DK3116891T3 - Immunglobulinrensning ved hjælp af forrensningstrin - Google Patents
Immunglobulinrensning ved hjælp af forrensningstrin Download PDFInfo
- Publication number
- DK3116891T3 DK3116891T3 DK15708522.6T DK15708522T DK3116891T3 DK 3116891 T3 DK3116891 T3 DK 3116891T3 DK 15708522 T DK15708522 T DK 15708522T DK 3116891 T3 DK3116891 T3 DK 3116891T3
- Authority
- DK
- Denmark
- Prior art keywords
- purification
- immunoglobulin
- steps
- purification steps
- immunoglobulin purification
- Prior art date
Links
- 238000000746 purification Methods 0.000 title 2
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/26—Cation exchangers for chromatographic processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/20—Anion exchangers for chromatographic processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Analytical Chemistry (AREA)
- Immunology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Water Supply & Treatment (AREA)
- Peptides Or Proteins (AREA)
- Treatment Of Liquids With Adsorbents In General (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1400131A HUP1400131A1 (hu) | 2014-03-10 | 2014-03-10 | Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával |
| HU1500053A HUP1500053A1 (hu) | 2015-02-09 | 2015-02-09 | Immunglobulin tisztítása elõtisztítási lépések alkalmazásával |
| PCT/EP2015/054862 WO2015135884A1 (en) | 2014-03-10 | 2015-03-09 | Immunoglobulin purification using pre-cleaning steps |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK3116891T3 true DK3116891T3 (da) | 2020-05-04 |
Family
ID=89991731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK15708522.6T DK3116891T3 (da) | 2014-03-10 | 2015-03-09 | Immunglobulinrensning ved hjælp af forrensningstrin |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10487138B2 (da) |
| EP (2) | EP3674310A1 (da) |
| JP (1) | JP6293907B2 (da) |
| KR (1) | KR101921552B1 (da) |
| CN (1) | CN106103465B (da) |
| CA (1) | CA2930350C (da) |
| DK (1) | DK3116891T3 (da) |
| ES (1) | ES2784749T3 (da) |
| HR (1) | HRP20200711T1 (da) |
| HU (1) | HUE048782T2 (da) |
| LT (1) | LT3116891T (da) |
| PL (1) | PL3116891T3 (da) |
| PT (1) | PT3116891T (da) |
| SI (1) | SI3116891T1 (da) |
| WO (1) | WO2015135884A1 (da) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PL3116891T3 (pl) | 2014-03-10 | 2020-07-27 | Richter Gedeon Nyrt. | Oczyszczanie immunoglobuliny z zastosowaniem etapów wstępnego oczyszczania |
| GB2539420B (en) * | 2015-06-16 | 2021-01-13 | Cytiva Sweden Ab | Determination of chromatography conditions |
| JP6851109B2 (ja) * | 2016-06-16 | 2021-03-31 | Jsr株式会社 | 抗体を精製する方法及び担体を洗浄する方法 |
| CN109563124A (zh) * | 2016-06-17 | 2019-04-02 | 豪夫迈·罗氏有限公司 | 多特异性抗体的纯化 |
| US20190211055A1 (en) * | 2016-09-14 | 2019-07-11 | Kinbio Ltd. | Methods of purifying and qualifying antibodies |
| KR20190131082A (ko) * | 2017-03-24 | 2019-11-25 | 카운슬 오브 사이언티픽 앤드 인더스트리얼 리서치 | 재조합 항체 단편을 정제하는 방법 |
| MA49962A (fr) * | 2017-08-22 | 2020-07-01 | Biogen Ma Inc | Procédés de purification d'anticorps présentant des agrégats réduits à poids moléculaire élevé |
