ME02499B - Anti-il- 23-antitijela - Google Patents
Anti-il- 23-antitijelaInfo
- Publication number
- ME02499B ME02499B MEP-2016-176A MEP2016176A ME02499B ME 02499 B ME02499 B ME 02499B ME P2016176 A MEP2016176 A ME P2016176A ME 02499 B ME02499 B ME 02499B
- Authority
- ME
- Montenegro
- Prior art keywords
- antibody
- seq
- amino acid
- acid sequence
- antigen
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/244—Interleukins [IL]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pulmonology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Neurosurgery (AREA)
- Transplantation (AREA)
- Pain & Pain Management (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Obesity (AREA)
Claims (26)
1. Humanizovano anti-IL-23p19 antitelo ili njegov antigen-vezujući fragment,pri čemu antitelo ili njegov antigen-vezujući fragment obuhvata: a) varijabilnu regiju lakog lanca koja obuhvata sekvencu aminokiseline SEQ ID NO:19 (CDR1-L); sekvencu aminokiseline SEQ ID NO:20 (CDR2-L); i sekvencu aminokiseline SEQ ID NO:21 (CDR3-L); ib) varijabilnu regiju teškog lanca koja obuhvata sekvencu aminokiseline SEQ ID NO: 66 ili 67 (CDR1-H); sekvencu aminokiseline SEQ ID NO:64 (CDR2-H); i sekvencu aminokiseline SEQ ID NO:65 (CDR3-H).
2.Humanizovano anti-IL-23p19 antitelo ili njegov antigen-vezujući fragment prema zahtevu 1, pri čemu antitelo ili njegov antigen-vezujući fragment obuhvata: a) varijabilnu regiju lakog lanca koja obuhvata sekvencu aminokiseline SEQ ID NO:19 (CDR1-L); sekvencu aminokiseline SEQ ID NO:20 (CDR2-L); i sekvencu aminokiseline SEQ ID NO:21 (CDR3-L); i b) varijabilnu regiju teškog lanca koja obuhvata sekvencu aminokiseline SEQ ID NO:66 (CDR1-H); sekvencu aminokiseline SEQ ID NO:64 (CDR2-H); i sekvencu aminokiseline SEQ ID NO:65 (CDR3-H).
3. Humanizovano anti-IL-23p19 antitelo ili njegov antigen-vezujući fragment prema zahtevu 1, pri čemu antitelo ili njegov antigen-vezujući fragment obuhvata: a) varijabilnu regiju lakog lanca koja obuhvata sekvencu aminokiseline SEQ ID NO:19 (CDR1-L); sekvencu aminokiseline SEQ ID NO:20 (CDR2-L); i sekvencu aminokiseline SEQ ID NO:21 (CDR3-L); i b) varijabilnu regiju teškog lanca koja obuhvata sekvencu aminokiseline SEQ ID NO:67 (CDR1-H); sekvencu aminokiseline SEQ ID NO:64 (CDR2-H); i sekvencu aminokiseline SEQ ID NO:65 (CDR3-H).
4. Humanizovano anti-IL-23p19 antitelo ili njegov antigen-vezujući fragment prema zahtevu 1, pri čemu antitelo ili njegov antigen-vezujući fragment obuhvata varijabilnu regiju lakog lanca koja obuhvata sekvencu aminokiseline bilo koju od SEQ ID NO:158, 160, 162 ili 164; i varijabilnu regiju teškog lanca koja obuhvata sekvencu aminokiseline bilo koju od SEQ ID NO:166 ili 168.
5. Humanizovano anti-IL-23p19 antitelo ili njegov antigen-vezujući fragment prema zahtevu 4, pri čemu antitelo ili njegov antigen-vezujući fragment obuhvata varijabilnu regiju lakog lanca koja obuhvata sekvencu aminokiseline SEQ ID NO:160 i varijabilnu regiju teškog lanca koja obuhvata sekvencu aminokiseline SEQ ID NO:166.
