JP2019509311A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2019509311A5 JP2019509311A5 JP2018549768A JP2018549768A JP2019509311A5 JP 2019509311 A5 JP2019509311 A5 JP 2019509311A5 JP 2018549768 A JP2018549768 A JP 2018549768A JP 2018549768 A JP2018549768 A JP 2018549768A JP 2019509311 A5 JP2019509311 A5 JP 2019509311A5
- Authority
- JP
- Japan
- Prior art keywords
- concentration
- formulation
- antibody molecule
- histidine
- optionally
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 24
- 238000009472 formulation Methods 0.000 claims 24
- 239000000203 mixture Substances 0.000 claims 24
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 13
- 239000011780 sodium chloride Substances 0.000 claims 12
- 229930006000 Sucrose Natural products 0.000 claims 10
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 10
- 239000005720 sucrose Substances 0.000 claims 10
- 239000001509 sodium citrate Substances 0.000 claims 8
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 8
- 239000004475 Arginine Substances 0.000 claims 7
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims 7
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 7
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 7
- 229920000053 polysorbate 80 Polymers 0.000 claims 7
- 229940068968 polysorbate 80 Drugs 0.000 claims 7
- 150000001720 carbohydrates Chemical class 0.000 claims 6
- 235000014633 carbohydrates Nutrition 0.000 claims 6
- 206010012310 Dengue fever Diseases 0.000 claims 4
- 150000001413 amino acids Chemical group 0.000 claims 4
- 208000025729 dengue disease Diseases 0.000 claims 4
- 208000001490 Dengue Diseases 0.000 claims 3
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 claims 2
- SRBFZHDQGSBBOR-IOVATXLUSA-N D-xylopyranose Chemical compound O[C@@H]1COC(O)[C@H](O)[C@H]1O SRBFZHDQGSBBOR-IOVATXLUSA-N 0.000 claims 2
- 229920002307 Dextran Polymers 0.000 claims 2
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 2
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 2
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 2
- RLSSMJSEOOYNOY-UHFFFAOYSA-N m-cresol Chemical compound CC1=CC=CC(O)=C1 RLSSMJSEOOYNOY-UHFFFAOYSA-N 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 229920001223 polyethylene glycol Polymers 0.000 claims 2
- 229920000642 polymer Polymers 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- 230000002335 preservative effect Effects 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 239000000600 sorbitol Substances 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 1
- OWEGMIWEEQEYGQ-UHFFFAOYSA-N 100676-05-9 Natural products OC1C(O)C(O)C(CO)OC1OCC1C(O)C(O)C(O)C(OC2C(OC(O)C(O)C2O)CO)O1 OWEGMIWEEQEYGQ-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 claims 1
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-QTVWNMPRSA-N D-mannopyranose Chemical compound OC[C@H]1OC(O)[C@@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-QTVWNMPRSA-N 0.000 claims 1
- 229930091371 Fructose Natural products 0.000 claims 1
- 239000005715 Fructose Substances 0.000 claims 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims 1
- 108010010803 Gelatin Proteins 0.000 claims 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 1
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-PICCSMPSSA-N Maltose Natural products O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@@H](CO)OC(O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-PICCSMPSSA-N 0.000 claims 1
