ATE360647T1 - Verfahren zur aufreinigung von il-18-bindendem protein - Google Patents
Verfahren zur aufreinigung von il-18-bindendem proteinInfo
- Publication number
- ATE360647T1 ATE360647T1 AT04798163T AT04798163T ATE360647T1 AT E360647 T1 ATE360647 T1 AT E360647T1 AT 04798163 T AT04798163 T AT 04798163T AT 04798163 T AT04798163 T AT 04798163T AT E360647 T1 ATE360647 T1 AT E360647T1
- Authority
- AT
- Austria
- Prior art keywords
- binding protein
- purifying
- purification
- fluid
- relates
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 2
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
- 102000044166 interleukin-18 binding protein Human genes 0.000 abstract 2
- 108010070145 interleukin-18 binding protein Proteins 0.000 abstract 2
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 239000012530 fluid Substances 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51744703P | 2003-11-05 | 2003-11-05 | |
| EP03104092 | 2003-11-05 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE360647T1 true ATE360647T1 (de) | 2007-05-15 |
Family
ID=34924126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04798163T ATE360647T1 (de) | 2003-11-05 | 2004-11-04 | Verfahren zur aufreinigung von il-18-bindendem protein |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7820800B2 (de) |
| EP (1) | EP1689777B1 (de) |
| JP (1) | JP4741504B2 (de) |
| AT (1) | ATE360647T1 (de) |
| AU (1) | AU2004291341B2 (de) |
| CA (1) | CA2544146C (de) |
| CY (1) | CY1106683T1 (de) |
| DE (1) | DE602004006157T2 (de) |
| DK (1) | DK1689777T3 (de) |
| ES (1) | ES2285543T3 (de) |
| HR (1) | HRP20070196T3 (de) |
| IL (1) | IL175431A (de) |
| ME (1) | ME01198B (de) |
| NO (1) | NO330538B1 (de) |
| PL (1) | PL1689777T3 (de) |
| PT (1) | PT1689777E (de) |
| RS (1) | RS50516B (de) |
| SI (1) | SI1689777T1 (de) |
| WO (1) | WO2005049649A1 (de) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2516157C (en) | 2003-03-11 | 2012-09-18 | Applied Research Systems Ars Holding N.V. | Expression vectors comprising the mcmv ie2 promoter |
| ATE549353T1 (de) * | 2003-05-13 | 2012-03-15 | Merck Serono Sa | Aktive varianten des il-18 bindenden proteins und dessen medizinische verwendungen |
| JP4745972B2 (ja) * | 2003-10-21 | 2011-08-10 | メルク セローノ ソシエテ アノニム | クロマチンインスレーターとして作用する極小ｄｎａ配列、及びタンパク質発現におけるその使用 |
| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| DE602005002829T2 (de) * | 2004-03-01 | 2008-07-10 | Ares Trading S.A. | Verwendung eines serumfreien zellkulturmediums zur produktion von il-18bp in säugerzellen |
| EP1761552B1 (de) | 2004-06-29 | 2008-09-17 | Ares Trading S.A. | Verfahren zur aufreinigung von il-18-bindendem protein |
| KR20080006601A (ko) | 2005-04-11 | 2008-01-16 | 메다렉스, 인코포레이티드 | 단백질 정제 방법 |
| ATE557038T1 (de) * | 2005-06-03 | 2012-05-15 | Ares Trading Sa | Herstellung von rekombinantem il-18 bindendem protein |
| SI1891088T1 (sl) * | 2005-06-10 | 2012-02-29 | Ares Trading Sa | Postopek za äśiĺ äśenje il-18 vezavnega proteina |
| EP3127921A1 (de) | 2007-09-26 | 2017-02-08 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur modifizierung eines isoelektrischen punkts eines antikörpers über aminosäuresubstition in cdr |
