PT1601776E - Vectores de expressão que compreendem o promotor ie2 do mcmv - Google Patents

Vectores de expressão que compreendem o promotor ie2 do mcmv Download PDF

Info

Publication number
PT1601776E
PT1601776E PT04718972T PT04718972T PT1601776E PT 1601776 E PT1601776 E PT 1601776E PT 04718972 T PT04718972 T PT 04718972T PT 04718972 T PT04718972 T PT 04718972T PT 1601776 E PT1601776 E PT 1601776E
Authority
PT
Portugal
Prior art keywords
mcmv
promoter
expression vectors
gene
expression
Prior art date
Application number
PT04718972T
Other languages
English (en)
Inventor
Philippe Chatellard
Markus Imhof
Original Assignee
Serono Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Serono Lab filed Critical Serono Lab
Publication of PT1601776E publication Critical patent/PT1601776E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/01—DNA viruses
    • C07K14/03—Herpetoviridae, e.g. pseudorabies virus
    • C07K14/04—Varicella-zoster virus
    • C07K14/045—Cytomegalovirus
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10—Cells modified by introduction of foreign genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
    • C12N2710/00011—Details
    • C12N2710/16011—Herpesviridae
    • C12N2710/16111—Cytomegalovirus, e.g. human herpesvirus 5
    • C12N2710/16141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/16143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/20—Vector systems having a special element relevant for transcription transcription of more than one cistron
    • C12N2830/205—Vector systems having a special element relevant for transcription transcription of more than one cistron bidirectional
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/60—Vector systems having a special element relevant for transcription from viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Cell Biology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
PT04718972T 2003-03-11 2004-03-10 Vectores de expressão que compreendem o promotor ie2 do mcmv PT1601776E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP03100617 2003-03-11

Publications (1)

Publication Number Publication Date
PT1601776E true PT1601776E (pt) 2008-09-17

Family

ID=32981915

Family Applications (1)

Application Number Title Priority Date Filing Date
PT04718972T PT1601776E (pt) 2003-03-11 2004-03-10 Vectores de expressão que compreendem o promotor ie2 do mcmv

Country Status (26)

