PL3083677T3 - Nowe komórki eukariotyczne i sposoby rekombinowanej ekspresji produktu będącego przedmiotem zainteresowania - Google Patents
Nowe komórki eukariotyczne i sposoby rekombinowanej ekspresji produktu będącego przedmiotem zainteresowaniaInfo
- Publication number
- PL3083677T3 PL3083677T3 PL14821860T PL14821860T PL3083677T3 PL 3083677 T3 PL3083677 T3 PL 3083677T3 PL 14821860 T PL14821860 T PL 14821860T PL 14821860 T PL14821860 T PL 14821860T PL 3083677 T3 PL3083677 T3 PL 3083677T3
- Authority
- PL
- Poland
- Prior art keywords
- interest
- methods
- product
- eukaryotic cells
- recombinantly expressing
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P21/00—Preparation of peptides or proteins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4702—Regulators; Modulating activity
- C07K14/4703—Inhibitors; Suppressors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6888—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for detection or identification of organisms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
- C12N15/90—Stable introduction of foreign DNA into chromosome
- C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
- C12N15/907—Stable introduction of foreign DNA into chromosome using homologous recombination in mammalian cells
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2510/00—Genetically modified cells
- C12N2510/02—Cells for production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2511/00—Cells for large scale production
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Molecular Biology (AREA)
- General Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Gastroenterology & Hepatology (AREA)
- Medicinal Chemistry (AREA)
- Toxicology (AREA)
- Analytical Chemistry (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Mycology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361919340P | 2013-12-20 | 2013-12-20 | |
EP14821860.5A EP3083677B1 (en) | 2013-12-20 | 2014-12-18 | Novel eukaryotic cells and methods for recombinantly expressing a product of interest |
PCT/IB2014/067076 WO2015092737A1 (en) | 2013-12-20 | 2014-12-18 | Novel eukaryotic cells and methods for recombinantly expressing a product of interest |
Publications (1)
Publication Number | Publication Date |
---|---|
PL3083677T3 true PL3083677T3 (pl) | 2020-03-31 |
Family
ID=52278688
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PL14821860T PL3083677T3 (pl) | 2013-12-20 | 2014-12-18 | Nowe komórki eukariotyczne i sposoby rekombinowanej ekspresji produktu będącego przedmiotem zainteresowania |
Country Status (18)
Country | Link |
---|---|
US (2) | US11242551B2 (pl) |
EP (2) | EP3083677B1 (pl) |
JP (1) | JP6709156B2 (pl) |
KR (1) | KR102288232B1 (pl) |
CN (1) | CN106029691A (pl) |
AU (1) | AU2014369177B2 (pl) |
BR (1) | BR112016013420A2 (pl) |
CA (1) | CA2934412C (pl) |
DK (1) | DK3083677T3 (pl) |
ES (1) | ES2758505T3 (pl) |
IL (1) | IL245856B (pl) |
LT (1) | LT3083677T (pl) |
MX (1) | MX2016008258A (pl) |
PL (1) | PL3083677T3 (pl) |
PT (1) | PT3083677T (pl) |
RU (1) | RU2712507C2 (pl) |
SG (1) | SG11201604218RA (pl) |
WO (1) | WO2015092737A1 (pl) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR102288857B1 (ko) | 2013-12-20 | 2021-08-11 | 노파르티스 아게 | 신규한 진핵 세포 및 관심 생성물의 재조합 발현 방법 |
