JP2013541528A5 - - Google Patents
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- JP2013541528A5 JP2013541528A5 JP2013529441A JP2013529441A JP2013541528A5 JP 2013541528 A5 JP2013541528 A5 JP 2013541528A5 JP 2013529441 A JP2013529441 A JP 2013529441A JP 2013529441 A JP2013529441 A JP 2013529441A JP 2013541528 A5 JP2013541528 A5 JP 2013541528A5
- Authority
- JP
- Japan
- Prior art keywords
- polypeptide
- engineered
- residue
- amino acid
- binds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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- 108090000765 processed proteins & peptides Proteins 0.000 claims description 121
- 229920001184 polypeptide Polymers 0.000 claims description 120
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 120
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 40
- 125000000539 amino acid group Chemical group 0.000 claims description 40
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 28
- MTCFGRXMJLQNBG-UHFFFAOYSA-N Serine Natural products OCC(N)C(O)=O MTCFGRXMJLQNBG-UHFFFAOYSA-N 0.000 claims description 28
- AYFVYJQAPQTCCC-UHFFFAOYSA-N Threonine Natural products CC(O)C(N)C(O)=O AYFVYJQAPQTCCC-UHFFFAOYSA-N 0.000 claims description 28
- 239000004473 Threonine Substances 0.000 claims description 28
- 235000006109 methionine Nutrition 0.000 claims description 28
- 229930182817 methionine Natural products 0.000 claims description 28
- 235000004400 serine Nutrition 0.000 claims description 28
- 235000008521 threonine Nutrition 0.000 claims description 28
- 239000004475 Arginine Substances 0.000 claims description 27
- 235000009697 arginine Nutrition 0.000 claims description 27
- ODKSFYDXXFIFQN-UHFFFAOYSA-N arginine Natural products OC(=O)C(N)CCCNC(N)=N ODKSFYDXXFIFQN-UHFFFAOYSA-N 0.000 claims description 27
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 claims description 24
- 235000005772 leucine Nutrition 0.000 claims description 24
- MTCFGRXMJLQNBG-REOHCLBHSA-N (2S)-2-Amino-3-hydroxypropansäure Chemical compound OC[C@H](N)C(O)=O MTCFGRXMJLQNBG-REOHCLBHSA-N 0.000 claims description 23
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 claims description 22
- AYFVYJQAPQTCCC-GBXIJSLDSA-N L-threonine Chemical compound C[C@@H](O)[C@H](N)C(O)=O AYFVYJQAPQTCCC-GBXIJSLDSA-N 0.000 claims description 21
- 239000004471 Glycine Substances 0.000 claims description 20
- ODKSFYDXXFIFQN-BYPYZUCNSA-P L-argininium(2+) Chemical compound NC(=[NH2+])NCCC[C@H]([NH3+])C(O)=O ODKSFYDXXFIFQN-BYPYZUCNSA-P 0.000 claims description 20
- 240000008042 Zea mays Species 0.000 claims description 20
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 claims description 20
- 235000002017 Zea mays subsp mays Nutrition 0.000 claims description 20
- 235000005822 corn Nutrition 0.000 claims description 20
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims description 18
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims description 18
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 18
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims description 18
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims description 18
- KDXKERNSBIXSRK-YFKPBYRVSA-N L-lysine Chemical compound NCCCC[C@H](N)C(O)=O KDXKERNSBIXSRK-YFKPBYRVSA-N 0.000 claims description 18
- KZSNJWFQEVHDMF-BYPYZUCNSA-N L-valine Chemical compound CC(C)[C@H](N)C(O)=O KZSNJWFQEVHDMF-BYPYZUCNSA-N 0.000 claims description 18
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims description 18
- 239000004472 Lysine Substances 0.000 claims description 18
- KZSNJWFQEVHDMF-UHFFFAOYSA-N Valine Natural products CC(C)C(N)C(O)=O KZSNJWFQEVHDMF-UHFFFAOYSA-N 0.000 claims description 18
- 235000004279 alanine Nutrition 0.000 claims description 18
- 235000018417 cysteine Nutrition 0.000 claims description 18
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims description 18
