HUE048782T2 - Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával - Google Patents
Immunoglobulin tisztítása elõtisztítási lépések alkalmazásávalInfo
- Publication number
- HUE048782T2 HUE048782T2 HUE15708522A HUE15708522A HUE048782T2 HU E048782 T2 HUE048782 T2 HU E048782T2 HU E15708522 A HUE15708522 A HU E15708522A HU E15708522 A HUE15708522 A HU E15708522A HU E048782 T2 HUE048782 T2 HU E048782T2
- Authority
- HU
- Hungary
- Prior art keywords
- cleaning steps
- immunoglobulin purification
- immunoglobulin
- purification
- cleaning
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title 1
- 238000004140 cleaning Methods 0.000 title 1
- 102000018358 immunoglobulin Human genes 0.000 title 1
- 238000000746 purification Methods 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
- C07K16/065—Purification, fragmentation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J39/00—Cation exchange; Use of material as cation exchangers; Treatment of material for improving the cation exchange properties
- B01J39/26—Cation exchangers for chromatographic processes
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
- B01J41/00—Anion exchange; Use of material as anion exchangers; Treatment of material for improving the anion exchange properties
- B01J41/20—Anion exchangers for chromatographic processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/241—Tumor Necrosis Factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2887—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against CD20
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| HU1400131A HUP1400131A1 (hu) | 2014-03-10 | 2014-03-10 | Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával |
| HU1500053A HUP1500053A1 (hu) | 2015-02-09 | 2015-02-09 | Immunglobulin tisztítása elõtisztítási lépések alkalmazásával |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE048782T2 true HUE048782T2 (hu) | 2020-08-28 |
Family
ID=89991731
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE15708522A HUE048782T2 (hu) | 2014-03-10 | 2015-03-09 | Immunoglobulin tisztítása elõtisztítási lépések alkalmazásával |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US10487138B2 (hu) |
| EP (2) | EP3674310A1 (hu) |
| JP (1) | JP6293907B2 (hu) |
| KR (1) | KR101921552B1 (hu) |
| CN (1) | CN106103465B (hu) |
| CA (1) | CA2930350C (hu) |
| DK (1) | DK3116891T3 (hu) |
| ES (1) | ES2784749T3 (hu) |
| HR (1) | HRP20200711T1 (hu) |
| HU (1) | HUE048782T2 (hu) |
| LT (1) | LT3116891T (hu) |
| PL (1) | PL3116891T3 (hu) |
| PT (1) | PT3116891T (hu) |
| SI (1) | SI3116891T1 (hu) |
| WO (1) | WO2015135884A1 (hu) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106103465B (zh) | 2014-03-10 | 2021-01-08 | 吉瑞工厂 | 使用预清洗步骤的免疫球蛋白纯化 |
| GB2539420B (en) * | 2015-06-16 | 2021-01-13 | Cytiva Sweden Ab | Determination of chromatography conditions |
| JP6851109B2 (ja) * | 2016-06-16 | 2021-03-31 | Jsr株式会社 | 抗体を精製する方法及び担体を洗浄する方法 |
| CN109563124A (zh) * | 2016-06-17 | 2019-04-02 | 豪夫迈·罗氏有限公司 | 多特异性抗体的纯化 |
| EP3512884A4 (en) * | 2016-09-14 | 2020-09-16 | Kinbio Ltd. | METHODS FOR CLEANING UP AND QUALIFYING ANTIBODIES |
| MX2019011343A (es) * | 2017-03-24 | 2019-11-18 | Council Scient Ind Res | Un procedimiento para la purificacion de fragmentos de anticuerpos recombinantes. |