| CN107033233A (zh) | 2008-01-18 | 2017-08-11 | 弗·哈夫曼-拉罗切有限公司 | 非糖基化蛋白质的纯化 |
| HUE067049T2 (hu) | 2008-04-11 | 2024-09-28 | Chugai Pharmaceutical Co Ltd | Két vagy több antigén-molekulát ismétlõdõen megkötni képes antigénkötõ molekula |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| WO2011156369A2 (en) * | 2010-06-07 | 2011-12-15 | Dr. Reddy's Laboratories Ltd. | Purification of modified cytokines |
| CN103328632A (zh) | 2010-11-30 | 2013-09-25 | 中外制药株式会社 | 与多分子的抗原重复结合的抗原结合分子 |
| EP3604330A1 (de) | 2011-02-25 | 2020-02-05 | Chugai Seiyaku Kabushiki Kaisha | Fcgammariib-spezifischer fc-antikörper |
| EP2691411B1 (de) | 2011-03-29 | 2020-02-26 | GlaxoSmithKline LLC | Puffersystem zur proteinreinigung |
| TW201817745A (zh) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 |
| WO2013047748A1 (ja) | 2011-09-30 | 2013-04-04 | 中外製薬株式会社 | 複数の生理活性を有する抗原の消失を促進する抗原結合分子 |
| SG10201609301QA (en) | 2011-11-30 | 2016-12-29 | Chugai Pharmaceutical Co Ltd | Drug containing carrier into cell for forming immune complex |
| KR102318483B1 (ko) | 2013-04-02 | 2021-10-27 | 추가이 세이야쿠 가부시키가이샤 | Ｆｃ영역 개변체 |
| CN106103465B (zh) * | 2014-03-10 | 2021-01-08 | 吉瑞工厂 | 使用预清洗步骤的免疫球蛋白纯化 |
| CN107001411B (zh) | 2014-12-15 | 2021-07-23 | 默克专利股份公司 | 从粗溶液捕获靶分子 |
| AR103162A1 (es) | 2014-12-19 | 2017-04-19 | Chugai Pharmaceutical Co Ltd | Anticuerpos anti-c5 y métodos para su uso |
| TWI779010B (zh) | 2014-12-19 | 2022-10-01 | 日商中外製藥股份有限公司 | 抗肌抑素之抗體、含變異Ｆｃ區域之多胜肽及使用方法 |
| CN114773470A (zh) | 2015-02-05 | 2022-07-22 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il-8-结合抗体及其应用 |
| SG11201705093UA (en) | 2015-02-27 | 2017-07-28 | Chugai Pharmaceutical Co Ltd | Composition for treating il-6-related diseases |
| WO2017110981A1 (en) | 2015-12-25 | 2017-06-29 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| JP6527643B2 (ja) | 2016-08-05 | 2019-06-05 | 中外製薬株式会社 | Ｉｌ−８関連疾患の治療用又は予防用組成物 |
| JP7191833B2 (ja) | 2017-01-30 | 2022-12-19 | 中外製薬株式会社 | 抗スクレロスチン抗体およびその使用 |
| WO2018203545A1 (ja) | 2017-05-02 | 2018-11-08 | 国立研究開発法人国立精神・神経医療研究センター | Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
| JP4216950B2 (ja) * | 1998-09-01 | 2009-01-28 | 株式会社林原生物化学研究所 | インターロイキン−１８結合蛋白質 |
| EP1110969A4 (de) | 1998-09-01 | 2002-01-09 | Hayashibara Biochem Lab | Interleukin 18-bindende proteine |
| US20020052475A1 (en) * | 2000-07-20 | 2002-05-02 | Schering Ag | High affinity soluble interleukin-18 receptor |
| IL157800A0 (en) * | 2001-03-08 | 2004-03-28 | Ares Trading Sa | Il-18 mutants, their production and use |
| BRPI0210579B8 (pt) * | 2001-06-26 | 2021-05-25 | Amgen Fremont Inc | anticorpo e composição farmacêutica |
| AU2003222664A1 (en) * | 2002-04-18 | 2003-11-03 | Genencor International, Inc. | Production of functional antibodies in filamentous fungi |
| CA2516157C (en) | 2003-03-11 | 2012-09-18 | Applied Research Systems Ars Holding N.V. | Expression vectors comprising the mcmv ie2 promoter |
| ATE549353T1 (de) * | 2003-05-13 | 2012-03-15 | Merck Serono Sa | Aktive varianten des il-18 bindenden proteins und dessen medizinische verwendungen |
