SG11201906666QA - Methods of preparing cytotoxic benzodiazepine derivatives - Google Patents
Methods of preparing cytotoxic benzodiazepine derivativesInfo
- Publication number
- SG11201906666QA SG11201906666QA SG11201906666QA SG11201906666QA SG11201906666QA SG 11201906666Q A SG11201906666Q A SG 11201906666QA SG 11201906666Q A SG11201906666Q A SG 11201906666QA SG 11201906666Q A SG11201906666Q A SG 11201906666QA SG 11201906666Q A SG11201906666Q A SG 11201906666QA
- Authority
- SG
- Singapore
- Prior art keywords
- international
- english
- applicant
- pct
- rule
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/16—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C201/00—Preparation of esters of nitric or nitrous acid or of compounds containing nitro or nitroso groups bound to a carbon skeleton
- C07C201/06—Preparation of nitro compounds
- C07C201/12—Preparation of nitro compounds by reactions not involving the formation of nitro groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
- C07C205/13—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups
- C07C205/19—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by hydroxy groups having nitro groups bound to carbon atoms of six-membered aromatic rings and hydroxy groups bound to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/44—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members
- C07D207/444—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5
- C07D207/448—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide
- C07D207/452—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having three double bonds between ring members or between ring members and non-ring members having two doubly-bound oxygen atoms directly attached in positions 2 and 5 with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. maleimide with hydrocarbon radicals, substituted by hetero atoms, directly attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
- C07D519/04—Dimeric indole alkaloids, e.g. vincaleucoblastine
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Abstract
INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (43) International Publication Date 02 August 2018 (02.08.2018) WI P0 I PCT omit VIII 110 VIII mil oil oimIE (10) International Publication Number WO 2018/140435 Al (51) International Patent Classification: C07C 205/19 (2006.01) C07D 207/452 (2006.01) C07D 487/04 (2006.01) C07D 519/04 (2006.01) (21) International Application Number: PCT/US2018/014956 (22) International Filing Date: 24 January 2018 (24.01.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/450,270 25 January 2017 (25.01.2017) US (71) Applicant: IMMUNOGEN, INC. [US/US]; 830 Winter Street, Waltham, MA 02451 (US). (72) Inventors: GERARD, Baudouin; 69 Dartmouth Street, Belmont, MA 02478 (US). SILVA, Richard, A.; 587 Greendale Avenue, Needham, MA 02492 (US). MILLER, Michael, Louis; 4 Maymont Drive, Framingham, MA 01701 (US) SHIZUKA, Manami; 253 Payson Road, Bel- mont, MA 02478 (US). (74) Agent: DAVIS, Steven, G. et al.; McCarter & English, LLP, 265 Franklin Street, Boston, MA 02110 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: as to applicant's entitlement to apply for and be granted a patent (Rule 4.170) as to the applicant's entitlement to claim the priority of the earlier application (Rule 4.17(iii)) Published: — with international search report (Art. 21(3)) (54) Title: METHODS OF PREPARING CYTOTOXIC BENZODIAZEPINE DERIVATIVES O (57) : The invention provides novel methods for preparing indolinobenzodiazepine dimer compounds and 0 precursors. their synthetic
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762450270P | 2017-01-25 | 2017-01-25 | |
| PCT/US2018/014956 WO2018140435A1 (en) | 2017-01-25 | 2018-01-24 | Methods of preparing cytotoxic benzodiazepine derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG11201906666QA true SG11201906666QA (en) | 2019-08-27 |
Family
ID=61189535
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG11201906666QA SG11201906666QA (en) | 2017-01-25 | 2018-01-24 | Methods of preparing cytotoxic benzodiazepine derivatives |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US10385071B2 (en) |
| EP (2) | EP4148044A1 (en) |
| JP (3) | JP7066725B2 (en) |
| KR (2) | KR20230005410A (en) |
| CN (3) | CN116554262A (en) |
| AU (3) | AU2018213202B2 (en) |
| CA (1) | CA3050262A1 (en) |
| DK (1) | DK3573948T3 (en) |
| ES (1) | ES2935346T3 (en) |
| FI (1) | FI3573948T3 (en) |
| HR (1) | HRP20230002T1 (en) |
| HU (1) | HUE060746T2 (en) |
| IL (3) | IL293645A (en) |