- 229930195725 Mannitol Natural products 0.000 claims 1
- MUPFEKGTMRGPLJ-RMMQSMQOSA-N Raffinose Natural products O(C[C@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](O[C@@]2(CO)[C@H](O)[C@@H](O)[C@@H](CO)O2)O1)[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 MUPFEKGTMRGPLJ-RMMQSMQOSA-N 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 1
- MUPFEKGTMRGPLJ-UHFFFAOYSA-N UNPD196149 Natural products OC1C(O)C(CO)OC1(CO)OC1C(O)C(O)C(O)C(COC2C(C(O)C(O)C(CO)O2)O)O1 MUPFEKGTMRGPLJ-UHFFFAOYSA-N 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 1
- PYMYPHUHKUWMLA-UHFFFAOYSA-N arabinose Natural products OCC(O)C(O)C(O)C=O PYMYPHUHKUWMLA-UHFFFAOYSA-N 0.000 claims 1
- SRBFZHDQGSBBOR-UHFFFAOYSA-N beta-D-Pyranose-Lyxose Natural products OC1COC(O)C(O)C1O SRBFZHDQGSBBOR-UHFFFAOYSA-N 0.000 claims 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-QUYVBRFLSA-N beta-maltose Chemical compound OC[C@H]1O[C@H](O[C@H]2[C@H](O)[C@@H](O)[C@H](O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@@H]1O GUBGYTABKSRVRQ-QUYVBRFLSA-N 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229920000159 gelatin Polymers 0.000 claims 1
- 239000008273 gelatin Substances 0.000 claims 1
- 235000019322 gelatine Nutrition 0.000 claims 1
- 235000011852 gelatine desserts Nutrition 0.000 claims 1
- 239000008103 glucose Substances 0.000 claims 1
- -1 hydroxylethyl Chemical group 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims 1
- 229960000367 inositol Drugs 0.000 claims 1
- FZWBNHMXJMCXLU-BLAUPYHCSA-N isomaltotriose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)[C@@H](OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O)O1 FZWBNHMXJMCXLU-BLAUPYHCSA-N 0.000 claims 1
- 239000008101 lactose Substances 0.000 claims 1
- 239000012669 liquid formulation Substances 0.000 claims 1
- 239000000594 mannitol Substances 0.000 claims 1
- 235000010355 mannitol Nutrition 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical group O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 claims 1
- MUPFEKGTMRGPLJ-ZQSKZDJDSA-N raffinose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO[C@@H]2[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O2)O)O1 MUPFEKGTMRGPLJ-ZQSKZDJDSA-N 0.000 claims 1
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- 239000012929 tonicity agent Substances 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022124806A JP2022172100A (ja) | 2016-03-25 | 2022-08-04 | デングウイルスに対する抗体分子の製剤 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662313558P | 2016-03-25 | 2016-03-25 | |
| US62/313,558 | 2016-03-25 | ||
| PCT/US2017/023973 WO2017165736A1 (en) | 2016-03-25 | 2017-03-24 | Formulation of antibody molecules to dengue virus |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022124806A Division JP2022172100A (ja) | 2016-03-25 | 2022-08-04 | デングウイルスに対する抗体分子の製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019509311A JP2019509311A (ja) | 2019-04-04 |
| JP2019509311A5 true JP2019509311A5 (enExample) | 2020-04-30 |
| JP7155009B2 JP7155009B2 (ja) | 2022-10-18 |
Family
ID=58489109
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018549768A Active JP7155009B2 (ja) | 2016-03-25 | 2017-03-24 | デングウイルスに対する抗体分子の製剤 |
| JP2022124806A Withdrawn JP2022172100A (ja) | 2016-03-25 | 2022-08-04 | デングウイルスに対する抗体分子の製剤 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022124806A Withdrawn JP2022172100A (ja) | 2016-03-25 | 2022-08-04 | デングウイルスに対する抗体分子の製剤 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US20170274076A1 (enExample) |