6. Humanizovano anti-IL-23p19 antitelo ili njegov antigen-vezujući fragment prema zahtevu 4, pri čemu antitelo ili njegov antigen-vezujući fragment obuhvata varijabilnu regiju lakog lanca koja obuhvata sekvencu aminokiseline SEQ ID NO:160 i varijabilnu regiju teškog lanca koja obuhvata sekvencu aminokiseline SEQ ID NO:168.
7. Humanizovano anti-IL-23p19 antitelo ili njegov antigen-vezujući fragment prema zahtevu 4, pri čemu antitelo ili njegov antigen-vezujući fragment obuhvata varijabilnu regiju lakog lanca koja obuhvata sekvencu aminokiseline SEQ ID NO:158 i varijabilnu regiju teškog lanca koja obuhvata sekvencu aminokiseline SEQ ID NO:166.
8.Humanizovano anti-IL-23p19 antitelo ili njegov antigen-vezujući fragment prema zahtevu 4, pri čemu antitelo ili njegov antigen-vezujući fragment obuhvata sekvencu aminokiseline SEQ ID NO:166 ili 168 vezanu za humanu IgG1 konstantnu regiju teškog lanca; i sekvencu aminokiseline SEQ ID NO:158 ili 160 vezanu za humanu kapa konstantnu regiju lakog lanca.
9.Humanizovano anti-IL-23p19 antitelo ili njegov antigen-vezujući fragment prema zahtevu 1, pri čemu antitelo ili njegov antigen-vezujući fragment obuhvata: a) humanizovani varijabilni domen lakog lanca koji obuhvata CDR-ove SEQ ID NO:158 ili 160 i okvirne regije koje imaju sekvencu aminokiseline koja je najmanje 90% identična sekvenci aminokiseline okvirne regije varijabilnog domena lakog lanca sekvence aminokiseline SEQ ID NO:158 ili 160; i b) humanizovani varijabilni domen teškog lanca koji obuhvata CDR-ove SEQ ID NO:166 ili 168 i okvirne regije koje imaju sekvencu aminokiseline koja je najmanje 90% identična sekvenci aminokiseline okvirne regije varijabilnog domena teškog lanca sekvence aminokiseline SEQ ID NO:166 ili 168.
10.Humanizovano anti-IL-23p19 antitelo prema bilo kom od zahteva 1 do 9, pri čemu je pomenuto antitelo monoklonsko antitelo.
11.Humanizovano anti-IL-23p19 antitelo prema zahtevu 1, pri čemu je antitelo humanizovano monoklonsko anti-IL-23p19 antitelo koje obuhvata laki lanac koji obuhvata sekvencu aminokiseline SEQ ID NO:174 ili 180 i težak lanac koji obuhvata sekvencu aminokiseline SEQ ID NO:176 ili 178.
12. Humanizovano monoklonsko anti-IL-23p19 antitelo prema zahtevu 11, pri čemu pomenuto antitelo obuhvata laki lanac koji obuhvata sekvencu aminokiseline SEQ ID NO:174 i težak lanac koji obuhvata sekvencu aminokiseline SEQ ID NO:176.
13.Humanizovano monoklonsko anti-IL-23p19 antitelo prema zahtevu 11, pri čemu pomenuto antitelo obuhvata laki lanac koji obuhvata sekvencu aminokiseline SEQ ID NO:174 i težak lanac koji obuhvata sekvencu aminokiseline SEQ ID NO:178.
14.Humanizovano monoklonsko anti-IL-23p19 antitelo prema zahtevu 11, pri čemu pomenuto antitelo obuhvata laki lanac koji obuhvata sekvencu aminokiseline SEQ ID NO:180 i težak lanac koji obuhvata sekvencu aminokiseline SEQ ID NO:176.
15.Antitelo ili antigen-vezujući fragment prema bilo kom od zahteva 1 do 14 za upotrebu u medicini.
16.Antitelo ili antigen-vezujući fragment prema zahtevu 15, pri čemu se koristi za tretiranje zapaljenske bolesti, autoimune bolesti, respiratorne bolesti, metaboličkog poremećaja ili kancera.
