EA200701094A1 - Усовершенствованное лечение рака с применением агонистов tlr3 - Google Patents

Усовершенствованное лечение рака с применением агонистов tlr3

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Publication number
EA200701094A1
EA200701094A1 EA200701094A EA200701094A EA200701094A1 EA 200701094 A1 EA200701094 A1 EA 200701094A1 EA 200701094 A EA200701094 A EA 200701094A EA 200701094 A EA200701094 A EA 200701094A EA 200701094 A1 EA200701094 A1 EA 200701094A1
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EA
Eurasian Patent Office
Prior art keywords
cancer
improved treatment
tlr3 agonists
tlr3
present
Prior art date
Application number
EA200701094A
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English (en)
Inventor
Фабрис Андре
Лоранс Зитвогель
Жан - Кристоф Сабурен
Original Assignee
Энститю Гюстав Русси
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Publication date
Application filed by Энститю Гюстав Русси filed Critical Энститю Гюстав Русси
Publication of EA200701094A1 publication Critical patent/EA200701094A1/ru

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Abstract

Настоящее изобретение относится главным образом к области генетики и медицины. В частности, настоящее изобретение относится к усовершенствованным способам лечения раков с применением агониста TLR3 при определении экспрессии рецептора TLR3 раковыми клетками.
EA200701094A 2004-11-19 2005-11-18 Усовершенствованное лечение рака с применением агонистов tlr3 EA200701094A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
PCT/IB2004/004093 WO2006054129A1 (en) 2004-11-19 2004-11-19 Improved treatment of cancer by double-stranded rna
US11/144,322 US7378249B2 (en) 2004-11-19 2005-06-03 Treatment of cancer using TLR3 agonists
PCT/IB2005/003641 WO2006054177A1 (en) 2004-11-19 2005-11-18 Improved treatment of cancer using tlr3 agonists

Publications (1)

Publication Number Publication Date
EA200701094A1 true EA200701094A1 (ru) 2007-12-28

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EA200701094A EA200701094A1 (ru) 2004-11-19 2005-11-18 Усовершенствованное лечение рака с применением агонистов tlr3

Country Status (8)

