|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
US4275149A
(en)
|
1978-11-24 |
1981-06-23 |
Syva Company |
Macromolecular environment control in specific receptor assays
|
|
US4318980A
(en)
|
1978-04-10 |
1982-03-09 |
Miles Laboratories, Inc. |
Heterogenous specific binding assay employing a cycling reactant as label
|
|
JPS6023084B2
(ja)
|
1979-07-11 |
1985-06-05 |
味の素株式会社 |
代用血液
|
|
WO1981001145A1
(en)
|
1979-10-18 |
1981-04-30 |
Univ Illinois |
Hydrolytic enzyme-activatible pro-drugs
|
|
US4419446A
(en)
|
1980-12-31 |
1983-12-06 |
The United States Of America As Represented By The Department Of Health And Human Services |
Recombinant DNA process utilizing a papilloma virus DNA as a vector
|
|
US4485045A
(en)
|
1981-07-06 |
1984-11-27 |
Research Corporation |
Synthetic phosphatidyl cholines useful in forming liposomes
|
|
NZ201705A
(en)
|
1981-08-31 |
1986-03-14 |
Genentech Inc |
Recombinant dna method for production of hepatitis b surface antigen in yeast
|
|
US4640835A
(en)
|
1981-10-30 |
1987-02-03 |
Nippon Chemiphar Company, Ltd. |
Plasminogen activator derivatives
|
|
US4741900A
(en)
|
1982-11-16 |
1988-05-03 |
Cytogen Corporation |
Antibody-metal ion complexes
|
|
US4601978A
(en)
|
1982-11-24 |
1986-07-22 |
The Regents Of The University Of California |
Mammalian metallothionein promoter system
|
|
US4560655A
(en)
|
1982-12-16 |
1985-12-24 |
Immunex Corporation |
Serum-free cell culture medium and process for making same
|
|
US4657866A
(en)
|
1982-12-21 |
1987-04-14 |
Sudhir Kumar |
Serum-free, synthetic, completely chemically defined tissue culture media
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
DD266710A3
(de)
|
1983-06-06 |
1989-04-12 |
Ve Forschungszentrum Biotechnologie |
Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
|
|
US4544545A
(en)
|
1983-06-20 |
1985-10-01 |
Trustees University Of Massachusetts |
Liposomes containing modified cholesterol for organ targeting
|
|
US4767704A
(en)
|
1983-10-07 |
1988-08-30 |
Columbia University In The City Of New York |
Protein-free culture medium
|
|
US4496689A
(en)
|
1983-12-27 |
1985-01-29 |
Miles Laboratories, Inc. |
Covalently attached complex of alpha-1-proteinase inhibitor with a water soluble polymer
|
|
US4965199A
(en)
|
1984-04-20 |
1990-10-23 |
Genentech, Inc. |
Preparation of functional human factor VIII in mammalian cells using methotrexate based selection
|
|
US4879231A
(en)
|
1984-10-30 |
1989-11-07 |
Phillips Petroleum Company |
Transformation of yeasts of the genus pichia
|
|
US4737456A
(en)
|
1985-05-09 |
1988-04-12 |
Syntex (U.S.A.) Inc. |
Reducing interference in ligand-receptor binding assays
|
|
EP0206448B1
(en)
|
1985-06-19 |
1990-11-14 |
Ajinomoto Co., Inc. |
Hemoglobin combined with a poly(alkylene oxide)
|
|
GB8516415D0
(en)
|
1985-06-28 |
1985-07-31 |
Celltech Ltd |
Culture of animal cells
|
|
US4927762A
(en)
|
1986-04-01 |
1990-05-22 |
Cell Enterprises, Inc. |
Cell culture medium with antioxidant
|
|
GB8610600D0
(en)
|
1986-04-30 |
1986-06-04 |
Novo Industri As |
Transformation of trichoderma
|
|
US4791192A
(en)
|
1986-06-26 |
1988-12-13 |
Takeda Chemical Industries, Ltd. |
Chemically modified protein with polyethyleneglycol
|
|
GB8705477D0
(en)
|
1987-03-09 |
1987-04-15 |
Carlton Med Prod |
