ATE531388T1 - Verwendung von anti-alpha5beta1-antikörpern zur hemmung der krebszellproliferation - Google Patents
Verwendung von anti-alpha5beta1-antikörpern zur hemmung der krebszellproliferationInfo
- Publication number
- ATE531388T1 ATE531388T1 AT05744016T AT05744016T ATE531388T1 AT E531388 T1 ATE531388 T1 AT E531388T1 AT 05744016 T AT05744016 T AT 05744016T AT 05744016 T AT05744016 T AT 05744016T AT E531388 T1 ATE531388 T1 AT E531388T1
- Authority
- AT
- Austria
- Prior art keywords
- cancer
- antibodies
- methods
- cancer cell
- cell proliferation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2839—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily
- C07K16/2842—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the integrin superfamily against integrin beta1-subunit-containing molecules, e.g. CD29, CD49
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55642204P | 2004-03-24 | 2004-03-24 | |
US55642104P | 2004-03-24 | 2004-03-24 | |
US62504904P | 2004-11-03 | 2004-11-03 | |
US65109805P | 2005-02-07 | 2005-02-07 | |
US65751405P | 2005-02-28 | 2005-02-28 | |
PCT/US2005/009939 WO2005092073A2 (en) | 2004-03-24 | 2005-03-24 | Use of anti-alpha5beta1 antibodies to inhibit cancer cell proliferation |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE531388T1 true ATE531388T1 (de) | 2011-11-15 |
Family
ID=35056776
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT05744016T ATE531388T1 (de) | 2004-03-24 | 2005-03-24 | Verwendung von anti-alpha5beta1-antikörpern zur hemmung der krebszellproliferation |
Country Status (15)
Country | Link |
---|---|
US (2) | US7662384B2 (de) |
EP (1) | EP1755659B1 (de) |
JP (1) | JP4857259B2 (de) |
KR (1) | KR20070009637A (de) |
AT (1) | ATE531388T1 (de) |
AU (1) | AU2005226736B2 (de) |
BR (1) | BRPI0509177A (de) |
CA (1) | CA2560508A1 (de) |
DK (1) | DK1755659T3 (de) |
ES (1) | ES2376556T3 (de) |
HK (1) | HK1101348A1 (de) |
IL (1) | IL178042A (de) |
NO (1) | NO20064794L (de) |
NZ (1) | NZ549893A (de) |
WO (1) | WO2005092073A2 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BR122017024057B8 (pt) | 2006-03-15 | 2021-05-25 | Alexion Pharma Inc | anticorpo que se liga à c5 e composição farmacêutica compreendendo dito anticorpo e um veículo farmaceuticamente aceitável |
NZ571068A (en) * | 2006-03-21 | 2012-06-29 | Genentech Inc | An antibody that can bind human alpha5beta1 |
WO2007114851A1 (en) * | 2006-04-04 | 2007-10-11 | The Board Of Trustees Of The University Of Illinois | Methods and compositions to induce cell death of invasive tumors |
MX2008014910A (es) * | 2006-05-24 | 2009-01-23 | Bayer Schering Pharma Ag | Anticuerpos bloqueantes de la funcion de la integrina ?5?1 humanos y humanizados de gran afinidad con inmunogenicidad reducida. |
WO2008061377A1 (en) * | 2006-11-22 | 2008-05-29 | Centre Hospitalier De L'universite De Montreal | Novel receptor for cd40l and uses thereof |
EP2193148A2 (de) * | 2007-07-27 | 2010-06-09 | Facet Biotech Corporation | Einen tyrosinkinaseinhibitor und einen antikörper gegen integrin alpha 1 beta 5 (cd49e) enthaltende pharmazeutische kombination |
RU2490277C2 (ru) * | 2007-09-26 | 2013-08-20 | Дженентек, Инк. | Новые антитела |
CN101970006B (zh) * | 2008-02-05 | 2014-08-06 | 百时美施贵宝公司 | α5-β1抗体和它们的用途 |
JP2012513194A (ja) | 2008-12-23 | 2012-06-14 | アストラゼネカ アクチボラグ | α5β1に向けられた標的結合剤およびその使用 |
PE20120770A1 (es) * | 2009-03-25 | 2012-07-10 | Genentech Inc | ANTICUERPOS ANTI alfa5ß1 CON ACTIVIDAD SOBRE GLIOBLASTOMAS |
