JP2016512554A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2016512554A5 JP2016512554A5 JP2016501801A JP2016501801A JP2016512554A5 JP 2016512554 A5 JP2016512554 A5 JP 2016512554A5 JP 2016501801 A JP2016501801 A JP 2016501801A JP 2016501801 A JP2016501801 A JP 2016501801A JP 2016512554 A5 JP2016512554 A5 JP 2016512554A5
- Authority
- JP
- Japan
- Prior art keywords
- antigen
- antibody
- seq
- binding fragment
- rsv
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000427 antigen Substances 0.000 claims 59
- 102000036639 antigens Human genes 0.000 claims 59
- 108091007433 antigens Proteins 0.000 claims 59
- 230000027455 binding Effects 0.000 claims 50
- 239000012634 fragment Substances 0.000 claims 49
- 125000003275 alpha amino acid group Chemical group 0.000 claims 26
- 241000725643 Respiratory syncytial virus Species 0.000 claims 24
- 241000351643 Metapneumovirus Species 0.000 claims 12
- 208000024891 symptom Diseases 0.000 claims 12
- 208000015181 infectious disease Diseases 0.000 claims 11
- 206010061603 Respiratory syncytial virus infection Diseases 0.000 claims 10
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 7
- 239000000203 mixture Substances 0.000 claims 7
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 6
- 206010019280 Heart failures Diseases 0.000 claims 6
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims 6
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims 6
- 239000004473 Threonine Substances 0.000 claims 6
- 125000000539 amino acid group Chemical group 0.000 claims 6
- 230000001684 chronic effect Effects 0.000 claims 6
- 229960000402 palivizumab Drugs 0.000 claims 6
- 125000003607 serino group Chemical group [H]N([H])[C@]([H])(C(=O)[*])C(O[H])([H])[H] 0.000 claims 6
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims 6
- 229960005486 vaccine Drugs 0.000 claims 6
- 230000003472 neutralizing effect Effects 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims 4
- 208000002330 Congenital Heart Defects Diseases 0.000 claims 4
- 201000003883 Cystic fibrosis Diseases 0.000 claims 4
- 208000000059 Dyspnea Diseases 0.000 claims 4
- 206010013975 Dyspnoeas Diseases 0.000 claims 4
- 206010062016 Immunosuppression Diseases 0.000 claims 4
- 208000019693 Lung disease Diseases 0.000 claims 4
- 208000028831 congenital heart disease Diseases 0.000 claims 4
- 230000001506 immunosuppresive effect Effects 0.000 claims 4
- 208000018360 neuromuscular disease Diseases 0.000 claims 4
- 241000712461 unidentified influenza virus Species 0.000 claims 4
- 208000037656 Respiratory Sounds Diseases 0.000 claims 3
- 241000144290 Sigmodon hispidus Species 0.000 claims 3
- 206010047924 Wheezing Diseases 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 210000004072 lung Anatomy 0.000 claims 3
- 230000002685 pulmonary effect Effects 0.000 claims 3
- 229940124597 therapeutic agent Drugs 0.000 claims 3
- 230000003612 virological effect Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 208000030507 AIDS Diseases 0.000 claims 2
- 206010011224 Cough Diseases 0.000 claims 2
- 208000005156 Dehydration Diseases 0.000 claims 2
- 206010021143 Hypoxia Diseases 0.000 claims 2
- 206010061598 Immunodeficiency Diseases 0.000 claims 2
- 208000029462 Immunodeficiency disease Diseases 0.000 claims 2
