ATE526037T1 - Verfahren zum abtöten von tumorzellen mittels targeting von auf apoptotischen tumorzellen exponierten internen antigenen - Google Patents

Verfahren zum abtöten von tumorzellen mittels targeting von auf apoptotischen tumorzellen exponierten internen antigenen

Info

Publication number
ATE526037T1
ATE526037T1 AT04812982T AT04812982T ATE526037T1 AT E526037 T1 ATE526037 T1 AT E526037T1 AT 04812982 T AT04812982 T AT 04812982T AT 04812982 T AT04812982 T AT 04812982T AT E526037 T1 ATE526037 T1 AT E526037T1
Authority
AT
Austria
Prior art keywords
tumor cells
apoptotic
killing
internal antigens
antigens exposed
Prior art date
Application number
AT04812982T
Other languages
English (en)
Inventor
Elizabeth E Evans
Mark J Paris
Deepak M Sahasrabudhe
Ernest S Smith
Maurice Zauderer
Original Assignee
Vaccinex Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vaccinex Inc filed Critical Vaccinex Inc
Application granted granted Critical
Publication of ATE526037T1 publication Critical patent/ATE526037T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
AT04812982T 2003-12-04 2004-12-06 Verfahren zum abtöten von tumorzellen mittels targeting von auf apoptotischen tumorzellen exponierten internen antigenen ATE526037T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US52657203P 2003-12-04 2003-12-04
US53168803P 2003-12-23 2003-12-23
PCT/US2004/040573 WO2005055936A2 (en) 2003-12-04 2004-12-06 Methods of killing tumor cells by targeting internal antigens exposed on apoptotic tumor cells

Publications (1)

Publication Number Publication Date
ATE526037T1 true ATE526037T1 (de) 2011-10-15

Family

ID=34681506

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04812982T ATE526037T1 (de) 2003-12-04 2004-12-06 Verfahren zum abtöten von tumorzellen mittels targeting von auf apoptotischen tumorzellen exponierten internen antigenen

Country Status (10)

Country Link
US (2) US20050158323A1 (de)
EP (1) EP1708751B1 (de)
JP (1) JP5042631B2 (de)
CN (1) CN1913921B (de)
AT (1) ATE526037T1 (de)
AU (1) AU2004296184B2 (de)
CA (1) CA2548180C (de)
IL (1) IL176007A (de)
NZ (1) NZ547591A (de)
WO (1) WO2005055936A2 (de)

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US20080305111A1 (en) * 2006-06-22 2008-12-11 Vaccinex, Inc. Anti-C35 antibodies for treating cancer
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CN101631454A (zh) 2006-12-08 2010-01-20 衣阿华州立大学研究基金公司 参与硝酸盐吸收和代谢的植物基因
WO2009070302A1 (en) 2007-11-30 2009-06-04 The Johns Hopkins University Prostate specific membrane antigen (psma) targeted nanoparticles for therapy of prostate cancer
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EP3320920A1 (de) 2009-05-08 2018-05-16 Vaccinex, Inc. Anti-cd100-antikörper und verfahren zur verwendung davon
EP2482843A4 (de) * 2009-10-02 2013-05-15 Univ Iowa Res Found Verfahren für verbesserte impfstoff-immunogenität
WO2011091419A2 (en) * 2010-01-25 2011-07-28 New York Universiy Recombinant derivatives of botulinum neurotoxins engineered for trafficking studies and neuronal delivery
EP2694102A4 (de) 2011-04-04 2015-03-04 Univ Iowa Res Found Verfahren für verbesserte impfstoff-immunogenität
SMT201900500T1 (it) * 2011-05-08 2019-11-13 Legochem Biosciences Inc Coniugati di agente protettivo-proteina e metodo per preparare i medesimi
EP2766093B1 (de) 2011-10-11 2018-02-21 Vaccinex, Inc. Verwendung von semaphorin-4d bindenden molekülen zur modulation der durchlässigkeit der blut-hirn-schranke
US9708601B2 (en) 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
WO2014069682A1 (ko) * 2012-10-29 2014-05-08 인제대학교 산학협력단 암 표적 항체 및 이를 포함하는 암 예방 또는 치료용 조성물
WO2014069681A1 (ko) * 2012-10-29 2014-05-08 인제대학교 산학협력단 암 표적 항체 및 이를 포함하는 암 예방 또는 치료용 조성물
SG10201902380SA (en) 2013-06-25 2019-04-29 Vaccinex Inc Use of semaphorin-4d inhibitory molecules in combination with an immune modulating therapy to inhibit tumor growth and metastases
CA2969463A1 (en) 2014-12-09 2016-06-16 New York University Clostridial neurotoxin fusion proteins, propeptide fusions, their expression, and use
CA2998611A1 (en) * 2015-09-14 2017-03-23 Leukemia Therapeutics, LLC Identification of novel diagnostics and therapeutics by modulating rhoh
EP3445397B1 (de) 2016-04-22 2022-11-09 Vaccinex, Inc. Integrale membranproteinanzeige auf extrazellulären umhüllten virionen des pockenvirus
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CA3032512C (en) 2016-08-02 2025-05-06 Vaccinex, Inc. IMPROVED PROCESSES FOR PRODUCING POLYNUCLEOTIDE LIBRARIES IN VACCINE VIRUS/EUKARYOTIC CELLS

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Also Published As

Publication number Publication date
JP2007515165A (ja) 2007-06-14
CN1913921B (zh) 2012-02-22
JP5042631B2 (ja) 2012-10-03
EP1708751A2 (de) 2006-10-11
US20090081210A1 (en) 2009-03-26
WO2005055936A2 (en) 2005-06-23
IL176007A (en) 2012-03-29
AU2004296184A1 (en) 2005-06-23
CA2548180A1 (en) 2005-06-23
CN1913921A (zh) 2007-02-14
CA2548180C (en) 2014-02-04
AU2004296184B2 (en) 2010-12-16
EP1708751B1 (de) 2011-09-28
NZ547591A (en) 2009-11-27
IL176007A0 (en) 2006-10-05
EP1708751A4 (de) 2007-11-07
US20050158323A1 (en) 2005-07-21
WO2005055936A3 (en) 2005-11-03

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