JP7265984B2 - 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 - Google Patents

抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 Download PDF

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JP7265984B2
JP7265984B2 JP2019521455A JP2019521455A JP7265984B2 JP 7265984 B2 JP7265984 B2 JP 7265984B2 JP 2019521455 A JP2019521455 A JP 2019521455A JP 2019521455 A JP2019521455 A JP 2019521455A JP 7265984 B2 JP7265984 B2 JP 7265984B2
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antibody
rsv
antibodies
antigen
infection
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JP2019534003A (ja
JP2019534003A5 (enExample
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ローラ エム． ウォーカー，
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アディマブ， エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/11—Paramyxoviridae (F); Pneumoviridae (F), e.g. respiratory syncytial virus [RSV]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Pulmonology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2019521455A 2016-10-21 2017-10-20 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 Active JP7265984B2 (ja)

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JP2022066241A JP2022087247A (ja) 2016-10-21 2022-04-13 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法
JP2023146397A JP2023158193A (ja) 2016-10-21 2023-09-08 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法
JP2023146398A JP7616813B2 (ja) 2016-10-21 2023-09-08 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法

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US201662411510P 2016-10-21 2016-10-21
US62/411,510 2016-10-21
PCT/US2017/057708 WO2018075954A2 (en) 2016-10-21 2017-10-20 Anti-respiratory syncytial virus antibodies, and methods of their generation and use

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JP2019534003A5 JP2019534003A5 (enExample) 2020-11-26
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JP2022066241A Withdrawn JP2022087247A (ja) 2016-10-21 2022-04-13 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法
JP2023146397A Withdrawn JP2023158193A (ja) 2016-10-21 2023-09-08 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法
JP2023146398A Active JP7616813B2 (ja) 2016-10-21 2023-09-08 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法

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JP2023146397A Withdrawn JP2023158193A (ja) 2016-10-21 2023-09-08 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法
JP2023146398A Active JP7616813B2 (ja) 2016-10-21 2023-09-08 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法

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US (3) US11479600B2 (enExample)
EP (1) EP3529272A2 (enExample)
JP (4) JP7265984B2 (enExample)
WO (1) WO2018075954A2 (enExample)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11201903287PA (en) 2016-10-21 2019-05-30 Adimab Llc Anti-respiratory syncytial virus antibodies, and methods of their generation and use
CA3040893A1 (en) 2016-10-21 2018-04-26 Adimab, Llc Anti-respiratory syncytial virus antibodies, and methods of their generation and use
US11479600B2 (en) 2016-10-21 2022-10-25 Adimab, Llc Anti-respiratory syncytial virus antibodies, and methods of their generation and use
CN112300279A (zh) * 2019-07-26 2021-02-02 上海复宏汉霖生物技术股份有限公司 针对抗cd73抗体和变体的方法和组合物
CN117136197A (zh) * 2021-02-09 2023-11-28 胡默波斯生物医学公司 抗呼吸道合胞病毒、人偏肺病毒和小鼠肺炎病毒的抗体和其使用方法
CN119264248A (zh) * 2022-07-22 2025-01-07 北京智仁美博生物科技有限公司 抗呼吸道合胞病毒中和性抗体及其用途
JP2025526405A (ja) * 2022-07-27 2025-08-13 ヒューマブス・バイオメッド・ソシエテ・アノニム Ｒｓｖ及びｍｐｖパラミクソウイルスに対する広域中和抗体
CN119546630A (zh) * 2022-12-08 2025-02-28 南京诺唯赞生物科技股份有限公司 特异性结合rsv的抗体
CN118108812B (zh) * 2023-05-04 2025-04-15 国药中生生物技术研究院有限公司 Rsv f蛋白的突变体
WO2024259075A1 (en) * 2023-06-14 2024-12-19 Tether Therapeutics, Inc. Polymer formulations for delivery of polynucleotides
WO2025104604A1 (en) * 2023-11-14 2025-05-22 Janssen Pharmaceuticals, Inc. Anti-respiratory syncytial virus antibodies and uses thereof

