JP2018506966A5 - - Google Patents
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- JP2018506966A5 JP2018506966A5 JP2017536549A JP2017536549A JP2018506966A5 JP 2018506966 A5 JP2018506966 A5 JP 2018506966A5 JP 2017536549 A JP2017536549 A JP 2017536549A JP 2017536549 A JP2017536549 A JP 2017536549A JP 2018506966 A5 JP2018506966 A5 JP 2018506966A5
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- Prior art keywords
- amino acid
- ebov
- acid sequence
- seq
- antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 125000003275 alpha amino acid group Chemical group 0.000 claims description 130
- 241001115402 Ebolavirus Species 0.000 claims description 96
- 239000000427 antigen Substances 0.000 claims description 74
- 108091007433 antigens Proteins 0.000 claims description 74
- 102000036639 antigens Human genes 0.000 claims description 74
- 239000012634 fragment Substances 0.000 claims description 74
- 239000008194 pharmaceutical composition Substances 0.000 claims description 58
- 239000000203 mixture Substances 0.000 claims description 47
- 238000000034 method Methods 0.000 claims description 30
- 239000003814 drug Substances 0.000 claims description 14
- 229940124597 therapeutic agent Drugs 0.000 claims description 14
- 230000008685 targeting Effects 0.000 claims description 12
- 201000011001 Ebola Hemorrhagic Fever Diseases 0.000 claims description 10
- 150000001413 amino acids Chemical class 0.000 claims description 8
- 238000010494 dissociation reaction Methods 0.000 claims description 8
- 230000005593 dissociations Effects 0.000 claims description 8
- 208000015181 infectious disease Diseases 0.000 claims description 8
- AMFDITJFBUXZQN-KUBHLMPHSA-N (2s,3s,4r,5r)-2-(4-amino-5h-pyrrolo[3,2-d]pyrimidin-7-yl)-5-(hydroxymethyl)pyrrolidine-3,4-diol Chemical compound C=1NC=2C(N)=NC=NC=2C=1[C@@H]1N[C@H](CO)[C@@H](O)[C@H]1O AMFDITJFBUXZQN-KUBHLMPHSA-N 0.000 claims description 6
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims description 6
- 102000014150 Interferons Human genes 0.000 claims description 6
- 108010050904 Interferons Proteins 0.000 claims description 6
- 108020000999 Viral RNA Proteins 0.000 claims description 6
- WXJFKKQWPMNTIM-VWLOTQADSA-N [(2s)-1-(4-amino-2-oxopyrimidin-1-yl)-3-hydroxypropan-2-yl]oxymethyl-(3-hexadecoxypropoxy)phosphinic acid Chemical compound CCCCCCCCCCCCCCCCOCCCOP(O)(=O)CO[C@H](CO)CN1C=CC(N)=NC1=O WXJFKKQWPMNTIM-VWLOTQADSA-N 0.000 claims description 6
- 230000000692 anti-sense effect Effects 0.000 claims description 6
- 239000003443 antiviral agent Substances 0.000 claims description 6
- 239000003246 corticosteroid Substances 0.000 claims description 6
- 239000003937 drug carrier Substances 0.000 claims description 6
- ZCGNOVWYSGBHAU-UHFFFAOYSA-N favipiravir Chemical compound NC(=O)C1=NC(F)=CNC1=O ZCGNOVWYSGBHAU-UHFFFAOYSA-N 0.000 claims description 6
- 229940079322 interferon Drugs 0.000 claims description 6
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims description 6
- 108091033319 polynucleotide Proteins 0.000 claims description 6
- 102000040430 polynucleotide Human genes 0.000 claims description 6
- 239000002157 polynucleotide Substances 0.000 claims description 6
- 208000024891 symptom Diseases 0.000 claims description 6
- 229960005486 vaccine Drugs 0.000 claims description 6
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims description 4