Drug delivery systems
|
|
US4975278A
(en)
|
1988-02-26 |
1990-12-04 |
Bristol-Myers Company |
Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells
|
|
DE68925971T2
(de)
|
1988-09-23 |
1996-09-05 |
Cetus Oncology Corp |
Zellenzuchtmedium für erhöhtes zellenwachstum, zur erhöhung der langlebigkeit und expression der produkte
|
|
FR2646437B1
(fr)
|
1989-04-28 |
1991-08-30 |
Transgene Sa |
Nouvelles sequences d'adn, leur application en tant que sequence codant pour un peptide signal pour la secretion de proteines matures par des levures recombinantes, cassettes d'expression, levures transformees et procede de preparation de proteines correspondant
|
|
EP0402226A1
(en)
|
1989-06-06 |
1990-12-12 |
Institut National De La Recherche Agronomique |
Transformation vectors for yeast yarrowia
|
|
US5013556A
(en)
|
1989-10-20 |
1991-05-07 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5122469A
(en)
|
1990-10-03 |
1992-06-16 |
Genentech, Inc. |
Method for culturing Chinese hamster ovary cells to improve production of recombinant proteins
|
|
WO1994004679A1
(en)
|
1991-06-14 |
1994-03-03 |
Genentech, Inc. |
Method for making humanized antibodies
|
|
EP0940468A1
(en)
|
1991-06-14 |
1999-09-08 |
Genentech, Inc. |
Humanized antibody variable domain
|
|
DK0656789T3
(da)
|
1992-08-21 |
1998-08-24 |
Genentech Inc |
Fremgangsmåde til behandling af en LFA-1-medieretforstyrrelse.
|
|
EP1005870B1
(en)
|
1992-11-13 |
2009-01-21 |
Biogen Idec Inc. |
Therapeutic application of chimeric antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma
|
|
US6096871A
(en)
|
1995-04-14 |
2000-08-01 |
Genentech, Inc. |
Polypeptides altered to contain an epitope from the Fc region of an IgG molecule for increased half-life
|
|
US6037454A
(en)
|
1996-11-27 |
2000-03-14 |
Genentech, Inc. |
Humanized anti-CD11a antibodies
|
|
US5888809A
(en)
|
1997-05-01 |
1999-03-30 |
Icos Corporation |
Hamster EF-1α transcriptional regulatory DNA
|
|
CO4810232A1
(es)
|
1997-07-25 |
1999-06-30 |
Schering Corp |
Citoquinas de mamiferos y sus secuencias codificadoras
|
|
US6060284A
(en)
|
1997-07-25 |
2000-05-09 |
Schering Corporation |
DNA encoding interleukin-B30
|
|
AU2661199A
(en)
|
1998-02-06 |
1999-08-23 |
Schering Corporation |
Mammalian receptor proteins; related reagents and methods
|
|
DE69942607D1
(de)
|
1998-04-14 |
2010-09-02 |
Chugai Pharmaceutical Co Ltd |
Neues cytokinartiges protein
|
|
US7090847B1
(en)
|
1999-09-09 |
2006-08-15 |
Schering Corporation |
Mammalian cytokines; related reagents and methods
|
|
HK1044170B
(en)
|
1999-09-09 |
2008-08-01 |
Merck Sharp & Dohme Corp. |
Mammalian interleukin-12 p40 and interleukin b30. combinations thereof. antibodies. uses in pharmaceutical compositions
|
|
CZ304022B6
(cs)
|
2000-05-10 |
2013-08-28 |
Merck Sharp & Dohme Corp. |
Savcí receptorové proteiny, cinidla a metody, které se jich týkají
|
|
US7422743B2
(en)
|
2000-05-10 |
2008-09-09 |
Schering Corporation |
Mammalian receptor protein DCRS5;methods of treatment
|
|
US20050039222A1
(en)
|
2001-10-24 |
2005-02-17 |
Kiyoshi Habu |
Sgrf gene-modified non-human animals
|
|
IL161677A0
(en)
|
2001-11-08 |
2004-09-27 |
Protein Design Labs |
Stable liquid pharmaceutical formulation of igg antibodies
|
|
EP2108660A1
(en)
|
2002-10-30 |