EP3015475A1 (en) | 2014-10-31 | 2016-05-04 | Novartis AG | Mammalian cells expressing cytomegalovirus antigens |
EP3048114A1 (en) | 2015-01-22 | 2016-07-27 | Novartis AG | Cytomegalovirus antigens and uses thereof |
CN108018302A (zh) * | 2016-10-31 | 2018-05-11 | 三生国健药业(上海)股份有限公司 | 一种高表达外源蛋白稳定细胞株的筛选方法 |
UY37758A (es) | 2017-06-12 | 2019-01-31 | Novartis Ag | Método de fabricación de anticuerpos biespecíficos, anticuerpos biespecíficos y uso terapéutico de dichos anticuerpos |
CN107723276B (zh) * | 2017-11-02 | 2021-08-13 | 上海交通大学 | 一种稳定高表达目标产物的细胞株的构建方法和试剂盒 |
EP3717640A1 (en) | 2017-11-28 | 2020-10-07 | Danmarks Tekniske Universitet | Glycosylation of proteins |
UY38299A (es) | 2018-07-18 | 2020-02-28 | Novartis Ag | Apirasas solubilizadas, métodos y usos |
WO2023083859A1 (en) | 2021-11-09 | 2023-05-19 | Danmarks Tekniske Universitet | Variants of alpha-1-antitrypsin |
Family Cites Families (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP2585532B2 (ja) | 1986-05-10 | 1997-02-26 | 三井東圧化学株式会社 | 動物細胞の形質転換体及びそれを得る方法並びにその形質転換体を用いてt−PAを生産する方法 |
DE69128037T2 (de) | 1990-11-13 | 1998-05-07 | Immunex Corp | Bifunktionelle wählbare fusionsgene |
ATE199023T1 (de) | 1991-03-29 | 2001-02-15 | Genentech Inc | Methoden zur selektion von rekombinanten wirtszellen welche hohe mengen von einem gewünschten protein exprimieren |
AU6953394A (en) | 1993-05-21 | 1994-12-20 | Targeted Genetics Corporation | Bifunctional selectable fusion genes based on the cytosine deaminase (cd) gene |
JP4031154B2 (ja) | 1999-07-30 | 2008-01-09 | 独立行政法人科学技術振興機構 | 遺伝子増幅細胞の迅速選択法 |
JP2004538002A (ja) | 2001-08-02 | 2004-12-24 | アルタナ ファルマ アクチエンゲゼルシャフト | 停止コドン抑制による組み換え遺伝子発現の新規方法 |
WO2003099996A2 (en) | 2002-05-22 | 2003-12-04 | Biogen Idec Ma Inc. | Detection of secreted polypeptides |
AU2003294217A1 (en) * | 2002-08-29 | 2004-05-04 | Five Prime Therapeutics, Inc. | Human polypeptides encoded by polynucleotides and methods of their use |
BRPI0408246A (pt) | 2003-03-11 | 2006-03-01 | Applied Research Systems | vetores de expressão que compreendem o promotor ie2 do mcmv |
GB0324044D0 (en) * | 2003-10-14 | 2003-11-19 | Astrazeneca Ab | Protein |
EP1716233B1 (en) | 2004-01-30 | 2009-08-26 | Maxygen Holdings Ltd. | Regulated stop codon readthrough |
US20050272061A1 (en) | 2004-02-19 | 2005-12-08 | Seattle Genetics, Inc. | Expression profiling in non-small cell lung cancer |
IL165484A0 (en) | 2004-11-30 | 2006-01-15 | Applied Research Systems | Production of proteins |
JP4870208B2 (ja) | 2006-05-17 | 2012-02-08 | エフ.ホフマン−ラ ロシュ アーゲー | ポリペプチド産生細胞 |
EP2078075B1 (en) * | 2006-10-30 | 2015-09-02 | Eli Lilly and Company | Random homozygous gene perturbation to enhance antibody production |
WO2008064095A1 (en) | 2006-11-17 | 2008-05-29 | 3M Innovative Properties Company | Ribbon curling device |
EP2115145A1 (en) | 2007-02-15 | 2009-11-11 | DSM IP Assets B.V. | A recombinant host cell for the production of a compound of interest |
BRPI0811843A2 (pt) | 2007-05-22 | 2014-10-07 | Basf Plant Science Gmbh | Métodos para a produção de uma planta transgênica, e para seleção de antagonistas, molécula, iniciador, mutante dominante negativo de um polipeptídeo, construto de ácido nucleico, vetor, célula de planta transgênica, planta ou uma parte da mesma, polipeptídeo isolado, anticorpo, tecido de planta, planta, material de planta colhido ou material de propagação de uma planta, processos para a produção de um polipeptídeo, e para a identificação de um composto, composição, e, uso da molécula de ácido nucleico, do construto de ácido nucleico e do vetor |
