BRPI0408246A - vetores de expressão que compreendem o promotor ie2 do mcmv - Google Patents

vetores de expressão que compreendem o promotor ie2 do mcmv

Info

Publication number
BRPI0408246A
BRPI0408246A BRPI0408246-0A BRPI0408246A BRPI0408246A BR PI0408246 A BRPI0408246 A BR PI0408246A BR PI0408246 A BRPI0408246 A BR PI0408246A BR PI0408246 A BRPI0408246 A BR PI0408246A
Authority
BR
Brazil
Prior art keywords
mcmv
promoter
expression vectors
gene
expression
Prior art date
Application number
BRPI0408246-0A
Other languages
English (en)
Inventor
Philippe Chatellard
Markus Imhof
Original Assignee
Applied Research Systems
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Applied Research Systems filed Critical Applied Research Systems
Publication of BRPI0408246A publication Critical patent/BRPI0408246A/pt

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/03—Herpetoviridae, e.g. pseudorabies virus
    • C07K14/04—Varicella-zoster virus
    • C07K14/045—Cytomegalovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
    • C12N2830/205—Vector systems having a special element relevant for transcription transcription of more than one cistron bidirectional
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

"VETORES DE EXPRESSãO QUE COMPREENDEM O PROMOTOR IE2 DO MCMV". A presente invenção refere-se a um vetor de expressão que compreende o promotor do gene mCMV-IE2 ou um fragmento promotor da expressão funcional do mesmo e/ou um intensificador do gene mCMV-IE2 ou um fragmento intensificador da expressão funcional do mesmo, em que o vetor de expressão não contém qualquer gene completo do mCMV.
BRPI0408246-0A 2003-03-11 2004-03-10 vetores de expressão que compreendem o promotor ie2 do mcmv BRPI0408246A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03100617 2003-03-11
PCT/EP2004/050280 WO2004081167A2 (en) 2003-03-11 2004-03-10 Expression vectors comprising the mcmv ie2 promoter

Publications (1)

Publication Number Publication Date
BRPI0408246A true BRPI0408246A (pt) 2006-03-01

Family

ID=32981915

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0408246-0A BRPI0408246A (pt) 2003-03-11 2004-03-10 vetores de expressão que compreendem o promotor ie2 do mcmv

Country Status (26)

Country Link
US (3) US7824907B2 (pt)
EP (1) EP1601776B1 (pt)
JP (3) JP5171033B2 (pt)
KR (1) KR101180139B1 (pt)
CN (1) CN100429315C (pt)
AT (1) ATE399872T1 (pt)
AU (1) AU2004219917B2 (pt)
BR (1) BRPI0408246A (pt)
CA (1) CA2516157C (pt)
CY (1) CY1108344T1 (pt)
DE (1) DE602004014738D1 (pt)
DK (1) DK1601776T3 (pt)
EA (1) EA010096B1 (pt)
ES (1) ES2309508T3 (pt)
HK (1) HK1085766A1 (pt)
HR (1) HRP20050705B1 (pt)
IL (1) IL170754A (pt)
MX (1) MXPA05009608A (pt)
NO (1) NO333818B1 (pt)
PL (1) PL1601776T4 (pt)
PT (1) PT1601776E (pt)
RS (1) RS50488B (pt)
SI (1) SI1601776T1 (pt)
UA (1) UA88138C2 (pt)
WO (1) WO2004081167A2 (pt)
ZA (1) ZA200506400B (pt)