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims description 4
- 108700012234 Ebola virus VP24 Proteins 0.000 claims description 4
- 102000003886 Glycoproteins Human genes 0.000 claims description 4
- 108090000288 Glycoproteins Proteins 0.000 claims description 4
- 241001115400 Zaire ebolavirus Species 0.000 claims description 4
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 4
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 4
- 238000003556 assay Methods 0.000 claims description 4
- 238000004140 cleaning Methods 0.000 claims description 4
- 230000003013 cytotoxicity Effects 0.000 claims description 4
- 231100000135 cytotoxicity Toxicity 0.000 claims description 4
- 230000001419 dependent effect Effects 0.000 claims description 4
- 239000003085 diluting agent Substances 0.000 claims description 4
- 238000012423 maintenance Methods 0.000 claims description 4
- 238000006386 neutralization reaction Methods 0.000 claims description 4
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims description 4
- 239000002245 particle Substances 0.000 claims description 4
- 238000002198 surface plasmon resonance spectroscopy Methods 0.000 claims description 4
- 230000004083 survival effect Effects 0.000 claims description 4
- 230000002458 infectious effect Effects 0.000 claims description 3
- 208000004998 Abdominal Pain Diseases 0.000 claims description 2
- 208000005156 Dehydration Diseases 0.000 claims description 2
- 206010012735 Diarrhoea Diseases 0.000 claims description 2
- 206010019233 Headaches Diseases 0.000 claims description 2
- 208000032843 Hemorrhage Diseases 0.000 claims description 2
- 206010061598 Immunodeficiency Diseases 0.000 claims description 2
- 208000000112 Myalgia Diseases 0.000 claims description 2
- 206010037660 Pyrexia Diseases 0.000 claims description 2
- 108020004459 Small interfering RNA Proteins 0.000 claims description 2
- 101150010086 VP24 gene Proteins 0.000 claims description 2
- 208000036142 Viral infection Diseases 0.000 claims description 2
- 206010047700 Vomiting Diseases 0.000 claims description 2
- 208000022531 anorexia Diseases 0.000 claims description 2
- 229940124599 anti-inflammatory drug Drugs 0.000 claims description 2
- 230000000740 bleeding effect Effects 0.000 claims description 2
- 230000030833 cell death Effects 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 229960001334 corticosteroids Drugs 0.000 claims description 2
- 206010061428 decreased appetite Diseases 0.000 claims description 2
- 230000018044 dehydration Effects 0.000 claims description 2
- 238000006297 dehydration reaction Methods 0.000 claims description 2
- 238000010790 dilution Methods 0.000 claims description 2
- 239000012895 dilution Substances 0.000 claims description 2
- 206010016256 fatigue Diseases 0.000 claims description 2
- 229950008454 favipiravir Drugs 0.000 claims description 2
- 231100000869 headache Toxicity 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 238000001727 in vivo Methods 0.000 claims description 2
- 230000003472 neutralizing effect Effects 0.000 claims description 2
- 239000004055 small Interfering RNA Substances 0.000 claims description 2
- 238000011277 treatment modality Methods 0.000 claims description 2
- 230000009385 viral infection Effects 0.000 claims description 2
- 230000008673 vomiting Effects 0.000 claims description 2
- 238000007918 intramuscular administration Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 238000007920 subcutaneous administration Methods 0.000 claims 2