| KR20190047376A (ko) | 2017-10-27 | 2019-05-08 | 주식회사 녹십자 | 개선된 면역글로불린의 정제방법 |
| WO2019173731A1 (en) * | 2018-03-08 | 2019-09-12 | Bio-Rad Laboratories, Inc. | Anionic exchange-hydrophobic mixed mode chromatography resin |
| CN111902720A (zh) | 2018-03-21 | 2020-11-06 | 沃特世科技公司 | 基于非抗体高亲和力的样品制备、吸附剂、装置和方法 |
| GB201805142D0 (en) * | 2018-03-29 | 2018-05-16 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| WO2020016417A1 (en) * | 2018-07-19 | 2020-01-23 | Ichnos Sciences S.A. | Liquid antibody formulation |
| KR102209790B1 (ko) * | 2018-12-20 | 2021-02-01 | 에이치케이이노엔 주식회사 | 친화성 크로마토그래피를 이용한 백신용 바이러스 정제방법 |
| CN113227789A (zh) * | 2018-12-30 | 2021-08-06 | 豪夫迈·罗氏有限公司 | 基于pH梯度SPR的结合测定 |
| US20220184526A1 (en) * | 2019-03-21 | 2022-06-16 | Agency For Science, Technology And Research | A Method of Capturing and/or Purifying a Target |
| HU231498B1 (hu) * | 2019-04-04 | 2024-05-28 | Richter Gedeon Nyrt | Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelőző flokkulálás alkalmazásával |
| CN114025843A (zh) * | 2019-06-10 | 2022-02-08 | 武田药品工业株式会社 | 抗体纯化方法及其组合物 |
| JP2022546901A (ja) | 2019-09-05 | 2022-11-10 | バイオ－ラッド・ラボラトリーズ・インコーポレーテッド | アニオン交換－疎水性混合モードクロマトグラフィー樹脂 |
| AU2021355325A1 (en) * | 2020-04-10 | 2022-11-03 | Plasma Technologies, Llc | Compositions and methods for simplified high efficiency isolation of proteins |
| CN113563469A (zh) * | 2020-04-28 | 2021-10-29 | 江苏中新医药有限公司 | 高回收率纯化阿达木单抗的方法 |
| AU2021265591A1 (en) * | 2020-05-01 | 2022-12-22 | Kashiv Biosciences, Llc | An improved process of purification of protein |
| AU2022359021A1 (en) * | 2021-10-08 | 2024-05-02 | Kashiv Biosciences, Llc | Separation of pre-peak in fusion protein sample by using size exclusion high performance liquid chromatography |
| AU2022361768A1 (en) * | 2021-10-08 | 2024-05-02 | Kashiv Biosciences, Llc | Separation of pre-peak and post-peak in fusion protein sample by using size exclusion high performance liquid chromatography |
| CN114133446A (zh) * | 2021-12-31 | 2022-03-04 | 方坦思(上海)生物医药有限公司 | 单克隆抗体的纯化方法 |
| CN115304673B (zh) * | 2022-06-24 | 2024-10-01 | 上海赛伦生物技术股份有限公司 | 一种马抗破伤风特异性免疫球蛋白F(ab’)2的纯化方法及其应用 |
Family Cites Families (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0368904A1 (en) * | 1987-07-16 | 1990-05-23 | Schering Corporation | Purification of gm-csf |
| CA1341235C (en) | 1987-07-24 | 2001-05-22 | Randy R. Robinson | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US4983722A (en) | 1988-06-08 | 1991-01-08 | Miles Inc. | Removal of protein A from antibody preparations |
| WO1991018975A1 (en) * | 1990-05-31 | 1991-12-12 | The United States Of America, Represented By The Secretary, United States Department Of Commerce | Method for purifying hiv reverse transcriptase |
| ES2156859T5 (es) | 1991-03-18 | 2008-03-16 | New York University | Anticuerpos monoclonales y quimericos especificos para el factor de necrosis tumoral humano. |
| WO1992022653A1 (en) | 1991-06-14 | 1992-12-23 | Genentech, Inc. | Method for making humanized antibodies |
