DE602004014738D1 - Expressionvektoren, die den promotor des ie2-gens des maus cytomegalovirus enthalten - Google Patents
Expressionvektoren, die den promotor des ie2-gens des maus cytomegalovirus enthaltenInfo
- Publication number
- DE602004014738D1 DE602004014738D1 DE602004014738T DE602004014738T DE602004014738D1 DE 602004014738 D1 DE602004014738 D1 DE 602004014738D1 DE 602004014738 T DE602004014738 T DE 602004014738T DE 602004014738 T DE602004014738 T DE 602004014738T DE 602004014738 D1 DE602004014738 D1 DE 602004014738D1
- Authority
- DE
- Germany
- Prior art keywords
- gene
- promoter
- expression vectors
- vectors containing
- mouse cytomegalovirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000013604 expression vector Substances 0.000 title abstract 3
- 241000701022 Cytomegalovirus Species 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 abstract 3
- 239000012634 fragment Substances 0.000 abstract 2
- 239000003623 enhancer Substances 0.000 abstract 1
- 230000002708 enhancing effect Effects 0.000 abstract 1
- 230000001737 promoting effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/01—DNA viruses
- C07K14/03—Herpetoviridae, e.g. pseudorabies virus
- C07K14/04—Varicella-zoster virus
- C07K14/045—Cytomegalovirus
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/16011—Herpesviridae
- C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
- C12N2710/16141—Use of virus, viral particle or viral elements as a vector
- C12N2710/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
- C12N2830/205—Vector systems having a special element relevant for transcription transcription of more than one cistron bidirectional
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2830/00—Vector systems having a special element relevant for transcription
- C12N2830/60—Vector systems having a special element relevant for transcription from viruses
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Virology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cell Biology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pharmacology & Pharmacy (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP03100617 | 2003-03-11 | ||
| PCT/EP2004/050280 WO2004081167A2 (en) | 2003-03-11 | 2004-03-10 | Expression vectors comprising the mcmv ie2 promoter |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004014738D1 true DE602004014738D1 (de) | 2008-08-14 |
Family
ID=32981915
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004014738T Expired - Lifetime DE602004014738D1 (de) | 2003-03-11 | 2004-03-10 | Expressionvektoren, die den promotor des ie2-gens des maus cytomegalovirus enthalten |
Country Status (26)
| Country | Link |
|---|---|
| US (3) | US7824907B2 (de) |
| EP (1) | EP1601776B1 (de) |
| JP (3) | JP5171033B2 (de) |
| KR (1) | KR101180139B1 (de) |
| CN (1) | CN100429315C (de) |
| AT (1) | ATE399872T1 (de) |
| AU (1) | AU2004219917B2 (de) |
| BR (1) | BRPI0408246A (de) |
| CA (1) | CA2516157C (de) |
| CY (1) | CY1108344T1 (de) |
| DE (1) | DE602004014738D1 (de) |
| DK (1) | DK1601776T3 (de) |
| EA (1) | EA010096B1 (de) |
| ES (1) | ES2309508T3 (de) |
| HK (1) | HK1085766A1 (de) |
| HR (1) | HRP20050705B1 (de) |
| IL (1) | IL170754A (de) |
| MX (1) | MXPA05009608A (de) |
| NO (1) | NO333818B1 (de) |
| PL (1) | PL1601776T4 (de) |
| PT (1) | PT1601776E (de) |
| RS (1) | RS50488B (de) |
| SI (1) | SI1601776T1 (de) |
| UA (1) | UA88138C2 (de) |
| WO (1) | WO2004081167A2 (de) |
| ZA (1) | ZA200506400B (de) |