Country Link
US (3) US7824907B2 (pt)
EP (1) EP1601776B1 (pt)
JP (3) JP5171033B2 (pt)
KR (1) KR101180139B1 (pt)
CN (1) CN100429315C (pt)
AT (1) ATE399872T1 (pt)
AU (1) AU2004219917B2 (pt)
BR (1) BRPI0408246A (pt)
CA (1) CA2516157C (pt)
CY (1) CY1108344T1 (pt)
DE (1) DE602004014738D1 (pt)
DK (1) DK1601776T3 (pt)
EA (1) EA010096B1 (pt)
ES (1) ES2309508T3 (pt)
HK (1) HK1085766A1 (pt)
HR (1) HRP20050705B1 (pt)
IL (1) IL170754A (pt)
MX (1) MXPA05009608A (pt)
NO (1) NO333818B1 (pt)
PL (1) PL1601776T4 (pt)
PT (1) PT1601776E (pt)
RS (1) RS50488B (pt)
SI (1) SI1601776T1 (pt)
UA (1) UA88138C2 (pt)
WO (1) WO2004081167A2 (pt)
ZA (1) ZA200506400B (pt)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0216648D0 (en) 2002-07-18 2002-08-28 Lonza Biologics Plc Method of expressing recombinant protein in CHO cells
US7824907B2 (en) * 2003-03-11 2010-11-02 Merck Serono Sa Expression vectors comprising the mCMV IE2 promoter
SI1622939T1 (sl) * 2003-05-13 2012-06-29 Merck Serono Sa Akrivne variante il-18 vezavnega proteina in medicinske uporabe le-tega
ES2354160T3 (es) * 2003-10-21 2011-03-10 Merck Serono Sa Secuencia de adn mínima que actúa como un aislante de cromatina, y su uso en la expresión de proteínas.
SI1689777T1 (sl) 2003-11-05 2007-08-31 Ares Trading Sa Postopek za äśiĺ äśenje il-18 vezavnega proteina
AU2005217154B2 (en) 2004-03-01 2010-02-18 Ares Trading S.A. Use of a serum-free cell culture medium for the production of IL-18BP in mammalian cells
AU2005259269B2 (en) * 2004-06-29 2010-12-09 Ares Trading S.A. Process for the purification of IL-18 binding protein
EP1819812B1 (en) * 2004-12-02 2012-05-30 Merck Serono SA The lupac bifunctional marker and its use in protein production
AU2006237193B2 (en) 2005-04-22 2012-02-02 Lonza Biologics Plc. Mammalian expression vector comprising the mCMV promoter and first intron of hCMV major immediate early gene
US20060258007A1 (en) * 2005-05-16 2006-11-16 Nicolaides Nicholas C Regulated vectors for selection of cells exhibiting desired phenotypes
WO2006128908A1 (en) * 2005-06-03 2006-12-07 Ares Trading S.A. Production of recombinant il-18 binding protein
EP1891088B1 (en) * 2005-06-10 2011-10-19 Ares Trading S.A. Process for the purification of il-18 binding protein
EP1760092A1 (en) * 2005-08-26 2007-03-07 Applied Research Systems ARS Holding N.V. System for screening cells for high expression of a protein of interest
PL2227549T3 (pl) * 2007-12-21 2015-12-31 Novartis Ag System selekcji do hodowli komórek eukariotycznych oparty na genie związanego z błoną receptora folianowego
JP2009276724A (ja) * 2008-05-19 2009-11-26 Nitto Denko Corp 光導波路装置の製造方法
MX2011009025A (es) 2009-02-27 2011-09-28 Novartis Ag Sistema de vector de expresion que comprende dos marcadores de seleccion.
JP5502406B2 (ja) * 2009-09-14 2014-05-28 ロンザ・バイオロジクス・ピーエルシー Ｃｈｏ細胞において組換えタンパク質を発現する方法
KR101038126B1 (ko) * 2010-11-30 2011-05-31 주식회사 엘지생명과학 새로운 융합 프로모터 및 이를 포함하는 재조합 벡터
US9249785B2 (en) * 2012-01-31 2016-02-02 Brightsource Industries (Isreal) Ltd. Method and system for operating a solar steam system during reduced-insolation events
ES2540753T3 (es) * 2012-09-24 2015-07-13 Lonza Biologics Plc. Vectores de expresión que comprenden secuencias quiméricas de promotor y amplificador de citomegalovirus
ITFI20120221A1 (it) * 2012-10-22 2014-04-23 Nuovo Pignone Srl "exhaust gas collector and gas turbine"
WO2014133468A1 (en) * 2013-02-28 2014-09-04 Agency For Science, Technology And Research Chimeric promoters for high gene expression level and stability in mammalian cells
CN103173480B (zh) * 2013-03-01 2015-06-24 上海中医药大学附属曙光医院 一种利用双荧光素酶报告基因筛选多药耐药相关microRNA的方法
CN103173481A (zh) * 2013-03-01 2013-06-26 上海中医药大学附属普陀医院 一种含有abcb1基因3′utr序列和报告基因的质粒载体及其构建方法和用途
WO2014141037A1 (en) 2013-03-11 2014-09-18 Novartis Ag Method of screening cell clones
DK3412684T3 (da) * 2013-07-31 2022-07-04 Novartis Ag Nye selektionsvektorer og fremgangsmåder til selektering af eukaryotiske værtsceller
US11203631B2 (en) 2013-12-20 2021-12-21 Novartis Ag Eukaryotic cells and methods for recombinantly expressing a product of interest
EP3083677B1 (en) 2013-12-20 2019-08-28 Novartis AG Novel eukaryotic cells and methods for recombinantly expressing a product of interest
JP6265020B2 (ja) * 2014-04-16 2018-01-24 Jnc株式会社 エビルシフェラーゼの触媒蛋白質の変異遺伝子とその使用法
AU2015254913B2 (en) 2014-04-29 2018-05-17 Novartis Ag Novel vertebrate cells and methods for recombinantly expressing a polypeptide of interest
CN106255757B (zh) * 2014-05-19 2020-08-11 豪夫迈·罗氏有限公司 生产多肽的方法
KR20160068558A (ko) 2014-12-05 2016-06-15 삼성바이오에피스 주식회사 마우스 cmv 프로모터를 포함하는 융합 폴리뉴클레오타이드 및 이를 이용한 목적 폴리펩타이드의 생산 방법
KR102511343B1 (ko) 2015-03-05 2023-03-17 에이비2 바이오 에스에이 염증성 질환에서 il-18 결합 단백질(ｉｌ-18ｂｐ) 및 항체
EP3283634B1 (en) * 2015-04-14 2019-05-22 Janssen Vaccines & Prevention B.V. Recombinant adenovirus expressing two transgenes with a bidirectional promoter
US11028410B2 (en) 2016-01-27 2021-06-08 Just-Evotec Biologics, Inc. Hybrid promoter and uses thereof
RU2758238C2 (ru) 2016-05-12 2021-10-26 Янссен Вэксинс Энд Превеншн Б.В. Эффективный и сбалансированный двунаправленный промотор
EP3472327B1 (en) 2016-06-20 2020-08-19 Janssen Vaccines & Prevention B.V. Potent and balanced bidirectional promoter
KR101864581B1 (ko) * 2016-11-04 2018-07-13 국립암센터 양방향 프로모터를 포함하는 렌티바이러스 발현 벡터 및 이의 용도
KR102111244B1 (ko) 2017-02-09 2020-05-15 얀센 백신스 앤드 프리벤션 비.브이. 이종 유전자의 발현을 위한 강력한 짧은 프로모터
EP3692153A1 (en) 2017-10-02 2020-08-12 Astrazeneca AB Cell lines and methods for increased protein production
WO2020117910A1 (en) * 2018-12-04 2020-06-11 Catalent Pharma Solutions, Llc Vectors for protein manufacture