| DE69329503T2 (de) | 1992-11-13 | 2001-05-03 | Idec Pharma Corp | Therapeutische Verwendung von chimerischen und markierten Antikörpern, die gegen ein Differenzierung-Antigen gerichtet sind, dessen Expression auf menschliche B Lymphozyt beschränkt ist, für die Behandlung von B-Zell-Lymphoma |
| US5429746A (en) * | 1994-02-22 | 1995-07-04 | Smith Kline Beecham Corporation | Antibody purification |
| CN103275221B (zh) | 1996-02-09 | 2016-08-17 | 艾伯维生物技术有限公司 | 结合人TNFα的人抗体 |
| DK0973804T3 (da) | 1997-04-07 | 2007-05-07 | Genentech Inc | Anti-VEGF-antistoffer |
| EP1222572A2 (en) | 1999-08-26 | 2002-07-17 | Symtec Limited | Methods and devices for selecting data files |
| YU103003A (sh) | 2001-06-26 | 2006-05-25 | Abgenix Inc. | Antitela za opgl |
| US20030040027A1 (en) * | 2001-08-16 | 2003-02-27 | Gerd Ritter | Method for determining protein component in a biological sample |
| DE10155984A1 (de) | 2001-11-15 | 2003-05-28 | Boehringer Ingelheim Pharma | Verfahren zur Reduktion des Liganden-leakage von Affinitätschromatographie-Matrices |
| ES2545067T3 (es) | 2002-04-26 | 2015-09-08 | Genentech, Inc. | Purificación de proteínas basada en la no afinidad |
| PT1601697E (pt) | 2003-02-28 | 2007-09-04 | Lonza Biologics Plc | Purificação de anticorpos através de proteína a e cromatografia de troca iónica. |
| EP1614693A4 (en) * | 2003-03-31 | 2006-07-19 | Kirin Brewery | PURIFICATION OF A HUMAN MONOCLONAL ANTIBODY AND A HUMAN POLYCLONAL ANTIBODY |
| DK3095793T3 (da) | 2003-07-28 | 2020-05-25 | Genentech Inc | Reducering af udvaskning af protein A under en protein A-affinitetskromatografi |
| ATE360647T1 (de) * | 2003-11-05 | 2007-05-15 | Ares Trading Sa | Verfahren zur aufreinigung von il-18-bindendem protein |
| EP1718386A1 (en) | 2004-02-27 | 2006-11-08 | GE Healthcare Bio-Sciences AB | A process for the purification of antibodies |
| US20080312425A1 (en) | 2004-08-30 | 2008-12-18 | Lonza Biologics Plc. | Ion Exchange Chromatography and Purification of Antibodies |
| KR20140015166A (ko) | 2007-10-30 | 2014-02-06 | 제넨테크, 인크. | 양이온 교환 크로마토그래피에 의한 항체 정제 |
| JP2011523408A (ja) | 2008-05-15 | 2011-08-11 | ノボ・ノルデイスク・エー／エス | 抗体精製方法 |
| AU2009347206C1 (en) | 2008-10-20 | 2016-12-08 | Abbvie Inc. | Isolation and purification of antibodies using Protein A affinity chromatography |
| EP2360183B1 (en) * | 2008-12-19 | 2016-07-27 | Takeda Pharmaceutical Company Limited | Antibody purification method by mixed mode chromatography utilizing an arginine-containing loading solution |
| SG178078A1 (en) * | 2009-07-24 | 2012-03-29 | Hoffmann La Roche | Optimizing the production of antibodies |
| US8536316B2 (en) * | 2009-08-07 | 2013-09-17 | Emd Millipore Corporation | Methods for purifying a target protein from one or more impurities in a sample |
| EP3736338A1 (en) * | 2009-09-01 | 2020-11-11 | F. Hoffmann-La Roche AG | Enhanced protein purification through a modified protein a elution |