- 230000007501 viral attachment Effects 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2020081768A JP7672200B2 (ja) | 2015-01-26 | 2020-05-07 | エボラウイルス糖タンパク質に対するヒト抗体 |
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562107581P | 2015-01-26 | 2015-01-26 | |
| US62/107,581 | 2015-01-26 | ||
| US201562161356P | 2015-05-14 | 2015-05-14 | |
| US62/161,356 | 2015-05-14 | ||
| US201562245703P | 2015-10-23 | 2015-10-23 | |
| US62/245,703 | 2015-10-23 | ||
| PCT/US2016/014720 WO2016123019A1 (en) | 2015-01-26 | 2016-01-25 | Human antibodies to ebola virus glycoprotein |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081768A Division JP7672200B2 (ja) | 2015-01-26 | 2020-05-07 | エボラウイルス糖タンパク質に対するヒト抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018506966A JP2018506966A (ja) | 2018-03-15 |
| JP2018506966A5 true JP2018506966A5 (enExample) | 2019-02-28 |
| JP6829199B2 JP6829199B2 (ja) | 2021-02-10 |
Family
ID=55300806
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017536549A Active JP6829199B2 (ja) | 2015-01-26 | 2016-01-25 | エボラウイルス糖タンパク質に対するヒト抗体 |
| JP2020081768A Active JP7672200B2 (ja) | 2015-01-26 | 2020-05-07 | エボラウイルス糖タンパク質に対するヒト抗体 |
| JP2023034449A Pending JP2023065648A (ja) | 2015-01-26 | 2023-03-07 | エボラウイルス糖タンパク質に対するヒト抗体 |
| JP2025019929A Active JP7796918B2 (ja) | 2015-01-26 | 2025-02-10 | エボラウイルス糖タンパク質に対するヒト抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2020081768A Active JP7672200B2 (ja) | 2015-01-26 | 2020-05-07 | エボラウイルス糖タンパク質に対するヒト抗体 |
| JP2023034449A Pending JP2023065648A (ja) | 2015-01-26 | 2023-03-07 | エボラウイルス糖タンパク質に対するヒト抗体 |
| JP2025019929A Active JP7796918B2 (ja) | 2015-01-26 | 2025-02-10 | エボラウイルス糖タンパク質に対するヒト抗体 |
Country Status (25)
| Country | Link |
|---|---|
| US (6) | US9771414B2 (enExample) |
| EP (2) | EP3250591B1 (enExample) |
| JP (4) | JP6829199B2 (enExample) |
| KR (1) | KR102641731B1 (enExample) |
| CN (2) | CN107667115B (enExample) |
| AU (2) | AU2016211783B2 (enExample) |
| BR (1) | BR112017015845A2 (enExample) |
| CA (1) | CA2974899A1 (enExample) |
| CL (3) | CL2017001920A1 (enExample) |
| CO (1) | CO2017007619A2 (enExample) |
| DK (1) | DK3250591T3 (enExample) |
| EA (1) | EA038993B1 (enExample) |
| FI (1) | FI3250591T3 (enExample) |
| IL (1) | IL253358B (enExample) |
| LT (1) | LT3250591T (enExample) |
| MA (1) | MA41421A (enExample) |
| MX (2) | MX392533B (enExample) |
| MY (4) | MY196224A (enExample) |
| PH (1) | PH12017501277B1 (enExample) |
| PT (1) | PT3250591T (enExample) |
| SG (2) | SG10202007835QA (enExample) |
| SM (1) | SMT202500454T1 (enExample) |
| TW (1) | TWI710573B (enExample) |
| UY (1) | UY36538A (enExample) |
| WO (1) | WO2016123019A1 (enExample) |
Families Citing this family (83)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10130697B2 (en) | 2010-03-23 | 2018-11-20 | Wisconsin Alumni Research Foundation (Warf) | Vaccines comprising mutant attenuated influenza viruses |
| JP2014527799A (ja) | 2011-08-26 | 2014-10-23 | ダブリュエーアールエフ−ウィスコンシン アラムナイ リサーチ ファウンデーション | 変異型ｐｂ２遺伝子セグメントを有する弱毒化生ワクチンとしてのインフルエンザウイルス |
| AR095196A1 (es) | 2013-03-15 | 2015-09-30 | Regeneron Pharma | Medio de cultivo celular libre de suero |
| WO2015196150A2 (en) | 2014-06-20 | 2015-12-23 | Wisconsin Alumni Research Foundation (Warf) | Mutations that confer genetic stability to additional genes in influenza viruses |