- 206010028735 Nasal congestion Diseases 0.000 claims 2
- 206010037660 Pyrexia Diseases 0.000 claims 2
- 108020004459 Small interfering RNA Proteins 0.000 claims 2
- 230000005856 abnormality Effects 0.000 claims 2
- 239000002671 adjuvant Substances 0.000 claims 2
- 239000003443 antiviral agent Substances 0.000 claims 2
- 208000008784 apnea Diseases 0.000 claims 2
- 230000004596 appetite loss Effects 0.000 claims 2
- 206010061428 decreased appetite Diseases 0.000 claims 2
- 230000007547 defect Effects 0.000 claims 2
- 230000018044 dehydration Effects 0.000 claims 2
- 238000006297 dehydration reaction Methods 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 208000019622 heart disease Diseases 0.000 claims 2
- 230000007954 hypoxia Effects 0.000 claims 2
- 210000000987 immune system Anatomy 0.000 claims 2
- 230000007813 immunodeficiency Effects 0.000 claims 2
- 229960003444 immunosuppressant agent Drugs 0.000 claims 2
- 230000001861 immunosuppressant effect Effects 0.000 claims 2
- 239000003018 immunosuppressive agent Substances 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 230000002458 infectious effect Effects 0.000 claims 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 208000019017 loss of appetite Diseases 0.000 claims 2
- 235000021266 loss of appetite Nutrition 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 229960001521 motavizumab Drugs 0.000 claims 2
- 230000003387 muscular Effects 0.000 claims 2
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 2
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 150000007523 nucleic acids Chemical class 0.000 claims 2
- 238000001959 radiotherapy Methods 0.000 claims 2
- 230000000241 respiratory effect Effects 0.000 claims 2
- 230000029058 respiratory gaseous exchange Effects 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- 208000013220 shortness of breath Diseases 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 claims 1
- 206010058314 Dysplasia Diseases 0.000 claims 1
- 241000700605 Viruses Species 0.000 claims 1
- 230000001668 ameliorated effect Effects 0.000 claims 1
- 238000010171 animal model Methods 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 206010006475 bronchopulmonary dysplasia Diseases 0.000 claims 1
- 210000000748 cardiovascular system Anatomy 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000036039 immunity Effects 0.000 claims 1
- 230000002163 immunogen Effects 0.000 claims 1
- 230000003340 mental effect Effects 0.000 claims 1
- 230000006996 mental state Effects 0.000 claims 1
- 210000000653 nervous system Anatomy 0.000 claims 1
- 230000003252 repetitive effect Effects 0.000 claims 1
- 208000002491 severe combined immunodeficiency Diseases 0.000 claims 1
- 230000009870 specific binding Effects 0.000 claims 1
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361782215P | 2013-03-14 | 2013-03-14 | |
| US61/782,215 | 2013-03-14 | ||
| US201361911093P | 2013-12-03 | 2013-12-03 | |
| US61/911,093 | 2013-12-03 | ||
| PCT/US2014/025259 WO2014159822A2 (en) | 2013-03-14 | 2014-03-13 | Human antibodies to respiratory syncytial virus f protein and methods of use thereof |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016512554A JP2016512554A (ja) | 2016-04-28 |