- 235000013922 glutamic acid Nutrition 0.000 claims description 18
- 239000004220 glutamic acid Substances 0.000 claims description 18
- 235000004554 glutamine Nutrition 0.000 claims description 18
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims description 18
- 235000018977 lysine Nutrition 0.000 claims description 18
- 235000014393 valine Nutrition 0.000 claims description 18
- 239000004474 valine Substances 0.000 claims description 18
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims description 16
- HNDVDQJCIGZPNO-YFKPBYRVSA-N L-histidine Chemical compound OC(=O)[C@@H](N)CC1=CN=CN1 HNDVDQJCIGZPNO-YFKPBYRVSA-N 0.000 claims description 16
- AGPKZVBTJJNPAG-WHFBIAKZSA-N L-isoleucine Chemical compound CC[C@H](C)[C@H](N)C(O)=O AGPKZVBTJJNPAG-WHFBIAKZSA-N 0.000 claims description 16
- 235000003704 aspartic acid Nutrition 0.000 claims description 16
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims description 16
- 235000014304 histidine Nutrition 0.000 claims description 16
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims description 16
- 235000014705 isoleucine Nutrition 0.000 claims description 16
- AGPKZVBTJJNPAG-UHFFFAOYSA-N isoleucine Natural products CCC(C)C(N)C(O)=O AGPKZVBTJJNPAG-UHFFFAOYSA-N 0.000 claims description 16
- 229960000310 isoleucine Drugs 0.000 claims description 16
- 238000000034 method Methods 0.000 claims description 14
- 229960005486 vaccine Drugs 0.000 claims description 13
- 150000004676 glycans Chemical class 0.000 claims description 12
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims description 10
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims description 10
- 150000001413 amino acids Chemical group 0.000 claims description 10
- 235000009582 asparagine Nutrition 0.000 claims description 10
- 229960001230 asparagine Drugs 0.000 claims description 10
- ONIBWKKTOPOVIA-BYPYZUCNSA-N L-Proline Chemical compound OC(=O)[C@@H]1CCCN1 ONIBWKKTOPOVIA-BYPYZUCNSA-N 0.000 claims description 8
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 claims description 8
- QIVBCDIJIAJPQS-VIFPVBQESA-N L-tryptophane Chemical compound C1=CC=C2C(C[C@H](N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-VIFPVBQESA-N 0.000 claims description 8
- OUYCCCASQSFEME-QMMMGPOBSA-N L-tyrosine Chemical compound OC(=O)[C@@H](N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-QMMMGPOBSA-N 0.000 claims description 8
- ONIBWKKTOPOVIA-UHFFFAOYSA-N Proline Natural products OC(=O)C1CCCN1 ONIBWKKTOPOVIA-UHFFFAOYSA-N 0.000 claims description 8
- QIVBCDIJIAJPQS-UHFFFAOYSA-N Tryptophan Natural products C1=CC=C2C(CC(N)C(O)=O)=CNC2=C1 QIVBCDIJIAJPQS-UHFFFAOYSA-N 0.000 claims description 8
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 claims description 8
- 235000008729 phenylalanine Nutrition 0.000 claims description 8
- 235000013930 proline Nutrition 0.000 claims description 8
- OUYCCCASQSFEME-UHFFFAOYSA-N tyrosine Natural products OC(=O)C(N)CC1=CC=C(O)C=C1 OUYCCCASQSFEME-UHFFFAOYSA-N 0.000 claims description 8
- 239000011230 binding agent Substances 0.000 claims description 6
- 206010022000 influenza Diseases 0.000 claims description 6
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 claims description 3
- OCUSNPIJIZCRSZ-ZTZWCFDHSA-N (2s)-2-amino-3-methylbutanoic acid;(2s)-2-amino-4-methylpentanoic acid;(2s,3s)-2-amino-3-methylpentanoic acid Chemical compound CC(C)[C@H](N)C(O)=O.CC[C@H](C)[C@H](N)C(O)=O.CC(C)C[C@H](N)C(O)=O OCUSNPIJIZCRSZ-ZTZWCFDHSA-N 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims description 2
- 239000002671 adjuvant Substances 0.000 claims description 2
- 230000002238 attenuated effect Effects 0.000 claims description 2
- 125000001909 leucine group Chemical group [H]N(*)C(C(*)=O)C([H])([H])C(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