Family Cites Families (45)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5824307A (en) 1991-12-23 1998-10-20 Medimmune, Inc. Human-murine chimeric antibodies against respiratory syncytial virus
AU686113B2 (en) 1992-09-16 1998-02-05 Scripps Research Institute, The Human neutralizing monoclonal antibodies to respiratory syncytial virus
NZ269735A (en) 1993-07-30 1998-01-26 Oravax Inc Monoclonal iga antibody against respiratory syncytial virus (rsv)
US5811524A (en) 1995-06-07 1998-09-22 Idec Pharmaceuticals Corporation Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof
EP0853487B1 (en) 1995-09-18 2000-07-05 Intracel Corporation Neutralizing monoclonal antibodies to respiratory syncytial virus
US20020141990A1 (en) 1996-11-01 2002-10-03 Smithkline Beecham Corporation Anti-RSV human monoclonal antibodies
CN1188111C (zh) 1999-10-29 2005-02-09 耐科塔医药公司 分散性得到改进的干粉组合物
WO2001064751A2 (en) 2000-03-01 2001-09-07 Medimmune, Inc. High potency recombinant antibodies and method for producing them
ATE474854T1 (de) 2000-01-27 2010-08-15 Medimmune Llc Rsv neutralisierende antikörper mit sehr hohen affinität
US7229619B1 (en) 2000-11-28 2007-06-12 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
US6565849B2 (en) 2000-03-02 2003-05-20 Medimmune, Inc. Methods of enhancing activity of vaccines and vaccine compositions
ATE457177T1 (de) 2000-05-03 2010-02-15 Medimmune Llc Kombinationstherapie zur behandlung respiratorischer krankheiten mittels antikörper und anti-entzündungs wirkstoffe
US6596541B2 (en) 2000-10-31 2003-07-22 Regeneron Pharmaceuticals, Inc. Methods of modifying eukaryotic cells
US6855493B2 (en) 2000-11-28 2005-02-15 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
US6818216B2 (en) 2000-11-28 2004-11-16 Medimmune, Inc. Anti-RSV antibodies
US7179900B2 (en) 2000-11-28 2007-02-20 Medimmune, Inc. Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment
PT1355919E (pt) 2000-12-12 2011-03-02 Medimmune Llc Moléculas com semivida longa, composições que as contêm e suas utilizações
US7658921B2 (en) 2000-12-12 2010-02-09 Medimmune, Llc Molecules with extended half-lives, compositions and uses thereof
US7425618B2 (en) 2002-06-14 2008-09-16 Medimmune, Inc. Stabilized anti-respiratory syncytial virus (RSV) antibody formulations
US20040101920A1 (en) 2002-11-01 2004-05-27 Czeslaw Radziejewski Modification assisted profiling (MAP) methodology
WO2010081856A1 (en) 2009-01-14 2010-07-22 Ablynx Nv Pulmonary administration of immunoglobulin single variable domains and constructs thereof
WO2004091499A2 (en) 2003-04-09 2004-10-28 Neose Technologies, Inc. Intracellular formation of peptide conjugates
WO2004091519A2 (en) 2003-04-11 2004-10-28 Medimmune, Inc. Methods of preventing or treating respiratory conditions
US7070786B2 (en) 2003-06-06 2006-07-04 Centocor, Inc. RSV proteins, antibodies, compositions, methods and uses
US7850962B2 (en) 2004-04-20 2010-12-14 Genmab A/S Human monoclonal antibodies against CD20
US7700720B2 (en) 2004-09-21 2010-04-20 Medimmune, Llc Antibodies against and methods for producing vaccines for respiratory syncytial virus
JP2008536815A (ja) 2005-03-14 2008-09-11 メディミューン，エルエルシー チオエーテル架橋を含む巨大分子
CA2663388C (en) 2006-09-07 2017-01-17 Crucell Holland B.V. Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof
EP2134747A2 (en) 2007-03-06 2009-12-23 Symphogen A/S Recombinant antibodies for treatment of respiratory syncytial virus infections
EP1997830A1 (en) 2007-06-01 2008-12-03 AIMM Therapeutics B.V. RSV specific binding molecules and means for producing them
EP2185590A2 (en) 2007-09-07 2010-05-19 Symphogen A/S Methods for recombinant manufacturing of anti-rsv antibodies
WO2009042589A1 (en) 2007-09-24 2009-04-02 Vanderbilt University Monoclonal antibodies to respiratory syncytial virus and uses thereof
KR100938998B1 (ko) 2008-01-08 2010-01-28 (주) 에이프로젠 호흡기 신시티움 바이러스에 대한 항체
JP5575377B2 (ja) 2008-07-18 2014-08-20 シスメックス株式会社 抗ｒｓウイルスモノクローナル抗体を用いたｒｓウイルス検出用キット及びイムノクロマトグラフィー用試験具、並びに新規な抗ｒｓウイルスモノクローナル抗体
EP2438087B1 (en) 2009-06-05 2017-05-10 Ablynx N.V. Trivalent anti human respiratory syncytial virus (hrsv) nanobody constructs for the prevention and/or treatment of respiratory tract infections
US8568726B2 (en) 2009-10-06 2013-10-29 Medimmune Limited RSV specific binding molecule
US20120315270A1 (en) 2009-10-21 2012-12-13 The United States Of America, As Represented By The Rsv immunogens, antibodies and compositions thereof
US10016496B2 (en) 2013-02-01 2018-07-10 Medimmune, Llc Respiratory syncytial virus F protein epitopes
TWI659968B (zh) 2013-03-14 2019-05-21 再生元醫藥公司 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法
US20140323315A1 (en) 2013-04-29 2014-10-30 Adimab, Llc Polyspecificity reagents, methods for their preparation and use
CA2933200C (en) * 2014-01-15 2025-05-06 Medimmune Limited RSV-SPECIFIC ANTIBODIES AND THEIR FUNCTIONAL PARTS
CA2965960A1 (en) * 2014-10-27 2016-05-06 Agency For Science, Technology And Research Anti-tim-3 antibodies
CA3040893A1 (en) 2016-10-21 2018-04-26 Adimab, Llc Anti-respiratory syncytial virus antibodies, and methods of their generation and use
SG11201903287PA (en) 2016-10-21 2019-05-30 Adimab Llc Anti-respiratory syncytial virus antibodies, and methods of their generation and use
US11479600B2 (en) 2016-10-21 2022-10-25 Adimab, Llc Anti-respiratory syncytial virus antibodies, and methods of their generation and use