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2007A (en) * 1841-03-16 Improvement in the mode of harvesting grain
JPS63502719A (ja) * 1985-12-18 1988-10-13 ジェネティックス・インスチチュ−ト・インコ−ポレ−テッド プロモ−タ−系
US4963481A (en) * 1985-12-18 1990-10-16 Genetics Institute Inc Promoter system
US4968615A (en) * 1985-12-18 1990-11-06 Ciba-Geigy Corporation Deoxyribonucleic acid segment from a virus
JP2002508956A (ja) * 1998-01-16 2002-03-26 カリフォルニア パシフィック メディカル センター リサーチ インスティテュート 遺伝子送達のための方法および組成物
AU2001245427A1 (en) * 2000-03-03 2001-09-17 Valentis, Inc. Nucleic acid formulations for gene delivery and methods of use
ME00554B (me) * 2000-05-05 2012-03-20 Serono Lab KORIŠĆENJE IL-18 INHIBITORA ZA LIJEČENJE l/ILI PREVENCIJU ATEROSKLEROZE
US7812148B2 (en) * 2001-04-05 2010-10-12 Millipore Corporation Vectors comprising CpG islands without position effect varigation and having increased expression
KR20040032105A (ko) * 2001-06-04 2004-04-14 엠엘 래보러토리즈 피엘씨 재조합 단백질의 조성물 및 재조합 단백질의 고수준대규모 생산방법
US7824907B2 (en) * 2003-03-11 2010-11-02 Merck Serono Sa Expression vectors comprising the mCMV IE2 promoter
SI1622939T1 (sl) 2003-05-13 2012-06-29 Merck Serono Sa Akrivne variante il-18 vezavnega proteina in medicinske uporabe le-tega
ES2354160T3 (es) * 2003-10-21 2011-03-10 Merck Serono Sa Secuencia de adn mínima que actúa como un aislante de cromatina, y su uso en la expresión de proteínas.
SI1689777T1 (sl) 2003-11-05 2007-08-31 Ares Trading Sa Postopek za äśiĺ äśenje il-18 vezavnega proteina
AU2005217154B2 (en) 2004-03-01 2010-02-18 Ares Trading S.A. Use of a serum-free cell culture medium for the production of IL-18BP in mammalian cells
AU2005259269B2 (en) * 2004-06-29 2010-12-09 Ares Trading S.A. Process for the purification of IL-18 binding protein
EP1819812B1 (en) * 2004-12-02 2012-05-30 Merck Serono SA The lupac bifunctional marker and its use in protein production
WO2006128908A1 (en) 2005-06-03 2006-12-07 Ares Trading S.A. Production of recombinant il-18 binding protein
EP1891088B1 (en) * 2005-06-10 2011-10-19 Ares Trading S.A. Process for the purification of il-18 binding protein
ES2620306T3 (es) * 2011-04-01 2017-06-28 Chugai Seiyaku Kabushiki Kaisha Método de producción de polipéptido recombinante

