JP2019534003A5 - - Google Patents
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- Publication number
- JP2019534003A5 JP2019534003A5 JP2019521455A JP2019521455A JP2019534003A5 JP 2019534003 A5 JP2019534003 A5 JP 2019534003A5 JP 2019521455 A JP2019521455 A JP 2019521455A JP 2019521455 A JP2019521455 A JP 2019521455A JP 2019534003 A5 JP2019534003 A5 JP 2019534003A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- adi
- nos
- antigen
- rsv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000427 antigen Substances 0.000 claims description 28
- 102000036639 antigens Human genes 0.000 claims description 28
- 108091007433 antigens Proteins 0.000 claims description 28
- 208000015181 infectious disease Diseases 0.000 claims description 25
- 241000725643 Respiratory syncytial virus Species 0.000 claims description 22
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 18
- 241000342334 Human metapneumovirus Species 0.000 claims description 15
- 239000012634 fragment Substances 0.000 claims description 15
- 230000002265 prevention Effects 0.000 claims description 15
- 241000351643 Metapneumovirus Species 0.000 claims description 12
- 208000024891 symptom Diseases 0.000 claims description 12
- 150000007523 nucleic acids Chemical group 0.000 claims description 11
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 108091028043 Nucleic acid sequence Proteins 0.000 claims description 10
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims description 9
- 229960005486 vaccine Drugs 0.000 claims description 6
- 230000001629 suppression Effects 0.000 claims description 5
- 230000003472 neutralizing effect Effects 0.000 claims description 4
- 241000712461 unidentified influenza virus Species 0.000 claims description 4
- 239000003814 drug Substances 0.000 claims description 3
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims description 2
- 108020004459 Small interfering RNA Proteins 0.000 claims description 2
- 239000003443 antiviral agent Substances 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims description 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 229940124597 therapeutic agent Drugs 0.000 claims description 2
- 108091035707 Consensus sequence Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 1
- -1 anti-RSV-G antibody Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000241 respiratory effect Effects 0.000 claims 1
- 239000013604 expression vector Substances 0.000 description 5
- 238000000034 method Methods 0.000 description 4
- 238000000338 in vitro Methods 0.000 description 2
- 229960000402 palivizumab Drugs 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 1
- 238000002955 isolation Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 239000000203 mixture Substances 0.000 description 1
- 230000009261 transgenic effect Effects 0.000 description 1
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022066241A JP2022087247A (ja) | 2016-10-21 | 2022-04-13 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| JP2023146398A JP7616813B2 (ja) | 2016-10-21 | 2023-09-08 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| JP2023146397A JP2023158193A (ja) | 2016-10-21 | 2023-09-08 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662411510P | 2016-10-21 | 2016-10-21 | |
| US62/411,510 | 2016-10-21 | ||
| PCT/US2017/057708 WO2018075954A2 (en) | 2016-10-21 | 2017-10-20 | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022066241A Division JP2022087247A (ja) | 2016-10-21 | 2022-04-13 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019534003A JP2019534003A (ja) | 2019-11-28 |
| JP2019534003A5 true JP2019534003A5 (enExample) | 2020-11-26 |
| JP7265984B2 JP7265984B2 (ja) | 2023-04-27 |
Family
ID=60263072