Non-Patent Citations (6)

* Cited by examiner, † Cited by third party
Title
BIRGITTE K GIERSING，VACCINE，NL，2016年04月25日，VOL:37，PAGE(S):7355 - 7362，http://dx.doi.org/10.1016/j.vaccine.2017.02.068
DAVIDE CORTI et al.，CROSS-NEUTRALIZATION OF FOUR PARAMYXOVIRUSES BY A HUMAN MONOCLONAL ANTIBODY，NATURE，2013年09月19日，VOl. 501，p. 439-443, SUPPLEMENTARY INFORMATION，http://dx.doi.org/10.1038/nature12442
JASON S MCLELLAN，NEUTRALIZING EPITOPES ON THE RESPIRATORY SYNCYTIAL VIRUS FUSION GLYCOPROTEIN，CURRENT OPINION IN VIROLOGY，英国，2015年04月01日，VOL:11，PAGE(S):70 - 75，http://dx.doi.org/10.1016/j.coviro.2015.03.002
Jiachen Huang et al.，Frontiers in Immunology，2019年11月，Vol. 10, Article 2778，p. 1-8
NGWUTA J O，PREFUSION F-SPECIFIC ANTIBODIES DETERMINE THE MAGNITUDE OF RSV NEUTRALIZING ACTIVITY IN HUMAN SERA，SCIENCE TRANSLATIONAL MEDICINE，米国，2015年10月14日，VOL:7, NR:309，PAGE(S):309RA162 (1 - 9)，http://dx.doi.org/10.1126/scitranslmed.aac4241
SCHUSTER J E，JOURNAL OF INFECTIOUS DISEASES，米国，2014年05月26日，VOL:211, NR:2，PAGE(S):216 - 225，http://dx.doi.org/10.1093/infdis/jiu307

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JP2019534003A (ja) 2019-11-28
JP7616813B2 (ja) 2025-01-17
JP2022087247A (ja) 2022-06-09
EP3529272A2 (en) 2019-08-28
JP2023158193A (ja) 2023-10-26
US20190256580A1 (en) 2019-08-22
JP2023158194A (ja) 2023-10-26
US12215141B2 (en) 2025-02-04
WO2018075954A3 (en) 2018-09-20
WO2018075954A2 (en) 2018-04-26
US20230303668A1 (en) 2023-09-28
US20250313612A1 (en) 2025-10-09
US11479600B2 (en) 2022-10-25

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