| US11697670B2 (en) | 2017-08-22 | 2023-07-11 | Biogen Ma Inc. | Methods for purifying antibodies having reduced high molecular weight aggregates |
| KR20190047376A (ko) * | 2017-10-27 | 2019-05-08 | 주식회사 녹십자 | 개선된 면역글로불린의 정제방법 |
| WO2019173731A1 (en) * | 2018-03-08 | 2019-09-12 | Bio-Rad Laboratories, Inc. | Anionic exchange-hydrophobic mixed mode chromatography resin |
| CN111902720A (zh) | 2018-03-21 | 2020-11-06 | 沃特世科技公司 | 基于非抗体高亲和力的样品制备、吸附剂、装置和方法 |
| GB201805142D0 (en) * | 2018-03-29 | 2018-05-16 | Ge Healthcare Bioprocess R&D Ab | Separation method |
| EP3823594A1 (en) * | 2018-07-19 | 2021-05-26 | Ichnos Sciences S.A. | Liquid antibody formulation |
| KR102209790B1 (ko) * | 2018-12-20 | 2021-02-01 | 에이치케이이노엔 주식회사 | 친화성 크로마토그래피를 이용한 백신용 바이러스 정제방법 |
| EP3903102B1 (en) * | 2018-12-30 | 2023-04-12 | F. Hoffmann-La Roche AG | Ph-gradient spr-based binding assay |
| WO2020190216A1 (en) * | 2019-03-21 | 2020-09-24 | Agency For Science, Technology And Research | A method of capturing and/or purifying a target |
| HUP1900112A1 (hu) | 2019-04-04 | 2020-10-28 | Richter Gedeon Nyrt | Immunglobulinok affinitás kromatográfiájának fejlesztése kötést megelõzõ flokkulálás alkalmazásával |
| US20220259291A1 (en) * | 2019-06-10 | 2022-08-18 | Takeda Pharmaceutical Company Limited | Antibody purification methods and compositions thereof |
| US11896969B2 (en) | 2019-09-05 | 2024-02-13 | Bio-Rad Laboratories, Inc. | Anionic exchange-hydrophobic mixed mode chromatography resins |
| WO2022071990A1 (en) * | 2020-04-10 | 2022-04-07 | Plasma Technologies, Llc | Compositions and methods for simplified high efficiency isolation of proteins |
| CN113563469A (zh) * | 2020-04-28 | 2021-10-29 | 江苏中新医药有限公司 | 高回收率纯化阿达木单抗的方法 |
| US20230166200A1 (en) * | 2020-05-01 | 2023-06-01 | Kashiv Biosciences, Llc | An improved process of purification of protein |
| WO2023057995A1 (en) * | 2021-10-08 | 2023-04-13 | Kashiv Biosciences, Llc | Separation of pre-peak and post-peak in fusion protein sample by using size exclusion high performance liquid chromatography |
| CA3234491A1 (en) * | 2021-10-08 | 2023-04-13 | Kashiv Biosciences, Llc | Separation of pre-peak in fusion protein sample by using size exclusion high performance liquid chromatography |
| CN114133446A (zh) * | 2021-12-31 | 2022-03-04 | 方坦思(上海)生物医药有限公司 | 单克隆抗体的纯化方法 |
| CN115304673A (zh) * | 2022-06-24 | 2022-11-08 | 上海赛伦生物技术股份有限公司 | 一种马抗破伤风特异性免疫球蛋白F(ab’)2的纯化方法及其应用 |
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| KR930007430B1 (ko) | 1987-07-16 | 1993-08-10 | 쉐링 코포레이션 | 크로마토그래피 단계에 의한 과립구-대식세포 콜로니-자극 인자의 정제방법 |
| CA1341235C (en) | 1987-07-24 | 2001-05-22 | Randy R. Robinson | Modular assembly of antibody genes, antibodies prepared thereby and use |
| US4983722A (en) | 1988-06-08 | 1991-01-08 | Miles Inc. | Removal of protein A from antibody preparations |
| AU8001291A (en) | 1990-05-31 | 1991-12-31 | United States of America, as represented by the Secretary, U.S. Department of Commerce, The | Method for purifying hiv reverse transcriptase |
| DK0610201T4 (da) | 1991-03-18 | 2008-02-04 | Centocor Inc | Monoklonale og kimære antistoffer, der er specifikke for human tumornekrosefaktor |
| ES2206447T3 (es) | 1991-06-14 | 2004-05-16 | Genentech, Inc. | Anticuerpo humanizado para heregulina. |
