ATE526037T1 - Verfahren zum abtöten von tumorzellen mittels targeting von auf apoptotischen tumorzellen exponierten internen antigenen - Google Patents
Verfahren zum abtöten von tumorzellen mittels targeting von auf apoptotischen tumorzellen exponierten internen antigenenInfo
- Publication number
- ATE526037T1 ATE526037T1 AT04812982T AT04812982T ATE526037T1 AT E526037 T1 ATE526037 T1 AT E526037T1 AT 04812982 T AT04812982 T AT 04812982T AT 04812982 T AT04812982 T AT 04812982T AT E526037 T1 ATE526037 T1 AT E526037T1
- Authority
- AT
- Austria
- Prior art keywords
- tumor cells
- apoptotic
- killing
- internal antigens
- antigens exposed
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52657203P | 2003-12-04 | 2003-12-04 | |
US53168803P | 2003-12-23 | 2003-12-23 | |
PCT/US2004/040573 WO2005055936A2 (en) | 2003-12-04 | 2004-12-06 | Methods of killing tumor cells by targeting internal antigens exposed on apoptotic tumor cells |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE526037T1 true ATE526037T1 (de) | 2011-10-15 |
Family
ID=34681506
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04812982T ATE526037T1 (de) | 2003-12-04 | 2004-12-06 | Verfahren zum abtöten von tumorzellen mittels targeting von auf apoptotischen tumorzellen exponierten internen antigenen |
Country Status (10)
Country | Link |
---|---|
US (2) | US20050158323A1 (de) |
EP (1) | EP1708751B1 (de) |
JP (1) | JP5042631B2 (de) |
CN (1) | CN1913921B (de) |
AT (1) | ATE526037T1 (de) |
AU (1) | AU2004296184B2 (de) |
CA (1) | CA2548180C (de) |
IL (1) | IL176007A (de) |
NZ (1) | NZ547591A (de) |
WO (1) | WO2005055936A2 (de) |
Families Citing this family (25)
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NZ522282A (en) * | 2000-04-04 | 2005-03-24 | Univ Rochester | A gene differentially expressed in breast and bladder cancer and encoded polypeptides |
NZ537579A (en) | 2002-06-10 | 2006-10-27 | Vaccinex Inc | C35 peptide epitopes and their analogs |
US20050158323A1 (en) * | 2003-12-04 | 2005-07-21 | Vaccinex, Inc. | Methods of killing tumor cells by targeting internal antigens exposed on apoptotic tumor cells |
CA2588758C (en) * | 2004-11-22 | 2017-01-03 | New York University | Genetically engineered clostridial genes, proteins encoded by the engineered genes, and uses thereof |
AU2006281980A1 (en) * | 2005-08-15 | 2007-02-22 | Cephalon Australia Pty Ltd | Engineered antibodies with new world primate framework regions |
CA2656918A1 (en) * | 2006-06-22 | 2007-12-27 | Vaccinex, Inc. | Anti-c35 antibodies for treating cancer |
AU2007325520A1 (en) * | 2006-10-13 | 2008-06-05 | The Regents Of The University Of California | Cancer treatment |
BRPI0720219A2 (pt) | 2006-12-08 | 2013-12-24 | Univ Iowa State Res Found Inc | Genes de planta envolvidos em absorção e metabolismo de nitrato |
WO2009070302A1 (en) | 2007-11-30 | 2009-06-04 | The Johns Hopkins University | Prostate specific membrane antigen (psma) targeted nanoparticles for therapy of prostate cancer |
CA2710680C (en) * | 2007-12-26 | 2018-10-16 | Vaccinex, Inc. | Anti-c35 antibody combination therapies and methods |
CN108912228B (zh) | 2009-05-08 | 2022-03-15 | 瓦西尼斯公司 | 抗-cd100抗体和其使用方法 |
AU2010300380B2 (en) * | 2009-10-02 | 2016-06-09 | University Of Iowa Research Foundation | Methods of improving vaccine immunogenicity |
US8980284B2 (en) * | 2010-01-25 | 2015-03-17 | New York University | Recombinant derivatives of botulinum neurotoxins engineered for trafficking studies and neuronal delivery |
KR20140027211A (ko) | 2011-04-04 | 2014-03-06 | 유니버시티 오브 아이오와 리써치 파운데이션 | 백신 면역원성의 개선 방법 |
RS59253B1 (sr) | 2011-05-08 | 2019-10-31 | Legochem Biosciences Inc | Konjugati aktivnog agensa proteina i postupak za njihovo dobijanje |