US8697397B2 (en) | 2007-08-07 | 2014-04-15 | Chugai Seiyaku Kabushiki Kaisha | Method of producing heterogeneous protein |
AU2008340017B2 (en) | 2007-12-21 | 2012-04-05 | Novartis Ag | Organic compounds |
JP5788796B2 (ja) | 2008-08-28 | 2015-10-07 | ノバルティス アーゲー | 終止コドンのリードスルーによるポリペプチドアイソフォームの細胞表面提示 |
JP5801207B2 (ja) | 2009-02-27 | 2015-10-28 | ノバルティス アーゲー | 2種類の選択マーカーを含む発現ベクター系 |
EP2430159A1 (en) | 2009-05-15 | 2012-03-21 | Boehringer Ingelheim International GmbH | Improved cell lines having reduced expression of nocr and use thereof |
KR102288857B1 (ko) | 2013-12-20 | 2021-08-11 | 노파르티스 아게 | 신규한 진핵 세포 및 관심 생성물의 재조합 발현 방법 |
-
2014
- 2014-12-18 ES ES14821860T patent/ES2758505T3/es active Active
- 2014-12-18 DK DK14821860T patent/DK3083677T3/da active
- 2014-12-18 JP JP2016541010A patent/JP6709156B2/ja active Active
- 2014-12-18 PT PT148218605T patent/PT3083677T/pt unknown
- 2014-12-18 MX MX2016008258A patent/MX2016008258A/es active IP Right Grant
- 2014-12-18 EP EP14821860.5A patent/EP3083677B1/en active Active
- 2014-12-18 SG SG11201604218RA patent/SG11201604218RA/en unknown
- 2014-12-18 RU RU2016129278A patent/RU2712507C2/ru active
- 2014-12-18 LT LT14821860T patent/LT3083677T/lt unknown
- 2014-12-18 EP EP19193493.4A patent/EP3604332A1/en active Pending
- 2014-12-18 US US15/104,601 patent/US11242551B2/en active Active
- 2014-12-18 BR BR112016013420A patent/BR112016013420A2/pt not_active Application Discontinuation
- 2014-12-18 CN CN201480076016.9A patent/CN106029691A/zh active Pending
- 2014-12-18 WO PCT/IB2014/067076 patent/WO2015092737A1/en active Application Filing
- 2014-12-18 AU AU2014369177A patent/AU2014369177B2/en active Active
- 2014-12-18 KR KR1020167019213A patent/KR102288232B1/ko active IP Right Grant
- 2014-12-18 PL PL14821860T patent/PL3083677T3/pl unknown
- 2014-12-18 CA CA2934412A patent/CA2934412C/en active Active
-
2016
- 2016-05-25 IL IL245856A patent/IL245856B/en active IP Right Grant
-
2021
- 2021-12-21 US US17/558,181 patent/US20220325310A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
EP3083677A1 (en) | 2016-10-26 |
DK3083677T3 (da) | 2019-11-25 |
BR112016013420A2 (pt) | 2017-09-26 |
RU2712507C2 (ru) | 2020-01-29 |
KR20160099675A (ko) | 2016-08-22 |
US11242551B2 (en) | 2022-02-08 |
CN106029691A (zh) | 2016-10-12 |
US20220325310A1 (en) | 2022-10-13 |
IL245856B (en) | 2021-06-30 |
MX2016008258A (es) | 2016-09-29 |
JP6709156B2 (ja) | 2020-06-10 |
ES2758505T3 (es) | 2020-05-05 |
KR102288232B1 (ko) | 2021-08-10 |
CA2934412C (en) | 2024-02-20 |
US20170058307A1 (en) | 2017-03-02 |
CA2934412A1 (en) | 2015-06-25 |
LT3083677T (lt) | 2019-12-10 |
AU2014369177A1 (en) | 2016-06-16 |
PT3083677T (pt) | 2019-12-02 |
WO2015092737A1 (en) | 2015-06-25 |
EP3604332A1 (en) | 2020-02-05 |
EP3083677B1 (en) | 2019-08-28 |
RU2016129278A (ru) | 2018-01-25 |
AU2014369177B2 (en) | 2017-04-20 |
IL245856A0 (en) | 2016-07-31 |
SG11201604218RA (en) | 2016-07-28 |
JP2016540518A (ja) | 2016-12-28 |
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