Country Link
US (4) US7378249B2 (ru)
EP (1) EP1812570B1 (ru)
AU (1) AU2005305604B2 (ru)
BR (1) BRPI0518307A2 (ru)
CA (1) CA2587676A1 (ru)
EA (1) EA200701094A1 (ru)
MX (1) MX2007006023A (ru)
WO (2) WO2006054129A1 (ru)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2258712A3 (en) 2002-03-15 2011-05-04 Multicell Immunotherapeutics, Inc. Compositions and Methods to Initiate or Enhance Antibody and Major-histocompatibility Class I or Class II-restricted T Cell Responses by Using Immunomodulatory, Non-coding RNA Motifs
JP2006522806A (ja) * 2003-03-26 2006-10-05 マルチセル・イミュノセラピューティクス，インコーポレイテッド 細胞死及び／又はアポトーシスを誘導するための、選択されたｒｎａモチーフ
EP1689758A2 (en) * 2003-12-02 2006-08-16 Innate Pharma New class of gamma delta t cells activators and use thereof
US20100291118A1 (en) * 2003-12-02 2010-11-18 Innate Pharma Class of Gamma Delta T Cells Activators and Use Thereof
WO2006054129A1 (en) * 2004-11-19 2006-05-26 Institut Gustave Roussy Improved treatment of cancer by double-stranded rna
WO2006113679A2 (en) * 2005-04-15 2006-10-26 Board Of Regents, The University Of Texas System Delivery of sirna by neutral lipid compositions
JP2009504803A (ja) 2005-08-22 2009-02-05 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア Ｔｌｒアゴニスト
WO2007142755A2 (en) 2006-05-31 2007-12-13 The Regents Of The University Of California Purine analogs
US20100021424A1 (en) 2006-06-02 2010-01-28 Vincent Brichard Method For Identifying Whether A Patient Will Be Responder or Not to Immunotherapy
EP1881080A1 (en) * 2006-07-18 2008-01-23 Institut Gustave Roussy Toll like receptor 4 dysfunction and the biological applications thereof
CN101790380B (zh) 2007-02-07 2013-07-10 加利福尼亚大学董事会 合成tlr激动剂的缀合物及其应用
US8067390B2 (en) * 2007-03-02 2011-11-29 The Board Of Regents Of The University Of Texas System Therapeutic targeting of interleukins using siRNA in neutral liposomes
US20100183638A1 (en) * 2007-03-05 2010-07-22 Gowen Brian B Restrictive agonist of toll-like receptor 3 (tlr3)
WO2008106803A1 (en) * 2007-03-07 2008-09-12 Nventa Biopharmaceuticals Corporation Double-stranded locked nucleic acid compositions
CA2705859A1 (en) * 2007-10-15 2009-04-23 John P. Stokes Convergent well irradiating plaque for choroidal melanoma
WO2009099650A2 (en) * 2008-02-07 2009-08-13 Carson Dennis A Treatment of bladder diseases with a tlr7 activator
WO2009102496A2 (en) * 2008-02-15 2009-08-20 Hemispherx Biopharma, Inc. Selective agonist of toll-like receptor 3
WO2009126819A1 (en) * 2008-04-09 2009-10-15 Advanced Immune Therapeutics, Inc. Methods for improving the bioactivity of therapeutic ige antibodies for the treatment of disease
EP2300022A2 (en) 2008-04-25 2011-03-30 Duke University Regulatory b cells and their uses
EP2281043B1 (en) 2008-04-25 2013-03-13 Innate Pharma Improved tlr3 agonist compositions
EP2116602A1 (en) * 2008-05-07 2009-11-11 Institut Gustave Roussy Combination products for treating cancer
ATE497978T1 (de) * 2008-06-27 2011-02-15 Theranor Sprl Pharmazeutische zusammensetzungen von antikörpern von viruserkrankungen
EP2334703B1 (en) * 2008-09-17 2015-07-08 Innate Pharma Compositions and methods for detecting tlr3
US20110196020A1 (en) * 2008-10-10 2011-08-11 Carter William A Treatment of chronic fatigue syndrome using selective agonists of toll-like receptor 3 (tlr3)
US20100160413A1 (en) * 2008-10-23 2010-06-24 Hemispherx Biopharma, Inc. Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity
US8722874B2 (en) 2008-10-23 2014-05-13 Hemispherx Biopharma, Inc. Double-stranded ribonucleic acids with rugged physico-chemical structure and highly specific biologic activity
PT2340307E (pt) * 2008-10-23 2015-12-01 Hemispherx Biopharma Inc Ácidos ribonucleicos de cadeia dupla com uma estrutura físico-química robusta e uma atividade biológica altamente específica
LT3098239T (lt) * 2008-12-22 2020-02-10 Targimmune Therapeutics Ag Į egfr nukreipiamas dvigrandis rnr vektorius, skirtas sisteminiam vėžio gydymui
WO2010088924A1 (en) 2009-02-06 2010-08-12 Telormedix Sa Pharmaceutical compositions comprising imidazoquinolin(amines) and derivatives thereof suitable for local administration
