DK1755659T3 - Anvendelse af anti-alfa5beta1-antistoffer til inhibering af kræftcelleproliferation - Google Patents
Anvendelse af anti-alfa5beta1-antistoffer til inhibering af kræftcelleproliferationInfo
- Publication number
- DK1755659T3 DK1755659T3 DK05744016.6T DK05744016T DK1755659T3 DK 1755659 T3 DK1755659 T3 DK 1755659T3 DK 05744016 T DK05744016 T DK 05744016T DK 1755659 T3 DK1755659 T3 DK 1755659T3
- Authority
- DK
- Denmark
- Prior art keywords
- cancer
- antibodies
- methods
- cancer cell
- cell proliferation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Mycology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55642104P | 2004-03-24 | 2004-03-24 | |
US55642204P | 2004-03-24 | 2004-03-24 | |
US62504904P | 2004-11-03 | 2004-11-03 | |
US65109805P | 2005-02-07 | 2005-02-07 | |
US65751405P | 2005-02-28 | 2005-02-28 | |
PCT/US2005/009939 WO2005092073A2 (en) | 2004-03-24 | 2005-03-24 | Use of anti-alpha5beta1 antibodies to inhibit cancer cell proliferation |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1755659T3 true DK1755659T3 (da) | 2012-02-27 |
Family
ID=35056776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05744016.6T DK1755659T3 (da) | 2004-03-24 | 2005-03-24 | Anvendelse af anti-alfa5beta1-antistoffer til inhibering af kræftcelleproliferation |
Country Status (15)
Country | Link |
---|---|
US (2) | US7662384B2 (da) |
EP (1) | EP1755659B1 (da) |
JP (1) | JP4857259B2 (da) |
KR (1) | KR20070009637A (da) |
AT (1) | ATE531388T1 (da) |
AU (1) | AU2005226736B2 (da) |
BR (1) | BRPI0509177A (da) |
CA (1) | CA2560508A1 (da) |
DK (1) | DK1755659T3 (da) |
ES (1) | ES2376556T3 (da) |
HK (1) | HK1101348A1 (da) |
IL (1) | IL178042A (da) |
NO (1) | NO20064794L (da) |
NZ (1) | NZ549893A (da) |
WO (1) | WO2005092073A2 (da) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP4316465A3 (en) | 2006-03-15 | 2024-04-24 | Alexion Pharmaceuticals, Inc. | Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement |
ES2544957T3 (es) * | 2006-03-21 | 2015-09-07 | Genentech, Inc. | Terapia combinada que implica antagonistas alfa5beta1 |
WO2007114851A1 (en) * | 2006-04-04 | 2007-10-11 | The Board Of Trustees Of The University Of Illinois | Methods and compositions to induce cell death of invasive tumors |
BRPI0711796A2 (pt) * | 2006-05-24 | 2011-12-06 | Bayer Schering Pharma Aktiendesellschaft | anticorpos de bloqueio de função de integrinas anti-alfa5beta1 humanos e humanizados com imunogenicidade reduzida |
WO2008061377A1 (en) * | 2006-11-22 | 2008-05-29 | Centre Hospitalier De L'universite De Montreal | Novel receptor for cd40l and uses thereof |
US20090041767A1 (en) * | 2007-07-27 | 2009-02-12 | Vanitha Ramakrishnan | Pharmaceutical combinations |
SI2200700T1 (sl) | 2007-09-26 | 2016-04-29 | Genentech, Inc. | Nova protitelesa |
US8039596B2 (en) * | 2008-02-05 | 2011-10-18 | Bristol-Myers Squibb Company | Alpha 5-beta 1 antibodies and their uses |
EP2379595A2 (en) | 2008-12-23 | 2011-10-26 | AstraZeneca AB | Targeted binding agents directed to 5 1 and uses thereof |
NZ594343A (en) * | 2009-03-25 | 2013-10-25 | Genentech Inc | Novel anti-alpha5beta1 antibodies and uses thereof |
US20110319335A1 (en) | 2010-06-23 | 2011-12-29 | Xiaodong Feng | Combined administration of integrin receptor antagonists for anti-angiogenic therapy |
MX354988B (es) | 2011-10-25 | 2018-03-28 | Prothena Biosciences Ltd | Formulaciones de anticuerpo y metodos. |
US8946159B2 (en) | 2011-12-22 | 2015-02-03 | California Northstate College Of Pharmacy, Llc | Administration of an antagonist of α5β1 for anti-angiogenesis and cancer treatment |
NO2760138T3 (da) | 2012-10-01 | 2018-08-04 | ||
JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
CA3060581A1 (en) | 2017-05-02 | 2018-11-08 | Merck Sharp & Dohme Corp. | Formulations of anti-lag3 antibodies and co-formulations of anti-lag3 antibodies and anti-pd-1 antibodies |
Family Cites Families (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4704366A (en) * | 1984-06-22 | 1987-11-03 | Bio-Rad Laboratories, Inc. | Process for binding IgG to protein A |
JPS61134325A (ja) * | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US4801687A (en) * | 1986-10-27 | 1989-01-31 | Bioprobe International, Inc. | Monoclonal antibody purification process using protein A |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
JP3854306B2 (ja) * | 1991-03-06 | 2006-12-06 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ヒト化及びキメラモノクローナル抗体 |
CA2078539C (en) * | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
GB9125979D0 (en) * | 1991-12-06 | 1992-02-05 | Wellcome Found | Antibody |
ATE171472T1 (de) * | 1992-02-19 | 1998-10-15 | Schering Corp | Klonierung und expression von humanisierten monoklonalen antikörpern gegen menschliches interleukin-4 |
US5639641A (en) * | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
EP0669988B2 (en) | 1992-10-29 | 2009-07-08 | The Australian National University | Angiogenesis inhibitory antibodies |
US5536814A (en) * | 1993-09-27 | 1996-07-16 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
US5981478A (en) | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
WO1995022618A1 (en) | 1994-02-22 | 1995-08-24 | Dana-Farber Cancer Institute | Nucleic acid delivery system, method of synthesis and uses thereof |
DE69516351T2 (de) * | 1994-09-21 | 2000-12-07 | Matsushita Electric Ind Co Ltd | Sekundäre Lithium Feststoffbatterie |
US5705154A (en) * | 1995-03-08 | 1998-01-06 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
WO1997033887A1 (en) | 1996-03-15 | 1997-09-18 | Du Pont Pharmaceuticals Company | Spirocycle integrin inhibitors |
US5922676A (en) * | 1996-09-20 | 1999-07-13 | The Burnham Institute | Methods of inhibiting cancer by using superfibronectin |
US5846536A (en) | 1996-10-04 | 1998-12-08 | The Regents Of The University Of California | Restoration of normal phenotype in cancer cells |
CA2250291A1 (en) | 1997-01-29 | 1998-07-30 | Toray Industries Inc. | Chimeric proteins, their heterodimer complexes, and platelet substitutes |
US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
WO1999037329A1 (en) * | 1998-01-22 | 1999-07-29 | Astrazeneca Ab | Pharmaceutical formulation comprising an antibody and a citrate buffer |
CA2330277A1 (en) | 1998-04-27 | 1999-11-04 | Sidney Kimmel Cancer Center | Reduced complexity nucleic acid targets and methods of using same |
EP2327451B1 (en) * | 1998-05-08 | 2013-10-23 | The Regents of the University of California | Method for detecting and inhibiting angiogenesis |
US6852318B1 (en) * | 1998-05-08 | 2005-02-08 | The Regents Of The University Of California | Methods for detecting and inhibiting angiogenesis |
MXPA02001439A (es) | 1999-08-11 | 2002-08-30 | Eos Biotechnology Inc | Nuevos metodos para el diagnostico de angiogenesis, composiciones y metodos de exhibicion de moduladores de la angiogenesis. |
EP1252162B1 (en) | 2000-01-20 | 2012-07-25 | Merck Sharp & Dohme Corp. | Alpha v integrin receptor antagonists |
WO2001053262A1 (en) | 2000-01-24 | 2001-07-26 | Merck & Co., Inc. | Alpha v integrin receptor antagonists |
US7740841B1 (en) * | 2000-01-28 | 2010-06-22 | Sunnybrook Health Science Center | Therapeutic method for reducing angiogenesis |
US20040259152A1 (en) * | 2000-02-22 | 2004-12-23 | Richard Murray | Novel methods of diagnosing and screening for modulators of tissue remodeling and treating related diseases |
AU2002257004A1 (en) | 2001-02-14 | 2002-10-15 | Protein Design Labs, Inc. | Methods of diagnosis of angiogenesis, compositions and methods of screening for angiogenesis modulators |
US7276589B2 (en) * | 2002-11-26 | 2007-10-02 | Pdl Biopharma, Inc. | Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis |
NZ540562A (en) * | 2002-11-26 | 2008-04-30 | Pdl Biopharma Inc | Therapeutic chimeric and humanized antibodies directed against alpha5beta1 integrin, methods for purification of these antibodies, and their use in treating conditions comprising undesirable tissue angiogenesis |
US20050002930A1 (en) * | 2003-04-03 | 2005-01-06 | Johnson Dale E. | Methods of production and use of anti-integrin antibodies for the control of tissue granulation |
KR101424624B1 (ko) * | 2003-05-14 | 2014-07-31 | 이뮤노젠 아이엔씨 | 약물 콘쥬게이트 조성물 |
-
2005
- 2005-03-24 JP JP2007505204A patent/JP4857259B2/ja not_active Expired - Fee Related
- 2005-03-24 EP EP05744016A patent/EP1755659B1/en active Active
- 2005-03-24 CA CA002560508A patent/CA2560508A1/en not_active Abandoned
- 2005-03-24 ES ES05744016T patent/ES2376556T3/es active Active
- 2005-03-24 KR KR1020067021955A patent/KR20070009637A/ko not_active Application Discontinuation
- 2005-03-24 WO PCT/US2005/009939 patent/WO2005092073A2/en active Application Filing
- 2005-03-24 AU AU2005226736A patent/AU2005226736B2/en not_active Ceased
- 2005-03-24 NZ NZ549893A patent/NZ549893A/en not_active IP Right Cessation
- 2005-03-24 BR BRPI0509177-2A patent/BRPI0509177A/pt not_active IP Right Cessation
- 2005-03-24 DK DK05744016.6T patent/DK1755659T3/da active
- 2005-03-24 US US11/090,331 patent/US7662384B2/en not_active Expired - Fee Related
- 2005-03-24 AT AT05744016T patent/ATE531388T1/de active
-
2006
- 2006-09-12 IL IL178042A patent/IL178042A/en not_active IP Right Cessation
- 2006-10-23 NO NO20064794A patent/NO20064794L/no not_active Application Discontinuation
-
2007
- 2007-06-08 HK HK07106150.6A patent/HK1101348A1/xx not_active IP Right Cessation
-
2009
- 2009-12-18 US US12/642,687 patent/US20100291111A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
US7662384B2 (en) | 2010-02-16 |
NZ549893A (en) | 2010-05-28 |
JP4857259B2 (ja) | 2012-01-18 |
JP2007530584A (ja) | 2007-11-01 |
US20100291111A1 (en) | 2010-11-18 |
HK1101348A1 (en) | 2007-10-18 |
EP1755659B1 (en) | 2011-11-02 |
IL178042A0 (en) | 2006-12-31 |
NO20064794L (no) | 2006-10-23 |
IL178042A (en) | 2011-05-31 |
EP1755659A2 (en) | 2007-02-28 |
US20050260210A1 (en) | 2005-11-24 |
WO2005092073A3 (en) | 2006-08-10 |
WO2005092073A2 (en) | 2005-10-06 |
AU2005226736A1 (en) | 2005-10-06 |
EP1755659A4 (en) | 2008-08-20 |
AU2005226736B2 (en) | 2009-11-26 |
CA2560508A1 (en) | 2005-10-06 |
BRPI0509177A (pt) | 2007-09-18 |
KR20070009637A (ko) | 2007-01-18 |
ES2376556T3 (es) | 2012-03-14 |
ATE531388T1 (de) | 2011-11-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1755659T3 (da) | Anvendelse af anti-alfa5beta1-antistoffer til inhibering af kræftcelleproliferation | |
ATE546158T1 (de) | Therapeutisches krebsmittel mit polymergebundenem antikörper | |
CY1119956T1 (el) | Μονοκλωνικα anti-gt468 αντισωματα για θεραπεια καρκiνου | |
EA200801853A1 (ru) | Пептиды, эффективные в лечении опухолей и других заболеваний, требующих удаления или разрушения клеток | |
EA200601433A1 (ru) | Способы и композиции для лечения опухолей и метастазирования | |
ECSP099523A (es) | Antagonistas específicos de VEGF para terapia adyuvante y neoadyuvante y el tratamiento de tumores en estadíos tempranos | |
ATE512146T1 (de) | Phenylharnstoffderivate als hemmstoffe von tyrosinkinasen zur behandlung von tumorerkrankungen | |
ATE294591T1 (de) | Verwendung von trifunktionellen bispezifischen und trispezifischen antikörpern zur behandlung von malignem aszites | |
CY1112739T1 (el) | Αντισωματα και ανοσοσυζευγματα αντι-cd79β και μεθοδοι χρησης | |
DK1771474T3 (da) | Inhibitorer af angiopoitin-like 4 protein, kombinationer og anvendelser deraf | |
DE602005026105D1 (de) | Verwendung von agonisten und antagonisten von interleukin-33 (il-33) | |
EA201300171A1 (ru) | Способы и композиции для терапии рака печени | |
DK1893196T3 (da) | Diarylhydantoin-forbindelse | |
CR10147A (es) | "ligandos que tienen especificidad de enlace para vegf y/o egfr y métodos de uso de los mismos" | |
WO2004000094A8 (en) | Predictive markers in cancer therapy | |
ATE526037T1 (de) | Verfahren zum abtöten von tumorzellen mittels targeting von auf apoptotischen tumorzellen exponierten internen antigenen | |
HK1116186A1 (en) | Azaxanthones and use thereof for treating tumors | |
WO2020107002A3 (en) | Methods for expansion of natural killer (nk) cell subset and related compositions and methods | |
EA200970884A1 (ru) | Способы лечения рака путем введения комбинаций человеческого интерлейкина ил-18 | |
MX2019015194A (es) | Composiciones y métodos para terapia de cáncer con virus de dengue y células dendríticas. | |
UA88294C2 (ru) | ПРИМЕНЕНИЕ АНТИ-α5β1 АНТИТЕЛ ДЛЯ УГНЕТЕНИЯ ПРОЛИФЕРАЦИИ РАКОВЫХ КЛЕТОК | |
IS5570A (is) | Meðhöndlun á risaeitlingasarkmeini með tálmum viðeitilfrumueiturslóðinni | |
AR055072A1 (es) | Uso de anticuerpos anti- madcam para el tratamiento de enfermedad celiaca y esprue tropical | |
ATE431742T1 (de) | Modifizierte zytokine für krebs therapie | |
ATE537838T1 (de) | Kombinationstherapie mit kloretazin(tm) |