| JP2016512554A5 true JP2016512554A5 (enExample) | 2017-03-30 |
| JP6537492B2 JP6537492B2 (ja) | 2019-07-03 |
Family
ID=50391532
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016501801A Active JP6537492B2 (ja) | 2013-03-14 | 2014-03-13 | 呼吸器合胞体ウイルスｆタンパク質に対するヒト抗体及びその使用方法 |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US9447173B2 (enExample) |
| EP (1) | EP2968534B1 (enExample) |
| JP (1) | JP6537492B2 (enExample) |
| KR (1) | KR102211907B1 (enExample) |
| CN (1) | CN105050622B (enExample) |
| AU (1) | AU2014244411B2 (enExample) |
| BR (1) | BR112015019066A2 (enExample) |
| CA (1) | CA2904995A1 (enExample) |
| CL (1) | CL2015002570A1 (enExample) |
| EA (1) | EA034767B1 (enExample) |
| IL (1) | IL240067A0 (enExample) |
| MX (1) | MX360253B (enExample) |
| MY (1) | MY174772A (enExample) |
| PH (1) | PH12015501558B1 (enExample) |
| SG (2) | SG11201505338RA (enExample) |
| TW (1) | TWI659968B (enExample) |
| UY (1) | UY35416A (enExample) |
| WO (1) | WO2014159822A2 (enExample) |
| ZA (1) | ZA201504952B (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI659968B (zh) * | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法 |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| CN107206069A (zh) | 2014-10-10 | 2017-09-26 | 埃博灵克斯股份有限公司 | Rsv感染的治疗 |
| CA2963030C (en) | 2014-10-10 | 2021-07-13 | Vectura Gmbh | Inhalation device for use in aerosol therapy of respiratory diseases |
| US9340604B1 (en) * | 2014-10-29 | 2016-05-17 | Aridis Pharmaceuticals, Inc. | Human monoclonal antibody specific for the F protein of respiratory syncytial virus (RSV) |
| US20180171125A1 (en) | 2015-06-25 | 2018-06-21 | Sabic Global Technologies B.V. | Polymer composition comprising linear low-density polyethylene |
| KR20180074654A (ko) * | 2015-07-02 | 2018-07-03 | 스프링 뱅크 파마슈티칼스, 인크. | 바이러스 감염의 치료를 위한 조성물 및 방법 |
| TW202440904A (zh) | 2015-08-04 | 2024-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法（二） |
| JO3555B1 (ar) | 2015-10-29 | 2020-07-05 | Merck Sharp & Dohme | جسم مضاد يبطل فعالية فيروس الالتهاب الرئوي البشري |
| CN106496324B (zh) * | 2015-11-30 | 2020-01-14 | 天津昊免生物技术有限公司 | 一种抗呼吸道合胞病毒的全人源抗体 |
| WO2018039499A1 (en) | 2016-08-24 | 2018-03-01 | Regeneron Pharmaceuticals, Inc. | Host cell protein modification |
| SG11201903287PA (en) * | 2016-10-21 | 2019-05-30 | Adimab Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| US11479600B2 (en) | 2016-10-21 | 2022-10-25 | Adimab, Llc | Anti-respiratory syncytial virus antibodies, and methods of their generation and use |
| JP2020503843A (ja) | 2016-10-21 | 2020-02-06 | アディマブ， エルエルシー | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 |
| US10259865B2 (en) | 2017-03-15 | 2019-04-16 | Adma Biologics, Inc. | Anti-pneumococcal hyperimmune globulin for the treatment and prevention of pneumococcal infection |
| KR20250041082A (ko) | 2017-07-06 | 2025-03-25 | 리제너론 파마슈티칼스 인코포레이티드 | 당단백질을 만들기 위한 세포 배양 과정 |
| EP3695003A4 (en) * | 2017-10-13 | 2021-12-22 | Adimab, LLC | ANTIBODIES TO RESPIRATORY SYNCYTIAL VIRUS AND METHOD OF GENERATING AND USING THEREOF |
| EP3727629A1 (en) | 2017-12-22 | 2020-10-28 | Regeneron Pharmaceuticals, Inc. | System and method for characterizing drug product impurities |
| MX2020008062A (es) * | 2018-01-31 | 2020-12-03 | Wistar Inst | Constructos de ácido nucleico de anticuerpos para usar contra el virus sincicial respiratorio. |
