CN109311974A - 抗人白细胞介素-17a单克隆抗体、其制备方法和应用 - Google Patents

抗人白细胞介素-17a单克隆抗体、其制备方法和应用 Download PDF

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CN109311974A
CN109311974A CN201780033670.5A CN201780033670A CN109311974A CN 109311974 A CN109311974 A CN 109311974A CN 201780033670 A CN201780033670 A CN 201780033670A CN 109311974 A CN109311974 A CN 109311974A
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human
monoclonal antibody
seq
amino acid
variable region
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CN109311974B (zh
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张成海
朱玲巧
郭锦林
赵杰
高宏海
马琳
党尉
杨燕
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Sunshine Guojian Pharmaceutical Shanghai Co Ltd
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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Abstract

提供了一种抗人IL‑17A单克隆抗体、其制备方法和应用。该抗人IL‑17A单克隆抗体能够特异性与人IL‑17A结合，具有良好的抑制IL‑17A诱导的各种细胞系分泌炎性细胞因子如IL‑6等的效果，可应用于制备治疗免疫介导的炎症反应的疾病的药物。

Description

PCT国内申请，说明书已公开。

Claims (15)

  1. PCT国内申请，权利要求书已公开。
CN201780033670.5A 2016-06-12 2017-06-09 抗人白细胞介素-17a单克隆抗体、其制备方法和应用 Active CN109311974B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201610405511.0A CN107488227A (zh) 2016-06-12 2016-06-12 抗人白细胞介素‑17a单克隆抗体、其制备方法和应用
CN2016104055110 2016-06-12
PCT/CN2017/087733 WO2017215524A1 (zh) 2016-06-12 2017-06-09 抗人白细胞介素-17a单克隆抗体、其制备方法和应用

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CN109311974A true CN109311974A (zh) 2019-02-05
CN109311974B CN109311974B (zh) 2021-07-09

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CN201780033670.5A Active CN109311974B (zh) 2016-06-12 2017-06-09 抗人白细胞介素-17a单克隆抗体、其制备方法和应用

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US (1) US10738112B2 (zh)
EP (1) EP3470427A4 (zh)
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WO (1) WO2017215524A1 (zh)

Cited By (4)

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Publication number Priority date Publication date Assignee Title
CN112250764A (zh) * 2020-10-22 2021-01-22 深圳市康瑞克生物科技有限责任公司 一种抗白细胞介素17a的单克隆抗体、其编码基因及应用
CN113817058A (zh) * 2021-09-30 2021-12-21 港科鹏禾生物(苏州)有限公司 一种抗人il-17rc的单克隆抗体及其应用
CN114920838A (zh) * 2022-03-25 2022-08-19 南京融捷康生物科技有限公司 一种抗il-17a的单域抗体及其用途
WO2023083243A1 (zh) * 2021-11-11 2023-05-19 三生国健药业（上海）股份有限公司 一种抗il-17/vegf双功能融合蛋白及其用途

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CN108640991B (zh) * 2018-05-17 2019-09-27 江苏荃信生物医药有限公司 抗人白介素17a单克隆抗体及其应用
CN110551215A (zh) * 2018-05-30 2019-12-10 中山康方生物医药有限公司 抗白细胞介素-17a抗体、其药物组合物及其用途
EP3689907A1 (en) * 2019-01-31 2020-08-05 Numab Therapeutics AG Antibodies targeting il-17a and methods of use thereof
SG11202107995SA (en) * 2019-01-31 2021-08-30 Numab Therapeutics AG Multispecific antibodies having specificity for tnfa and il-17a, antibodies targeting il-17a, and methods of use thereof
CN110124030A (zh) * 2019-06-10 2019-08-16 通化东宝生物科技有限公司 一种苏金单抗注射液及其制备方法
WO2021018191A1 (zh) * 2019-07-30 2021-02-04 江苏恒瑞医药股份有限公司 Il-17拮抗剂治疗自身免疫疾病的方法
CN110585430B (zh) * 2019-09-29 2023-09-08 华博生物医药技术（上海）有限公司 一种人源化抗人il-17a单克隆抗体的药物组合物
CN111647624A (zh) * 2020-06-10 2020-09-11 成都和同易创生物科技有限公司 Tsab人源单克隆抗体重组载体、重组抗体及其制备方法
CN112142841B (zh) * 2020-09-27 2022-03-22 江苏荃信生物医药股份有限公司 一种新的抗人il-17a单克隆抗体、包含其的试剂盒及其检测方法
CN112390890B (zh) * 2020-11-06 2022-06-24 江苏荃信生物医药股份有限公司 一种定量检测血清中抗人白介素17单克隆抗体含量的酶联免疫分析方法
CN113896793B (zh) * 2021-09-30 2023-05-26 港科鹏禾生物(苏州)有限公司 一种抗人il-17rc的单克隆抗体及其应用
CN115806615B (zh) * 2022-07-22 2023-07-14 深圳贝蒂斯生物科技有限公司 抗体和间充质干细胞外泌体制备方法以及联合治疗疾病的用途
CN115819579B (zh) * 2022-11-10 2023-11-07 浙江大学 全人源抗白介素17A单链抗体No.34及应用
CN117866902A (zh) * 2024-03-12 2024-04-12 北京贝来生物科技有限公司 具有抗il-17a活性的基因修饰干细胞及其制备方法以及药物组合物

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WO2008134659A2 (en) * 2007-04-27 2008-11-06 Zymogenetics, Inc. Antagonists to il-17a, il-17f, and il-23p19 and methods of use
WO2009136286A9 (en) * 2008-05-05 2010-04-22 Novimmune Sa Anti-il 17a/il-17f cross-reactive antibodies and methods of use thereof
CN105073775A (zh) * 2013-02-08 2015-11-18 诺华股份有限公司 抗-il-17a抗体及其在治疗自身免疫性和炎性病症中的用途

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112250764A (zh) * 2020-10-22 2021-01-22 深圳市康瑞克生物科技有限责任公司 一种抗白细胞介素17a的单克隆抗体、其编码基因及应用
CN113817058A (zh) * 2021-09-30 2021-12-21 港科鹏禾生物(苏州)有限公司 一种抗人il-17rc的单克隆抗体及其应用
CN113817058B (zh) * 2021-09-30 2023-05-26 港科鹏禾生物(苏州)有限公司 一种抗人il-17rc的单克隆抗体及其应用
WO2023083243A1 (zh) * 2021-11-11 2023-05-19 三生国健药业（上海）股份有限公司 一种抗il-17/vegf双功能融合蛋白及其用途
CN114920838A (zh) * 2022-03-25 2022-08-19 南京融捷康生物科技有限公司 一种抗il-17a的单域抗体及其用途
CN114920838B (zh) * 2022-03-25 2023-11-24 南京融捷康生物科技有限公司 一种抗il-17a的单域抗体及其用途

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US20190161544A1 (en) 2019-05-30
JP6883591B2 (ja) 2021-06-09
WO2017215524A1 (zh) 2017-12-21
JP2019525730A (ja) 2019-09-12
EP3470427A4 (en) 2020-03-04
CN109311974B (zh) 2021-07-09
US10738112B2 (en) 2020-08-11
EP3470427A1 (en) 2019-04-17
CN107488227A (zh) 2017-12-19

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