2009-10-14 |
Genentech, Inc. |
Inhibition of IL-17 production
|
|
JP4902961B2
(ja)
|
2002-12-23 |
2012-03-21 |
シェーリング コーポレイション |
哺乳動物サイトカインの用途;関連試薬
|
|
US20040219150A1
(en)
|
2003-02-06 |
2004-11-04 |
Cua Daniel J. |
Uses of mammalian cytokine; related reagents
|
|
SI1601694T1
(sl)
|
2003-03-10 |
2010-01-29 |
Schering Corp |
Uporabe IL-23 antagonistov; sorodni reagenti
|
|
WO2005005612A2
(en)
|
2003-07-01 |
2005-01-20 |
University Of Virginia Patent Foundation |
Tag-1 and tag-2 proteins and uses thereof
|
|
DK1684805T3
(da)
|
2003-11-04 |
2010-10-04 |
Novartis Vaccines & Diagnostic |
Anvendelse af antagonist anti-CD40-monoklonale antistoffer til behandling af multipel myeloma
|
|
SG148143A1
(en)
|
2003-11-04 |
2008-12-31 |
Novartis Vaccines & Diagnostic |
Antagonist anti-cd40 monoclonal antibodies and methods for their use
|
|
US8277810B2
(en)
|
2003-11-04 |
2012-10-02 |
Novartis Vaccines & Diagnostics, Inc. |
Antagonist anti-CD40 antibodies
|
|
US20050100965A1
(en)
|
2003-11-12 |
2005-05-12 |
Tariq Ghayur |
IL-18 binding proteins
|
|
AU2005215527B2
(en)
|
2004-02-17 |
2011-04-07 |
Merck Sharp & Dohme Corp. |
Methods of modulating IL-23 activity; related reagents
|
|
WO2005108616A1
(en)
|
2004-05-03 |
2005-11-17 |
Schering Corporation |
Use of il-17 expression to predict skin inflammation; methods of treatment
|
|
US20050287593A1
(en)
|
2004-05-03 |
2005-12-29 |
Schering Corporation |
Use of cytokine expression to predict skin inflammation; methods of treatment
|
|
CA2581505A1
(en)
*
|
2004-09-27 |
2006-04-06 |
Centocor, Inc. |
Srage mimetibody, compositions, methods and uses
|
|
JO3000B1
(ar)
|
2004-10-20 |
2016-09-05 |
Genentech Inc |
مركبات أجسام مضادة .
|
|
EP2292758A3
(en)
|
2004-12-20 |
2013-12-25 |
Merck Sharp & Dohme Corp. |
Uses of mammalian cytokine; related reagents
|
|
PT2452694T
(pt)
*
|
2005-06-30 |
2019-02-21 |
Janssen Biotech Inc |
Anticorpos anti-il-23, composições, métodos e utilizações
|
|
AU2006265898A1
(en)
|
2005-06-30 |
2007-01-11 |
Archemix Corp. |
Polynucleotides and polypeptides of the IL-12 family of cytokines
|
|
CN101248088A
(zh)
*
|
2005-08-25 |
2008-08-20 |
伊莱利利公司 |
抗il-23抗体
|
|
AU2006283194B9
(en)
*
|
2005-08-25 |
2011-02-03 |
Eli Lilly And Company |
Anti-IL-23 Antibodies
|
|
LT1931710T
(lt)
*
|
2005-08-31 |
2017-03-27 |
Merck Sharp & Dohme Corp. |
Rekombinantiniai anti-il-23 antikūnai
|
|
EP2322219A3
(en)
|
2005-09-01 |
2013-06-05 |
Merck Sharp & Dohme Corp. |
Use of IL-23 and IL-17 antagonists to treat autoimmune ocular inflammatory disease
|
|
WO2007076523A2
(en)
|
2005-12-28 |
2007-07-05 |
Centocor, Inc. |
Markers and methods for assessing and treating psoriasis and related disorders
|
|
EA035459B1
(ru)
|
2005-12-29 |
2020-06-19 |
Сентокор, Инк. |
Антитело против il-23p19
|
|
US7910703B2
(en)
|
2006-03-10 |
2011-03-22 |
Zymogenetics, Inc. |
Antagonists to IL-17A, IL-17F, and IL-23P19 and methods of use
|
|
US20080311043A1
(en)
|
2006-06-08 |
2008-12-18 |
Hoffman Rebecca S |
Uses and compositions for treatment of psoriatic arthritis
|
|
EP2044118A2
(en)
|
2006-06-13 |
2009-04-08 |
Zymogenetics, Inc. |
Il-17 and il-23 antagonists and methods of using the same
|
|
MX2008015446A
(es)
|
2006-06-19 |
2008-12-12 |
Wyeth Corp |
Metodos de modulacion il-22 e il-17.