| EP (1) | EP3433274A1 (enExample) |
| JP (2) | JP7155009B2 (enExample) |
| CN (1) | CN109311986A (enExample) |
| AU (1) | AU2017238651B2 (enExample) |
| CA (1) | CA3018216A1 (enExample) |
| TW (2) | TW202302144A (enExample) |
| WO (1) | WO2017165736A1 (enExample) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3212977A1 (en) | 2014-02-11 | 2015-08-20 | Visterra, Inc. | Antibody molecules to dengue virus and uses thereof |
| CN109311986A (zh) | 2016-03-25 | 2019-02-05 | 威特拉公司 | 登革热病毒抗体分子的制剂 |
| CN112274637A (zh) | 2016-08-17 | 2021-01-29 | 康姆普根有限公司 | 抗tigit抗体、抗pvrig抗体及其组合 |
| US20200131251A1 (en) * | 2016-12-23 | 2020-04-30 | Serum Institute Of India Private Limited | Improved methods for enhancing antibody productivity in mammalian cell culture and minimizing aggregation during downstream, formulation processes and stable antibody formulations obtained thereof |
| BR112020011205A8 (pt) | 2017-12-07 | 2023-02-07 | Merck Sharp & Dohme | Formulações de composições de vacina contra o vírus da dengue |
| SG11202108627SA (en) | 2019-02-18 | 2021-09-29 | Lilly Co Eli | Therapeutic antibody formulation |
| CN109856383B (zh) * | 2019-03-05 | 2022-04-15 | 肖国林 | 一种用于宫颈癌辅助诊断的免疫化学染色试剂盒 |
| US12491217B2 (en) * | 2019-05-07 | 2025-12-09 | The Regents Of The University Of California | Compositions and methods for promoting healthy neural development in an unborn baby |
| US20220372079A1 (en) * | 2019-06-24 | 2022-11-24 | Jonathan R. Lai | Resurfaced dengue virus and ziki virus glycoprotein e diii variants and uses thereof |
| BR112022001575A2 (pt) * | 2019-07-29 | 2022-04-19 | Compugen Ltd | Formulações de anticorpos anti-pvrig e usos dos mesmos |
| US20230235037A1 (en) * | 2020-04-22 | 2023-07-27 | Chemomab Ltd. | Method of treatment using anti-ccl24 antibody |
| BR112022026482A2 (pt) * | 2020-07-03 | 2023-01-31 | CSL Innovation Pty Ltd | Formulação altamente concentrada de proteínas de ligação ao antígeno do fator xii |
Family Cites Families (54)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| JPS6147500A (ja) | 1984-08-15 | 1986-03-07 | Res Dev Corp Of Japan | キメラモノクロ−ナル抗体及びその製造法 |
| EP0173494A3 (en) | 1984-08-27 | 1987-11-25 | The Board Of Trustees Of The Leland Stanford Junior University | Chimeric receptors by dna splicing and expression |
| GB8422238D0 (en) | 1984-09-03 | 1984-10-10 | Neuberger M S | Chimeric proteins |
| JPS61134325A (ja) | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
| GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| AU600575B2 (en) | 1987-03-18 | 1990-08-16 | Sb2, Inc. | Altered antibodies |
| EP1541682A3 (en) | 1988-09-02 | 2005-07-06 | Dyax Corp. | Generation and selection of recombinant varied binding proteins |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| GB8905669D0 (en) | 1989-03-13 | 1989-04-26 | Celltech Ltd | Modified antibodies |
| WO1991000906A1 (en) | 1989-07-12 | 1991-01-24 | Genetics Institute, Inc. | Chimeric and transgenic animals capable of producing human antibodies |
| ES2087997T3 (es) | 1990-01-12 | 1996-08-01 | Cell Genesys Inc | Generacion de anticuerpos xenogenicos. |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| JPH06508511A (ja) | 1990-07-10 | 1994-09-29 | ケンブリッジ アンティボディー テクノロジー リミティド | 特異的な結合ペアーの構成員の製造方法 |
| WO1992003917A1 (en) | 1990-08-29 | 1992-03-19 | Genpharm International | Homologous recombination in mammalian cells |
| ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
