MA51285A - Dérivés d'azaindole comme inhibiteurs de rho-kinase - Google Patents

Dérivés d'azaindole comme inhibiteurs de rho-kinase

Info

Publication number
MA51285A
MA51285A MA051285A MA51285A MA51285A MA 51285 A MA51285 A MA 51285A MA 051285 A MA051285 A MA 051285A MA 51285 A MA51285 A MA 51285A MA 51285 A MA51285 A MA 51285A
Authority
MA
Morocco
Prior art keywords
rho
kinase inhibitors
azaindole derivatives
azaindole
derivatives
Prior art date
Application number
MA051285A
Other languages
English (en)
Inventor
Alessandro Accetta
Christine Edwards
Andrea Nuzzi
Fabio Rancati
Original Assignee
Chiesi Farm Spa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chiesi Farm Spa filed Critical Chiesi Farm Spa
Publication of MA51285A publication Critical patent/MA51285A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/007—Pulmonary tract; Aromatherapy
    • A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
MA051285A 2017-12-18 2018-12-14 Dérivés d'azaindole comme inhibiteurs de rho-kinase MA51285A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP17208193 2017-12-18

Publications (1)

Publication Number Publication Date
MA51285A true MA51285A (fr) 2021-04-28

Family

ID=60673855

Family Applications (1)

Application Number Title Priority Date Filing Date
MA051285A MA51285A (fr) 2017-12-18 2018-12-14 Dérivés d'azaindole comme inhibiteurs de rho-kinase

Country Status (5)

Country Link
US (1) US11332468B2 (fr)
EP (1) EP3728248B1 (fr)
AR (1) AR113947A1 (fr)
MA (1) MA51285A (fr)
WO (1) WO2019121406A1 (fr)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116568304A (zh) 2020-12-15 2023-08-08 奇斯药制品公司 作为rho-激酶抑制剂的二氢呋喃并吡啶衍生物
WO2022128851A1 (fr) 2020-12-15 2022-06-23 Chiesi Farmaceutici S.P.A. Dérivés de dihydrofuropyridine utilisés comme inhibiteurs de la rho kinase
MX2023005866A (es) 2020-12-15 2023-06-05 Chiesi Farm Spa Derivados de dihidrofuropiridina como inhibidores de rho-cinasa.
WO2023110700A1 (fr) 2021-12-13 2023-06-22 Chiesi Farmaceutici S.P.A. Dérivés de dihydrofuropyridine utilisés comme inhibiteurs de la rho-kinase

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR100600550B1 (ko) * 2000-10-20 2006-07-13 에자이 가부시키가이샤 질소 함유 방향환 유도체
CA2503646C (fr) 2002-10-28 2011-09-27 Bayer Healthcare Ag Phenylaminopyrimidine substituee par heteroaryloxy et utilisee en tant qu'inhibiteur de kinase
WO2006009889A1 (fr) 2004-06-17 2006-01-26 Smithkline Beecham Corporation Inhibiteurs novateurs de protéines rho-kinases
CA2709918A1 (fr) 2007-12-21 2009-06-25 The Scripps Research Institute Benzopyranes et analogues utilises comme inhibiteurs de la rho kinase
EP2331507A2 (fr) 2008-09-18 2011-06-15 Astellas Pharma Inc. Composés de carboxamide hétérocycliques
SI2593452T1 (sl) 2010-07-14 2017-06-30 Novartis Ag Heterociklične spojine agonisti receptorja IP
WO2014032755A2 (fr) * 2012-08-29 2014-03-06 Merck Patent Gmbh Inhibiteurs de ddr2 pour le traitement de l'arthrose
SI2951172T1 (sl) 2013-01-29 2017-08-31 Redx Pharma Plc Piridin derivati kot inhibitorji mehkih kamnov
TWI800498B (zh) 2016-12-21 2023-05-01 義大利商吉斯藥品公司 作為Rho-激酶抑制劑之雙環二氫嘧啶-羧醯胺衍生物
CA3047212A1 (fr) 2017-01-30 2018-08-02 Chiesi Farmaceutici S.P.A. Derives de tyrosine amide utilises en tant qu'inhibiteurs de la rho-kinase

Also Published As

Publication number Publication date
EP3728248A1 (fr) 2020-10-28
WO2019121406A1 (fr) 2019-06-27
US20200392133A1 (en) 2020-12-17
US11332468B2 (en) 2022-05-17
EP3728248B1 (fr) 2022-02-02
AR113947A1 (es) 2020-07-01

Similar Documents

Publication Publication Date Title
MA43753A (fr) Dérivés 1-cyano-pyrrolidine comme inhibiteurs de dbu
MA45591A (fr) Dérivés de 1,3-dihydroxy-phényle utiles comme immunomodulateurs
EP3687543A4 (fr) Agents pharmaceutiques en combinaison en tant qu'inhibiteurs de rsv
IL268004B (en) History of tyrosine amide as rho-kinase inhibitors
MA41251A (fr) Dérivés de thiéno[2,3-c]pyrrol-4-one comme inhibiteurs erk
MA46339A (fr) Dérivés de cyanopyrrolidine ayant une activité en tant qu'inhibiteurs de l'usp 30
EP3402799A4 (fr) Composés hétérocycliques utilisés comme inhibiteurs du vrs
MA45646A (fr) Derives de benzimidazole comme des modulateurs de ror-gamma
TWI800498B (zh) 作為Rho-激酶抑制劑之雙環二氫嘧啶-羧醯胺衍生物
MA52413A (fr) Inhibiteurs de cd73
DK3324977T3 (da) Benzodiazepinderivater som rsv-inhibitorer
IL277455A (en) History of aminopyrimidines as CTPS1 inhibitors
MA40774A (fr) Dérivés de diaryle-urée en tant qu'inhibiteurs de kinase p38
MA41140A (fr) Dérivés de 2,4-dioxo-quinazoline-6-sulfonamide en tant qu'inhibiteurs de la parg
MA46981A (fr) Dérivés de benzimidazole en tant qu'inhibiteurs de bromodomaine
MA51285A (fr) Dérivés d'azaindole comme inhibiteurs de rho-kinase
MA42597A (fr) 2-amino-3-fluoro-3-(fluorométhyl)-6-méthyl-6-phényl-3,4,5,6-tétrahydropyridines comme inhibiteurs de bace1
MA52891A (fr) Dérivés aza-indoliques utilisés comme inhibiteurs de rho-kinase
EP3556758C0 (fr) Dérivés de 1,2-dihydro-1,6-naphthyridin-2-one en tant qu'inhibiteurs de cdk4/6
HK1257565A1 (zh) 作為htra1抑制劑的新型三氟甲基丙酰胺衍生物
DK3717488T3 (da) Substituerede furanopyrimidinforbindelser som pde1-inhibitorer
MA49006A (fr) Inhibiteurs d'ip6k
EA201690523A1 (ru) Триазолопиридины, композиции и способы их применения
IL264785B (en) History of concentrated thiophenes useful as napi-iib inhibitors
HK1257567A1 (zh) 作為htra1抑制劑的新型二氟酮酰胺衍生物