| JP7349998B2 (ja) | 2018-01-31 | 2023-09-25 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | サイズバリアントおよび電荷バリアントである薬物製品不純物を特徴解析するためのシステムおよび方法 |
| TW202311746A (zh) | 2018-02-02 | 2023-03-16 | 美商再生元醫藥公司 | 用於表徵蛋白質二聚合之系統及方法 |
| JP2021514609A (ja) | 2018-02-28 | 2021-06-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ウイルス混入物質を同定するためのシステムおよび方法 |
| MY202358A (en) | 2018-03-19 | 2024-04-24 | Regeneron Pharma | Microchip capillary electrophoresis assays and reagents |
| US12259355B2 (en) | 2018-03-19 | 2025-03-25 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| US12253490B2 (en) | 2018-03-19 | 2025-03-18 | Regeneron Pharmaceuticals, Inc. | Microchip capillary electrophoresis assays and reagents |
| TW202016125A (zh) | 2018-05-10 | 2020-05-01 | 美商再生元醫藥公司 | 用於定量及調節蛋白質黏度之系統與方法 |
| EP3774841A1 (en) | 2018-08-27 | 2021-02-17 | Regeneron Pharmaceuticals, Inc. | Use of raman spectroscopy in downstream purification |
| CA3100038A1 (en) | 2018-08-30 | 2020-03-05 | Regeneron Pharmaceuticals, Inc. | Methods for characterizing protein complexes |
| WO2020061560A1 (en) * | 2018-09-21 | 2020-03-26 | The University Of North Carolina At Chapel Hill | Synthetic binding agents for limiting permeation through mucus |
| CN110016079B (zh) * | 2018-12-18 | 2019-12-24 | 珠海泰诺麦博生物技术有限公司 | 抗呼吸道合胞病毒的中和抗体及其应用 |
| BR112021009543A2 (pt) | 2019-01-16 | 2021-08-17 | Regeneron Pharmaceuticals, Inc. | métodos para identificar tióis livres em um medicamento de proteína, de identificação de heterogeneidade de dissulfeto em um medicamento de proteína e para selecionar um medicamento de proteína, e, composição farmacêutica |
| CN111606993B (zh) * | 2019-02-26 | 2022-06-28 | 中国科学院上海生命科学研究院 | 抗呼吸道合胞病毒的全人广谱中和抗体4f1及其应用 |
| SG11202110911RA (en) | 2019-05-13 | 2021-10-28 | Regeneron Pharma | Improved competitive ligand binding assays |
| PH12022550630A1 (en) | 2019-09-24 | 2023-03-27 | Regeneron Pharma | Systems and methods for chromatography use and regeneration |
| US12297451B1 (en) | 2019-10-25 | 2025-05-13 | Regeneron Pharmaceuticals, Inc. | Cell culture medium |
| US11730793B2 (en) | 2019-11-25 | 2023-08-22 | Regeneron Pharmaceuticals, Inc. | Sustained release formulations using non-aqueous emulsions |
| WO2021150558A1 (en) | 2020-01-21 | 2021-07-29 | Regeneron Pharmaceuticals, Inc. | Deglycosylation methods for electrophoresis of glycosylated proteins |
| BR112023003273A2 (pt) | 2020-08-31 | 2023-05-02 | Regeneron Pharma | Estratégias de alimentação de asparagina para melhorar desempenho da cultura celular e mitigar variantes da sequência de asparagina |
| FR3114970B1 (fr) * | 2020-10-08 | 2023-06-30 | Univ Tours | Combinaison d’anticorps inhalés avec des agents immunomodulateurs pour le traitement ou la prévention d’inféctions respiratoires |
| US12239687B2 (en) | 2020-11-25 | 2025-03-04 | Regeneron Pharmaceuticals, Inc. | Sustained release formulations using non-aqueous membrane emulsification |
| KR20230121854A (ko) | 2020-12-17 | 2023-08-21 | 리제너론 파아마슈티컬스, 인크. | 단백질-캡슐화 마이크로겔의 제작 |
| AU2022209730A1 (en) | 2021-01-20 | 2023-07-13 | Regeneron Pharmaceuticals, Inc. | Methods of improving protein titer in cell culture |