|
|
EP2114451A2
(en)
|
2007-01-09 |
2009-11-11 |
Wyeth a Corporation of the State of Delaware |
Anti-il-13 antibody formulations and uses thereof
|
|
TWI426918B
(zh)
|
2007-02-12 |
2014-02-21 |
Merck Sharp & Dohme |
Il-23拮抗劑於治療感染之用途
|
|
EP2124889A2
(en)
|
2007-02-16 |
2009-12-02 |
Wyeth a Corporation of the State of Delaware |
Protein formulations containing sorbitol
|
|
PL2059534T3
(pl)
|
2007-02-23 |
2012-09-28 |
Merck Sharp & Dohme |
Przeciwciała Anty-IL-23p19 wytworzone metodą inżynierii genetycznej
|
|
CN103396489A
(zh)
|
2007-02-23 |
2013-11-20 |
默沙东公司 |
工程改造的抗IL-23p19抗体
|
|
CN101668531B
(zh)
|
2007-02-28 |
2014-05-07 |
默沙东公司 |
用于治疗免疫病症的联合治疗
|
|
CA2698357C
(en)
|
2007-09-04 |
2017-06-06 |
The Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services |
Deletions in domain ii of pseudomonas exotoxin a that reduce non-specific toxicity
|
|
AR068723A1
(es)
|
2007-10-05 |
2009-12-02 |
Glaxo Group Ltd |
Proteina que se une a antigenos que se une a il-23 humana y sus usos
|
|
CA2703333A1
(en)
|
2007-10-26 |
2009-04-30 |
Galderma Research & Development |
Non-invasive method to perform skin inflammatory disease pharmaco-genomic studies and diagnosis method thereof
|
|
CA2607771A1
(en)
|
2007-11-01 |
2009-05-01 |
Her Majesty The Queen In Right Of Canada As Represented By The Minister Of National Defence |
Humanized anti-venezuelan equine encephalitis virus recombinant antibody
|
|
NZ622583A
(en)
|
2007-11-30 |
2015-08-28 |
Abbvie Biotechnology Ltd |
Protein formulations and methods of making same
|
|
WO2009082624A2
(en)
|
2007-12-10 |
2009-07-02 |
Zymogenetics, Inc. |
Antagonists of il-17a, il-17f, and il-23 and methods of using the same
|
|
AR073060A1
(es)
|
2008-08-14 |
2010-10-13 |
Arana Therapeutic Ltd |
Anticuerpos anti-il-12/il-23
|
|
CN102202655B
(zh)
|
2008-08-27 |
2013-06-19 |
默沙东公司 |
基因工程抗IL-23p19抗体的冻干制剂
|
|
US8420089B2
(en)
|
2008-11-25 |
2013-04-16 |
Alderbio Holdings Llc |
Antagonists of IL-6 to raise albumin and/or lower CRP
|
|
CA2757237A1
(en)
|
2009-04-01 |
2010-10-14 |
Jane Elizabeth Clarkson |
Anti-il-23 immunoglobulins
|
|
WO2010115092A2
(en)
|
2009-04-02 |
2010-10-07 |
The Johns Hopkins University |
Compositions and methods for treating or preventing inflammatory bowel disease and colon cancer
|
|
US20120269765A1
(en)
|
2009-07-24 |
2012-10-25 |
Garcia K Christopher |
Cytokine compositions and methods of use thereof
|
|
JO3244B1
(ar)
|
2009-10-26 |
2018-03-08 |
Amgen Inc |
بروتينات ربط مستضادات il – 23 البشرية
|
|