| LT (1) | LT3573948T (en) |
| PL (1) | PL3573948T3 (en) |
| PT (1) | PT3573948T (en) |
| RS (1) | RS63871B1 (en) |
| RU (2) | RU2021138005A (en) |
| SG (1) | SG11201906666QA (en) |
| SI (1) | SI3573948T1 (en) |
| TW (3) | TW202400551A (en) |
| WO (1) | WO2018140435A1 (en) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LT3573948T (en) | 2017-01-25 | 2023-02-10 | Immunogen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| EP4361128A2 (en) | 2018-11-12 | 2024-05-01 | ImmunoGen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| EP3880656B1 (en) | 2018-11-12 | 2024-03-20 | ImmunoGen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| CN113661172A (en) * | 2019-03-29 | 2021-11-16 | 伊缪诺金公司 | Cytotoxic bis-benzodiazepine derivatives and conjugates thereof with cell-binding agents for use in inhibiting abnormal cell growth or treating proliferative diseases |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9018601D0 (en) | 1990-08-24 | 1990-10-10 | Fujisawa Pharmaceutical Co | Tricyclic compounds |
| NZ610939A (en) | 2010-12-21 | 2014-07-25 | Janssen Pharmaceutica Nv | Novel antifungal 5,6-dihydro-4h-pyrrolo[1,2-a][1,4]- benzodiazepines and 6h-pyrrolo[1,2-a][1,4]benzodiazepines substituted with bicyclic benzene derivatives |
| KR20190089048A (en) * | 2011-02-15 | 2019-07-29 | 이뮤노젠 아이엔씨 | Methods of preparation of conjugates |
| KR20170102980A (en) * | 2015-01-14 | 2017-09-12 | 브리스톨-마이어스 스큅 컴퍼니 | Benzodiazepine dimer, conjugates thereof, and methods of making and using |
| JP7203497B2 (en) * | 2015-06-29 | 2023-01-13 | イミュノジェン・インコーポレーテッド | Anti-CD123 Antibodies, and Conjugates and Derivatives Thereof |
| WO2017015495A1 (en) * | 2015-07-21 | 2017-01-26 | Immunogen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
| LT3573948T (en) | 2017-01-25 | 2023-02-10 | Immunogen, Inc. | Methods of preparing cytotoxic benzodiazepine derivatives |
-
2018
- 2018-01-24 LT LTEPPCT/US2018/014956T patent/LT3573948T/en unknown
- 2018-01-24 RU RU2021138005A patent/RU2021138005A/en unknown
- 2018-01-24 ES ES18704352T patent/ES2935346T3/en active Active
- 2018-01-24 CN CN202310124650.6A patent/CN116554262A/en active Pending
- 2018-01-24 PT PT187043526T patent/PT3573948T/en unknown
- 2018-01-24 EP EP22199432.0A patent/EP4148044A1/en active Pending
- 2018-01-24 US US15/878,991 patent/US10385071B2/en active Active
- 2018-01-24 CN CN201880008141.4A patent/CN110225904B/en active Active
- 2018-01-24 AU AU2018213202A patent/AU2018213202B2/en active Active
- 2018-01-24 KR KR1020227044421A patent/KR20230005410A/en not_active Application Discontinuation
- 2018-01-24 CA CA3050262A patent/CA3050262A1/en active Pending
- 2018-01-24 TW TW112117953A patent/TW202400551A/en unknown
- 2018-01-24 RU RU2019125133A patent/RU2762891C2/en active
- 2018-01-24 TW TW111114178A patent/TWI805325B/en active
- 2018-01-24 HU HUE18704352A patent/HUE060746T2/en unknown
- 2018-01-24 DK DK18704352.6T patent/DK3573948T3/en active
- 2018-01-24 FI FIEP18704352.6T patent/FI3573948T3/en active
- 2018-01-24 SI SI201830832T patent/SI3573948T1/en unknown
- 2018-01-24 WO PCT/US2018/014956 patent/WO2018140435A1/en unknown
- 2018-01-24 TW TW107102506A patent/TWI763771B/en active
- 2018-01-24 PL PL18704352.6T patent/PL3573948T3/en unknown
- 2018-01-24 KR KR1020197024738A patent/KR102480594B1/en active IP Right Grant
- 2018-01-24 HR HRP20230002TT patent/HRP20230002T1/en unknown
- 2018-01-24 RS RS20221193A patent/RS63871B1/en unknown
- 2018-01-24 SG SG11201906666QA patent/SG11201906666QA/en unknown
- 2018-01-24 IL IL293645A patent/IL293645A/en unknown
- 2018-01-24 JP JP2019540404A patent/JP7066725B2/en active Active
- 2018-01-24 IL IL287405A patent/IL287405B/en unknown
- 2018-01-24 EP EP18704352.6A patent/EP3573948B1/en active Active
- 2018-01-24 CN CN202310124604.6A patent/CN116102615A/en active Pending
-
2019
- 2019-06-17 US US16/442,718 patent/US10844078B2/en active Active
- 2019-07-22 IL IL268213A patent/IL268213B/en unknown
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2020
- 2020-10-22 US US17/077,688 patent/US11390633B2/en active Active
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2022
- 2022-03-07 AU AU2022201572A patent/AU2022201572B2/en active Active
- 2022-04-27 JP JP2022072946A patent/JP7400005B2/en active Active
- 2022-06-15 US US17/841,026 patent/US20230039161A1/en active Pending
-
2023
- 2023-12-06 JP JP2023205788A patent/JP2024028860A/en active Pending
-
2024
- 2024-02-21 AU AU2024201119A patent/AU2024201119A1/en active Pending
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