| AR102198A1 (es) | 2014-10-09 | 2017-02-08 | Regeneron Pharma | Proceso para reducir partículas subvisibles en una formulación farmacéutica |
| TWI710573B (zh) | 2015-01-26 | 2020-11-21 | 美商再生元醫藥公司 | 抗伊波拉病毒醣蛋白之人類抗體 |
| TW202440904A (zh) | 2015-08-04 | 2024-10-16 | 美商再生元醫藥公司 | 補充牛磺酸之細胞培養基及用法（二） |
| US11197925B2 (en) | 2016-02-19 | 2021-12-14 | Wisconsin Alumni Research Foundation (Warf) | Influenza B virus replication for vaccine development |
| US11542332B2 (en) | 2016-03-26 | 2023-01-03 | Bioatla, Inc. | Anti-CTLA4 antibodies, antibody fragments, their immunoconjugates and uses thereof |
| EP3487521A4 (en) | 2016-07-21 | 2020-07-01 | Emory University | ANTIBODIES AGAINST EBOLA VIRUS AND LIAISON AGENTS DERIVED THEREFROM |
| JP2019529350A (ja) | 2016-08-16 | 2019-10-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッドＲｅｇｅｎｅｒｏｎ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． | 混合物から個々の抗体を定量する方法 |
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| BR112019006689A2 (pt) | 2016-10-25 | 2019-06-25 | Regeneron Pharma | métodos e sistemas para análise de dados de cromatografia |
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| KR20250041082A (ko) | 2017-07-06 | 2025-03-25 | 리제너론 파마슈티칼스 인코포레이티드 | 당단백질을 만들기 위한 세포 배양 과정 |
| WO2019139648A2 (en) * | 2017-09-15 | 2019-07-18 | David Weiner | Dna antibody constructs for use against ebola virus |
| KR102798879B1 (ko) | 2017-09-19 | 2025-04-30 | 리제너론 파아마슈티컬스, 인크. | 입자 형성을 감소시키는 방법 및 그것에 의해 형성된 조성물 |
| WO2019084310A1 (en) | 2017-10-25 | 2019-05-02 | Yoshihiro Kawaoka | HAS RECOMBINANT INFLUENZA VIRUSES STABILIZED FOR EGG REPLICATION |
| RU2686630C1 (ru) * | 2017-12-22 | 2019-04-29 | федеральное государственное бюджетное учреждение "Национальный исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации | Штаммы гибридных клеток животных Mus. Musculus - продуценты моноклональных антител к белку GP вируса Эбола (subtype Zaire) и моноклональные антитела к белку GP вируса Эбола (subtype Zaire) |
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| WO2019136029A1 (en) * | 2018-01-02 | 2019-07-11 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Neutralizing antibodies to ebola virus glycoprotein and their use |
| WO2019152607A1 (en) * | 2018-01-31 | 2019-08-08 | The Wistar Institute Of Anatomy And Biology | Nucleic acid antibody constructs for use against ebola virus |
| JP7349998B2 (ja) | 2018-01-31 | 2023-09-25 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | サイズバリアントおよび電荷バリアントである薬物製品不純物を特徴解析するためのシステムおよび方法 |
| TW202311746A (zh) | 2018-02-02 | 2023-03-16 | 美商再生元醫藥公司 | 用於表徵蛋白質二聚合之系統及方法 |
| JP2021514609A (ja) | 2018-02-28 | 2021-06-17 | リジェネロン・ファーマシューティカルズ・インコーポレイテッド | ウイルス混入物質を同定するためのシステムおよび方法 |
| CN108373500A (zh) * | 2018-03-12 | 2018-08-07 | 中国科学院微生物研究所 | 一种热稳定性埃博拉治疗性抗体的制备及应用 |
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| US11939370B2 (en) | 2018-07-12 | 2024-03-26 | Vanderbilt University | Pan-ebola virus neutralizing human antibodies and methods of use therefor |
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| CN111138526B (zh) * | 2018-11-06 | 2021-07-30 | 中国人民解放军军事科学院军事医学研究院 | 一种抗埃博拉病毒糖蛋白gp2亚基的单克隆抗体2g1及应用 |
| CN111138528B (zh) * | 2018-11-06 | 2021-07-30 | 中国人民解放军军事科学院军事医学研究院 | 特异性结合于埃博拉病毒糖蛋白聚糖帽的单克隆抗体5a8 |
| CN111138527B (zh) * | 2018-11-06 | 2021-07-30 | 中国人民解放军军事科学院军事医学研究院 | 抗埃博拉病毒糖蛋白gp1亚基的单克隆抗体4f1及应用 |
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