methods for the preparation of indolinobenzodiazepine derivatives |
-
2018
- 2018-04-19 IL IL311609A patent/IL311609A/en unknown
- 2018-04-19 SG SG11201909564X patent/SG11201909564XA/en unknown
- 2018-04-19 TW TW107113286A patent/TWI790228B/zh active
- 2018-04-19 CN CN202211145894.4A patent/CN115448926A/zh active Pending
- 2018-04-19 MA MA051510A patent/MA51510A/fr unknown
- 2018-04-19 KR KR1020237036717A patent/KR20230154089A/ko not_active Application Discontinuation
- 2018-04-19 JP JP2019556698A patent/JP7170663B2/ja active Active
- 2018-04-19 EP EP18723156.8A patent/EP3612533A1/fr active Pending
- 2018-04-19 IL IL270008A patent/IL270008B/en unknown
- 2018-04-19 CN CN201880025787.3A patent/CN110573510B/zh active Active
- 2018-04-19 CA CA3060086A patent/CA3060086A1/fr active Pending
- 2018-04-19 US US15/956,835 patent/US10442809B2/en active Active
- 2018-04-19 AU AU2018254463A patent/AU2018254463B2/en active Active
- 2018-04-19 IL IL293192A patent/IL293192B2/en unknown
- 2018-04-19 IL IL305224A patent/IL305224B1/en unknown
- 2018-04-19 WO PCT/US2018/028253 patent/WO2018195245A1/fr unknown
- 2018-04-19 KR KR1020197033777A patent/KR102595714B1/ko active IP Right Grant
-
2019
- 2019-09-04 US US16/560,379 patent/US10968228B2/en active Active
-
2021
- 2021-02-26 US US17/186,234 patent/US11760759B2/en active Active
-
2022
- 2022-08-11 AU AU2022215237A patent/AU2022215237B2/en active Active
- 2022-10-31 JP JP2022174347A patent/JP2023015178A/ja active Pending
-
2023
- 2023-08-02 US US18/229,579 patent/US20240067652A1/en active Pending
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