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ES2354160T3 (es) 2003-10-21 2011-03-10 Merck Serono Sa Secuencia de adn mínima que actúa como un aislante de cromatina, y su uso en la expresión de proteínas.
ME01198B (me) * 2003-11-05 2013-03-20 Ares Trading Sa Prečišćavanje il-18 vezujućeg proteina
WO2005083058A1 (en) 2004-03-01 2005-09-09 Ares Trading S.A. Use of a serum-free cell culture medium for the production of il-18bp in mammalian cells
AU2005259269B2 (en) * 2004-06-29 2010-12-09 Ares Trading S.A. Process for the purification of IL-18 binding protein
CA2593429A1 (en) * 2004-12-02 2006-06-08 Laboratoires Serono S.A. The lupac bifunctional marker and its use in protein production
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CA2608656A1 (en) * 2005-05-16 2006-11-23 Morphotek, Inc. Regulated vectors for selection of cells exhibiting desired phenotypes
DK2267024T3 (da) * 2005-06-03 2012-06-25 Ares Trading Sa Fremstilling af rekombinant II-18 bindingsprotein
SI1891088T1 (sl) * 2005-06-10 2012-02-29 Ares Trading Sa Postopek za äśiĺ äśenje il-18 vezavnega proteina
EP1760092A1 (en) 2005-08-26 2007-03-07 Applied Research Systems ARS Holding N.V. System for screening cells for high expression of a protein of interest
PL2227549T3 (pl) * 2007-12-21 2015-12-31 Novartis Ag System selekcji do hodowli komórek eukariotycznych oparty na genie związanego z błoną receptora folianowego
JP2009276724A (ja) * 2008-05-19 2009-11-26 Nitto Denko Corp 光導波路装置の製造方法
SG173456A1 (en) * 2009-02-27 2011-09-29 Novartis Ag Expression vector system comprising two selection markers
JP5502406B2 (ja) * 2009-09-14 2014-05-28 ロンザ・バイオロジクス・ピーエルシー Ｃｈｏ細胞において組換えタンパク質を発現する方法
KR101038126B1 (ko) * 2010-11-30 2011-05-31 주식회사 엘지생명과학 새로운 융합 프로모터 및 이를 포함하는 재조합 벡터
US9249785B2 (en) * 2012-01-31 2016-02-02 Brightsource Industries (Isreal) Ltd. Method and system for operating a solar steam system during reduced-insolation events
EP2711426B1 (en) * 2012-09-24 2015-04-08 Lonza Biologics plc Expression vectors comprising chimeric cytomegalovirus promoter and enhancer sequences
ITFI20120221A1 (it) * 2012-10-22 2014-04-23 Nuovo Pignone Srl "exhaust gas collector and gas turbine"
WO2014133468A1 (en) * 2013-02-28 2014-09-04 Agency For Science, Technology And Research Chimeric promoters for high gene expression level and stability in mammalian cells
CN103173481A (zh) * 2013-03-01 2013-06-26 上海中医药大学附属普陀医院 一种含有abcb1基因3′utr序列和报告基因的质粒载体及其构建方法和用途
CN103173480B (zh) * 2013-03-01 2015-06-24 上海中医药大学附属曙光医院 一种利用双荧光素酶报告基因筛选多药耐药相关microRNA的方法
EP2970956A1 (en) 2013-03-11 2016-01-20 Novartis AG Method of screening cell clones
MX369109B (es) * 2013-07-31 2019-10-29 Novartis Ag Selección novedosa de vectores y métodos de selección de células hospederas eucarióticas.
PL3083677T3 (pl) 2013-12-20 2020-03-31 Novartis Ag Nowe komórki eukariotyczne i sposoby rekombinowanej ekspresji produktu będącego przedmiotem zainteresowania
AU2014369175B2 (en) 2013-12-20 2017-03-02 Novartis Ag Novel eukaryotic cells and methods for recombinantly expressing a product of interest
JP6265020B2 (ja) * 2014-04-16 2018-01-24 Jnc株式会社 エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法
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CA2943719A1 (en) * 2014-05-19 2015-11-26 F. Hoffmann-La Roche Ag Method for production of polypeptides
KR20160068558A (ko) 2014-12-05 2016-06-15 삼성바이오에피스 주식회사 마우스 cmv 프로모터를 포함하는 융합 폴리뉴클레오타이드 및 이를 이용한 목적 폴리펩타이드의 생산 방법
AU2016227644B2 (en) 2015-03-05 2022-06-16 Ab2 Bio Sa IL-18 Binding Protein (IL-18BP) and antibodies in inflammatory diseases
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KR101864581B1 (ko) * 2016-11-04 2018-07-13 국립암센터 양방향 프로모터를 포함하는 렌티바이러스 발현 벡터 및 이의 용도
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EP1278540B1 (en) * 2000-05-05 2008-05-14 Laboratoires Serono SA Use of il-18 inhibitors for the treatment and/or prevention of atherosclerosis
US7812148B2 (en) * 2001-04-05 2010-10-12 Millipore Corporation Vectors comprising CpG islands without position effect varigation and having increased expression
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ATE399872T1 (de) * 2003-03-11 2008-07-15 Serono Lab Expressionvektoren, die den promotor des ie2-gens des maus cytomegalovirus enthalten
WO2004101617A1 (en) 2003-05-13 2004-11-25 Applied Research Systems Ars Holding N.V. Active variants of the il-18 binding protein and medical uses thereof
ES2354160T3 (es) 2003-10-21 2011-03-10 Merck Serono Sa Secuencia de adn mínima que actúa como un aislante de cromatina, y su uso en la expresión de proteínas.
ME01198B (me) 2003-11-05 2013-03-20 Ares Trading Sa Prečišćavanje il-18 vezujućeg proteina
WO2005083058A1 (en) 2004-03-01 2005-09-09 Ares Trading S.A. Use of a serum-free cell culture medium for the production of il-18bp in mammalian cells
AU2005259269B2 (en) * 2004-06-29 2010-12-09 Ares Trading S.A. Process for the purification of IL-18 binding protein
CA2593429A1 (en) * 2004-12-02 2006-06-08 Laboratoires Serono S.A. The lupac bifunctional marker and its use in protein production
DK2267024T3 (da) 2005-06-03 2012-06-25 Ares Trading Sa Fremstilling af rekombinant II-18 bindingsprotein
SI1891088T1 (sl) 2005-06-10 2012-02-29 Ares Trading Sa Postopek za äśiĺ äśenje il-18 vezavnega proteina
CN103459608B (zh) * 2011-04-01 2018-05-01 中外制药株式会社 重组多肽的制造方法

