JP2016512554A5 - - Google Patents
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- JP2016512554A5 JP2016512554A5 JP2016501801A JP2016501801A JP2016512554A5 JP 2016512554 A5 JP2016512554 A5 JP 2016512554A5 JP 2016501801 A JP2016501801 A JP 2016501801A JP 2016501801 A JP2016501801 A JP 2016501801A JP 2016512554 A5 JP2016512554 A5 JP 2016512554A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antibody
- seq
- binding fragment
- rsv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 239000000427 antigen Substances 0.000 claims 59
- 102000036639 antigens Human genes 0.000 claims 59
- 108091007433 antigens Proteins 0.000 claims 59
- 230000027455 binding Effects 0.000 claims 50
- 239000012634 fragment Substances 0.000 claims 49
- 125000003275 alpha amino acid group Chemical group 0.000 claims 26
- 241000725643 Respiratory syncytial virus Species 0.000 claims 24
- 241000351643 Metapneumovirus Species 0.000 claims 12
- 208000024891 symptom Diseases 0.000 claims 12
- 208000015181 infectious disease Diseases 0.000 claims 11
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 6
- 206010019280 Heart failures Diseases 0.000 claims 6
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 6
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 6
- 239000004473 Threonine Substances 0.000 claims 6
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 230000001684 chronic effect Effects 0.000 claims 6
- 229960000402 palivizumab Drugs 0.000 claims 6
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 6
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 6
- 229960005486 vaccine Drugs 0.000 claims 6
- 230000003472 neutralizing effect Effects 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 4
- 208000002330 Congenital Heart Defects Diseases 0.000 claims 4
- 201000003883 Cystic fibrosis Diseases 0.000 claims 4
- 208000000059 Dyspnea Diseases 0.000 claims 4
- 206010013975 Dyspnoeas Diseases 0.000 claims 4
- 206010062016 Immunosuppression Diseases 0.000 claims 4
- 208000019693 Lung disease Diseases 0.000 claims 4
- 208000028831 congenital heart disease Diseases 0.000 claims 4
- 230000001506 immunosuppresive effect Effects 0.000 claims 4
- 208000018360 neuromuscular disease Diseases 0.000 claims 4
- 241000712461 unidentified influenza virus Species 0.000 claims 4
- 208000037656 Respiratory Sounds Diseases 0.000 claims 3
- 241000144290 Sigmodon hispidus Species 0.000 claims 3
- 206010047924 Wheezing Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 210000004072 lung Anatomy 0.000 claims 3
- 230000002685 pulmonary effect Effects 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 2
- 206010011224 Cough Diseases 0.000 claims 2
- 208000005156 Dehydration Diseases 0.000 claims 2
- 206010021143 Hypoxia Diseases 0.000 claims 2
- 206010061598 Immunodeficiency Diseases 0.000 claims 2
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 2
- 206010028735 Nasal congestion Diseases 0.000 claims 2
- 206010037660 Pyrexia Diseases 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 230000005856 abnormality Effects 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 239000003443 antiviral agent Substances 0.000 claims 2
- 208000008784 apnea Diseases 0.000 claims 2
- 230000004596 appetite loss Effects 0.000 claims 2
- 206010061428 decreased appetite Diseases 0.000 claims 2
- 230000007547 defect Effects 0.000 claims 2
- 230000018044 dehydration Effects 0.000 claims 2
- 238000006297 dehydration reaction Methods 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 208000019622 heart disease Diseases 0.000 claims 2
- 230000007954 hypoxia Effects 0.000 claims 2
- 210000000987 immune system Anatomy 0.000 claims 2
- 230000007813 immunodeficiency Effects 0.000 claims 2
- 229960003444 immunosuppressant agent Drugs 0.000 claims 2
- 230000001861 immunosuppressant effect Effects 0.000 claims 2
- 239000003018 immunosuppressive agent Substances 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000002458 infectious effect Effects 0.000 claims 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 208000019017 loss of appetite Diseases 0.000 claims 2
- 235000021266 loss of appetite Nutrition 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229960001521 motavizumab Drugs 0.000 claims 2
