MX2010003685A - Analogos de quinolona y metodos relacionados con los mismos. - Google Patents

Analogos de quinolona y metodos relacionados con los mismos.

Info

Publication number
MX2010003685A
MX2010003685A MX2010003685A MX2010003685A MX2010003685A MX 2010003685 A MX2010003685 A MX 2010003685A MX 2010003685 A MX2010003685 A MX 2010003685A MX 2010003685 A MX2010003685 A MX 2010003685A MX 2010003685 A MX2010003685 A MX 2010003685A
Authority
MX
Mexico
Prior art keywords
methods related
quinolone analogs
methods
present
compounds
Prior art date
Application number
MX2010003685A
Other languages
English (en)
Inventor
Jeffrey P Whitten
Fabrice Pierre
Mustapha Haddach
Johnny Yasuo Nagasawa
Michael Schwaebe
Levan Darjania
Original Assignee
Cylene Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cylene Pharmaceuticals Inc filed Critical Cylene Pharmaceuticals Inc
Publication of MX2010003685A publication Critical patent/MX2010003685A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/16—Peri-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Virology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Epidemiology (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

La presente invención se proporciona compuestos de quinolina novedosos y composición farmacéutica de los mismos que pueden inhibir la proliferación celular y/o inducir la apoptosis celular. La presente invención también proporciona métodos para preparar tales compuestos y composiciones, y métodos para hacerlos y usarlos.
MX2010003685A 2007-10-05 2008-10-03 Analogos de quinolona y metodos relacionados con los mismos. MX2010003685A (es)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US97804207P 2007-10-05 2007-10-05
US3868108P 2008-03-21 2008-03-21
US4593308P 2008-04-17 2008-04-17
PCT/US2008/078859 WO2009046383A1 (en) 2007-10-05 2008-10-03 Quinolone analogs and methods related thereto

Publications (1)

Publication Number Publication Date
MX2010003685A true MX2010003685A (es) 2010-06-02

Family

ID=40523786

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010003685A MX2010003685A (es) 2007-10-05 2008-10-03 Analogos de quinolona y metodos relacionados con los mismos.

Country Status (19)

Country Link
US (2) US7928100B2 (es)
EP (2) EP3092901B1 (es)
JP (2) JP5824213B2 (es)
KR (2) KR101682867B1 (es)
CN (1) CN101888780B (es)
AU (1) AU2008308485B2 (es)
BR (1) BRPI0817806A2 (es)
CA (1) CA2701630C (es)
DK (1) DK3092901T3 (es)
ES (2) ES2582662T3 (es)
HK (1) HK1150728A1 (es)
IL (2) IL204844A (es)
MX (1) MX2010003685A (es)
NO (1) NO20100596L (es)
NZ (1) NZ584892A (es)
PL (2) PL2214491T3 (es)
PT (2) PT3092901T (es)
RU (1) RU2549895C2 (es)
WO (1) WO2009046383A1 (es)