Also Published As

Publication number Publication date
WO2004081167A2 (en) 2004-09-23
HRP20050705B1 (hr) 2013-08-31
CN100429315C (zh) 2008-10-29
MXPA05009608A (es) 2006-03-21
RS20050687A (en) 2007-11-15
SI1601776T1 (sl) 2008-10-31
EA200501444A1 (ru) 2006-02-24
AU2004219917B2 (en) 2008-01-31
CA2516157C (en) 2012-09-18
PL1601776T3 (pl) 2008-12-31
US20110008839A1 (en) 2011-01-13
ZA200506400B (en) 2006-12-27
JP5848202B2 (ja) 2016-01-27
EP1601776B1 (en) 2008-07-02
KR20050113193A (ko) 2005-12-01
CY1108344T1 (el) 2014-02-12
JP2006520589A (ja) 2006-09-14
DE602004014738D1 (de) 2008-08-14
CA2516157A1 (en) 2004-09-23
RS50488B (sr) 2010-03-02
WO2004081167A3 (en) 2004-11-04
HRP20050705A2 (en) 2005-12-31
US20150252383A1 (en) 2015-09-10
US20070258962A1 (en) 2007-11-08
PL1601776T4 (pl) 2009-05-29
US9051582B2 (en) 2015-06-09
UA88138C2 (en) 2009-09-25
NO20054642L (no) 2005-10-10
JP5171033B2 (ja) 2013-03-27
BRPI0408246A (pt) 2006-03-01
ATE399872T1 (de) 2008-07-15
CN1759184A (zh) 2006-04-12
JP2012235787A (ja) 2012-12-06
HK1085766A1 (en) 2006-09-01
ES2309508T3 (es) 2008-12-16
JP2015180222A (ja) 2015-10-15
EP1601776A2 (en) 2005-12-07
EA010096B1 (ru) 2008-06-30
IL170754A (en) 2010-11-30
AU2004219917A1 (en) 2004-09-23
NO333818B1 (no) 2013-09-23
KR101180139B1 (ko) 2012-09-13
US7824907B2 (en) 2010-11-02
DK1601776T3 (da) 2008-10-13

Similar Documents

Publication Publication Date Title
HK1085766A1 (en) Expression vectors comprising the mcmv ie2 promoter
WO2003011115A3 (en) Peptide-based multimeric targeted contrast agents
WO2003060017A3 (de) Stabilisierte wässrige polyurethan-polyharnstoff dispersionen
WO2004087874A3 (en) Novel nucleic acids and polypeptides
EP1344827A3 (en) Antifreeze proteins from basidiomycetes
WO2003074546A8 (de) Streptavidin-bindungspeptid
WO2002068465A3 (en) Novel p53-inducible protein
ATE333520T1 (de) Neuartige polynukleotide und polypeptide des ifnalpha-21 gens
SG146640A1 (en) Isolated photoprotein mtclytin, and use thereof
HK1096423A1 (en) Isolated luciferases and the use thereof
ZA200308303B (en) Condensates for the retanning of fe-tanned leather.
HK1082510A1 (en) Promoter to il-18bp, its preparation and use
WO2003093300A3 (en) Anti-microbial peptides and compositions
WO2002036780A3 (en) Stearoyl-coa desaturase gene promoter
WO2004053052A3 (en) HUMAN RECOMBINANT ENDOOLIGOPEPTIDASE A (hEOPA)
EP1532177A4 (en) IMMUNOMODULATORY CONSTRUCTIONS AND USES THEREOF
WO2002083727A3 (de) Nukleinsäuresequenzen von hyperplasien und tumoren der schilddrüse
TW200617021A (en) Isolated photoprotein aequorin y89f, and its use
TW200716177A (en) Isolated photoprotein aqdecay, and its use
DE60330140D1 (de) Gen-silencing-vektor und diesen verwendendes gen-silencing-verfahren
AU2003267971A8 (en) Improved alphavirus vectors having attenuated virion structural proteins
WO2002006321A3 (en) Polycomb gene zmfie2 from maize
WO2003050259A3 (en) Nucleic acids related to plant retroelements
WO2003104261A3 (en) PABLO, POLYPEPTIDE INTERACTING WITH BCL-XL, AND USES THEREOF
TW200500081A (en) Novel rotaviruses and use thereof