BRPI1008383A2 (pt) * 2009-02-11 2016-02-23 Univ California composto, composição farmacêutica, método para prevenir, inibir ou tratar uma condição, e, uso de um composto
GB0917457D0 (en) 2009-10-06 2009-11-18 Glaxosmithkline Biolog Sa Method
CA2774999A1 (en) 2009-09-30 2011-04-07 President And Fellows Of Harvard College Methods for modulation of autophagy through the modulation of autophagy-enhancing gene products
DK2513311T4 (da) * 2009-12-18 2021-06-14 Bavarian Nordic As Produktion af ifn-lambda ved hjælp af traditionelle dendritceller og anvendelser deraf
EP3269811B1 (en) * 2010-07-28 2020-10-07 Advanced Innovation Development Co. Ltd. Nucleic acid having adjuvant activity and use thereof
US10131875B2 (en) 2010-08-04 2018-11-20 Duke University Regulatory B cells and their uses
US8217163B2 (en) * 2010-09-20 2012-07-10 Biomics Biotechnologies Co., Ltd. Application of highly conserved domain sequences from viral genome as template to design therapeutic slirnas
US9814740B2 (en) 2010-12-21 2017-11-14 Duke University Methods and compositions combining immunotherapy with monocyte activation
US8569255B2 (en) 2011-02-02 2013-10-29 Her Majesty The Queen In Right Of Canada, As Represented By The Minister Of National Defence Post-exposure therapy of influenza A infections
DK2675474T3 (en) * 2011-02-15 2019-04-23 Vaxiion Therapeutics Llc THERAPEUTIC COMPOSITIONS AND PROCEDURES FOR TARGETED ADMINISTRATION OF BIOACTIVE MOLECULES BY BACK-TERIAL MINICLES BASED ON ANTIBODY AND FC-CONTAINING TAR-GETING MOLECULES
US20130323231A1 (en) * 2011-03-31 2013-12-05 Royal College Of Surgeons In Ireland Treatment and prognosis of solid tumour cancers
EP2734237A4 (en) * 2011-07-22 2015-03-25 Pawel Kalinski TUMOR LENS CHEMOKIN MODULATION
US10017739B2 (en) 2012-09-06 2018-07-10 Duke University Methods of expanding and assessing B cells and using expanded B cells to treat disease
EP2708236A1 (en) * 2012-09-12 2014-03-19 Medizinische Universität Wien Tumor treatment
WO2014165296A1 (en) * 2013-03-12 2014-10-09 Multicell Immunotherapeutics, Inc. Methods and formulations to achieve tumor targeted double stranded rna mediated cell death
US20160184356A1 (en) * 2013-03-15 2016-06-30 Ke Jian Jim Liu Arsenic-based treatment of cancers and inflammatory disorders
KR102472590B1 (ko) 2014-05-14 2022-11-30 타르그이뮨 테라퓨틱스 아게 개선된 폴리에틸렌이민 폴리에틸렌글리콜 벡터
WO2016049677A1 (en) * 2014-10-03 2016-04-07 The Walter And Eliza Hall Institute Of Medical Research Method of treating cancer
PL3270915T3 (pl) 2015-03-16 2020-08-24 F. Hoffmann-La Roche Ag Leczenie skojarzone z zastosowaniem agonisty tlr7 i inhibitora składania kapsydu hbv
US11697851B2 (en) 2016-05-24 2023-07-11 The Regents Of The University Of California Early ovarian cancer detection diagnostic test based on mRNA isoforms
EP3321362A1 (en) * 2016-11-10 2018-05-16 Centre Leon Berard Tlr3 agonist for use for inducing apoptosis in senescent cancer cells
US20180206726A1 (en) 2016-12-07 2018-07-26 Progenity Inc. Gastrointestinal tract detection methods, devices and systems
EP3554344A1 (en) 2016-12-14 2019-10-23 Progenity, Inc. Treatment of a disease of the gastrointestinal tract with a tlr modulator
CN110248668B (zh) 2016-12-15 2023-05-30 杜克大学 用于消耗调节性b10细胞的抗体和方法以及与免疫检查点抑制剂的联用
CN112352052A (zh) * 2018-05-04 2021-02-09 托利斯有限公司 激活上皮细胞和髓样细胞的tlr3配体
WO2020030634A1 (en) 2018-08-06 2020-02-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treating cancers
WO2020232226A1 (en) 2019-05-16 2020-11-19 The Johns Hopkins University Compositions and methods for skin rejuvenation
US20220387475A1 (en) * 2019-10-22 2022-12-08 Aim Immunotech Inc. Methods and compositions for treating endometriosis
WO2021174024A1 (en) 2020-02-28 2021-09-02 First Wave Bio, Inc. Methods of treating iatrogenic autoimmune colitis
AU2021300632A1 (en) 2020-07-02 2023-02-02 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Method of achieving HIV viral remission using long-acting antiretroviral agents
WO2022189861A1 (en) * 2021-03-08 2022-09-15 Tollys Carbohydrate conjugates of tlr3 ligands and uses thereof