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WO2008131134A1 (en) * 2007-04-17 2008-10-30 Cylene Pharmaceuticals, Inc. Hydrazide compounds and uses thereof
PT3092901T (pt) * 2007-10-05 2020-05-21 Senhwa Biosciences Inc Análogos de quinolona e respetivos métodos relacionados
DK2470546T3 (da) 2009-08-28 2013-10-14 Takeda Pharmaceutical HEXAHYDROOXAZINOPTERIDIN- forbindelser til anvendelse som mTOR INHIBITORER
EP2480531B1 (en) 2009-09-21 2014-11-05 ChemoCentryx, Inc. Pyrrolidinone carboxamide derivatives as chemerin-r (chemr23) modulators
EP2678342B1 (en) 2011-02-25 2015-01-07 Takeda Pharmaceutical Company Limited N-substituted oxazinopteridines and oxazinopteridinones
US20140086839A1 (en) 2011-03-17 2014-03-27 Tel Hashomer Medical Research Infrastructure And Services Ltd. Quinolone analogs for treating autoimmune diseases
GB201206384D0 (en) * 2012-04-11 2012-05-23 Redx Pharma Ltd Antibacterial drug derivatives
CN104177379B (zh) * 2013-05-22 2016-12-28 中国科学院上海药物研究所 一种喹诺酮类化合物或其立体化学异构体、包含该化合物的药物组合物及其用途
ES2754207T3 (es) 2013-11-28 2020-04-16 Tel Hashomer Medical Res Infrastructure & Services Ltd Inhibidores de la ARN polimerasa I y usos de los mismos
EA034235B1 (ru) * 2014-05-09 2020-01-20 Паймера, Инк. Новые композиции, их использование и способы получения
US9758518B2 (en) 2015-03-04 2017-09-12 Pimera, Inc. Compositions, uses and methods for making them
KR20180113976A (ko) * 2015-11-20 2018-10-17 센화 바이오사이언시즈 인코포레이티드 암을 치료하기 위한 테트라사이클릭 퀴놀론 유사체의 병행 요법
CA3006502A1 (en) * 2015-12-14 2017-06-22 Senhwa Biosciences, Inc. Crystalline forms of quinolone analogs and their salts
TWI765848B (zh) * 2015-12-14 2022-06-01 生華生物科技股份有限公司 喹諾酮類似物及其鹽的結晶形式
US9957282B2 (en) * 2015-12-14 2018-05-01 Senhwa Biosciences, Inc. Crystalline forms of quinolone analogs and their salts
JP2020512975A (ja) 2017-03-28 2020-04-30 ピメラ，インク． Ｐｏｌ１阻害剤の新規な結晶形態
US11071727B2 (en) 2018-01-26 2021-07-27 Northwestern University Therapeutic targeting of proteolytic cleavage of the mixed lineage leukemia gene product (MLL1) by taspase1 using kinase inhibitors
US20190374550A1 (en) * 2018-02-15 2019-12-12 Senhwa Biosciences, Inc. Quinolone analogs and their salts, compositions, and method for their use
WO2020051342A1 (en) * 2018-09-06 2020-03-12 Cornell University Methods for treating metastatic disease using ribosome biogenesis inhibitor cx 5461
CN114599368A (zh) * 2019-08-14 2022-06-07 生华生物科技股份有限公司 四环化合物及其盐、组合物以及其使用方法
AU2020328593A1 (en) * 2019-08-14 2022-03-10 Senhwa Biosciences, Inc. Crystalline forms of quinoline analogs and salts thereof, compositions, and their methods for use
JP2020189888A (ja) * 2020-08-28 2020-11-26 センワ バイオサイエンシズ インコーポレイテッド キノロン類似体及びその塩の結晶形
CN114573604B (zh) * 2020-12-01 2024-06-18 中国科学院上海药物研究所 一类基于喹诺酮的化合物、其制备方法、包含其的药物组合物及其用途
MX2023011004A (es) 2021-03-19 2024-01-08 Trained Therapeutix Discovery Inc Compuestos para regular la inmunidad entrenada y métodos para usarlos.
CN114409681A (zh) * 2022-03-18 2022-04-29 信义核新(北京)生物科技有限公司 用于治疗dna损伤修复缺陷肿瘤的喹诺酮类似物及其应用

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Also Published As

Publication number Publication date
EP3092901B1 (en) 2020-04-29
JP5824213B2 (ja) 2015-11-25
KR101601332B1 (ko) 2016-03-08
EP2214491A4 (en) 2010-11-10
AU2008308485A1 (en) 2009-04-09
CN101888780A (zh) 2010-11-17
WO2009046383A1 (en) 2009-04-09
RU2549895C2 (ru) 2015-05-10
ES2582662T3 (es) 2016-09-14
KR101682867B1 (ko) 2016-12-05
AU2008308485B2 (en) 2014-08-07
US20090093455A1 (en) 2009-04-09
PL3092901T3 (pl) 2020-10-19
NZ584892A (en) 2012-06-29
HK1150728A1 (en) 2012-01-13
KR20160020578A (ko) 2016-02-23
BRPI0817806A2 (pt) 2014-10-07
US8853234B2 (en) 2014-10-07
CA2701630C (en) 2016-10-25
NO20100596L (no) 2010-06-10
RU2010117225A (ru) 2011-11-10
KR20100064392A (ko) 2010-06-14
IL249906B (en) 2020-10-29
IL204844A0 (en) 2010-11-30
IL204844A (en) 2017-01-31
US20110218184A1 (en) 2011-09-08
CN101888780B (zh) 2014-08-13
EP3092901A1 (en) 2016-11-16
PT3092901T (pt) 2020-05-21
US7928100B2 (en) 2011-04-19
JP2014159474A (ja) 2014-09-04
PT2214491T (pt) 2016-10-25
JP2010540663A (ja) 2010-12-24
EP2214491A1 (en) 2010-08-11
EP2214491B1 (en) 2016-07-13
DK3092901T3 (da) 2020-05-18
ES2791305T3 (es) 2020-11-03
IL249906A0 (en) 2017-03-30
CA2701630A1 (en) 2009-04-09
PL2214491T3 (pl) 2016-11-30

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