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019521455A Active JP7265984B2 (ja) | 2016-10-21 | 2017-10-20 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| JP2022066241A Withdrawn JP2022087247A (ja) | 2016-10-21 | 2022-04-13 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| JP2023146397A Withdrawn JP2023158193A (ja) | 2016-10-21 | 2023-09-08 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| JP2023146398A Active JP7616813B2 (ja) | 2016-10-21 | 2023-09-08 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022066241A Withdrawn JP2022087247A (ja) | 2016-10-21 | 2022-04-13 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| JP2023146397A Withdrawn JP2023158193A (ja) | 2016-10-21 | 2023-09-08 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| JP2023146398A Active JP7616813B2 (ja) | 2016-10-21 | 2023-09-08 | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (3) | US11479600B2 (enExample) |
| EP (1) | EP3529272A2 (enExample) |
| JP (4) | JP7265984B2 (enExample) |
| WO (1) | WO2018075954A2 (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11479600B2 (en) | 2016-10-21 | 2022-10-25 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| EP3974447A3 (en) | 2016-10-21 | 2022-09-07 | Adimab, LLC | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| SG11201903287PA (en) | 2016-10-21 | 2019-05-30 | Adimab Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| EP4562034A1 (en) * | 2022-07-27 | 2025-06-04 | Humabs Biomed SA | Broadly neutralizing antibodies against rsv and mpv paramyxoviruses |
| CN118108812B (zh) * | 2023-05-04 | 2025-04-15 | 国药中生生物技术研究院有限公司 | Rsv f蛋白的突变体 |
| WO2024259075A1 (en) * | 2023-06-14 | 2024-12-19 | Tether Therapeutics, Inc. | Polymer formulations for delivery of polynucleotides |
| WO2025104604A1 (en) * | 2023-11-14 | 2025-05-22 | Janssen Pharmaceuticals, Inc. | Anti-respiratory syncytial virus antibodies and uses thereof |
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| US5824307A (en) | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
| US5762905A (en) | 1992-09-16 | 1998-06-09 | The Scripps Research Institute | Human neutralizing monoclonal antibodies to respiratory syncytial virus |
| EP0724602A4 (en) | 1993-07-30 | 1998-12-23 | Oravax Inc | MONOCLONAL IgA ANTIBODIES AGAINST RESPIRATORY SYNCYTIAL VIRUS |
| US5811524A (en) | 1995-06-07 | 1998-09-22 | Idec Pharmaceuticals Corporation | Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof |
| WO1997010846A1 (en) | 1995-09-18 | 1997-03-27 | Intracel Corporation | Neutralizing monoclonal antibodies to respiratory syncytial virus |
| US20020141990A1 (en) | 1996-11-01 | 2002-10-03 | Smithkline Beecham Corporation | Anti-RSV human monoclonal antibodies |
| CN1188111C (zh) | 1999-10-29 | 2005-02-09 | 耐科塔医药公司 | 分散性得到改进的干粉组合物 |
| US6656467B2 (en) | 2000-01-27 | 2003-12-02 | Medimmune, Inc. | Ultra high affinity neutralizing antibodies |
| US7229619B1 (en) | 2000-11-28 | 2007-06-12 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
| EP2341074A1 (en) | 2000-03-01 | 2011-07-06 | MedImmune, LLC | Antibodies binding to the f protein of a respiratory syncytial virus (rsv) |
| AU2001241918A1 (en) | 2000-03-02 | 2001-09-12 | Med Immune, Inc. | Methods of enhancing activity of vaccines and vaccine compositions |
| CA2407292A1 (en) | 2000-05-03 | 2001-11-08 | Medimmune, Inc. | Combination therapy of respiratory diseases using antibodies and anti-inflammatory agents |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| US6818216B2 (en) | 2000-11-28 | 2004-11-16 | Medimmune, Inc. | Anti-RSV antibodies |
| US6855493B2 (en) | 2000-11-28 | 2005-02-15 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
| US7179900B2 (en) | 2000-11-28 | 2007-02-20 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
| US7658921B2 (en) | 2000-12-12 | 2010-02-09 | Medimmune, Llc | Molecules with extended half-lives, compositions and uses thereof |
| PT1355919E (pt) | 2000-12-12 | 2011-03-02 | Medimmune Llc | Moléculas com semivida longa, composições que as contêm e suas utilizações |
