HRP20070196T3 - Process for the purification of il-18 binding protein - Google Patents
Process for the purification of il-18 binding proteinInfo
- Publication number
- HRP20070196T3 HRP20070196T3 HR20070196T HRP20070196T HRP20070196T3 HR P20070196 T3 HRP20070196 T3 HR P20070196T3 HR 20070196 T HR20070196 T HR 20070196T HR P20070196 T HRP20070196 T HR P20070196T HR P20070196 T3 HRP20070196 T3 HR P20070196T3
- Authority
- HR
- Croatia
- Prior art keywords
- binding protein
- purification
- purified
- production
- charge induction
- Prior art date
Links
- 102000044166 interleukin-18 binding protein Human genes 0.000 title abstract 3
- 108010070145 interleukin-18 binding protein Proteins 0.000 title abstract 3
- 238000000034 method Methods 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 230000002209 hydrophobic effect Effects 0.000 abstract 1
- 230000006698 induction Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/715—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons
- C07K14/7155—Receptors; Cell surface antigens; Cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Immunology (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cell Biology (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51744703P | 2003-11-05 | 2003-11-05 | |
| EP03104092 | 2003-11-05 | ||
| PCT/EP2004/052807 WO2005049649A1 (en) | 2003-11-05 | 2004-11-04 | Process for the purification of il-18 binding protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HRP20070196T3 true HRP20070196T3 (en) | 2007-06-30 |
Family
ID=34924126
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HR20070196T HRP20070196T3 (en) | 2003-11-05 | 2007-05-07 | Process for the purification of il-18 binding protein |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7820800B2 (xx) |
| EP (1) | EP1689777B1 (xx) |
| JP (1) | JP4741504B2 (xx) |
| AT (1) | ATE360647T1 (xx) |
| AU (1) | AU2004291341B2 (xx) |
| CA (1) | CA2544146C (xx) |
| CY (1) | CY1106683T1 (xx) |
| DE (1) | DE602004006157T2 (xx) |
| DK (1) | DK1689777T3 (xx) |
| ES (1) | ES2285543T3 (xx) |
| HR (1) | HRP20070196T3 (xx) |
| IL (1) | IL175431A (xx) |
| ME (1) | ME01198B (xx) |
| NO (1) | NO330538B1 (xx) |
| PL (1) | PL1689777T3 (xx) |
| PT (1) | PT1689777E (xx) |
| RS (1) | RS50516B (xx) |
| SI (1) | SI1689777T1 (xx) |
| WO (1) | WO2005049649A1 (xx) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| BRPI0408246A (pt) * | 2003-03-11 | 2006-03-01 | Applied Research Systems | vetores de expressão que compreendem o promotor ie2 do mcmv |
| ES2384241T3 (es) * | 2003-05-13 | 2012-07-02 | Merck Serono Sa | Variantes activas de la proteína que fija IL-18 y usos médicos de las mismas |
| PT1675956E (pt) * | 2003-10-21 | 2010-11-04 | Merck Serono Sa | Sequência mínima de adn que actua como um isolador de cromatina e sua utilização na expressão de proteína |
| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| WO2005083058A1 (en) * | 2004-03-01 | 2005-09-09 | Ares Trading S.A. | Use of a serum-free cell culture medium for the production of il-18bp in mammalian cells |
| EP1761552B1 (en) * | 2004-06-29 | 2008-09-17 | Ares Trading S.A. | Process for the purification of il-18 binding protein |
| WO2006110277A1 (en) | 2005-04-11 | 2006-10-19 | Medarex, Inc. | Protein purification using hcic amd ion exchange chromatography |
| ATE557038T1 (de) * | 2005-06-03 | 2012-05-15 | Ares Trading Sa | Herstellung von rekombinantem il-18 bindendem protein |