| WO2011049798A1 (en) | 2009-10-20 | 2011-04-28 | Merck Sharp & Dohme Corp. | Use of mixed mode chromatography for the capture and purification of basic antibody products |
| US20130116413A1 (en) | 2009-12-29 | 2013-05-09 | Dr. Reddy's Laboratories, Inc. | Purification of proteins |
| HRP20171095T4 (hr) | 2010-05-25 | 2022-07-22 | F. Hoffmann - La Roche Ag | Postupci pročišćavanja polipeptida |
| CA2813747A1 (en) * | 2010-10-11 | 2012-04-19 | Chen Wang | Processes for purification of proteins |
| JP6261499B2 (ja) * | 2011-07-11 | 2018-01-17 | グレンマーク ファーマシューティカルズ， エセ．アー． | Ｏｘ４０と結合する抗体およびその使用 |
| EP2773439A4 (en) | 2011-10-31 | 2015-07-01 | Merck Sharp & Dohme | CHROMATOGRAPHY METHOD FOR DECOMPOSING HETEROGENEOUS ANTIBODY AGGREGATES |
| PL3257564T5 (pl) | 2011-11-02 | 2024-10-07 | F. Hoffmann-La Roche Ag | Chromatografia elucyjna z przeładowaniem |
| WO2013180647A1 (en) * | 2012-05-31 | 2013-12-05 | Agency For Science, Technology And Research | Chromatographic purification of immunoglobulin g preparations with particles having multimodal functionalities |
| PL3116891T3 (pl) | 2014-03-10 | 2020-07-27 | Richter Gedeon Nyrt. | Oczyszczanie immunoglobuliny z zastosowaniem etapów wstępnego oczyszczania |
-
2015
- 2015-03-09 PL PL15708522T patent/PL3116891T3/pl unknown
- 2015-03-09 CN CN201580012972.5A patent/CN106103465B/zh active Active
- 2015-03-09 DK DK15708522.6T patent/DK3116891T3/da active
- 2015-03-09 HU HUE15708522A patent/HUE048782T2/hu unknown
- 2015-03-09 WO PCT/EP2015/054862 patent/WO2015135884A1/en active Application Filing
- 2015-03-09 CA CA2930350A patent/CA2930350C/en active Active
- 2015-03-09 ES ES15708522T patent/ES2784749T3/es active Active
- 2015-03-09 SI SI201531188T patent/SI3116891T1/sl unknown
- 2015-03-09 US US15/120,359 patent/US10487138B2/en active Active
- 2015-03-09 EP EP20155836.8A patent/EP3674310A1/en active Pending
- 2015-03-09 KR KR1020167022454A patent/KR101921552B1/ko active IP Right Grant
- 2015-03-09 LT LTEP15708522.6T patent/LT3116891T/lt unknown
- 2015-03-09 EP EP15708522.6A patent/EP3116891B1/en active Active
- 2015-03-09 PT PT157085226T patent/PT3116891T/pt unknown
- 2015-03-09 JP JP2016544089A patent/JP6293907B2/ja active Active
-
2020
- 2020-05-04 HR HRP20200711TT patent/HRP20200711T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PL3116891T3 (pl) | 2020-07-27 |
| CA2930350C (en) | 2021-04-06 |
| WO2015135884A1 (en) | 2015-09-17 |
| JP6293907B2 (ja) | 2018-03-14 |
| CN106103465A (zh) | 2016-11-09 |
| US10487138B2 (en) | 2019-11-26 |
| HUE048782T2 (hu) | 2020-08-28 |
| HRP20200711T1 (hr) | 2020-07-24 |
| JP2017507907A (ja) | 2017-03-23 |
| EP3116891A1 (en) | 2017-01-18 |
| LT3116891T (lt) | 2020-03-25 |
| PT3116891T (pt) | 2020-05-18 |
| CN106103465B (zh) | 2021-01-08 |
| SI3116891T1 (sl) | 2020-07-31 |
| CA2930350A1 (en) | 2015-09-17 |
| ES2784749T3 (es) | 2020-09-30 |
| KR20160124107A (ko) | 2016-10-26 |
| EP3674310A1 (en) | 2020-07-01 |
| KR101921552B1 (ko) | 2018-11-23 |
| EP3116891B1 (en) | 2020-02-12 |
| US20170058019A1 (en) | 2017-03-02 |
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