17.Antitelo ili antigen-vezujući fragment prema zahtevu 16, pri čemu se koristi za tretiranje psorijaze, zapaljenske bolesti creva, psorijaznog artritisa, multipla skleroze, reumatoidnog artritisa, Kronove bolesti, ulceroznog kolitisa ili ankilozirajućeg spondilitisa.
18.Antitelo ili antigen-vezujući fragment prema zahtevu 16, pri čemu se koristi za tretiranje astme ili HOBP (hronične opstruktivne bolesti pluća).
19.Farmaceutska kompozicija koja obuhvata antitelo ili antigen-vezujući fragment prema bilo kom od zahteva 1 do 14 i farmaceutski prihvatljivi nosač.
20.Izolovani polinukleotid koji obuhvata sekvencu koja kodira varijabilnu regiju lakog lanca antitela ili fragmenta antitela koja ima sekvencu aminokiseline SEQ ID NO:158, 160, 162 ili 164, i koja kodira varijabilnu regiju teškog lanca antitela ili fragmenta antitela koja ima sekvencu aminokiseline SEQ ID NO: 166 ili 168.
21.Izolovani polinukleotid prema zahtevu 20, pri čemu pomenuti polinukleotid obuhvata sekvencu koja kodira laki lanac antitela koji ima sekvencu aminokiseline SEQ ID NO:174 ili 180, i koja kodira težak lanac antitela koji ima sekvencu aminokiseline SEQ ID NO:176 ili 178.
22.Ekspresioni vektor koji obuhvata polinukleotid prema zahtevu 20 ili 21.
23.Ćelija domaćina koja obuhvata: a) izolovani polinukleotid koji obuhvata sekvencu koja kodira varijabilnu regiju lakog lanca antitela ili fragmenta antitela koja ima sekvencu aminokiseline SEQ ID NO:158, 160, 162 ili 164; i b) izolovani polinukleotid koji obuhvata sekvencu koja kodira varijabilnu regiju teškog lanca antitela ili fragmenta antitela koja ima sekvencu aminokiseline SEQ ID NO: 166 ili 168.
24.Ćelija domaćina koja obuhvata: a) izolovani polinukleotid koji obuhvata sekvencu koja kodira laki lanac antitela koji ima sekvencu aminokiseline SEQ ID NO:174 ili 180; i b) izolovani polinukleotid koji obuhvata sekvencu koja kodira težak lanac antitela koji ima sekvencu aminokiseline SEQ ID NO:176 ili 178.
25.Postupak proizvodnje antitela ili antigen-vezujućeg fragmenta koji obuhvata: a) dobijanje ćelije domaćina prema zahtevu 23 ili 24; i b) kultivisanje ćelije domaćina.
26.Postupak prema zahtevu 25, koji dalje obuhvata izolovanje i prečišćavanje antitela ili antigen-vezujućeg fragmenta.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US41015810P | 2010-11-04 | 2010-11-04 | |
| US41195310P | 2010-11-10 | 2010-11-10 | |
| US41259410P | 2010-11-11 | 2010-11-11 | |
| US201161448785P | 2011-03-03 | 2011-03-03 | |
| PCT/US2011/058869 WO2012061448A1 (en) | 2010-11-04 | 2011-11-02 | Anti-il-23 antibodies |
| EP11781949.0A EP2635601B1 (en) | 2010-11-04 | 2011-11-02 | Anti-il-23 antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ME02499B true ME02499B (me) | 2017-02-20 |
Family
ID=44936573
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MEP-2016-176A ME02499B (me) | 2010-11-04 | 2012-11-02 | Anti-il- 23-antitijela |
