|
US4307016A
(en)
|
1978-03-24 |
1981-12-22 |
Takeda Chemical Industries, Ltd. |
Demethyl maytansinoids
|
|
US4256746A
(en)
|
1978-11-14 |
1981-03-17 |
Takeda Chemical Industries |
Dechloromaytansinoids, their pharmaceutical compositions and method of use
|
|
JPS55162791A
(en)
|
1979-06-05 |
1980-12-18 |
Takeda Chem Ind Ltd |
Antibiotic c-15003pnd and its preparation
|
|
JPS5645483A
(en)
|
1979-09-19 |
1981-04-25 |
Takeda Chem Ind Ltd |
C-15003phm and its preparation
|
|
EP0028683A1
(en)
|
1979-09-21 |
1981-05-20 |
Takeda Chemical Industries, Ltd. |
Antibiotic C-15003 PHO and production thereof
|
|
JPS5645485A
(en)
|
1979-09-21 |
1981-04-25 |
Takeda Chem Ind Ltd |
Production of c-15003pnd
|
|
WO1982001188A1
(en)
|
1980-10-08 |
1982-04-15 |
Takeda Chemical Industries Ltd |
4,5-deoxymaytansinoide compounds and process for preparing same
|
|
US4450254A
(en)
|
1980-11-03 |
1984-05-22 |
Standard Oil Company |
Impact improvement of high nitrile resins
|
|
US4313946A
(en)
|
1981-01-27 |
1982-02-02 |
The United States Of America As Represented By The Secretary Of Agriculture |
Chemotherapeutically active maytansinoids from Trewia nudiflora
|
|
US4315929A
(en)
|
1981-01-27 |
1982-02-16 |
The United States Of America As Represented By The Secretary Of Agriculture |
Method of controlling the European corn borer with trewiasine
|
|
US4563304A
(en)
|
1981-02-27 |
1986-01-07 |
Pharmacia Fine Chemicals Ab |
Pyridine compounds modifying proteins, polypeptides or polysaccharides
|
|
US4475196A
(en)
|
1981-03-06 |
1984-10-02 |
Zor Clair G |
Instrument for locating faults in aircraft passenger reading light and attendant call control system
|
|
US4447233A
(en)
|
1981-04-10 |
1984-05-08 |
Parker-Hannifin Corporation |
Medication infusion pump
|
|
JPS57192389A
(en)
|
1981-05-20 |
1982-11-26 |
Takeda Chem Ind Ltd |
Novel maytansinoid
|
|
US4439196A
(en)
|
1982-03-18 |
1984-03-27 |
Merck & Co., Inc. |
Osmotic drug delivery system
|
|
US4522811A
(en)
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
ZA836080B
(en)
*
|
1982-08-23 |
1984-04-25 |
Scripps Clinic Res |
Broad spectrum influenza antisera
|
|
US4447224A
(en)
|
1982-09-20 |
1984-05-08 |
Infusaid Corporation |
Variable flow implantable infusion apparatus
|
|
US4487603A
(en)
|
1982-11-26 |
1984-12-11 |
Cordis Corporation |
Implantable microinfusion pump system
|
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
US4486194A
(en)
|
1983-06-08 |
1984-12-04 |
James Ferrara |
Therapeutic device for administering medicaments through the skin
|
|
JPS60222842A
(ja)
|
1984-04-19 |
1985-11-07 |
Fuji Photo Film Co Ltd |
ハロゲン化銀写真乳剤およびその製造方法
|
|
US4596556A
(en)
|
1985-03-25 |
1986-06-24 |
Bioject, Inc. |
Hypodermic injection apparatus
|
|
US4683202A
(en)
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4965188A
(en)
|
1986-08-22 |
1990-10-23 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
|
|
US5374548A
(en)
|
1986-05-02 |
1994-12-20 |
Genentech, Inc. |
Methods and compositions for the attachment of proteins to liposomes using a glycophospholipid anchor
|
|
MX9203291A
(es)
|
1985-06-26 |
1992-08-01 |
Liposome Co Inc |
Metodo para acoplamiento de liposomas.