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0216648D0 (en) | 2002-07-18 | 2002-08-28 | Lonza Biologics Plc | Method of expressing recombinant protein in CHO cells |
| MXPA05009608A (es) * | 2003-03-11 | 2006-03-21 | Applied Research Systems | Vectores de expresion que comprenden el promotor mcmv ie2. |
| US20080076708A1 (en) * | 2003-05-13 | 2008-03-27 | Valter Altarocca | Active Variants of the Il-18 Binding Protein and Medical Uses Thereof |
| DE602004029598D1 (de) | 2003-10-21 | 2010-11-25 | Merck Serono Sa | Minimale dna sequenz, die als chromatin-isolator wirkt, und deren verwendung für die protein-expression |
| SI1689777T1 (sl) * | 2003-11-05 | 2007-08-31 | Ares Trading Sa | Postopek za äśiĺ äśenje il-18 vezavnega proteina |
| WO2005083058A1 (en) | 2004-03-01 | 2005-09-09 | Ares Trading S.A. | Use of a serum-free cell culture medium for the production of il-18bp in mammalian cells |
| JP5043654B2 (ja) * | 2004-06-29 | 2012-10-10 | アレス トレーディング ソシエテ アノニム | Ｉｌ−１８結合タンパク質の精製のための方法 |
| AU2005311246B2 (en) * | 2004-12-02 | 2010-12-02 | Merck Serono Sa | The Lupac bifunctional marker and its use in protein production |
| EP1874929A2 (de) | 2005-04-22 | 2008-01-09 | Lonza Biologics plc | Säugerexpressionsvektor mit dem mcmv-promotor und dem ersten intron des major-immediate-early-gens von hcmv |
| US20060258007A1 (en) * | 2005-05-16 | 2006-11-16 | Nicolaides Nicholas C | Regulated vectors for selection of cells exhibiting desired phenotypes |
| ATE517917T1 (de) | 2005-06-03 | 2011-08-15 | Ares Trading Sa | Herstellung eines rekombinanten il-18-bindenden proteins |
| SI1891088T1 (sl) | 2005-06-10 | 2012-02-29 | Ares Trading Sa | Postopek za äśiĺ äśenje il-18 vezavnega proteina |
| EP1760092A1 (de) * | 2005-08-26 | 2007-03-07 | Applied Research Systems ARS Holding N.V. | System für Screening von Zellen mit hoher Expression von einem interessierenden Protein |
| KR101706390B1 (ko) * | 2007-12-21 | 2017-02-13 | 노파르티스 아게 | 유기 화합물 |
| JP2009276724A (ja) * | 2008-05-19 | 2009-11-26 | Nitto Denko Corp | 光導波路装置の製造方法 |
| CA2753814C (en) * | 2009-02-27 | 2018-07-31 | Novartis Ag | Novel selection vectors and methods of selecting eukaryotic host cells |
| JP5502406B2 (ja) * | 2009-09-14 | 2014-05-28 | ロンザ・バイオロジクス・ピーエルシー | Ｃｈｏ細胞において組換えタンパク質を発現する方法 |
| KR101038126B1 (ko) * | 2010-11-30 | 2011-05-31 | 주식회사 엘지생명과학 | 새로운 융합 프로모터 및 이를 포함하는 재조합 벡터 |
| US9249785B2 (en) * | 2012-01-31 | 2016-02-02 | Brightsource Industries (Isreal) Ltd. | Method and system for operating a solar steam system during reduced-insolation events |
| HUE026516T2 (en) | 2012-09-24 | 2016-06-28 | Lonza Biologics Plc | Expression vectors containing chimeric cytomegalovirus promoter and enhancer sequences |
| ITFI20120221A1 (it) * | 2012-10-22 | 2014-04-23 | Nuovo Pignone Srl | "exhaust gas collector and gas turbine" |
| WO2014133468A1 (en) * | 2013-02-28 | 2014-09-04 | Agency For Science, Technology And Research | Chimeric promoters for high gene expression level and stability in mammalian cells |
| CN103173481A (zh) * | 2013-03-01 | 2013-06-26 | 上海中医药大学附属普陀医院 | 一种含有abcb1基因3′utr序列和报告基因的质粒载体及其构建方法和用途 |
| CN103173480B (zh) * | 2013-03-01 | 2015-06-24 | 上海中医药大学附属曙光医院 | 一种利用双荧光素酶报告基因筛选多药耐药相关microRNA的方法 |
| EP2970956A1 (de) | 2013-03-11 | 2016-01-20 | Novartis AG | Verfahren zum screening von zellklonen |
| JP6576924B2 (ja) | 2013-07-31 | 2019-09-18 | ノバルティス アーゲー | 新規の選択ベクターおよび真核宿主細胞を選択する方法 |
| EP3083676B1 (de) | 2013-12-20 | 2019-08-28 | Novartis AG | Neuartige eukaryotische zellen und verfahren zur rekombinanten expression eines produkts von interesse |