| BR112023017442A2 (pt) | 2021-03-03 | 2023-09-26 | Regeneron Pharma | Métodos para identificar regiões em uma proteína e para modificar a viscosidade de uma droga proteica, e, droga proteica |
| KR20230162932A (ko) | 2021-03-26 | 2023-11-29 | 리제너론 파아마슈티컬스, 인크. | 혼합 프로토콜 개발을 위한 방법 및 시스템 |
| EP4348234A1 (en) | 2021-06-01 | 2024-04-10 | Regeneron Pharmaceuticals, Inc. | Micropchip capillary electrophoresis assays and reagents |
| WO2023039457A1 (en) | 2021-09-08 | 2023-03-16 | Regeneron Pharmaceuticals, Inc. | A high-throughput and mass-spectrometry-based method for quantitating antibodies and other fc-containing proteins |
| EP4405390A1 (en) | 2021-09-20 | 2024-07-31 | Regeneron Pharmaceuticals, Inc. | Methods of controlling antibody heterogeneity |
| WO2023059803A1 (en) | 2021-10-07 | 2023-04-13 | Regeneron Pharmaceuticals, Inc. | Ph meter calibration and correction |
| CA3230984A1 (en) | 2021-10-07 | 2023-04-13 | Ross BROWNE | Systems and methods of ph modeling and control |
| IL312372A (en) | 2021-10-26 | 2024-06-01 | Regeneron Pharma | Systems and methods for producing laboratory water and dispersing laboratory water at different temperatures |
| KR20240164561A (ko) | 2022-03-18 | 2024-11-19 | 리제너론 파아마슈티컬스, 인크. | 폴리펩타이드 변종을 분석하기 위한 방법 및 시스템 |
| JP2026500269A (ja) | 2022-12-16 | 2026-01-06 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | クロマトグラフィーカラムの完全性を評価するための方法及びシステム |
| US20240245779A1 (en) | 2023-01-25 | 2024-07-25 | Regeneron Pharmaceuticals, Inc. | Methods of modeling liquid protein composition stability |
| WO2024158961A1 (en) | 2023-01-25 | 2024-08-02 | Regeneron Pharmaceuticals, Inc. | Mass spectrometry-based characterization of antibodies co-expressed in vivo |
| WO2024163708A1 (en) | 2023-02-01 | 2024-08-08 | Regeneron Pharmaceuticals, Inc. | Asymmetrical flow field-flow fractionation with mass spectrometry for biomacromolecule analysis |
| TW202446462A (zh) | 2023-02-22 | 2024-12-01 | 美商再生元醫藥公司 | 系統適用性參數及管柱老化 |
| TW202508625A (zh) | 2023-05-01 | 2025-03-01 | 美商再生元醫藥公司 | 使用苯酚或苯甲醇之多劑量抗體藥物產品 |
| WO2025054406A1 (en) | 2023-09-08 | 2025-03-13 | Regeneron Pharmaceuticals, Inc. | Methods and systems for assessing chromatographic column integrity |
| WO2025064403A2 (en) | 2023-09-18 | 2025-03-27 | Regeneron Pharmaceuticals, Inc. | Methods and systems for developing chromatography protocols |
| US20250109905A1 (en) | 2023-09-29 | 2025-04-03 | Regeneron Pharmaceuticals, Inc. | Lyophilization using controlled nucleation |
| US20250129117A1 (en) | 2023-10-18 | 2025-04-24 | Regeneron Pharmaceuticals, Inc. | Rapid purification of monoclonal antibody from in-process upstream cell culture material |
| TW202535934A (zh) | 2023-11-02 | 2025-09-16 | 美商再生元醫藥公司 | 利用應力來降低脂酶活性的方法 |
| WO2025104604A1 (en) | 2023-11-14 | 2025-05-22 | Janssen Pharmaceuticals, Inc. | Anti-respiratory syncytial virus antibodies and uses thereof |
| WO2025166281A1 (en) | 2024-02-01 | 2025-08-07 | Regeneron Pharmaceuticals, Inc. | Platform for charge-detection mass spectrometry analysis of aavs |
| WO2025175164A1 (en) | 2024-02-16 | 2025-08-21 | Regeneron Pharmaceuticals, Inc. | Methods of producing concentrated formulated drug substances comprising proteins, and concentrated formulated drug substance made by the methods |
