EA200870185A1 - Комбинации ингибиторов ang2 и vegf - Google Patents

Комбинации ингибиторов ang2 и vegf

Info

Publication number
EA200870185A1
EA200870185A1 EA200870185A EA200870185A EA200870185A1 EA 200870185 A1 EA200870185 A1 EA 200870185A1 EA 200870185 A EA200870185 A EA 200870185A EA 200870185 A EA200870185 A EA 200870185A EA 200870185 A1 EA200870185 A1 EA 200870185A1
Authority
EA
Eurasian Patent Office
Prior art keywords
combination
ang2
vegf inhibitors
inhibitors
treatment
Prior art date
Application number
EA200870185A
Other languages
English (en)
Inventor
Джонатан Олинер
Ричард Кендалл
Ракеш Кумар
Original Assignee
Эмджен Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эмджен Инк. filed Critical Эмджен Инк.
Publication of EA200870185A1 publication Critical patent/EA200870185A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Изобретение предлагает способы применения ингибиторов Ang2 в комбинации с ингибиторами VEGF для лечения заболеваний. Изобретение также предлагает фармацевтические композиции, наборы и специфические подходы к лечению заболеваний, относящиеся к указанным ингибиторам.
EA200870185A 2006-01-27 2007-01-19 Комбинации ингибиторов ang2 и vegf EA200870185A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US76249306P 2006-01-27 2006-01-27
PCT/US2007/001365 WO2007089445A2 (en) 2006-01-27 2007-01-19 Ang2 and vegf inhibitor combinations

Publications (1)

Publication Number Publication Date
EA200870185A1 true EA200870185A1 (ru) 2008-12-30

Family

ID=38327861

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200870185A EA200870185A1 (ru) 2006-01-27 2007-01-19 Комбинации ингибиторов ang2 и vegf

Country Status (18)

Country Link
US (1) US20090304694A1 (ru)
EP (1) EP1976529B1 (ru)
JP (1) JP5615496B2 (ru)
KR (1) KR20080100810A (ru)
CN (1) CN101374522A (ru)
AR (1) AR059066A1 (ru)
AU (1) AU2007210234B2 (ru)
BR (1) BRPI0707173A2 (ru)
CA (1) CA2637836A1 (ru)
CR (1) CR10226A (ru)
EA (1) EA200870185A1 (ru)
ES (1) ES2441955T3 (ru)
IL (1) IL192732A0 (ru)
MX (1) MX2008009196A (ru)
NO (1) NO20083202L (ru)
PE (1) PE20081187A1 (ru)
TW (1) TW200738263A (ru)
WO (1) WO2007089445A2 (ru)

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AU2007210234A1 (en) 2007-08-09
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AR059066A1 (es) 2008-03-12
WO2007089445A2 (en) 2007-08-09
CN101374522A (zh) 2009-02-25
ES2441955T3 (es) 2014-02-07
BRPI0707173A2 (pt) 2011-04-26
NO20083202L (no) 2008-10-24
JP2009525965A (ja) 2009-07-16
EP1976529B1 (en) 2013-12-11
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CR10226A (es) 2008-10-29
WO2007089445A3 (en) 2008-04-10
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AU2007210234B2 (en) 2010-07-29
CA2637836A1 (en) 2007-08-09
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