Also Published As

Publication number Publication date
CY1108344T1 (el) 2014-02-12
CA2516157C (en) 2012-09-18
US20070258962A1 (en) 2007-11-08
WO2004081167A2 (en) 2004-09-23
US20150252383A1 (en) 2015-09-10
CN100429315C (zh) 2008-10-29
JP2006520589A (ja) 2006-09-14
CA2516157A1 (en) 2004-09-23
UA88138C2 (en) 2009-09-25
ZA200506400B (en) 2006-12-27
JP5848202B2 (ja) 2016-01-27
KR101180139B1 (ko) 2012-09-13
HRP20050705A2 (en) 2005-12-31
AU2004219917A1 (en) 2004-09-23
PT1601776E (pt) 2008-09-17
DK1601776T3 (da) 2008-10-13
WO2004081167A3 (en) 2004-11-04
AU2004219917B2 (en) 2008-01-31
US9051582B2 (en) 2015-06-09
EA200501444A1 (ru) 2006-02-24
PL1601776T3 (pl) 2008-12-31
CN1759184A (zh) 2006-04-12
SI1601776T1 (sl) 2008-10-31
RS20050687A (en) 2007-11-15
EP1601776B1 (en) 2008-07-02
RS50488B (sr) 2010-03-02
EA010096B1 (ru) 2008-06-30
JP5171033B2 (ja) 2013-03-27
US20110008839A1 (en) 2011-01-13
EP1601776A2 (en) 2005-12-07
US7824907B2 (en) 2010-11-02
HRP20050705B1 (hr) 2013-08-31
HK1085766A1 (en) 2006-09-01
KR20050113193A (ko) 2005-12-01
JP2015180222A (ja) 2015-10-15
MXPA05009608A (es) 2006-03-21
NO20054642L (no) 2005-10-10
ATE399872T1 (de) 2008-07-15
NO333818B1 (no) 2013-09-23
JP2012235787A (ja) 2012-12-06
IL170754A (en) 2010-11-30
ES2309508T3 (es) 2008-12-16
DE602004014738D1 (de) 2008-08-14
PL1601776T4 (pl) 2009-05-29

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B25A Requested transfer of rights approved

Owner name: LABORATOIRES SERONO S.A. (CH)

Free format text: TRANSFERIDO DE: APPLIED RESEARCH SYSTEMS ARS HOLDING N.V.

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B25D Requested change of name of applicant approved

Owner name: MERCK SERONO S.A. (CH)

B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]

Free format text: NOTIFICACAO DE ANUENCIA RELACIONADA COM O ART 229 DA LPI

B06F Objections, documents and/or translations needed after an examination request according [chapter 6.6 patent gazette]
B06A Patent application procedure suspended [chapter 6.1 patent gazette]
B11B Dismissal acc. art. 36, par 1 of ipl - no reply within 90 days to fullfil the necessary requirements