DK3757214T3 - Sammensætninger til modulering af sod-1-ekspression - Google Patents

Sammensætninger til modulering af sod-1-ekspression Download PDF

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Publication number
DK3757214T3
DK3757214T3 DK20176637.5T DK20176637T DK3757214T3 DK 3757214 T3 DK3757214 T3 DK 3757214T3 DK 20176637 T DK20176637 T DK 20176637T DK 3757214 T3 DK3757214 T3 DK 3757214T3
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moduling
sod
expression
compositions
moduling sod
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DK20176637.5T
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English (en)
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Eric E Swayze
Tracy Cole
Holly Kordasiewicz
Susan M Freier
Thomas P Condon
Edward Wancewicz
Trisha Lockhart
Timothy Vickers
Priyam Singh
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Biogen Ma Inc
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/711—Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N2310/11—Antisense
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/31—Chemical structure of the backbone
    • C12N2310/315—Phosphorothioates
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/321—2'-O-R Modification
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    • C12N2310/32—Chemical structure of the sugar
    • C12N2310/323—Chemical structure of the sugar modified ring structure
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/341—Gapmers, i.e. of the type ===---===
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
    • C—CHEMISTRY; METALLURGY
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    • C12Y115/00—Oxidoreductases acting on superoxide as acceptor (1.15)
    • C12Y115/01—Oxidoreductases acting on superoxide as acceptor (1.15) with NAD or NADP as acceptor (1.15.1)
    • C12Y115/01001—Superoxide dismutase (1.15.1.1)
DK20176637.5T 2014-04-01 2015-04-01 Sammensætninger til modulering af sod-1-ekspression DK3757214T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461973803P 2014-04-01 2014-04-01
EP15773965.7A EP3126499B1 (en) 2014-04-01 2015-04-01 Compositions for modulating sod-1 expression

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DK3757214T3 true DK3757214T3 (da) 2022-07-04

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DK15773965.7T DK3126499T3 (da) 2014-04-01 2015-04-01 Sammensætninger til modulering af sod-1-ekspression

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US (3) US10385341B2 (da)
EP (3) EP3126499B1 (da)
JP (4) JP6622214B2 (da)
KR (4) KR20210097225A (da)
CN (2) CN111440798A (da)
AU (3) AU2015240761B2 (da)
BR (1) BR112016021848B1 (da)
CA (1) CA2942394A1 (da)
CL (3) CL2016002509A1 (da)
CY (1) CY1123288T1 (da)
DK (2) DK3757214T3 (da)
ES (2) ES2818236T3 (da)
HR (2) HRP20220798T1 (da)
HU (2) HUE050704T2 (da)
IL (2) IL247714B (da)
LT (2) LT3126499T (da)
MX (2) MX2016012922A (da)
MY (2) MY175665A (da)
NZ (1) NZ724100A (da)
PL (2) PL3126499T3 (da)
PT (2) PT3126499T (da)
RS (2) RS60707B1 (da)
RU (1) RU2704619C2 (da)
SG (3) SG10201906520RA (da)
SI (2) SI3126499T1 (da)
WO (1) WO2015153800A2 (da)

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