|
|
US4800159A
(en)
|
1986-02-07 |
1989-01-24 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences
|
|
US5182205A
(en)
|
1986-11-27 |
1993-01-26 |
Hoffmann-La Roche Inc. |
Nucleotide sequences which are selectively expressed in pre-B cells and probes therefor
|
|
EP0269127B1
(en)
|
1986-11-27 |
1994-02-23 |
F. Hoffmann-La Roche Ag |
Nucleotide sequences which are selectively expressed in pre-B cells and probes therefor
|
|
US4790824A
(en)
|
1987-06-19 |
1988-12-13 |
Bioject, Inc. |
Non-invasive hypodermic injection device
|
|
US4941880A
(en)
|
1987-06-19 |
1990-07-17 |
Bioject, Inc. |
Pre-filled ampule and non-invasive hypodermic injection device assembly
|
|
US5108921A
(en)
|
1989-04-03 |
1992-04-28 |
Purdue Research Foundation |
Method for enhanced transmembrane transport of exogenous molecules
|
|
US5208020A
(en)
|
1989-10-25 |
1993-05-04 |
Immunogen Inc. |
Cytotoxic agents comprising maytansinoids and their therapeutic use
|
|
US5312335A
(en)
|
1989-11-09 |
1994-05-17 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
US5064413A
(en)
|
1989-11-09 |
1991-11-12 |
Bioject, Inc. |
Needleless hypodermic injection device
|
|
US5183884A
(en)
|
1989-12-01 |
1993-02-02 |
United States Of America |
Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
IL101943A0
(en)
|
1991-05-24 |
1992-12-30 |
Genentech Inc |
Structure,production and use of heregulin
|
|
US5622929A
(en)
|
1992-01-23 |
1997-04-22 |
Bristol-Myers Squibb Company |
Thioether conjugates
|
|
US5474765A
(en)
|
1992-03-23 |
1995-12-12 |
Ut Sw Medical Ctr At Dallas |
Preparation and use of steroid-polyanionic polymer-based conjugates targeted to vascular endothelial cells
|
|
DK0563475T3
(da)
|
1992-03-25 |
2000-09-18 |
Immunogen Inc |
Konjugater af cellebindende midler og derivater af CC-1065
|
|
US5383851A
(en)
|
1992-07-24 |
1995-01-24 |
Bioject Inc. |
Needleless hypodermic injection device
|
|
US6337070B1
(en)
*
|
1993-04-29 |
2002-01-08 |
Takara Shuzo Co., Ltd. |
Polypeptides for use in generating anti-human influenza virus antibodies
|
|
FR2706982B1
(enExample)
|
1993-06-21 |
1995-08-04 |
Thermique Generale Vinicole |
|
|
GB9522351D0
(en)
|
1995-11-01 |
1996-01-03 |
Medeva Holdings Bv |
Vaccine compositions
|
|
ATE234635T1
(de)
|
1995-12-22 |
2003-04-15 |
Bristol Myers Squibb Co |
Verzweigte hydrazongruppen enthaltende kuppler
|
|
AU781952B2
(en)
|
1999-05-28 |
2005-06-23 |
Genentech Inc. |
DR4 antibodies and uses thereof
|
|
ES2462532T3
(es)
|
1999-10-18 |
2014-05-23 |
Novartis Vaccines And Diagnostics, Inc. |
Composiciones y métodos para estimular una respuesta inmune contra agentes infecciosos
|
|
US20030215453A1
(en)
|
2002-05-14 |
2003-11-20 |
Dedera Douglas A. |
Methods of therapy and diagnosis using immunotargeting of cells expressing VpreB1 protein
|
|
EP1255561B1
(en)
|
2000-02-15 |
2006-06-28 |
ID Biomedical Corporation of Quebec |
Proteosome influenza vaccine
|
|
US7476383B2
(en)
|
2000-05-02 |
2009-01-13 |
The Uab Research Foundation |
Antibody selective for DR4 and uses thereof
|
|
US6333410B1
(en)
|
2000-08-18 |
2001-12-25 |
Immunogen, Inc. |
Process for the preparation and purification of thiol-containing maytansinoids
|
|
PT1324776E
(pt)
|
2000-10-12 |
2009-12-23 |
Genentech Inc |
Formulações de proteína concentradas de viscosidade reduzida
|
|
US7115717B2
(en)
|
2001-05-18 |
2006-10-03 |
Kirin Beer Kabushiki Kaisha |
Anti-TRAIL-R antibodies
|
|
US6441163B1
(en)
|
2001-05-31 |
2002-08-27 |
Immunogen, Inc. |
Methods for preparation of cytotoxic conjugates of maytansinoids and cell binding agents
|
|
GB0113179D0