| US11242551B2 (en) | 2013-12-20 | 2022-02-08 | Novartis Ag | Eukaryotic cells and methods for recombinantly expressing a product of interest |
| JP6265020B2 (ja) * | 2014-04-16 | 2018-01-24 | Jnc株式会社 | エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法 |
| EP4332231A3 (de) | 2014-04-29 | 2024-05-29 | Novartis AG | Neuartige wirbeltierzellen und verfahren zur rekombinanten expression eines polypeptids von interesse |
| MX2016014473A (es) * | 2014-05-19 | 2017-01-23 | Hoffmann La Roche | Metodo para produccion de polipeptidos. |
| KR20160068558A (ko) | 2014-12-05 | 2016-06-15 | 삼성바이오에피스 주식회사 | 마우스 cmv 프로모터를 포함하는 융합 폴리뉴클레오타이드 및 이를 이용한 목적 폴리펩타이드의 생산 방법 |
| BR112017017076A2 (pt) | 2015-03-05 | 2018-04-10 | Ab2 Bio Sa | inibidor de il-18, anticorpo, métodos para o tratamento de uma doença ou um distúrbio associado a il-18 em um indivíduo, para determinar a quantidade de il-18 livre em uma amostra ou in situ, para diagnosticar uma predisposição a uma doença ou um distúrbio associado a il-18, para monitorar doença residual mínima em um paciente que segue o tratamento com o inibidor de il-18 ou a composição e para prever uma resposta de um paciente a um tratamento com o inibidor de il-18 ou composição, e, kit diagnóstico para detectar il-18 livre. |
| CA2981841A1 (en) * | 2015-04-14 | 2016-10-20 | Janssen Vaccines & Prevention B.V. | Recombinant adenovirus expressing two transgenes with a bidirectional promoter |
| JP6937309B2 (ja) | 2016-01-27 | 2021-09-22 | ジャスト−エヴォテック バイオロジックス、インコーポレイテッド | ハイブリッドプロモーターおよびその使用 |
| RU2758238C2 (ru) | 2016-05-12 | 2021-10-26 | Янссен Вэксинс Энд Превеншн Б.В. | Эффективный и сбалансированный двунаправленный промотор |
| RU2745500C2 (ru) | 2016-06-20 | 2021-03-25 | Янссен Вэксинс Энд Превеншн Б.В. | Эффективный и сбалансированный двунаправленный промотор |
| KR101864581B1 (ko) * | 2016-11-04 | 2018-07-13 | 국립암센터 | 양방향 프로모터를 포함하는 렌티바이러스 발현 벡터 및 이의 용도 |
| KR102111244B1 (ko) | 2017-02-09 | 2020-05-15 | 얀센 백신스 앤드 프리벤션 비.브이. | 이종 유전자의 발현을 위한 강력한 짧은 프로모터 |
| WO2019070638A1 (en) | 2017-10-02 | 2019-04-11 | Astrazeneca Ab | CELL LINES AND METHODS FOR INCREASED PROTEIN PRODUCTION |
| BR112021010785A2 (pt) * | 2018-12-04 | 2021-11-16 | Catalent Pharma Solutions Llc | Vetores para fabricação de proteínas |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2007A (en) * | 1841-03-16 | Improvement in the mode of harvesting grain | ||
| US4963481A (en) * | 1985-12-18 | 1990-10-16 | Genetics Institute Inc | Promoter system |
| US4968615A (en) * | 1985-12-18 | 1990-11-06 | Ciba-Geigy Corporation | Deoxyribonucleic acid segment from a virus |
| JPS63502719A (ja) * | 1985-12-18 | 1988-10-13 | ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド | プロモ−タ−系 |
| EP1047774A1 (de) * | 1998-01-16 | 2000-11-02 | California Pacific Medical Center Research Institute | Verfahren und zusammensetzungen für den gentransfer |
| AU2001245427A1 (en) * | 2000-03-03 | 2001-09-17 | Valentis, Inc. | Nucleic acid formulations for gene delivery and methods of use |
| WO2001085201A2 (en) * | 2000-05-05 | 2001-11-15 | Applied Research Systems Ars Holding N.V. | Use of il-18 inhibitors for the treatment and/or prevention of atherosclerosis |
| US7812148B2 (en) * | 2001-04-05 | 2010-10-12 | Millipore Corporation | Vectors comprising CpG islands without position effect varigation and having increased expression |
| EP1402006A4 (de) * | 2001-06-04 | 2005-11-23 | Ml Lab Plc | Zusammensetzungen und verfahren zur produktion rekombinanter proteine auf hohem niveau und im grossmassstab |