- 239000002245 particle Substances 0.000 claims description 2
- 229940031626 subunit vaccine Drugs 0.000 claims description 2
- 125000000341 threoninyl group Chemical group [H]OC([H])(C([H])([H])[H])C([H])(N([H])[H])C(*)=O 0.000 claims description 2
- 241000712461 unidentified influenza virus Species 0.000 claims description 2
- 241000282412 Homo Species 0.000 description 1
- 208000015181 infectious disease Diseases 0.000 description 1
- 230000002458 infectious effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38478010P | 2010-09-21 | 2010-09-21 | |
| US61/384,780 | 2010-09-21 | ||
| PCT/US2011/052670 WO2012040406A2 (en) | 2010-09-21 | 2011-09-21 | Influenza treatment and/or characterization; human-adapted ha polypeptides; vaccines |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016030487A Division JP2016094484A (ja) | 2010-09-21 | 2016-02-19 | ヒト適応ｈａポリペプチド、ワクチン、およびインフルエンザの処置 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2013541528A JP2013541528A (ja) | 2013-11-14 |
| JP2013541528A5 true JP2013541528A5 (enExample) | 2014-11-13 |
Family
ID=45874368
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013529441A Pending JP2013541528A (ja) | 2010-09-21 | 2011-09-21 | ヒト適応ｈａポリペプチド、ワクチン、およびインフルエンザの処置 |
| JP2016030487A Pending JP2016094484A (ja) | 2010-09-21 | 2016-02-19 | ヒト適応ｈａポリペプチド、ワクチン、およびインフルエンザの処置 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2016030487A Pending JP2016094484A (ja) | 2010-09-21 | 2016-02-19 | ヒト適応ｈａポリペプチド、ワクチン、およびインフルエンザの処置 |
Country Status (6)
| Country | Link |
|---|---|
| US (3) | US8802110B2 (enExample) |
| EP (1) | EP2640405A4 (enExample) |
| JP (2) | JP2013541528A (enExample) |
| AU (1) | AU2011305371B2 (enExample) |
| CA (1) | CA2811023A1 (enExample) |
| WO (1) | WO2012040406A2 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2011305371B2 (en) | 2010-09-21 | 2015-05-21 | Massachusetts Institute Of Technology | Human-adapted HA polypeptides, vaccines, and influenza treatment |
| US9969794B2 (en) | 2012-05-10 | 2018-05-15 | Visterra, Inc. | HA binding agents |
| US10526375B2 (en) | 2013-06-05 | 2020-01-07 | Massachusetts Institute Of Technology | Human Adaptation of H7 HA |
| WO2017083627A1 (en) | 2015-11-13 | 2017-05-18 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| CA3015347A1 (en) | 2016-02-24 | 2017-08-31 | Visterra, Inc. | Formulations of antibody molecules to influenza virus |
| WO2019086463A1 (en) | 2017-10-30 | 2019-05-09 | Baxalta GmbH | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
| EP3731862A1 (en) * | 2017-12-29 | 2020-11-04 | Development Center for Biotechnology | A universal vaccine against influenza |
| EP3946613A1 (en) | 2019-03-25 | 2022-02-09 | Visterra, Inc. | Compositions and methods for treating and preventing influenza |
| CA3142339A1 (en) | 2019-05-31 | 2020-12-03 | Rubryc Therapeutics, Inc. | Machine learning-based apparatus for engineering meso-scale peptides and methods and system for the same |
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2011
- 2011-09-21 AU AU2011305371A patent/AU2011305371B2/en active Active
- 2011-09-21 US US13/239,376 patent/US8802110B2/en active Active
- 2011-09-21 WO PCT/US2011/052670 patent/WO2012040406A2/en not_active Ceased
- 2011-09-21 CA CA2811023A patent/CA2811023A1/en not_active Abandoned
- 2011-09-21 EP EP11827500.7A patent/EP2640405A4/en not_active Withdrawn
- 2011-09-21 JP JP2013529441A patent/JP2013541528A/ja active Pending
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2014
- 2014-07-25 US US14/341,285 patent/US9745352B2/en active Active
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2016
- 2016-02-19 JP JP2016030487A patent/JP2016094484A/ja active Pending
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2017
- 2017-07-13 US US15/648,540 patent/US20180009850A1/en not_active Abandoned