| EP1891088B1 (en) * | 2005-06-10 | 2011-10-19 | Ares Trading S.A. | Process for the purification of il-18 binding protein |
| WO2009041643A1 (ja) | 2007-09-26 | 2009-04-02 | Chugai Seiyaku Kabushiki Kaisha | Cdrのアミノ酸置換により抗体の等電点を改変する方法 |
| EP2245044A2 (en) | 2008-01-18 | 2010-11-03 | F. Hoffmann-La Roche AG | Purification of non-glycosylated proteins |
| JP4954326B2 (ja) * | 2008-04-11 | 2012-06-13 | 中外製薬株式会社 | 複数分子の抗原に繰り返し結合する抗原結合分子 |
| TWI440469B (zh) | 2008-09-26 | 2014-06-11 | Chugai Pharmaceutical Co Ltd | Improved antibody molecules |
| WO2011156369A2 (en) * | 2010-06-07 | 2011-12-15 | Dr. Reddy's Laboratories Ltd. | Purification of modified cytokines |
| EP4231014A3 (en) | 2010-11-30 | 2024-03-20 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule capable of binding to plurality of antigen molecules repeatedly |
| US20140093496A1 (en) | 2011-02-25 | 2014-04-03 | Chugai Seiyaku Kabushiki Kaisha | Fc-gamma-RIIb-SPECIFIC Fc ANTIBODY |
| CA2831787A1 (en) | 2011-03-29 | 2012-10-04 | Glaxosmithkline Llc | Buffer system for protein purification |
| EP2762493B1 (en) | 2011-09-30 | 2021-06-09 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecule promoting disappearance of antigens having plurality of biological activities |
| TW201326209A (zh) | 2011-09-30 | 2013-07-01 | Chugai Pharmaceutical Co Ltd | 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 |
| KR20210074395A (ko) | 2011-11-30 | 2021-06-21 | 추가이 세이야쿠 가부시키가이샤 | 면역 복합체를 형성하는 세포내로의 운반체（캐리어）를 포함하는 의약 |
| KR102318483B1 (ko) | 2013-04-02 | 2021-10-27 | 추가이 세이야쿠 가부시키가이샤 | Ｆｃ영역 개변체 |
| KR101921552B1 (ko) * | 2014-03-10 | 2018-11-23 | 리히터 게데온 닐트. | 사전 세정 단계를 이용하는 면역글로불린 정제 |
| CN107001411B (zh) | 2014-12-15 | 2021-07-23 | 默克专利股份公司 | 从粗溶液捕获靶分子 |
| EA201791366A1 (ru) | 2014-12-19 | 2018-02-28 | Чугаи Сейяку Кабусики Кайся | Антитела к c5 и способы их применения |
| MY181199A (en) | 2014-12-19 | 2020-12-21 | Chugai Pharmaceutical Co Ltd | Anti-myostatin antibodies, polypeptides containing variant fc regions, and methods of use |
| CN107108729A (zh) | 2015-02-05 | 2017-08-29 | 中外制药株式会社 | 包含离子浓度依赖性的抗原结合结构域的抗体，fc区变体，il‑8‑结合抗体，及其应用 |
| BR112017014067B1 (pt) | 2015-02-27 | 2021-01-12 | Chugai Seiyaku Kabushiki Kaisha | usos de um anticorpo receptor de il-6 para no tratamento de doenças relacionadas a il-6 |
| US11359009B2 (en) | 2015-12-25 | 2022-06-14 | Chugai Seiyaku Kabushiki Kaisha | Anti-myostatin antibodies and methods of use |
| KR20230079499A (ko) | 2016-08-05 | 2023-06-07 | 추가이 세이야쿠 가부시키가이샤 | Il-8 관련 질환의 치료용 또는 예방용 조성물 |
| JP7191833B2 (ja) | 2017-01-30 | 2022-12-19 | 中外製薬株式会社 | 抗スクレロスチン抗体およびその使用 |
| WO2018203545A1 (ja) | 2017-05-02 | 2018-11-08 | 国立研究開発法人国立精神・神経医療研究センター | Ｉｌ－６及び好中球の関連する疾患の治療効果の予測及び判定方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL121860A0 (en) | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
| WO2000012555A1 (fr) | 1998-09-01 | 2000-03-09 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | Proteine de liaison de l'interleukine 18 |
| JP4216950B2 (ja) * | 1998-09-01 | 2009-01-28 | 株式会社林原生物化学研究所 | インターロイキン−１８結合蛋白質 |
| US20020052475A1 (en) * | 2000-07-20 | 2002-05-02 | Schering Ag | High affinity soluble interleukin-18 receptor |
| AU2002324249B2 (en) * | 2001-03-08 | 2007-04-05 | Ares Trading S.A. | Interleukin-18 mutants, their production and use |
