WO2003104261A3 - Pablo, a polypeptide that interacts with bcl-xl, and uses related thereto - Google Patents

Pablo, a polypeptide that interacts with bcl-xl, and uses related thereto Download PDF

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Publication number
WO2003104261A3
WO2003104261A3 PCT/US2003/018197 US0318197W WO03104261A3 WO 2003104261 A3 WO2003104261 A3 WO 2003104261A3 US 0318197 W US0318197 W US 0318197W WO 03104261 A3 WO03104261 A3 WO 03104261A3
Authority
WO
WIPO (PCT)
Prior art keywords
pablo
polypeptide
bcl
interacts
uses related
Prior art date
Application number
PCT/US2003/018197
Other languages
French (fr)
Other versions
WO2003104261A2 (en
Inventor
Robert John Mark
Kathleen Hart Young
Andrew Timothy Wood
Seung Poon Kwak
Original Assignee
Wyeth Corp
Robert John Mark
Kathleen Hart Young
Andrew Timothy Wood
Seung Poon Kwak
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Wyeth Corp, Robert John Mark, Kathleen Hart Young, Andrew Timothy Wood, Seung Poon Kwak filed Critical Wyeth Corp
Priority to AU2003247516A priority Critical patent/AU2003247516A1/en
Publication of WO2003104261A2 publication Critical patent/WO2003104261A2/en
Publication of WO2003104261A3 publication Critical patent/WO2003104261A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4747—Apoptosis related proteins
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2207/00—Modified animals
    • A01K2207/15—Humanized animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/05—Animals comprising random inserted nucleic acids (transgenic)
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases

Landscapes

  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Environmental Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biotechnology (AREA)
  • Animal Husbandry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)

Abstract

The present invention relates, at least in part, to transgenic animals comprising an exogenous polynucleotide or gene encoding a Pablo polypeptide and relates also to transgenic animals having a functional disruption of an endogenous Pablo gene.
PCT/US2003/018197 2002-06-10 2003-06-09 Pablo, a polypeptide that interacts with bcl-xl, and uses related thereto WO2003104261A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU2003247516A AU2003247516A1 (en) 2002-06-10 2003-06-09 Pablo, a polypeptide that interacts with bcl-xl, and uses related thereto

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US16591002A 2002-06-10 2002-06-10
US10/165,910 2002-06-10

Publications (2)

Publication Number Publication Date
WO2003104261A2 WO2003104261A2 (en) 2003-12-18
WO2003104261A3 true WO2003104261A3 (en) 2004-03-25

Family

ID=29732096

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/018197 WO2003104261A2 (en) 2002-06-10 2003-06-09 Pablo, a polypeptide that interacts with bcl-xl, and uses related thereto

Country Status (2)

Country Link
AU (1) AU2003247516A1 (en)
WO (1) WO2003104261A2 (en)

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
HUANG D. ET AL.: "The conserved N-terminal BH4 domain of Bcl-2 homologues is essential for inhibition of apoptosis and interaction with CED-4", THE EMBO JOURNAL, vol. 17, no. 4, 1998, pages 1029 - 1039, XP002970527 *
MAC FARLANE M. ET AL.: "Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 39, 27 September 2002 (2002-09-27), pages 36611 - 36616, XP002970526 *
MEDEK A. ET AL.: "The use of differential chemical shifts for determining the binding site location and orientation of protein-bound ligands", J. AM. CHEM. SOC., vol. 122, 2000, pages 1241 - 1242, XP002970528 *
YAMAGUCHI H. ET AL.: "Bcl-XL protects BimEL-induced Bax conformational change and cytochrome c release independent of interacting with Bax or BimEl", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 277, no. 44, 1 November 2002 (2002-11-01), pages 41604 - 41612, XP002970525 *

Also Published As

Publication number Publication date
WO2003104261A2 (en) 2003-12-18
AU2003247516A1 (en) 2003-12-22
AU2003247516A8 (en) 2003-12-22

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