(en)
|
2001-05-31 |
2001-07-25 |
Novartis Ag |
Organic compounds
|
|
US6716821B2
(en)
|
2001-12-21 |
2004-04-06 |
Immunogen Inc. |
Cytotoxic agents bearing a reactive polyethylene glycol moiety, cytotoxic conjugates comprising polyethylene glycol linking groups, and methods of making and using the same
|
|
EP1517921B1
(en)
|
2002-06-28 |
2006-06-07 |
Domantis Limited |
Dual specific ligands with increased serum half-life
|
|
DK1545613T3
(da)
|
2002-07-31 |
2011-11-14 |
Seattle Genetics Inc |
Auristatinkonjugater og deres anvendelse til behandling af cancer, en autoimmun sygdom eller en infektiøs sygdom
|
|
US8088387B2
(en)
|
2003-10-10 |
2012-01-03 |
Immunogen Inc. |
Method of targeting specific cell populations using cell-binding agent maytansinoid conjugates linked via a non-cleavable linker, said conjugates, and methods of making said conjugates
|
|
US7276497B2
(en)
|
2003-05-20 |
2007-10-02 |
Immunogen Inc. |
Cytotoxic agents comprising new maytansinoids
|
|
CN107213469A
(zh)
|
2003-11-06 |
2017-09-29 |
西雅图基因公司 |
能够与配体偶联的单甲基缬氨酸化合物
|
|
RU2402548C2
(ru)
|
2004-05-19 |
2010-10-27 |
Медарекс, Инк. |
Химические линкеры и их конъюгаты
|
|
WO2006065533A2
(en)
|
2004-11-29 |
2006-06-22 |
Seattle Genetics, Inc. |
Engineered antibodies and immunoconjugates
|
|
US20060147997A1
(en)
|
2004-11-30 |
2006-07-06 |
Virosys Pharmaceuticals, Inc. |
PenetraBodies: receptor-mediated targeted delivery of functionally-active human antibody fragments into cytosol for the treatment of chronic infections and diseases
|
|
EP3479844B1
(en)
|
2005-04-15 |
2023-11-22 |
MacroGenics, Inc. |
Covalent diabodies and uses thereof
|
|
US7612181B2
(en)
|
2005-08-19 |
2009-11-03 |
Abbott Laboratories |
Dual variable domain immunoglobulin and uses thereof
|
|
AR056857A1
(es)
|
2005-12-30 |
2007-10-24 |
U3 Pharma Ag |
Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos
|
|
FR2896162B1
(fr)
|
2006-01-13 |
2008-02-15 |
Sanofi Pasteur Sa |
Emulsion huile dans eau thermoreversible
|
|
US8148085B2
(en)
*
|
2006-05-15 |
2012-04-03 |
Sea Lane Biotechnologies, Llc |
Donor specific antibody libraries
|
|
WO2007134327A2
(en)
*
|
2006-05-15 |
2007-11-22 |
Sea Lane Biotechnologies, Llc. |
Neutralizing antibodies to influenza viruses
|
|
CA2663388C
(en)
*
|
2006-09-07 |
2017-01-17 |
Crucell Holland B.V. |
Human binding molecules capable of neutralizing influenza virus h5n1 and uses thereof
|
|
CN101548034B
(zh)
|
2006-10-02 |
2013-11-13 |
航道生物技术有限责任公司 |
多样性合成肽和多肽文库的设计和构建
|
|
CA2675137A1
(en)
*
|
2007-01-12 |
2008-07-24 |
Sea Lane Biotechnologies, Llc. |
Combinatorial libraries of conformationally constrained polypeptide sequences
|
|
PL2129396T3
(pl)
|
2007-02-16 |
2014-02-28 |
Merrimack Pharmaceuticals Inc |
Przeciwciała przeciw ERBB3 i ich zastosowania
|
|
EP2132312B1
(en)
|
2007-03-27 |
2016-01-27 |
Sea Lane Biotechnologies,llc. |
Constructs and libraries comprising antibody surrogate light chain sequences
|
|
WO2008153236A1
(en)
*
|
2007-06-15 |
2008-12-18 |
Protheon Co., Ltd |
An attenuated influenza virus and a live vaccine comprising the same
|
|
EP2187973A2
(en)
|
2007-08-13 |
2010-05-26 |
Sea Lane Biotechnologies,llc. |
Spore displaying antigens
|
|
CA2696263C
(en)
|
2007-08-15 |
2017-06-13 |
Bing Liu |
Monospecific and multispecific antibodies and method of use
|
|
DK2211904T3
(en)
|
2007-10-19 |
2016-10-24 |
Seattle Genetics Inc |
Cd19-binding agents and uses thereof
|
|
MX2010006148A
(es)
*
|
2007-12-06 |
2011-02-23 |
Dana Farber Cancer Inst Inc |
Anti-cuerpos contra el virus de la influenza y metodos de uso de los mismos.