| CN1547486A (zh) * | 2001-06-26 | 2004-11-17 | 抗opgl抗体 | |
| US20040018573A1 (en) * | 2002-04-18 | 2004-01-29 | Power Scott D | Production of functional antibodies in filamentous fungi |
| BRPI0408246A (pt) * | 2003-03-11 | 2006-03-01 | Applied Research Systems | vetores de expressão que compreendem o promotor ie2 do mcmv |
| ES2384241T3 (es) | 2003-05-13 | 2012-07-02 | Merck Serono Sa | Variantes activas de la proteína que fija IL-18 y usos médicos de las mismas |
| PT1675956E (pt) | 2003-10-21 | 2010-11-04 | Merck Serono Sa | Sequência mínima de adn que actua como um isolador de cromatina e sua utilização na expressão de proteína |
| WO2005083058A1 (en) * | 2004-03-01 | 2005-09-09 | Ares Trading S.A. | Use of a serum-free cell culture medium for the production of il-18bp in mammalian cells |
| EP1761552B1 (en) | 2004-06-29 | 2008-09-17 | Ares Trading S.A. | Process for the purification of il-18 binding protein |
| ATE557038T1 (de) | 2005-06-03 | 2012-05-15 | Ares Trading Sa | Herstellung von rekombinantem il-18 bindendem protein |
| EP1891088B1 (en) * | 2005-06-10 | 2011-10-19 | Ares Trading S.A. | Process for the purification of il-18 binding protein |
-
2004
- 2004-11-04 DE DE602004006157T patent/DE602004006157T2/de active Active
- 2004-11-04 RS RSP-2007/0216A patent/RS50516B/sr unknown
- 2004-11-04 US US10/576,372 patent/US7820800B2/en active Active
- 2004-11-04 EP EP04798163A patent/EP1689777B1/en active Active
- 2004-11-04 AT AT04798163T patent/ATE360647T1/de active
- 2004-11-04 ME MEP-2008-580A patent/ME01198B/me unknown
- 2004-11-04 CA CA2544146A patent/CA2544146C/en active Active
- 2004-11-04 ES ES04798163T patent/ES2285543T3/es active Active
- 2004-11-04 PT PT04798163T patent/PT1689777E/pt unknown
- 2004-11-04 AU AU2004291341A patent/AU2004291341B2/en active Active
- 2004-11-04 DK DK04798163T patent/DK1689777T3/da active
- 2004-11-04 JP JP2006537319A patent/JP4741504B2/ja active Active
- 2004-11-04 PL PL04798163T patent/PL1689777T3/pl unknown
- 2004-11-04 WO PCT/EP2004/052807 patent/WO2005049649A1/en active Application Filing
- 2004-11-04 SI SI200430322T patent/SI1689777T1/sl unknown
-
2006
- 2006-05-04 IL IL175431A patent/IL175431A/en active IP Right Grant
- 2006-06-02 NO NO20062545A patent/NO330538B1/no unknown
-
2007
- 2007-05-07 HR HR20070196T patent/HRP20070196T3/xx unknown
- 2007-06-28 CY CY20071100852T patent/CY1106683T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP4741504B2 (ja) | 2011-08-03 |
| ME01198B (me) | 2013-03-20 |
| AU2004291341A1 (en) | 2005-06-02 |
| CY1106683T1 (el) | 2012-05-23 |
| IL175431A (en) | 2011-02-28 |
| PT1689777E (pt) | 2007-05-31 |
| DE602004006157D1 (de) | 2007-06-06 |
| ATE360647T1 (de) | 2007-05-15 |
| US7820800B2 (en) | 2010-10-26 |
| SI1689777T1 (sl) | 2007-08-31 |
| WO2005049649A1 (en) | 2005-06-02 |
| NO330538B1 (no) | 2011-05-09 |
| DE602004006157T2 (de) | 2008-01-03 |
| PL1689777T3 (pl) | 2007-09-28 |
| IL175431A0 (en) | 2006-09-05 |
| CA2544146C (en) | 2012-10-02 |
| EP1689777A1 (en) | 2006-08-16 |
| NO20062545L (no) | 2006-08-03 |
| JP2007533651A (ja) | 2007-11-22 |
| AU2004291341B2 (en) | 2010-08-05 |
| ES2285543T3 (es) | 2007-11-16 |
| DK1689777T3 (da) | 2007-06-11 |
| CA2544146A1 (en) | 2005-06-02 |
| EP1689777B1 (en) | 2007-04-25 |
| RS50516B (sr) | 2010-05-07 |
| US20070037734A1 (en) | 2007-02-15 |
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