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3666646A (en) 1970-05-15 1972-05-30 Merck & Co Inc Reduction of molecular weight in polynucleotides using ultrasonic radiation
DE3380200D1 (en) * 1982-09-16 1989-08-24 William Alvin Carter Anti-proliferative action of dsnras on tumor cells
US5298614A (en) 1986-01-06 1994-03-29 Nippon Shinyaku Co. Ltd. Size limited double stranded poly I poly(cytidylate/4-thiouridylate)
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
PH24467A (en) * 1987-03-03 1990-07-18 Hem Res Inc Synergistics interplay of lymphokines and dsrnas
JP3040121B2 (ja) * 1988-01-12 2000-05-08 ジェネンテク，インコーポレイテッド 増殖因子レセプターの機能を阻害することにより腫瘍細胞を処置する方法
EP1798288B1 (en) 1997-05-07 2009-09-16 Schering Corporation Human Toll-like receptor proteins, related reagents and methods
CA2359674A1 (en) 1999-02-15 2000-08-17 Nippon Shinyaku Co., Ltd. Chain-shortened polynucleotide and method for preparation thereof
EP1714980A1 (en) 2000-05-25 2006-10-25 Schering Corporation Human receptor proteins, related reagents and methods
US20030165479A1 (en) 2001-03-19 2003-09-04 Velleca Mark A. Methods for isolating proteins expressed by dendritic cells
CA2461315A1 (en) 2001-10-05 2003-04-17 Coley Pharmaceutical Gmbh Toll-like receptor 3 signaling agonists and antagonists
US20040121348A1 (en) * 2001-10-26 2004-06-24 Ribopharma Ag Compositions and methods for treating pancreatic cancer
JP3810731B2 (ja) 2002-11-29 2006-08-16 独立行政法人科学技術振興機構 哺乳動物のＴｏｌｌ様受容体３に結合する新規アダプタータンパク質およびその遺伝子
AU2003287316A1 (en) 2002-12-11 2004-06-30 3M Innovative Properties Company Assays relating to toll-like receptor activity
WO2004053057A2 (en) 2002-12-11 2004-06-24 3M Innovative Properties Company Gene expression systems and recombinant cell lines
WO2004094671A2 (en) 2003-04-22 2004-11-04 Coley Pharmaceutical Gmbh Methods and products for identification and assessment of tlr ligands
WO2006010838A2 (fr) 2004-06-25 2006-02-02 Institut Gustave Roussy Produits contenant au moins un principe actif anticancereux peu diffusible et un principe actif immunostimulant
JP2008507530A (ja) 2004-07-20 2008-03-13 シェーリング　コーポレイション Ｔｏｌｌ様受容体を発現する腫瘍細胞におけるアポトーシスの誘導
WO2006054129A1 (en) * 2004-11-19 2006-05-26 Institut Gustave Roussy Improved treatment of cancer by double-stranded rna

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US7378249B2 (en) 2008-05-27
US20100266680A1 (en) 2010-10-21
MX2007006023A (es) 2008-01-14
WO2006054129A1 (en) 2006-05-26
US8409813B2 (en) 2013-04-02
WO2006054177A1 (en) 2006-05-26
US20080317811A1 (en) 2008-12-25
US20060110746A1 (en) 2006-05-25
US20080253998A1 (en) 2008-10-16
AU2005305604A1 (en) 2006-05-26
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BRPI0518307A2 (pt) 2008-11-11
AU2005305604B2 (en) 2011-05-12

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