US20110319335A1 (en) | 2010-06-23 | 2011-12-29 | Xiaodong Feng | Combined administration of integrin receptor antagonists for anti-angiogenic therapy |
CN104023743B (zh) | 2011-10-25 | 2017-05-03 | 普罗西纳治疗有限公司 | 抗体制剂和方法 |
US8946159B2 (en) | 2011-12-22 | 2015-02-03 | California Northstate College Of Pharmacy, Llc | Administration of an antagonist of α5β1 for anti-angiogenesis and cancer treatment |
NO2760138T3 (de) | 2012-10-01 | 2018-08-04 | ||
CN110913906A (zh) | 2017-05-02 | 2020-03-24 | 默沙东公司 | 抗lag3抗体的制剂和抗lag3抗体与抗pd-1抗体的共制剂 |
JOP20190260A1 (ar) | 2017-05-02 | 2019-10-31 | Merck Sharp & Dohme | صيغ ثابتة لأجسام مضادة لمستقبل الموت المبرمج 1 (pd-1) وطرق استخدامها |
Family Cites Families (36)
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US4704366A (en) * | 1984-06-22 | 1987-11-03 | Bio-Rad Laboratories, Inc. | Process for binding IgG to protein A |
JPS61134325A (ja) * | 1984-12-04 | 1986-06-21 | Teijin Ltd | ハイブリツド抗体遺伝子の発現方法 |
US5618920A (en) * | 1985-11-01 | 1997-04-08 | Xoma Corporation | Modular assembly of antibody genes, antibodies prepared thereby and use |
US4946778A (en) * | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US4801687A (en) * | 1986-10-27 | 1989-01-31 | Bioprobe International, Inc. | Monoclonal antibody purification process using protein A |
US5530101A (en) * | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
JP3854306B2 (ja) * | 1991-03-06 | 2006-12-06 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | ヒト化及びキメラモノクローナル抗体 |
CA2078539C (en) * | 1991-09-18 | 2005-08-02 | Kenya Shitara | Process for producing humanized chimera antibody |
GB9125979D0 (en) * | 1991-12-06 | 1992-02-05 | Wellcome Found | Antibody |
JPH07502901A (ja) * | 1992-02-19 | 1995-03-30 | シェリング・コーポレーション | ヒトインターロイキン−4に対するヒト化モノクローナル抗体のクローニング及び発現 |
US5639641A (en) * | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
AU673865B2 (en) | 1992-10-29 | 1996-11-28 | Australian National University, The | Angiogenesis inhibitory antibodies |
US5536814A (en) * | 1993-09-27 | 1996-07-16 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
US5981478A (en) | 1993-11-24 | 1999-11-09 | La Jolla Cancer Research Foundation | Integrin-binding peptides |
EP0745134A1 (de) | 1994-02-22 | 1996-12-04 | Danafarber Cancer Institute | Nukleinsäureverabreichungs-system, verfahren zur dessen synthese und seine verwendungen |
EP0704920B1 (de) * | 1994-09-21 | 2000-04-19 | Matsushita Electric Industrial Co., Ltd. | Sekundäre Lithium Feststoffbatterie |
US5705154A (en) * | 1995-03-08 | 1998-01-06 | Schering Corporation | Humanized monoclonal antibodies against human interleukin-4 |
JP2001527513A (ja) | 1996-03-15 | 2001-12-25 | デュポン ファーマシューティカルズ カンパニー | スピロ環インテグリン阻害剤 |
US5922676A (en) * | 1996-09-20 | 1999-07-13 | The Burnham Institute | Methods of inhibiting cancer by using superfibronectin |
US5846536A (en) | 1996-10-04 | 1998-12-08 | The Regents Of The University Of California | Restoration of normal phenotype in cancer cells |
EP0896002A4 (de) | 1997-01-29 | 2005-02-02 | Toray Industries | Chimäre proteine, deren heterodimere komplexe und blutplättchenersatz |
US6171586B1 (en) * | 1997-06-13 | 2001-01-09 | Genentech, Inc. | Antibody formulation |
AU2444899A (en) * | 1998-01-22 | 1999-08-09 | Astrazeneca Ab | Pharmaceutical formulation comprising an antibody and a citrate buffer |
WO1999055913A2 (en) | 1998-04-27 | 1999-11-04 | Sidney Kimmel Cancer Center | Reduced complexity nucleic acid targets and methods of using same |
US6852318B1 (en) * | 1998-05-08 | 2005-02-08 | The Regents Of The University Of California | Methods for detecting and inhibiting angiogenesis |