| WO2025194126A1 (en) * | 2024-03-15 | 2025-09-18 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Respiratory syncytial virus (rsv) g and f antibodies with high rsv-neutralizing potency |
| WO2025194043A1 (en) | 2024-03-15 | 2025-09-18 | Regeneron Pharmaceuticals, Inc. | Polysorbate and polyoxyethylene sorbitan as excipients for stable protein formulations |
| WO2025259840A1 (en) | 2024-06-13 | 2025-12-18 | Regeneron Pharmaceuticals, Inc. | Methods and systems for scaled chromatography |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5824307A (en) | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
| WO1994006448A1 (en) | 1992-09-16 | 1994-03-31 | The Scripps Research Institute | Human neutralizing monoclonal antibodies to respiratory syncytial virus |
| US5811524A (en) | 1995-06-07 | 1998-09-22 | Idec Pharmaceuticals Corporation | Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof |
| CA2230127A1 (en) | 1995-09-18 | 1997-03-27 | Intracel Corporation | Neutralizing monoclonal antibodies to respiratory syncytial virus |
| AR030019A1 (es) | 1999-05-18 | 2003-08-13 | Smithkline Beecham Corp | Anticuerpos monoclonales humanos y fragmentos funcionales del mismo, un procedimiento para su produccion, composiciones farmaceuticas que los comprenden, una molecula aislada de acido nucleico, un plasmido recombinante, una celula hospedante y el uso de dichos anticuerpos para la manufactura de un m |
| US6750008B1 (en) * | 1999-07-09 | 2004-06-15 | Trimeris, Inc. | Methods and compositions for inhibition of membrane fusion-associated events, including HIV transmission |
| CA2398466A1 (en) | 2000-01-27 | 2001-08-02 | Medimmune, Inc. | Ultra high affinity neutralizing antibodies |
| EP1259547B1 (en) | 2000-03-01 | 2012-07-11 | Medimmune, Inc. | High potency recombinant antibodies and method for producing them |
| US6855493B2 (en) * | 2000-11-28 | 2005-02-15 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
| WO2006041970A2 (en) | 2004-10-08 | 2006-04-20 | Abbott Biotechnology Ltd. | Treatment of respiratory syncytial virus (rsv) infection |
| KR20080113223A (ko) | 2006-03-06 | 2008-12-29 | 심포젠 에이/에스 | 호흡기세포 융합 바이러스 감염 치료용 재조합 폴리클로날 항체 |
| EP1997830A1 (en) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
| US7736648B2 (en) | 2007-10-25 | 2010-06-15 | Trellis Bioscience, Inc. | Anti-RSV G protein antibodies |
| WO2010087927A2 (en) * | 2009-02-02 | 2010-08-05 | Medimmune, Llc | Antibodies against and methods for producing vaccines for respiratory syncytial virus |
| WO2011008974A2 (en) | 2009-07-15 | 2011-01-20 | Novartis Ag | Rsv f protein compositions and methods for making same |
| PL2464664T3 (pl) | 2009-08-13 | 2016-02-29 | Crucell Holland Bv | Przeciwciała przeciwko ludzkiemu syncytialnemu wirusowi oddechowemu (RSV) i sposoby zastosowania |
| US20110097358A1 (en) | 2009-10-12 | 2011-04-28 | Techno Vax, Inc. | RESPIRATORY SYNCYTIAL VIRUS (RSV) VIRUS-LIKE PARTICLES (VLPs) |
| CN102850454B (zh) * | 2011-09-27 | 2014-06-25 | 上海博沃生物科技有限公司 | 抗呼吸道合胞病毒的人单克隆抗体 |
| DK2828293T3 (en) | 2012-03-20 | 2018-01-08 | Humabs Biomed S A | ANTIBODIES NEUTRALIZING RSV, MPV AND PVM AND USE THEREOF |
| JP6450688B2 (ja) | 2013-02-01 | 2019-01-09 | メディミューン，エルエルシー | 呼吸器合胞体ウイルスｆタンパク質エピトープ |
| TWI659968B (zh) * | 2013-03-14 | 2019-05-21 | 再生元醫藥公司 | 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法 |