| US7425618B2 (en) | 2002-06-14 | 2008-09-16 | Medimmune, Inc. | Stabilized anti-respiratory syncytial virus (RSV) antibody formulations |
| US20040101920A1 (en) | 2002-11-01 | 2004-05-27 | Czeslaw Radziejewski | Modification assisted profiling (MAP) methodology |
| WO2010081856A1 (en) | 2009-01-14 | 2010-07-22 | Ablynx Nv | Pulmonary administration of immunoglobulin single variable domains and constructs thereof |
| WO2004091499A2 (en) | 2003-04-09 | 2004-10-28 | Neose Technologies, Inc. | Intracellular formation of peptide conjugates |
| EP1617805A4 (en) | 2003-04-11 | 2012-07-04 | Medimmune Llc | METHODS FOR PREVENTING OR TREATING RESPIRATORY CONDITIONS |
| US7070786B2 (en) | 2003-06-06 | 2006-07-04 | Centocor, Inc. | RSV proteins, antibodies, compositions, methods and uses |
| EP1740946B1 (en) | 2004-04-20 | 2013-11-06 | Genmab A/S | Human monoclonal antibodies against cd20 |
| EP1793850A4 (en) | 2004-09-21 | 2010-06-30 | Medimmune Inc | ANTIBODIES TO THE METHOD AND METHOD FOR THE PRODUCTION OF VACCINES AGAINST THE RESPIRATORY SYNCYTIAL VIRUS |
| AU2006223002A1 (en) | 2005-03-14 | 2006-09-21 | Medimmune, Llc | Macromolecules comprising a thioether cross-link |
| MY170607A (en) | 2006-09-07 | 2019-08-20 | Crucell Holland Bv | Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof |
| CN101679513A (zh) | 2007-03-06 | 2010-03-24 | 西福根有限公司 | 用于治疗呼吸道合胞病毒感染的重组抗体 |
| EP1997830A1 (en) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
| CN101821289A (zh) | 2007-09-07 | 2010-09-01 | 西福根有限公司 | 重组制造抗rsv抗体的方法 |
| WO2009042589A1 (en) | 2007-09-24 | 2009-04-02 | Vanderbilt University | Monoclonal antibodies to respiratory syncytial virus and uses thereof |
| KR100938998B1 (ko) | 2008-01-08 | 2010-01-28 | (주) 에이프로젠 | 호흡기 신시티움 바이러스에 대한 항체 |
| JP5575377B2 (ja) | 2008-07-18 | 2014-08-20 | シスメックス株式会社 | 抗ｒｓウイルスモノクローナル抗体を用いたｒｓウイルス検出用キット及びイムノクロマトグラフィー用試験具、並びに新規な抗ｒｓウイルスモノクローナル抗体 |
| MX340541B (es) | 2009-06-05 | 2016-07-13 | Alblynx Nv | Secuencias de aminoacidos mejoradas dirigidas contra virus sincitial respiratorio humano y polipeptidos que comprenden las mismas para la prevencion y/o tratamiento de infecciones del tracto respiratorio. |
| US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
| WO2011050168A2 (en) | 2009-10-21 | 2011-04-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Servic | Rsv immunogens, antibodies and compositions thereof |
| DK2950886T3 (da) * | 2013-02-01 | 2020-03-23 | Medimmune Llc | Respiratorisk syncytialvirus-f-protein-epitoper |
| TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法 |
| HK1221908A1 (zh) | 2013-04-29 | 2017-06-16 | Adimab, Llc | 多特异(polyspecificity)试剂，其制备方法和用途 |
| SI3094353T1 (sl) | 2014-01-15 | 2020-07-31 | Medimmune, Llc | RSY-specifična protitelesa in njihovi funkcionalni deli |
| SG11201703403TA (en) * | 2014-10-27 | 2017-05-30 | Agency Science Tech & Res | Anti-tim-3 antibodies |
| EP3974447A3 (en) | 2016-10-21 | 2022-09-07 | Adimab, LLC | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| US11479600B2 (en) | 2016-10-21 | 2022-10-25 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| SG11201903287PA (en) | 2016-10-21 | 2019-05-30 | Adimab Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
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2017
- 2017-10-20 US US16/343,273 patent/US11479600B2/en active Active
- 2017-10-20 JP JP2019521455A patent/JP7265984B2/ja active Active
- 2017-10-20 WO PCT/US2017/057708 patent/WO2018075954A2/en not_active Ceased
- 2017-10-20 EP EP17794544.1A patent/EP3529272A2/en active Pending
-
2022
- 2022-04-13 JP JP2022066241A patent/JP2022087247A/ja not_active Withdrawn
- 2022-09-13 US US17/931,629 patent/US12215141B2/en active Active
-
2023
- 2023-09-08 JP JP2023146397A patent/JP2023158193A/ja not_active Withdrawn
- 2023-09-08 JP JP2023146398A patent/JP7616813B2/ja active Active
-
2025
- 2025-01-09 US US19/014,419 patent/US20250313612A1/en active Pending