| DE69129154T2 (de) | 1990-12-03 | 1998-08-20 | Genentech, Inc., South San Francisco, Calif. | Verfahren zur anreicherung von proteinvarianten mit geänderten bindungseigenschaften |
| DE69233769D1 (de) | 1991-03-01 | 2009-09-24 | Dyax Corp | Chimäres Protein mit Mikroprotein mit zwei oder mehr Disulfidbindungen und Ausgestaltungen davon |
| ATE414768T1 (de) | 1991-04-10 | 2008-12-15 | Scripps Research Inst | Bibliotheken heterodimerer rezeptoren mittels phagemiden |
| DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| EP1498427B1 (en) | 1992-08-21 | 2009-12-16 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
| EP2290108B1 (en) | 2001-05-22 | 2014-07-23 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by the SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Development of mutations useful for attenuating dengue viruses and chimeric dengue viruses |
| US7232888B2 (en) | 2002-07-01 | 2007-06-19 | Massachusetts Institute Of Technology | Antibodies against tumor surface antigens |
| US7473424B2 (en) | 2003-01-31 | 2009-01-06 | The Scripps Research Institute | Anti-dengue virus antibodies and compositions |
| CA2894300A1 (en) | 2003-12-08 | 2005-06-23 | The Government Of The United States Of America, As Represented By The Secreatary, Department Of Health And Human Services | Monoclonal antibodies that bind or neutralize dengue virus |
| US8052974B2 (en) | 2005-05-12 | 2011-11-08 | Crucell Holland B.V. | Host cell specific binding molecules capable of neutralizing viruses and uses thereof |
| US7943134B2 (en) | 2005-08-31 | 2011-05-17 | Academia Sinica | Compositions and methods for identifying response targets and treating flavivirus infection responses |
| CU23586A1 (es) | 2005-11-22 | 2010-10-30 | Ct Ingenieria Genetica Biotech | Métodos y proteínas para el tratamiento profiláctico y/o terapéutico de los cuatro serotipos del virus de dengue y otros flavivirus |
| CU23632A1 (es) | 2006-04-28 | 2011-02-24 | Ct Ingenieria Genetica Biotech | Métodos para la identificación de candidatos terapéuticos contra enfermedades causadas por flavivirus y moléculas antivirales. |
| WO2009011941A2 (en) | 2007-04-04 | 2009-01-22 | The Government Of U.S.A., As Represented By The Secretary, Departmetnt Of Health & Human Services | Monoclonal antibodies against dengue and other viruses with deletion in fc region |
| WO2008125985A2 (en) | 2007-04-11 | 2008-10-23 | Novartis Ag | Blocking interaction between pathogen factors and factor h to inhibit hemorrhagic syndromes |
| NZ592054A (en) | 2008-10-13 | 2013-06-28 | Inst Research In Biomedicine | Dengue virus neutralizing antibodies and uses thereof |
| WO2010093335A1 (en) | 2009-02-10 | 2010-08-19 | Nanyang Technological University | Antibodies for diagnosis and treatment of flaviviral infections |
| AU2010221156A1 (en) | 2009-03-06 | 2011-09-22 | Genentech, Inc. | Antibody formulation |
| WO2011028962A1 (en) | 2009-09-04 | 2011-03-10 | Xoma Technology Ltd. | Antibody coformulations |
| IT1395574B1 (it) | 2009-09-14 | 2012-10-16 | Guala Dispensing Spa | Dispositivo di erogazione |
| AU2010338305A1 (en) * | 2009-12-29 | 2012-05-24 | F. Hoffmann-La Roche Ag | Antibody formulation |
| US8637035B2 (en) | 2010-07-16 | 2014-01-28 | Academia Sinica | Anti-dengue virus antibodies |
| EP2651975B1 (en) | 2010-12-14 | 2017-08-09 | National University of Singapore | Human monoclonal antibody with specificity for dengue virus serotype 1 e protein and uses thereof |