| US10047145B2 (en) | 2013-07-24 | 2018-08-14 | Humabs Biomed Sa | Antibodies that potently neutralize RSV and uses thereof |
-
2014
- 2014-03-12 TW TW103108584A patent/TWI659968B/zh not_active IP Right Cessation
- 2014-03-13 EA EA201591771A patent/EA034767B1/ru unknown
- 2014-03-13 EP EP14714125.3A patent/EP2968534B1/en active Active
- 2014-03-13 SG SG11201505338RA patent/SG11201505338RA/en unknown
- 2014-03-13 MY MYPI2015702227A patent/MY174772A/en unknown
- 2014-03-13 JP JP2016501801A patent/JP6537492B2/ja active Active
- 2014-03-13 KR KR1020157021198A patent/KR102211907B1/ko not_active Expired - Fee Related
- 2014-03-13 BR BR112015019066A patent/BR112015019066A2/pt not_active IP Right Cessation
- 2014-03-13 AU AU2014244411A patent/AU2014244411B2/en not_active Ceased
- 2014-03-13 CN CN201480014354.XA patent/CN105050622B/zh not_active Expired - Fee Related
- 2014-03-13 MX MX2015009416A patent/MX360253B/es active IP Right Grant
- 2014-03-13 CA CA2904995A patent/CA2904995A1/en not_active Abandoned
- 2014-03-13 SG SG10201610336QA patent/SG10201610336QA/en unknown
- 2014-03-13 WO PCT/US2014/025259 patent/WO2014159822A2/en not_active Ceased
- 2014-03-13 US US14/207,797 patent/US9447173B2/en active Active
- 2014-03-13 UY UY0001035416A patent/UY35416A/es not_active Application Discontinuation
-
2015
- 2015-07-09 ZA ZA2015/04952A patent/ZA201504952B/en unknown
- 2015-07-13 PH PH12015501558A patent/PH12015501558B1/en unknown
- 2015-07-21 IL IL240067A patent/IL240067A0/en unknown
- 2015-09-10 CL CL2015002570A patent/CL2015002570A1/es unknown
-
2016
- 2016-08-05 US US15/229,567 patent/US10125188B2/en active Active
-
2018
- 2018-10-15 US US16/160,374 patent/US20190031741A1/en not_active Abandoned
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2016512554A5 (enExample) | ||
| JP2010528601A5 (enExample) | ||
| TWI659968B (zh) | 針對呼吸道融合病毒ｆ蛋白質的人類抗體及其使用方法 | |
| JP5734988B2 (ja) | Ｒｓｖ特異的結合分子 | |
| RU2015136392A (ru) | Композиции и способы, основанные на нейтрализующих антителах, доставляемых интраназально, для улучшенной терапевтической эффективности | |
| JP2020518599A5 (enExample) | ||
| Mejias et al. | Development and clinical applications of novel antibodies for prevention and treatment of respiratory syncytial virus infection | |
| Verwey et al. | Review and update of active and passive immunization against respiratory syncytial virus | |
| JP2012504955A5 (enExample) | ||
| JP2011528902A5 (enExample) | ||
| JP2022028898A (ja) | 抗呼吸器合胞体ウイルス抗体、及び、それらの生成及び使用の方法 | |
| JP2018506966A5 (enExample) | ||
| JP2018535650A5 (enExample) | ||
| JP2011155980A5 (enExample) | ||
| JP2019534003A5 (enExample) | ||
| JP2017507139A5 (enExample) | ||
| JP2014500009A5 (enExample) | ||
| JP2012525128A5 (enExample) | ||
| JP2015522252A5 (enExample) | ||
| JP2013543384A5 (enExample) | ||
| JP2019531293A5 (enExample) | ||
| Diethelm-Varela et al. | New developments and challenges in antibody-based therapies for the respiratory syncytial virus | |
| Li et al. | Vaccine and therapeutic agents against the respiratory syncytial virus: resolved and unresolved issue | |
| Bergeron et al. | Immunogenicity and protective efficacy of an RSV G S177Q central conserved domain nanoparticle vaccine | |
| JP2012510814A5 (enExample) |