SG11201909564XA - Methods of preparing indolinobenzodiazepine derivatives - Google Patents

Abstract

INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 25 October 2018 (25.10.2018) WIP0 I PCT 0111111010 0111 °nolo omuliolomunom oimIE (10) International Publication Number WO 2018/195245 Al (51) International Patent Classification: C07D 487/04 (2006.01) (21) International Application Number: PCT/US2018/028253 (22) International Filing Date: 19 April 2018 (19.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/487,695 20 April 2017 (20.04.2017) US (71) Applicant: IMMUNOGEN, INC. [US/US]; 830 Winter Street, Waltham, MA 02451 (US). (72) Inventors: GERARD, Baudouin; 69 Dartmouth Street, Belmont, MA 02478 (US). SILVA, Richard, A.; 587 Greendale Avenue, Needham, MA 02492 (US). MILLER, Michael, Louis; 4 Maymont Drive, Framingham, MA 01701 (US) SHIZUKA, Manami; 253 Payson Road, Bel- mont, MA 02478 (US). (74) Agent: DAVIS, Steven, G. et al.; McCarter & English, LLP, 265 Franklin Street, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a 1 patent (Rule 4.17(0) 71' as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) 1 1 1-1 Published: — with international search report (Art. 21(3)) 1-1 (54) Title: METHODS OF PREPARING INDOLINOBENZODIAZEPINE DERIVATIVES \" (57) : The invention provides novel methods for preparing indolinobenzodiazepine monomer compounds and their synthetic 0 precursors.