ES2322723T5 (es) | 1998-05-08 | 2013-03-11 | The Regents Of The University Of California | Métodos para detectar e inhibir la angiogénesis |
JP2003517816A (ja) | 1999-08-11 | 2003-06-03 | イオス バイオテクノロジー, インコーポレイテッド | 新脈管形成の診断の新規方法、新脈管形成調節因子についてのスクリーニングの組成物および方法 |
WO2001053297A1 (en) | 2000-01-20 | 2001-07-26 | Merck & Co., Inc. | Alpha v integrin receptor antagonists |
AU780988B2 (en) | 2000-01-24 | 2005-04-28 | Merck & Co., Inc. | Alpha V integrin receptor antagonists |
US7740841B1 (en) * | 2000-01-28 | 2010-06-22 | Sunnybrook Health Science Center | Therapeutic method for reducing angiogenesis |
US20040259152A1 (en) * | 2000-02-22 | 2004-12-23 | Richard Murray | Novel methods of diagnosing and screening for modulators of tissue remodeling and treating related diseases |
EP1418943A1 (de) | 2001-02-14 | 2004-05-19 | Protein Design Labs, Inc. | Diagnoseverfahren für angiogenese, zusammensetzungen und verfahren zum screening auf angiogenese-modulatoren |
US7276589B2 (en) * | 2002-11-26 | 2007-10-02 | Pdl Biopharma, Inc. | Chimeric and humanized antibodies to α5β1 integrin that modulate angiogenesis |
JP4741242B2 (ja) | 2002-11-26 | 2011-08-03 | アボット バイオセラピューティクス コーポレイション | 新脈管形成を調節するα5β1インテグリンへのキメラ及びヒト化抗体 |
WO2004089988A2 (en) | 2003-04-03 | 2004-10-21 | Protein Design Labs, Inc | Inhibitors of integrin alpha5beta1 and their use for the control of tissue granulation |
CR20120384A (es) | 2003-05-14 | 2016-12-02 | Immunogen Inc | Composición de farmaco conjugado |
-
2005
- 2005-03-24 ES ES05744016T patent/ES2376556T3/es active Active
- 2005-03-24 BR BRPI0509177-2A patent/BRPI0509177A/pt not_active IP Right Cessation
- 2005-03-24 AT AT05744016T patent/ATE531388T1/de active
- 2005-03-24 WO PCT/US2005/009939 patent/WO2005092073A2/en active Application Filing
- 2005-03-24 DK DK05744016.6T patent/DK1755659T3/da active
- 2005-03-24 CA CA002560508A patent/CA2560508A1/en not_active Abandoned
- 2005-03-24 NZ NZ549893A patent/NZ549893A/en not_active IP Right Cessation
- 2005-03-24 US US11/090,331 patent/US7662384B2/en not_active Expired - Fee Related
- 2005-03-24 KR KR1020067021955A patent/KR20070009637A/ko not_active Application Discontinuation
- 2005-03-24 AU AU2005226736A patent/AU2005226736B2/en not_active Ceased
- 2005-03-24 EP EP05744016A patent/EP1755659B1/de active Active
- 2005-03-24 JP JP2007505204A patent/JP4857259B2/ja not_active Expired - Fee Related
-
2006
- 2006-09-12 IL IL178042A patent/IL178042A/en not_active IP Right Cessation
- 2006-10-23 NO NO20064794A patent/NO20064794L/no not_active Application Discontinuation
-
2007
- 2007-06-08 HK HK07106150.6A patent/HK1101348A1/xx not_active IP Right Cessation
-
2009
- 2009-12-18 US US12/642,687 patent/US20100291111A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
NZ549893A (en) | 2010-05-28 |
BRPI0509177A (pt) | 2007-09-18 |
CA2560508A1 (en) | 2005-10-06 |
NO20064794L (no) | 2006-10-23 |
EP1755659A2 (de) | 2007-02-28 |
AU2005226736A1 (en) | 2005-10-06 |
US20050260210A1 (en) | 2005-11-24 |
IL178042A (en) | 2011-05-31 |
HK1101348A1 (en) | 2007-10-18 |
WO2005092073A3 (en) | 2006-08-10 |
ES2376556T3 (es) | 2012-03-14 |
EP1755659A4 (de) | 2008-08-20 |
US7662384B2 (en) | 2010-02-16 |
US20100291111A1 (en) | 2010-11-18 |
KR20070009637A (ko) | 2007-01-18 |
DK1755659T3 (da) | 2012-02-27 |
AU2005226736B2 (en) | 2009-11-26 |
JP4857259B2 (ja) | 2012-01-18 |
WO2005092073A2 (en) | 2005-10-06 |
JP2007530584A (ja) | 2007-11-01 |
EP1755659B1 (de) | 2011-11-02 |
IL178042A0 (en) | 2006-12-31 |
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