CN102740888B
(zh)
|
2009-11-24 |
2016-10-12 |
奥尔德生物制药公司 |
Il-6抗体及其用途
|
|
CN102695465A
(zh)
|
2009-12-02 |
2012-09-26 |
斯帕泰克医疗股份有限公司 |
结合具有可偏转柱和复合脊柱杆的骨锚固件的小轮廓脊柱假体
|
|
GB201013975D0
(en)
|
2010-08-20 |
2010-10-06 |
Imp Innovations Ltd |
Method of treating desease
|
|
BR112012019881A2
(pt)
|
2010-02-18 |
2017-06-27 |
Bristol Myers Squibb Co |
proteínas de domínio estrutural baseadas na fibronectina que ligam-se à il-23
|
|
CN107496917B
(zh)
|
2010-02-26 |
2021-06-11 |
诺沃—诺迪斯克有限公司 |
包含稳定抗体的组合物
|
|
BR112012022223B1
(pt)
|
2010-03-01 |
2022-08-09 |
Cytodyn Inc |
Formulação de proteína concentrada, uso e método de preparação da mesma
|
|
JP2013531499A
(ja)
|
2010-06-15 |
2013-08-08 |
セルジーン コーポレイション |
乾癬の治療のためのバイオマーカー
|
|
US20110311527A1
(en)
|
2010-06-16 |
2011-12-22 |
Allergan, Inc. |
IL23p19 ANTIBODY INHIBITOR FOR TREATING OCULAR AND OTHER CONDITIONS
|
|
CA2805653A1
(en)
|
2010-07-20 |
2012-01-26 |
Cephalon Australia Pty Ltd |
Anti-il-23 heterodimer specific antibodies
|
|
WO2012032181A2
(en)
|
2010-09-10 |
2012-03-15 |
Allozyne, Inc |
Novel antibody derivatives
|
|
SG190006A1
(en)
|
2010-11-04 |
2013-06-28 |
Boehringer Ingelheim Int |
Anti-il-23 antibodies
|
|
GB201100282D0
(en)
|
2011-01-07 |
2011-02-23 |
Ucb Pharma Sa |
Biological methods
|
|
TW201309330A
(zh)
|
2011-01-28 |
2013-03-01 |
Abbott Lab |
包含糖基化抗體之組合物及其用途
|
|
US9078894B2
(en)
|
2011-02-04 |
2015-07-14 |
Ab Science |
Treatment of severe persistant asthma with masitinib
|
|
NZ700802A
(en)
|
2012-05-03 |
2017-06-30 |
Boehringer Ingelheim Int |
Anti-il-23p19 antibodies
|
|
ES2729603T3
(es)
|
2012-06-27 |
2019-11-05 |
Merck Sharp & Dohme |
Anticuerpos IL-23 antihumanos cristalinos
|
|
EP3689369A1
(en)
|
2013-03-15 |
2020-08-05 |
Amgen, Inc |
Methods for treating psoriasis using an anti-il-23 antibody
|
|
WO2014143540A1
(en)
|
2013-03-15 |
2014-09-18 |
Amgen Inc. |
Methods for treating crohn's disease using an anti-il23 antibody
|
|
KR20140119396A
(ko)
|
2013-03-29 |
2014-10-10 |
삼성전자주식회사 |
단백질 약물의 액상 제형
|
|
MY192824A
(en)
|
2014-09-03 |
2022-09-12 |
Boehringer Ingelheim Int |
Compound targeting il-23a and tnf-alpha and uses thereof
|
|
IL321788A
(en)
|
2015-02-04 |
2025-08-01 |
Boehringer Ingelheim Int |
Methods of treating inflammatory diseases
|
|
AU2016297575B2
(en)
|
2015-07-23 |
2021-05-27 |
Boehringer Ingelheim International Gmbh |
Compound targeting IL-23A and B-cell activating factor (BAFF) and uses thereof
|
|
TWI811716B
(zh)
|
2015-09-18 |
2023-08-11 |
德商百靈佳殷格翰國際股份有限公司 |
治療發炎性疾病之方法
|