JP2015535237A5 - - Google Patents

Info

Publication number

JP2015535237A5

JP2015535237A5 JP2015538612A JP2015538612A JP2015535237A5 JP 2015535237 A5 JP2015535237 A5 JP 2015535237A5 JP 2015538612 A JP2015538612 A JP 2015538612A JP 2015538612 A JP2015538612 A JP 2015538612A JP 2015535237 A5 JP2015535237 A5 JP 2015535237A5

Authority

JP

Japan

Prior art keywords

composition

phosphate

citrate buffer

pharmaceutical composition

sucrose

Prior art date

2013-10-24

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000000203 mixture Substances 0.000 claims 15
• FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 14
• 239000008194 pharmaceutical composition Substances 0.000 claims 10
• 239000007981 phosphate-citrate buffer Substances 0.000 claims 9
• 229930006000 Sucrose Natural products 0.000 claims 8
• 239000005720 sucrose Substances 0.000 claims 8
• 108010008165 Etanercept Proteins 0.000 claims 7
• CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 7
• 229960000403 etanercept Drugs 0.000 claims 7
• 239000011780 sodium chloride Substances 0.000 claims 7
• ODLHGICHYURWBS-LKONHMLTSA-N trappsol cyclo Chemical compound CC(O)COC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](COCC(C)O)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)COCC(O)C)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1COCC(C)O ODLHGICHYURWBS-LKONHMLTSA-N 0.000 claims 6
• 230000002744 anti-aggregatory effect Effects 0.000 claims 5
• 239000003381 stabilizer Substances 0.000 claims 5
• 229920000858 Cyclodextrin Polymers 0.000 claims 4
• KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 4
• 108091006020 Fc-tagged proteins Proteins 0.000 claims 4
• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 4
• 108060008683 Tumor Necrosis Factor Receptor Proteins 0.000 claims 4
• XSQUKJJJFZCRTK-UHFFFAOYSA-N Urea Chemical compound NC(N)=O XSQUKJJJFZCRTK-UHFFFAOYSA-N 0.000 claims 4
• 239000004202 carbamide Substances 0.000 claims 4
• 102000003298 tumor necrosis factor receptor Human genes 0.000 claims 4
• 239000003146 anticoagulant agent Substances 0.000 claims 3
• 239000007951 isotonicity adjuster Substances 0.000 claims 3
• WCUXLLCKKVVCTQ-UHFFFAOYSA-M Potassium chloride Chemical compound [Cl-].[K+] WCUXLLCKKVVCTQ-UHFFFAOYSA-M 0.000 claims 2
• 239000002738 chelating agent Substances 0.000 claims 2
• 239000003795 chemical substances by application Substances 0.000 claims 2
• 239000007788 liquid Substances 0.000 claims 2
• 239000012929 tonicity agent Substances 0.000 claims 2
• HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
• UXVMQQNJUSDDNG-UHFFFAOYSA-L Calcium chloride Chemical compound [Cl-].[Cl-].[Ca+2] UXVMQQNJUSDDNG-UHFFFAOYSA-L 0.000 claims 1
• FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
• WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 229930195725 Mannitol Natural products 0.000 claims 1
• HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
• HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
• 150000001413 amino acids Chemical class 0.000 claims 1
• WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
• 239000001110 calcium chloride Substances 0.000 claims 1
• 229910001628 calcium chloride Inorganic materials 0.000 claims 1
• 150000001720 carbohydrates Chemical class 0.000 claims 1
• 239000008103 glucose Substances 0.000 claims 1
• 239000008176 lyophilized powder Substances 0.000 claims 1
• 239000000594 mannitol Substances 0.000 claims 1
• 235000010355 mannitol Nutrition 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 238000007911 parenteral administration Methods 0.000 claims 1
• 239000001103 potassium chloride Substances 0.000 claims 1
• 235000011164 potassium chloride Nutrition 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• 125000000185 sucrose group Chemical group 0.000 claims 1