Country Status (39)
| Country | Link |
|---|---|
| US (6) | US8778346B2 (me) |
| EP (4) | EP2635601B1 (me) |
| JP (3) | JP6126532B2 (me) |
| KR (2) | KR102049223B1 (me) |
| CN (2) | CN103282382B (me) |
| AP (1) | AP3953A (me) |
| AR (1) | AR083747A1 (me) |
| AU (3) | AU2011323426B2 (me) |
| BR (1) | BR112013011065B1 (me) |
| CA (2) | CA2816950C (me) |
| CO (1) | CO6801628A2 (me) |
| CY (2) | CY1118014T1 (me) |
| DK (1) | DK2635601T3 (me) |
| EA (2) | EA201890548A1 (me) |
| EC (1) | ECSP13012649A (me) |
| ES (1) | ES2593754T3 (me) |
| GE (1) | GEP201706733B (me) |
| HR (1) | HRP20161141T1 (me) |
| HU (2) | HUE030916T2 (me) |
| IL (2) | IL225648A (me) |
| LT (2) | LT2635601T (me) |
| LU (1) | LUC00132I2 (me) |
| MA (1) | MA34641B1 (me) |
| ME (1) | ME02499B (me) |
| MX (3) | MX343858B (me) |
| MY (1) | MY162791A (me) |
| NL (1) | NL301013I2 (me) |
| NO (1) | NO2019038I1 (me) |
| NZ (1) | NZ610592A (me) |
| PE (1) | PE20141162A1 (me) |
| PH (1) | PH12013500810B1 (me) |
| PL (1) | PL2635601T3 (me) |
| PT (1) | PT2635601T (me) |
| RS (1) | RS55161B1 (me) |
| SG (2) | SG190006A1 (me) |
| SI (1) | SI2635601T1 (me) |
| TW (2) | TWI545133B (me) |
| UY (1) | UY33703A (me) |
| WO (1) | WO2012061448A1 (me) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JO3244B1 (ar) | 2009-10-26 | 2018-03-08 | Amgen Inc | بروتينات ربط مستضادات il – 23 البشرية |
| PE20141162A1 (es) | 2010-11-04 | 2014-09-18 | Boehringer Ingelheim Int | Anticuerpos anti-il-23 |
| EP4039275A1 (en) * | 2012-05-03 | 2022-08-10 | Boehringer Ingelheim International GmbH | Anti-il-23p19 antibodies |
| AR094877A1 (es) * | 2013-03-08 | 2015-09-02 | Lilly Co Eli | Anticuerpos que se unen a il-23 |
| KR20150128859A (ko) | 2013-03-15 | 2015-11-18 | 암젠 인크 | 항-il23 항체를 사용하여 크론병을 치료하는 방법 |
| EP2968488A1 (en) | 2013-03-15 | 2016-01-20 | Amgen Inc. | Methods for treating psoriasis using an anti-il-23 antibody |
| EP3172339A1 (en) * | 2014-07-24 | 2017-05-31 | Boehringer Ingelheim International GmbH | Biomarkers useful in the treatment of il-23a related diseases |
| UA123624C2 (uk) * | 2014-09-03 | 2021-05-05 | Бьорінґер Інґельхайм Інтернаціональ Ґмбх | Сполука, специфічна до іл-23а та фнп-альфа, та її застосування |
| CN107206081A (zh) * | 2015-02-04 | 2017-09-26 | 勃林格殷格翰国际有限公司 | 治疗炎性疾病的方法 |
| EP3283109A1 (en) | 2015-04-14 | 2018-02-21 | Boehringer Ingelheim International GmbH | Methods of treating diseases |
| IL256665B2 (en) | 2015-07-23 | 2023-10-01 | Boehringer Ingelheim Int | IL-23A Targeting Compound and B-Cell Activating Factor Nucleic Acids Encoding Them and Use of Products Containing Them |
| JP6909208B2 (ja) * | 2015-09-17 | 2021-07-28 | アムジェン インコーポレイテッド | Ｉｌ２３経路バイオマーカーを使用するｉｌ２３アンタゴニストに対する臨床応答の予測 |
| TWI811716B (zh) * | 2015-09-18 | 2023-08-11 | 德商百靈佳殷格翰國際股份有限公司 | 治療發炎性疾病之方法 |
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