HRP20190030T1 - Postupak pročišćavanja protutijela - Google Patents

Postupak pročišćavanja protutijela

Info

Publication number
HRP20190030T1
HRP20190030T1 HRP20190030TT HRP20190030T HRP20190030T1 HR P20190030 T1 HRP20190030 T1 HR P20190030T1 HR P20190030T T HRP20190030T T HR P20190030TT HR P20190030 T HRP20190030 T HR P20190030T HR P20190030 T1 HRP20190030 T1 HR P20190030T1
Authority
HR
Croatia
Prior art keywords
purifying
antibody
Prior art date
Application number
HRP20190030TT
Other languages
English (en)
Inventor
Bastiaan Pieter Arian KOKKE
Everdina Josephina Wilhelmina VAN WIJK-BASTEN
Thomas Antonius Bernardus DE BEIJER
Michel Hendrikus Maria Eppink
Maria Marzá Pérez
Original Assignee
Synthon Biopharmaceuticals B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Synthon Biopharmaceuticals B.V. filed Critical Synthon Biopharmaceuticals B.V.
Publication of HRP20190030T1 publication Critical patent/HRP20190030T1/hr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/06—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies from serum
    • C07K16/065—Purification, fragmentation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/16—Extraction; Separation; Purification by chromatography
    • C07K1/18—Ion-exchange chromatography
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14—Specific host cells or culture conditions, e.g. components, pH or temperature

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Water Supply & Treatment (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
HRP20190030TT 2012-06-21 2019-01-04 Postupak pročišćavanja protutijela HRP20190030T1 (hr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
PCT/EP2012/062014 WO2013189544A1 (en) 2012-06-21 2012-06-21 Method of purifying an antibody
EP12728608.6A EP2864346B1 (en) 2012-06-21 2012-06-21 Method of purifying an antibody

Publications (1)

Publication Number Publication Date
HRP20190030T1 true HRP20190030T1 (hr) 2019-02-22

Family

ID=46321045

Family Applications (1)

Application Number Title Priority Date Filing Date
HRP20190030TT HRP20190030T1 (hr) 2012-06-21 2019-01-04 Postupak pročišćavanja protutijela

Country Status (14)

Country Link
US (1) US9845338B2 (hr)
EP (1) EP2864346B1 (hr)
KR (1) KR101941742B1 (hr)
CN (1) CN104487448B (hr)
CY (1) CY1121394T1 (hr)
DK (1) DK2864346T3 (hr)
ES (1) ES2704487T3 (hr)
HR (1) HRP20190030T1 (hr)
HU (1) HUE043121T2 (hr)
LT (1) LT2864346T (hr)
PL (1) PL2864346T3 (hr)
PT (1) PT2864346T (hr)
SG (1) SG11201408502XA (hr)
WO (1) WO2013189544A1 (hr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7032046B2 (ja) * 2016-01-22 2022-03-08 旭化成メディカル株式会社 生理活性物質の連続的な定流速精製方法
US11149060B2 (en) 2016-02-19 2021-10-19 University Of Delaware Functionalized nanoparticles for enhanced affinity precipitation of proteins
WO2019183334A1 (en) 2018-03-21 2019-09-26 Waters Technologies Corporation Non-antibody high-affinity-based sample preparation, sorbents, devices and methods
EP3546475A1 (en) * 2018-03-27 2019-10-02 Sanofi Full flow-through process for purifying recombinant proteins
KR102337683B1 (ko) * 2018-09-21 2021-12-13 주식회사 녹십자 고효율 항-tfpi 항체 조성물
WO2020247574A1 (en) * 2019-06-05 2020-12-10 Seattle Genetics, Inc. Methods of purifying masked antibodies
CN114539351B (zh) * 2022-01-26 2023-03-03 上海健士拜生物科技有限公司 纳米抗体的纯化方法
CN114409787A (zh) * 2022-02-18 2022-04-29 南京英瀚斯生物科技有限公司 一种针对her3纳米抗体的分离纯化方法
WO2023249892A1 (en) * 2022-06-20 2023-12-28 Amgen Inc. Clearance of aggregates from uf/df pools in downstream antibody purification

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2003062375A2 (en) * 2001-12-19 2003-07-31 Genentech, Inc. Stabilizing polypeptides which have been exposed to urea
US7553938B2 (en) * 2004-02-27 2009-06-30 Octapharma Ag Method of providing a purified, virus safe antibody preparation
EA014182B1 (ru) * 2004-07-20 2010-10-29 Симфоген А/С КОМПОЗИЦИЯ ПОЛИКЛОНАЛЬНЫХ АНТИ-RhD АНТИТЕЛ, СПОСОБ ЕЁ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЕ КОМПОЗИЦИИ
TWI392684B (zh) * 2006-04-05 2013-04-11 Abbott Biotech Ltd 抗體之純化
WO2009085765A1 (en) * 2007-12-21 2009-07-09 Genentech, Inc. Crystallization of anti-cd20 antibodies
NZ592094A (en) * 2008-10-20 2013-01-25 Abbott Lab Antibodies that bind to il-18 and methods of purifying the same
EP3461840A1 (en) * 2009-04-27 2019-04-03 Immuron Limited Anti-lps enriched immunoglobulin preparation for use in treatment and/or prophylaxis of non alcoholic steatohepatitis
CA2764545C (en) * 2009-06-15 2019-05-14 Katholieke Universiteit Leuven, K.U.Leuven R&D Bace1 inhibitory antibodies
US9345661B2 (en) * 2009-07-31 2016-05-24 Genentech, Inc. Subcutaneous anti-HER2 antibody formulations and uses thereof
WO2011015920A2 (en) * 2009-08-03 2011-02-10 Avesthagen Limited A highly efficient process of purification and production of recombinant trastuzumab
GB201012603D0 (en) * 2010-07-27 2010-09-08 Ucb Pharma Sa Protein purification
US20120238730A1 (en) * 2011-03-15 2012-09-20 Abbott Laboratories Integrated approach to the isolation and purification of antibodies

Also Published As

Publication number Publication date
HUE043121T2 (hu) 2019-08-28
US9845338B2 (en) 2017-12-19
DK2864346T3 (en) 2019-02-04
SG11201408502XA (en) 2015-01-29
EP2864346B1 (en) 2018-10-17
CN104487448B (zh) 2020-04-24
LT2864346T (lt) 2019-01-25
KR20150027807A (ko) 2015-03-12
EP2864346A1 (en) 2015-04-29
ES2704487T3 (es) 2019-03-18
CY1121394T1 (el) 2020-05-29
WO2013189544A1 (en) 2013-12-27
PT2864346T (pt) 2018-12-12
US20160002289A1 (en) 2016-01-07
PL2864346T3 (pl) 2019-04-30
CN104487448A (zh) 2015-04-01
KR101941742B1 (ko) 2019-01-23

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