- 230000003387 muscular Effects 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- 230000000241 respiratory effect Effects 0.000 claims 2
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 208000013220 shortness of breath Diseases 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 1
- 206010058314 Dysplasia Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000001668 ameliorated effect Effects 0.000 claims 1
- 238000010171 animal model Methods 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 206010006475 bronchopulmonary dysplasia Diseases 0.000 claims 1
- 210000000748 cardiovascular system Anatomy 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 230000003340 mental effect Effects 0.000 claims 1
- 230000006996 mental state Effects 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 230000003252 repetitive effect Effects 0.000 claims 1
- 208000002491 severe combined immunodeficiency Diseases 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361782215P | 2013-03-14 | 2013-03-14 | |
| US61/782,215 | 2013-03-14 | ||
| US201361911093P | 2013-12-03 | 2013-12-03 | |
| US61/911,093 | 2013-12-03 | ||
| PCT/US2014/025259 WO2014159822A2 (en) | 2013-03-14 | 2014-03-13 | Human antibodies to respiratory syncytial virus f protein and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512554A JP2016512554A (ja) | 2016-04-28 |
| JP2016512554A5 true JP2016512554A5 (enExample) | 2017-03-30 |
| JP6537492B2 JP6537492B2 (ja) | 2019-07-03 |
Family
ID=50391532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501801A Active JP6537492B2 (ja) | 2013-03-14 | 2014-03-13 | 呼吸器合胞体ウイルスｆタンパク質に対するヒト抗体及びその使用方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9447173B2 (enExample) |
| EP (1) | EP2968534B1 (enExample) |
| JP (1) | JP6537492B2 (enExample) |
| KR (1) | KR102211907B1 (enExample) |
| CN (1) | CN105050622B (enExample) |
| AU (1) | AU2014244411B2 (enExample) |
| BR (1) | BR112015019066A2 (enExample) |
| CA (1) | CA2904995A1 (enExample) |
| CL (1) | CL2015002570A1 (enExample) |
| EA (1) | EA034767B1 (enExample) |
| IL (1) | IL240067A0 (enExample) |
| MX (1) | MX360253B (enExample) |
| MY (1) | MY174772A (enExample) |
| PH (1) | PH12015501558B1 (enExample) |
| SG (2) | SG10201610336QA (enExample) |
| TW (1) | TWI659968B (enExample) |
| UY (1) | UY35416A (enExample) |
| WO (1) | WO2014159822A2 (enExample) |
| ZA (1) | ZA201504952B (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
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| TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法 |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| AU2015329936A1 (en) | 2014-10-10 | 2017-04-20 | Ablynx N.V. | Methods of treating RSV infections |
| EP3204095B8 (en) | 2014-10-10 | 2019-07-10 | Ablynx N.V. | Inhalation device for use in aerosol therapy of respiratory diseases |
| US9340604B1 (en) * | 2014-10-29 | 2016-05-17 | Aridis Pharmaceuticals, Inc. | Human monoclonal antibody specific for the F protein of respiratory syncytial virus (RSV) |
| US20180171125A1 (en) | 2015-06-25 | 2018-06-21 | Sabic Global Technologies B.V. | Polymer composition comprising linear low-density polyethylene |
| CA2991156A1 (en) * | 2015-07-02 | 2017-01-05 | Spring Bank Pharmaceuticals, Inc. | Compositions and methods for the treatment of viral infection |
| TWI870789B (zh) | 2015-08-04 | 2025-01-21 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法 |
| JO3555B1 (ar) | 2015-10-29 | 2020-07-05 | Merck Sharp & Dohme | جسم مضاد يبطل فعالية فيروس الالتهاب الرئوي البشري |
| CN106496324B (zh) * | 2015-11-30 | 2020-01-14 | 天津昊免生物技术有限公司 | 一种抗呼吸道合胞病毒的全人源抗体 |
| WO2018039499A1 (en) | 2016-08-24 | 2018-03-01 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
| CA3040886A1 (en) * | 2016-10-21 | 2018-04-26 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| US11479600B2 (en) | 2016-10-21 | 2022-10-25 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| AU2017345786B2 (en) | 2016-10-21 | 2024-08-01 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| AU2018298039B2 (en) | 2017-07-06 | 2023-02-02 | Regeneron Pharmaceuticals, Inc. | Cell culture process for making a glycoprotein |