| CA2149329C (en) | 1992-11-13 | 2008-07-15 | Darrell R. Anderson | Therapeutic application of chimeric and radiolabeled antibodies to human b lymphocyte restricted differentiation antigen for treatment of b cell lymphoma |
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| RU2270030C2 (ru) | 1996-02-09 | 2006-02-20 | Абботт Байотекнолоджи эЛтиди. | СПОСОБ ИНГИБИРОВАНИЯ АКТИВНОСТИ ЧЕЛОВЕЧЕСКОГО TNFα (ВАРИАНТЫ), ПРИМЕНЕНИЕ ВЫДЕЛЕННОГО АНТИТЕЛА ЧЕЛОВЕКА ИЛИ ЕГО АНТИГЕНСВЯЗЫВАЮЩЕГО ФРАГМЕНТА В КАЧЕСТВЕ КОМПОНЕНТА ДЛЯ ПРОИЗВОДСТВА ЛЕКАРСТВЕННОГО СРЕДСТВА (ВАРИАНТЫ) И ВЫДЕЛЕННОЕ ЧЕЛОВЕЧЕСКОЕ АНТИТЕЛО ИЛИ ЕГО АНТИГЕНСВЯЗЫВАЮЩИЙ ФРАГМЕНТ |
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| EP2519537A4 (en) | 2009-12-29 | 2013-07-10 | Reddys Lab Ltd Dr | CLEANING PROTEINS |
| ES2637613T5 (es) | 2010-05-25 | 2022-07-20 | Hoffmann La Roche | Procedimientos de purificación de polipéptidos |
| KR20130142128A (ko) * | 2010-10-11 | 2013-12-27 | 애브비 인코포레이티드 | 단백질의 정제 방법 |
| LT2731677T (lt) * | 2011-07-11 | 2018-07-10 | Glenmark Pharmaceuticals S.A. | Antikūnai, kurie prisiriša prie ox40, ir jų panaudojimas |
| US20140288278A1 (en) | 2011-10-31 | 2014-09-25 | Joseph Nti-Gyabaah | Chromatography process for resolving heterogeneous antibody aggregates |
| JP6356607B2 (ja) | 2011-11-02 | 2018-07-11 | ジェネンテック， インコーポレイテッド | オーバーロード／溶出クロマトグラフィー |
| JP6297029B2 (ja) * | 2012-05-31 | 2018-03-20 | エイジェンシー・フォー・サイエンス，テクノロジー・アンド・リサーチ | 多様な官能基を有する粒子による免疫グロブリンｇ調製物のクロマトグラフィー精製 |
| CN106103465B (zh) | 2014-03-10 | 2021-01-08 | 吉瑞工厂 | 使用预清洗步骤的免疫球蛋白纯化 |
-
2015
- 2015-03-09 CN CN201580012972.5A patent/CN106103465B/zh active Active
- 2015-03-09 US US15/120,359 patent/US10487138B2/en active Active
- 2015-03-09 PL PL15708522T patent/PL3116891T3/pl unknown
- 2015-03-09 WO PCT/EP2015/054862 patent/WO2015135884A1/en active Application Filing
- 2015-03-09 PT PT157085226T patent/PT3116891T/pt unknown
- 2015-03-09 JP JP2016544089A patent/JP6293907B2/ja active Active
- 2015-03-09 DK DK15708522.6T patent/DK3116891T3/da active
- 2015-03-09 EP EP20155836.8A patent/EP3674310A1/en active Pending
- 2015-03-09 CA CA2930350A patent/CA2930350C/en active Active
- 2015-03-09 SI SI201531188T patent/SI3116891T1/sl unknown
- 2015-03-09 ES ES15708522T patent/ES2784749T3/es active Active
- 2015-03-09 HU HUE15708522A patent/HUE048782T2/hu unknown
- 2015-03-09 EP EP15708522.6A patent/EP3116891B1/en active Active
- 2015-03-09 KR KR1020167022454A patent/KR101921552B1/ko active IP Right Grant
- 2015-03-09 LT LTEP15708522.6T patent/LT3116891T/lt unknown
-
2020
- 2020-05-04 HR HRP20200711TT patent/HRP20200711T1/hr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2930350A1 (en) | 2015-09-17 |
| JP6293907B2 (ja) | 2018-03-14 |
| US10487138B2 (en) | 2019-11-26 |
| US20170058019A1 (en) | 2017-03-02 |
| PL3116891T3 (pl) | 2020-07-27 |
| JP2017507907A (ja) | 2017-03-23 |
| EP3674310A1 (en) | 2020-07-01 |
| WO2015135884A1 (en) | 2015-09-17 |
| CN106103465A (zh) | 2016-11-09 |
| CA2930350C (en) | 2021-04-06 |
| CN106103465B (zh) | 2021-01-08 |
| EP3116891B1 (en) | 2020-02-12 |
| KR20160124107A (ko) | 2016-10-26 |
| HRP20200711T1 (hr) | 2020-07-24 |
| KR101921552B1 (ko) | 2018-11-23 |
| SI3116891T1 (sl) | 2020-07-31 |
| LT3116891T (lt) | 2020-03-25 |
| DK3116891T3 (da) | 2020-05-04 |
| ES2784749T3 (es) | 2020-09-30 |
| PT3116891T (pt) | 2020-05-18 |
| EP3116891A1 (en) | 2017-01-18 |
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