JP7265984B2 - 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 - Google Patents

抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 Download PDF

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JP7265984B2
JP7265984B2 JP2019521455A JP2019521455A JP7265984B2 JP 7265984 B2 JP7265984 B2 JP 7265984B2 JP 2019521455 A JP2019521455 A JP 2019521455A JP 2019521455 A JP2019521455 A JP 2019521455A JP 7265984 B2 JP7265984 B2 JP 7265984B2
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antibody
rsv
antibodies
antigen
infection
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JP2019534003A (ja
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ローラ エム． ウォーカー，
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アディマブ， エルエルシー
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/08—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from viruses
    • C07K16/10—RNA viruses
    • C07K16/11—Paramyxoviridae (F); Pneumoviridae (F), e.g. respiratory syncytial virus [RSV]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/42—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum viral
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Mycology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2019521455A 2016-10-21 2017-10-20 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 Active JP7265984B2 (ja)

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JP2022066241A JP2022087247A (ja) 2016-10-21 2022-04-13 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法
JP2023146398A JP7616813B2 (ja) 2016-10-21 2023-09-08 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法
JP2023146397A JP2023158193A (ja) 2016-10-21 2023-09-08 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法

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US201662411510P 2016-10-21 2016-10-21
US62/411,510 2016-10-21
PCT/US2017/057708 WO2018075954A2 (en) 2016-10-21 2017-10-20 Anti-respiratory syncytial virus antibodies, and methods of their generation and use

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JP2019534003A JP2019534003A (ja) 2019-11-28
JP2019534003A5 JP2019534003A5 (enExample) 2020-11-26
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JP2022066241A Withdrawn JP2022087247A (ja) 2016-10-21 2022-04-13 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法
JP2023146397A Withdrawn JP2023158193A (ja) 2016-10-21 2023-09-08 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法
JP2023146398A Active JP7616813B2 (ja) 2016-10-21 2023-09-08 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法

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JP2023146397A Withdrawn JP2023158193A (ja) 2016-10-21 2023-09-08 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法
JP2023146398A Active JP7616813B2 (ja) 2016-10-21 2023-09-08 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法

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US (3) US11479600B2 (enExample)
EP (1) EP3529272A2 (enExample)
JP (4) JP7265984B2 (enExample)
WO (1) WO2018075954A2 (enExample)

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CN112300279A (zh) * 2019-07-26 2021-02-02 上海复宏汉霖生物技术股份有限公司 针对抗cd73抗体和变体的方法和组合物
CN117136197A (zh) * 2021-02-09 2023-11-28 胡默波斯生物医学公司 抗呼吸道合胞病毒、人偏肺病毒和小鼠肺炎病毒的抗体和其使用方法
CN119264248A (zh) * 2022-07-22 2025-01-07 北京智仁美博生物科技有限公司 抗呼吸道合胞病毒中和性抗体及其用途
CN119836435A (zh) * 2022-07-27 2025-04-15 胡默波斯生物医学公司 抗rsv和mpv副粘病毒的广泛中和抗体
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JP2022087247A (ja) 2022-06-09
JP2019534003A (ja) 2019-11-28
EP3529272A2 (en) 2019-08-28
JP2023158194A (ja) 2023-10-26
US20190256580A1 (en) 2019-08-22
US20230303668A1 (en) 2023-09-28
US12215141B2 (en) 2025-02-04
JP2023158193A (ja) 2023-10-26
US11479600B2 (en) 2022-10-25
US20250313612A1 (en) 2025-10-09
WO2018075954A2 (en) 2018-04-26
JP7616813B2 (ja) 2025-01-17
WO2018075954A3 (en) 2018-09-20

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