| JP4745972B2 (ja) | 2003-10-21 | 2011-08-10 | メルク セローノ ソシエテ アノニム | クロマチンインスレーターとして作用する極小ｄｎａ配列、及びタンパク質発現におけるその使用 |
| DE602005002829T2 (de) | 2004-03-01 | 2008-07-10 | Ares Trading S.A. | Verwendung eines serumfreien zellkulturmediums zur produktion von il-18bp in säugerzellen |
| EP1761552B1 (de) | 2004-06-29 | 2008-09-17 | Ares Trading S.A. | Verfahren zur aufreinigung von il-18-bindendem protein |
| ATE557038T1 (de) | 2005-06-03 | 2012-05-15 | Ares Trading Sa | Herstellung von rekombinantem il-18 bindendem protein |
| SI1891088T1 (sl) * | 2005-06-10 | 2012-02-29 | Ares Trading Sa | Postopek za äśiĺ äśenje il-18 vezavnega proteina |
-
2004
- 2004-11-04 AU AU2004291341A patent/AU2004291341B2/en not_active Expired
- 2004-11-04 DE DE602004006157T patent/DE602004006157T2/de not_active Expired - Lifetime
- 2004-11-04 PT PT04798163T patent/PT1689777E/pt unknown
- 2004-11-04 ES ES04798163T patent/ES2285543T3/es not_active Expired - Lifetime
- 2004-11-04 EP EP04798163A patent/EP1689777B1/de not_active Expired - Lifetime
- 2004-11-04 DK DK04798163T patent/DK1689777T3/da active
- 2004-11-04 WO PCT/EP2004/052807 patent/WO2005049649A1/en not_active Ceased
- 2004-11-04 CA CA2544146A patent/CA2544146C/en not_active Expired - Lifetime
- 2004-11-04 HR HR20070196T patent/HRP20070196T3/xx unknown
- 2004-11-04 US US10/576,372 patent/US7820800B2/en not_active Expired - Lifetime
- 2004-11-04 PL PL04798163T patent/PL1689777T3/pl unknown
- 2004-11-04 RS RSP-2007/0216A patent/RS50516B/sr unknown
- 2004-11-04 SI SI200430322T patent/SI1689777T1/sl unknown
- 2004-11-04 ME MEP-2008-580A patent/ME01198B/me unknown
- 2004-11-04 JP JP2006537319A patent/JP4741504B2/ja not_active Expired - Lifetime
- 2004-11-04 AT AT04798163T patent/ATE360647T1/de active
-
2006
- 2006-05-04 IL IL175431A patent/IL175431A/en active IP Right Grant
- 2006-06-02 NO NO20062545A patent/NO330538B1/no unknown
-
2007
- 2007-06-28 CY CY20071100852T patent/CY1106683T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2007533651A (ja) | 2007-11-22 |
| CA2544146C (en) | 2012-10-02 |
| CY1106683T1 (el) | 2012-05-23 |
| EP1689777B1 (de) | 2007-04-25 |
| US7820800B2 (en) | 2010-10-26 |
| IL175431A (en) | 2011-02-28 |
| RS50516B (sr) | 2010-05-07 |
| DK1689777T3 (da) | 2007-06-11 |
| PT1689777E (pt) | 2007-05-31 |
| DE602004006157D1 (de) | 2007-06-06 |
| HRP20070196T3 (hr) | 2007-06-30 |
| ES2285543T3 (es) | 2007-11-16 |
| IL175431A0 (en) | 2006-09-05 |
| JP4741504B2 (ja) | 2011-08-03 |
| AU2004291341B2 (en) | 2010-08-05 |
| PL1689777T3 (pl) | 2007-09-28 |
| ME01198B (me) | 2013-03-20 |
| US20070037734A1 (en) | 2007-02-15 |
| EP1689777A1 (de) | 2006-08-16 |
| NO20062545L (no) | 2006-08-03 |
| AU2004291341A1 (en) | 2005-06-02 |
| WO2005049649A1 (en) | 2005-06-02 |
| SI1689777T1 (sl) | 2007-08-31 |
| DE602004006157T2 (de) | 2008-01-03 |
| CA2544146A1 (en) | 2005-06-02 |
| NO330538B1 (no) | 2011-05-09 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| UEP | Publication of translation of european patent specification |
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