| MXPA05009608A (es) * | 2003-03-11 | 2006-03-21 | Applied Research Systems | Vectores de expresion que comprenden el promotor mcmv ie2. |
| US20080076708A1 (en) | 2003-05-13 | 2008-03-27 | Valter Altarocca | Active Variants of the Il-18 Binding Protein and Medical Uses Thereof |
| DE602004029598D1 (de) | 2003-10-21 | 2010-11-25 | Merck Serono Sa | Minimale dna sequenz, die als chromatin-isolator wirkt, und deren verwendung für die protein-expression |
| SI1689777T1 (sl) | 2003-11-05 | 2007-08-31 | Ares Trading Sa | Postopek za äśiĺ äśenje il-18 vezavnega proteina |
| WO2005083058A1 (en) * | 2004-03-01 | 2005-09-09 | Ares Trading S.A. | Use of a serum-free cell culture medium for the production of il-18bp in mammalian cells |
| JP5043654B2 (ja) | 2004-06-29 | 2012-10-10 | アレス トレーディング ソシエテ アノニム | Ｉｌ−１８結合タンパク質の精製のための方法 |
| AU2005311246B2 (en) * | 2004-12-02 | 2010-12-02 | Merck Serono Sa | The Lupac bifunctional marker and its use in protein production |
| ATE517917T1 (de) * | 2005-06-03 | 2011-08-15 | Ares Trading Sa | Herstellung eines rekombinanten il-18-bindenden proteins |
| SI1891088T1 (sl) | 2005-06-10 | 2012-02-29 | Ares Trading Sa | Postopek za äśiĺ äśenje il-18 vezavnega proteina |
| AU2012239382B2 (en) * | 2011-04-01 | 2016-04-21 | Chugai Seiyaku Kabushiki Kaisha | Recombinant polypeptide production method |
-
2004
- 2004-03-10 MX MXPA05009608A patent/MXPA05009608A/es active IP Right Grant
- 2004-03-10 RS YUP-2005/0687A patent/RS50488B/sr unknown
- 2004-03-10 CA CA2516157A patent/CA2516157C/en not_active Expired - Lifetime
- 2004-03-10 PL PL04718972T patent/PL1601776T4/pl unknown
- 2004-03-10 SI SI200430835T patent/SI1601776T1/sl unknown
- 2004-03-10 PT PT04718972T patent/PT1601776E/pt unknown
- 2004-03-10 EA EA200501444A patent/EA010096B1/ru not_active IP Right Cessation
- 2004-03-10 CN CNB2004800067294A patent/CN100429315C/zh not_active Expired - Lifetime
- 2004-03-10 JP JP2006505456A patent/JP5171033B2/ja not_active Expired - Lifetime
- 2004-03-10 AT AT04718972T patent/ATE399872T1/de active
- 2004-03-10 DE DE602004014738T patent/DE602004014738D1/de not_active Expired - Lifetime
- 2004-03-10 BR BRPI0408246-0A patent/BRPI0408246A/pt not_active Application Discontinuation
- 2004-03-10 ES ES04718972T patent/ES2309508T3/es not_active Expired - Lifetime
- 2004-03-10 EP EP04718972A patent/EP1601776B1/de not_active Expired - Lifetime
- 2004-03-10 US US10/548,364 patent/US7824907B2/en active Active
- 2004-03-10 AU AU2004219917A patent/AU2004219917B2/en not_active Expired
- 2004-03-10 KR KR1020057015746A patent/KR101180139B1/ko active IP Right Grant
- 2004-03-10 DK DK04718972T patent/DK1601776T3/da active
- 2004-03-10 WO PCT/EP2004/050280 patent/WO2004081167A2/en active IP Right Grant
- 2004-10-03 UA UAA200509529A patent/UA88138C2/ru unknown
-
2005
- 2005-08-09 HR HRP20050705AA patent/HRP20050705B1/hr not_active IP Right Cessation
- 2005-08-11 ZA ZA200506400A patent/ZA200506400B/en unknown
- 2005-09-08 IL IL170754A patent/IL170754A/en unknown
- 2005-10-10 NO NO20054642A patent/NO333818B1/no unknown
-
2006
- 2006-07-14 HK HK06107903A patent/HK1085766A1/xx not_active IP Right Cessation
-
2008
- 2008-09-16 CY CY20081100997T patent/CY1108344T1/el unknown
-
2010
- 2010-08-31 US US12/872,151 patent/US9051582B2/en active Active
-
2012
- 2012-07-13 JP JP2012157563A patent/JP5848202B2/ja not_active Expired - Lifetime
-
2015
- 2015-05-20 US US14/716,937 patent/US20150252383A1/en not_active Abandoned
- 2015-06-10 JP JP2015117538A patent/JP2015180222A/ja active Pending
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