| WO2019075433A1 (en) * | 2017-10-13 | 2019-04-18 | Adimab, Llc | ANTIBODIES AGAINST SYNCYTIAL RESPIRATORY VIRUS AND METHODS FOR THEIR GENERATION AND USE |
| AU2018392334A1 (en) | 2017-12-22 | 2020-05-28 | Regeneron Pharmaceuticals, Inc. | System and method for characterizing drug product impurities |
| US20210047390A1 (en) * | 2018-01-31 | 2021-02-18 | The Wistar Institute Of Anatomy And Biology | Nucleic acid antibody constructs for use against respiratory syncytial virus |
| SG11202005235WA (en) | 2018-01-31 | 2020-07-29 | Regeneron Pharma | System and method for characterizing size and charge variant drug product impurities |
| TWI786265B (zh) | 2018-02-02 | 2022-12-11 | 美商再生元醫藥公司 | 用於表徵蛋白質二聚合之系統及方法 |
| CN111771000A (zh) | 2018-02-28 | 2020-10-13 | 瑞泽恩制药公司 | 用于鉴定病毒污染物的系统和方法 |
| US12259355B2 (en) | 2018-03-19 | 2025-03-25 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
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| TW202016125A (zh) | 2018-05-10 | 2020-05-01 | 美商再生元醫藥公司 | 用於定量及調節蛋白質黏度之系統與方法 |
| CN112218877B (zh) | 2018-08-27 | 2025-07-25 | 瑞泽恩制药公司 | 拉曼光谱在下游纯化中的应用 |
| US11754569B2 (en) | 2018-08-30 | 2023-09-12 | Regeneron Pharmaceuticals, Inc. | Methods for characterizing protein complexes |
| US20210347885A1 (en) * | 2018-09-21 | 2021-11-11 | The University Of North Carolina At Chapel Hill | Synthetic binding agents for limiting permeation through mucus |
| WO2020124846A1 (zh) * | 2018-12-18 | 2020-06-25 | 珠海泰诺麦博生物技术有限公司 | 抗呼吸道合胞病毒的中和抗体及其应用 |
| EP3857236A1 (en) | 2019-01-16 | 2021-08-04 | Regeneron Pharmaceuticals, Inc. | Methods for identifying free thiols in proteins |
| CN111606993B (zh) * | 2019-02-26 | 2022-06-28 | 中国科学院上海生命科学研究院 | 抗呼吸道合胞病毒的全人广谱中和抗体4f1及其应用 |
| KR20220007586A (ko) | 2019-05-13 | 2022-01-18 | 리제너론 파마슈티칼스 인코포레이티드 | 개선된 경쟁적 리간드 결합 검정 |
| IL317159A (en) | 2019-09-24 | 2025-01-01 | Regeneron Pharma | Systems and methods for use in chromatography and regeneration |
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| CN114760986A (zh) | 2019-11-25 | 2022-07-15 | 里珍纳龙药品有限公司 | 使用非水性乳液的持续释放调配物 |
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| FR3114970B1 (fr) * | 2020-10-08 | 2023-06-30 | Univ Tours | Combinaison d’anticorps inhalés avec des agents immunomodulateurs pour le traitement ou la prévention d’inféctions respiratoires |
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| KR20240097864A (ko) | 2021-10-26 | 2024-06-27 | 리제너론 파마슈티칼스 인코포레이티드 | 상이한 온도에서 실험실 용수를 생성하고 실험실 용수를 분배하는 시스템 및 방법 |
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| US10016496B2 (en) | 2013-02-01 | 2018-07-10 | Medimmune, Llc | Respiratory syncytial virus F protein epitopes |
| TWI659968B (zh) | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法 |
| WO2015010792A1 (en) | 2013-07-24 | 2015-01-29 | Humabs Biomed Sa | Antibodies that potently neutralize rsv and uses thereof |
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2014
- 2014-03-12 TW TW103108584A patent/TWI659968B/zh not_active IP Right Cessation
- 2014-03-13 CN CN201480014354.XA patent/CN105050622B/zh not_active Expired - Fee Related
- 2014-03-13 UY UY0001035416A patent/UY35416A/es not_active Application Discontinuation
- 2014-03-13 WO PCT/US2014/025259 patent/WO2014159822A2/en not_active Ceased
- 2014-03-13 US US14/207,797 patent/US9447173B2/en active Active
- 2014-03-13 EA EA201591771A patent/EA034767B1/ru unknown
- 2014-03-13 MX MX2015009416A patent/MX360253B/es active IP Right Grant
- 2014-03-13 KR KR1020157021198A patent/KR102211907B1/ko not_active Expired - Fee Related
- 2014-03-13 SG SG10201610336QA patent/SG10201610336QA/en unknown
- 2014-03-13 EP EP14714125.3A patent/EP2968534B1/en active Active
- 2014-03-13 CA CA2904995A patent/CA2904995A1/en not_active Abandoned
- 2014-03-13 SG SG11201505338RA patent/SG11201505338RA/en unknown
- 2014-03-13 AU AU2014244411A patent/AU2014244411B2/en not_active Ceased
- 2014-03-13 MY MYPI2015702227A patent/MY174772A/en unknown
- 2014-03-13 BR BR112015019066A patent/BR112015019066A2/pt not_active IP Right Cessation
- 2014-03-13 JP JP2016501801A patent/JP6537492B2/ja active Active
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