| SG11201400100SA (en) | 2011-09-09 | 2014-06-27 | Univ Osaka | Dengue-virus serotype neutralizing antibodies |
| US20140349321A1 (en) | 2011-12-16 | 2014-11-27 | Agency For Science, Technology And Research | Binding molecules against dengue virus and uses thereof |
| US8920804B2 (en) | 2011-12-22 | 2014-12-30 | Inbios International, Inc. | Methods and materials for the detection of dengue virus infection |
| EP2834265A4 (en) | 2012-04-02 | 2015-10-14 | Univ North Carolina | METHOD AND COMPOSITIONS FOR DENGUE VIRUS EPITOPES |
| US9556254B2 (en) | 2012-05-14 | 2017-01-31 | The Usa, As Represented By The Secretary, Dept. Of Health And Human Services | Cross-reactive antibodies against dengue virus and uses thereof |
| KR102165384B1 (ko) | 2012-08-07 | 2020-10-16 | 메사추세츠 인스티튜트 오브 테크놀로지 | 항-뎅기 바이러스 항체 및 이들의 용도 |
| WO2014110092A1 (en) | 2013-01-08 | 2014-07-17 | Humabs Biomed Sa | Methods of generating robust passive and active immune responses |
| CN105051064A (zh) * | 2013-01-24 | 2015-11-11 | 葛兰素史克知识产权开发有限公司 | 抗TNF-α抗原结合蛋白 |
| CA3212977A1 (en) * | 2014-02-11 | 2015-08-20 | Visterra, Inc. | Antibody molecules to dengue virus and uses thereof |
| CA2938495A1 (en) | 2014-02-11 | 2015-08-20 | Massachusetts Institute Of Technology | Full spectrum anti-dengue antibody |
| CN109311986A (zh) | 2016-03-25 | 2019-02-05 | 威特拉公司 | 登革热病毒抗体分子的制剂 |
-
2017
- 2017-03-24 CN CN201780028226.4A patent/CN109311986A/zh active Pending
- 2017-03-24 TW TW111113141A patent/TW202302144A/zh unknown
- 2017-03-24 WO PCT/US2017/023973 patent/WO2017165736A1/en not_active Ceased
- 2017-03-24 CA CA3018216A patent/CA3018216A1/en active Pending
- 2017-03-24 JP JP2018549768A patent/JP7155009B2/ja active Active
- 2017-03-24 EP EP17715615.5A patent/EP3433274A1/en active Pending
- 2017-03-24 AU AU2017238651A patent/AU2017238651B2/en active Active
- 2017-03-24 TW TW106109843A patent/TWI763660B/zh active
- 2017-03-24 US US15/468,434 patent/US20170274076A1/en not_active Abandoned
-
2019
- 2019-10-08 US US16/596,239 patent/US11918651B2/en active Active
-
2022
- 2022-08-04 JP JP2022124806A patent/JP2022172100A/ja not_active Withdrawn
-
2024
- 2024-01-23 US US18/420,532 patent/US20240366758A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2019509311A5 (enExample) | ||
| JP6416841B2 (ja) | 医薬製剤 | |
| AU2005330672B2 (en) | Stabilized anti-hepatitis B (HBV) antibody formulations | |
| TWI738632B (zh) | 穩定的含有高濃度抗vegf抗體之蛋白質溶液調配物 | |
| TWI721020B (zh) | 一種抗ｐｄ-１抗體製劑及其在醫藥上的應用 | |
| JP2021504372A5 (enExample) | ||
| JP2020138981A5 (enExample) | ||
| JP2019512012A5 (enExample) | ||
| JP2015231997A5 (enExample) | ||
| JP2013500947A5 (enExample) | ||
| HRP20241131T1 (hr) | Visokokoncentrirane formulacije inhibitornih antitijela masp-2 niske viskoznosti, pribori i metode | |
| JP2010512356A5 (enExample) | ||
| RU2019100887A (ru) | Композиции антитела и белка | |
| WO2011012637A4 (en) | Subcutaneous anti-her2 antibody formulation | |
| CA2794929A1 (en) | Concentrated protein formulations and uses thereof | |
| CN102711833A (zh) | 蛋白质药物制剂 | |
| US20090068196A1 (en) | Pharmaceutical formulation of an antibody against IL13Ralpha1 | |
| JP7467438B2 (ja) | 抗ｒｓｖ抗体の製剤及びその使用方法 | |
| TW201438764A (zh) | 多肽之調配物 | |
| CA2888442A1 (en) | Stable pharmaceutical composition of peginterferon alpha-2b | |
| JP2016534062A (ja) | 新規な安定製剤 | |
| RU2024121592A (ru) | Лиофилизированная композиция, содержащая слитый белок, включающий α-галактозидазу А | |
| OA17126A (en) | Pharmaceutical formulations of TNF-alpha antibodies |