|
|
WO2009111707A1
(en)
|
2008-03-06 |
2009-09-11 |
Genentech, Inc. |
Combination therapy with c-met and her antagonists
|
|
WO2009121004A2
(en)
|
2008-03-28 |
2009-10-01 |
Sea Lane Biotechnologies, Llc |
Neutralizing molecules to viral antigens
|
|
HUE034763T2
(en)
|
2008-04-30 |
2018-02-28 |
Immunogen Inc |
Crosslinkers and their use
|
|
CN102083461B
(zh)
|
2008-04-30 |
2014-09-17 |
伊缪诺金公司 |
有效的偶联物和亲水性连接体
|
|
CN102149727A
(zh)
|
2008-07-11 |
2011-08-10 |
航道生物技术有限责任公司 |
包含抗体替代卡帕轻链序列的构建体和文库
|
|
SG172983A1
(en)
|
2009-01-15 |
2011-08-29 |
Lab Corp America Holdings |
Methods of determining patient response by measurement of her-3
|
|
NZ594665A
(en)
|
2009-03-20 |
2013-08-30 |
Genentech Inc |
Bispecific anti-her antibodies
|
|
CA2787099A1
(en)
|
2009-03-30 |
2010-10-14 |
Anice C. Lowen |
Influenza virus hemagglutinin polypeptides containing stem domains, vaccines and uses thereof
|
|
CN102482345A
(zh)
|
2009-05-13 |
2012-05-30 |
航道生物技术有限责任公司 |
针对流感病毒的中和分子
|
|
US8969082B2
(en)
|
2009-06-26 |
2015-03-03 |
Sea Lane Biotechnologies, Llc |
Expression of surrogate light chains
|
|
EP2509997B1
(en)
|
2009-12-07 |
2017-08-30 |
i2 Pharmaceuticals, Inc. |
Conjugates comprising an antibody surrogate scaffold with improved pharmacokinetic properties
|
|
EP2944322B1
(en)
|
2010-03-12 |
2018-01-17 |
Merial, Inc |
Bluetongue virus recombinant vaccines and uses thereof
|
|
BR112012025730B1
(pt)
|
2010-04-09 |
2020-12-08 |
Aveo Pharmaceuticals, Inc |
anticorpo isolado que se liga ao erbb3 humano, seus usos, seu processo de produção e vetor de expressão
|
|
SMT202000095T1
(it)
|
2010-05-14 |
2020-03-13 |
Amgen Inc |
Formulazioni di anticorpi anti-sclerostina ad alta concentrazione
|
|
AU2011261270A1
(en)
|
2010-06-03 |
2012-12-13 |
Abraxis Bioscience, Llc |
Peripheral blood SPARC antibodies and uses thereof
|
|
US8790649B2
(en)
|
2010-10-29 |
2014-07-29 |
Immunogen, Inc. |
EGFR-binding molecules and immunoconjugates thereof
|
|
WO2013003652A1
(en)
|
2011-06-28 |
2013-01-03 |
Sea Lane Biotechnologies, Llc |
Multispecific stacked variable domain binding proteins
|
|
EP2736928B1
(en)
|
2011-07-28 |
2019-01-09 |
i2 Pharmaceuticals, Inc. |
Sur-binding proteins against erbb3
|
|
EP2793940B1
(en)
|
2011-12-22 |
2018-11-14 |
i2 Pharmaceuticals, Inc. |
Surrogate binding proteins
|
|
US20150011736A1
(en)
|
2012-01-20 |
2015-01-08 |
Sea Lane Biotechnologies, Llc |
Binding molecule conjugates
|