EA029023B1 (ru) | 2011-10-11 | 2018-01-31 | Вэксинекс, Инк. | Применение молекул, связывающих семафорин-4d, для модуляции проницаемости гематоэнцефалического барьера |
US9708601B2 (en) | 2012-04-26 | 2017-07-18 | Vaccinex, Inc. | Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus |
WO2014069682A1 (ko) * | 2012-10-29 | 2014-05-08 | 인제대학교 산학협력단 | 암 표적 항체 및 이를 포함하는 암 예방 또는 치료용 조성물 |
WO2014069681A1 (ko) * | 2012-10-29 | 2014-05-08 | 인제대학교 산학협력단 | 암 표적 항체 및 이를 포함하는 암 예방 또는 치료용 조성물 |
MX2015017485A (es) | 2013-06-25 | 2016-03-31 | Vaccinex Inc | Uso de moleculas inhibidoras de semaforina-4d en combinacion con una terapia de modulacion inmune para inhibir crecimiento tumoral y metastasis. |
CA2969463A1 (en) | 2014-12-09 | 2016-06-16 | New York University | Clostridial neurotoxin fusion proteins, propeptide fusions, their expression, and use |
EP3350595B1 (de) * | 2015-09-14 | 2021-08-04 | Leukemia Therapeutics, LLC | Identifizierung neuartiger diagnostika und therapeutika durch modulation von rhoh |
RU2759846C2 (ru) | 2016-04-22 | 2021-11-18 | Вэксинекс, Инк. | Дисплей интегрального мембранного белка на внеклеточных оболочечных вирионах поксвируса |
US10994033B2 (en) * | 2016-06-01 | 2021-05-04 | Bristol-Myers Squibb Company | Imaging methods using 18F-radiolabeled biologics |
WO2018026715A1 (en) | 2016-08-02 | 2018-02-08 | Vaccinex, Inc. | Improved methods for producing polynucleotide libraries in vaccinia virus/eukaryotic cells |
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CN1306272C (zh) * | 2000-11-17 | 2007-03-21 | 罗切斯特大学 | 筛选编码抗原特异性免疫球蛋白分子或其抗原特异性片段的方法 |
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NZ537579A (en) * | 2002-06-10 | 2006-10-27 | Vaccinex Inc | C35 peptide epitopes and their analogs |
US20050158323A1 (en) * | 2003-12-04 | 2005-07-21 | Vaccinex, Inc. | Methods of killing tumor cells by targeting internal antigens exposed on apoptotic tumor cells |
-
2004
- 2004-12-06 US US11/003,819 patent/US20050158323A1/en not_active Abandoned
- 2004-12-06 CA CA2548180A patent/CA2548180C/en not_active Expired - Fee Related
- 2004-12-06 WO PCT/US2004/040573 patent/WO2005055936A2/en active Application Filing
- 2004-12-06 JP JP2006542802A patent/JP5042631B2/ja not_active Expired - Fee Related
- 2004-12-06 AU AU2004296184A patent/AU2004296184B2/en not_active Ceased
- 2004-12-06 CN CN2004800413850A patent/CN1913921B/zh not_active Expired - Fee Related
- 2004-12-06 EP EP04812982A patent/EP1708751B1/de not_active Not-in-force
- 2004-12-06 NZ NZ547591A patent/NZ547591A/en not_active IP Right Cessation
- 2004-12-06 AT AT04812982T patent/ATE526037T1/de not_active IP Right Cessation
-
2006
- 2006-05-30 IL IL176007A patent/IL176007A/en not_active IP Right Cessation
-
2008
- 2008-05-22 US US12/125,849 patent/US20090081210A1/en not_active Abandoned
Also Published As
Publication number | Publication date |
---|---|
AU2004296184B2 (en) | 2010-12-16 |
CN1913921A (zh) | 2007-02-14 |
JP5042631B2 (ja) | 2012-10-03 |
CA2548180C (en) | 2014-02-04 |
AU2004296184A1 (en) | 2005-06-23 |
EP1708751A2 (de) | 2006-10-11 |
US20050158323A1 (en) | 2005-07-21 |
CN1913921B (zh) | 2012-02-22 |
CA2548180A1 (en) | 2005-06-23 |
EP1708751B1 (de) | 2011-09-28 |
US20090081210A1 (en) | 2009-03-26 |
WO2005055936A3 (en) | 2005-11-03 |
EP1708751A4 (de) | 2007-11-07 |
WO2005055936A2 (en) | 2005-06-23 |
NZ547591A (en) | 2009-11-27 |
IL176007A (en) | 2012-03-29 |
JP2007515165A (ja) | 2007-06-14 |
IL176007A0 (en) | 2006-10-05 |
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Date | Code | Title | Description |
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RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |