JP2010508030A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2010508030A5 JP2010508030A5 JP2009534896A JP2009534896A JP2010508030A5 JP 2010508030 A5 JP2010508030 A5 JP 2010508030A5 JP 2009534896 A JP2009534896 A JP 2009534896A JP 2009534896 A JP2009534896 A JP 2009534896A JP 2010508030 A5 JP2010508030 A5 JP 2010508030A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- vaccine
- nucleic acid
- amino acid
- vector
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims 24
- 102000004169 proteins and genes Human genes 0.000 claims 24
- 229960005486 vaccine Drugs 0.000 claims 12
- 108020004707 nucleic acids Proteins 0.000 claims 11
- 102000039446 nucleic acids Human genes 0.000 claims 11
- 150000007523 nucleic acids Chemical class 0.000 claims 11
- 150000001413 amino acids Chemical class 0.000 claims 8
- 239000013598 vector Substances 0.000 claims 8
- 108090000765 processed proteins & peptides Proteins 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 239000000427 antigen Substances 0.000 claims 5
- 102000036639 antigens Human genes 0.000 claims 5
- 108091007433 antigens Proteins 0.000 claims 5
- 206010022000 influenza Diseases 0.000 claims 5
- 241000712461 unidentified influenza virus Species 0.000 claims 5
- 101710154606 Hemagglutinin Proteins 0.000 claims 4
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 4
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 4
- 101710176177 Protein A56 Proteins 0.000 claims 4
- 239000000185 hemagglutinin Substances 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 230000005764 inhibitory process Effects 0.000 claims 4
- 239000000546 pharmaceutical excipient Substances 0.000 claims 4
- 230000002265 prevention Effects 0.000 claims 4
- 230000003612 virological effect Effects 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 239000008194 pharmaceutical composition Substances 0.000 claims 3
- 238000002360 preparation method Methods 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 2
- 239000013604 expression vector Substances 0.000 claims 2
- 244000052769 pathogen Species 0.000 claims 2
- 230000001717 pathogenic effect Effects 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 244000144977 poultry Species 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 241000271566 Aves Species 0.000 claims 1
- 206010069767 H1N1 influenza Diseases 0.000 claims 1
- 241000238631 Hexapoda Species 0.000 claims 1
- 208000002979 Influenza in Birds Diseases 0.000 claims 1
- KDXKERNSBIXSRK-UHFFFAOYSA-N Lysine Natural products NCCCCC(N)C(O)=O KDXKERNSBIXSRK-UHFFFAOYSA-N 0.000 claims 1
- 239000004472 Lysine Substances 0.000 claims 1
- 208000009620 Orthomyxoviridae Infections Diseases 0.000 claims 1
- 241000282898 Sus scrofa Species 0.000 claims 1
- 206010064097 avian influenza Diseases 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 201000010740 swine influenza Diseases 0.000 claims 1
- 241000701447 unidentified baculovirus Species 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US86314206P | 2006-10-27 | 2006-10-27 | |
| US60/863,142 | 2006-10-27 | ||
| US11/923,326 | 2007-10-24 | ||
| US11/923,326 US8202967B2 (en) | 2006-10-27 | 2007-10-24 | H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use |
| PCT/US2007/082699 WO2008052173A2 (en) | 2006-10-27 | 2007-10-26 | Novel h5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013165132A Division JP2014012008A (ja) | 2006-10-27 | 2013-08-08 | 新規ｈ５タンパク質、それらをコードする核酸分子およびベクター、ならびにそれらの医薬的使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010508030A JP2010508030A (ja) | 2010-03-18 |
| JP2010508030A5 true JP2010508030A5 (enExample) | 2010-12-16 |
| JP5442442B2 JP5442442B2 (ja) | 2014-03-12 |
Family
ID=39325469
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009534896A Active JP5442442B2 (ja) | 2006-10-27 | 2007-10-26 | 新規ｈ５タンパク質、それらをコードする核酸分子およびベクター、ならびにそれらの医薬的使用 |
| JP2013165132A Withdrawn JP2014012008A (ja) | 2006-10-27 | 2013-08-08 | 新規ｈ５タンパク質、それらをコードする核酸分子およびベクター、ならびにそれらの医薬的使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013165132A Withdrawn JP2014012008A (ja) | 2006-10-27 | 2013-08-08 | 新規ｈ５タンパク質、それらをコードする核酸分子およびベクター、ならびにそれらの医薬的使用 |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US8202967B2 (enExample) |
| EP (1) | EP2086576B8 (enExample) |
| JP (2) | JP5442442B2 (enExample) |
| KR (2) | KR101520307B1 (enExample) |
| AU (1) | AU2007308869B2 (enExample) |
| BR (1) | BRPI0718183B8 (enExample) |
| CA (1) | CA2664914C (enExample) |
| CO (1) | CO6210831A2 (enExample) |
| DK (1) | DK2086576T3 (enExample) |
| ES (1) | ES2391123T3 (enExample) |
| MX (1) | MX2009004243A (enExample) |
| MY (1) | MY150226A (enExample) |
| PL (1) | PL2086576T3 (enExample) |
| PT (1) | PT2086576E (enExample) |
| RU (1) | RU2479589C2 (enExample) |
| SG (1) | SG176419A1 (enExample) |
| SI (1) | SI2086576T1 (enExample) |
| WO (1) | WO2008052173A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2626866A1 (en) * | 2005-10-28 | 2007-05-10 | Boehringer Ingelheim Vetmedica, Inc. | Use of vaccines for the treatment/ prevention of the transmission of influenza pathogens between species |
| US8202967B2 (en) * | 2006-10-27 | 2012-06-19 | Boehringer Ingelheim Vetmedica, Inc. | H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use |
| CA2683977C (en) | 2007-03-14 | 2017-04-25 | Ligocyte Pharmaceuticals, Inc. | A method of norovirus virus-like particle purification comprising ion exchange chromatography |
| CN102271704A (zh) | 2008-11-28 | 2011-12-07 | 梅里亚有限公司 | 重组禽流感疫苗及其用途 |
| SG183514A1 (en) * | 2010-03-11 | 2012-10-30 | Immune Design Corp | Vaccines for pandemic influenza |
| SG10201709806VA (en) | 2010-10-04 | 2017-12-28 | Massachusetts Inst Technology | Hemagglutinin polypeptides, and reagents and methods relating thereto |
| AR088028A1 (es) * | 2011-08-15 | 2014-05-07 | Boehringer Ingelheim Vetmed | Proteinas h5, de h5n1 para un uso medicinal |
| JOP20130186B1 (ar) | 2012-06-22 | 2021-08-17 | Takeda Vaccines Montana Inc | تنقية الجزيئات الشبيهة بالفيروسات |
| MX360137B (es) * | 2013-02-21 | 2018-10-24 | Boehringer Ingelheim Vetmedica Gmbh | Proteínas h5 del virus de la influenza h5n1 para usarse como un medicamento. |
| JP2015015931A (ja) * | 2013-07-12 | 2015-01-29 | 株式会社Ｕｍｎファーマ | ウイルス様粒子を含む培養物の製造方法 |
| JOP20190088A1 (ar) | 2016-10-21 | 2019-04-21 | Us Agriculture | نواقل مؤتلفة للتعبير عن مولدات مضاد فيروس انفلونزا الطيور و استخداماتها |
| JP7337921B2 (ja) * | 2018-11-06 | 2023-09-04 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | 鳥インフルエンザウイルスｈ５亜型に対する免疫原性組成物 |
| CN117229370B (zh) * | 2022-06-08 | 2024-11-01 | 中科南京生命健康高等研究院 | H5n6禽流感广谱性疫苗的开发及其应用 |
| WO2026013162A1 (en) | 2024-07-10 | 2026-01-15 | Boehringer Ingelheim Vetmedica Gmbh | Herpes virus of turkey vector based h5ha vaccine for the treatment and prevention of avian influenza infections in turkeys |
| WO2026013161A1 (en) | 2024-07-10 | 2026-01-15 | Boehringer Ingelheim Vetmedica Gmbh | Prime and boost vaccination for the treatment and prevention of avian influenza infections in avians |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US382425A (en) | 1888-05-08 | Brandt | ||
| US2909462A (en) | 1955-12-08 | 1959-10-20 | Bristol Myers Co | Acrylic acid polymer laxative compositions |
| US4769331A (en) | 1981-09-16 | 1988-09-06 | University Patents, Inc. | Recombinant methods and materials |
| US5338683A (en) | 1981-12-24 | 1994-08-16 | Health Research Incorporated | Vaccinia virus containing DNA sequences encoding herpesvirus glycoproteins |
| US5833975A (en) | 1989-03-08 | 1998-11-10 | Virogenetics Corporation | Canarypox virus expressing cytokine and/or tumor-associated antigen DNA sequence |
| US4603112A (en) | 1981-12-24 | 1986-07-29 | Health Research, Incorporated | Modified vaccinia virus |
| US5364773A (en) | 1991-03-07 | 1994-11-15 | Virogenetics Corporation | Genetically engineered vaccine strain |
| US4769330A (en) | 1981-12-24 | 1988-09-06 | Health Research, Incorporated | Modified vaccinia virus and methods for making and using the same |
| US5174993A (en) | 1981-12-24 | 1992-12-29 | Health Research Inc. | Recombinant avipox virus and immunological use thereof |
| US5505941A (en) | 1981-12-24 | 1996-04-09 | Health Research, Inc. | Recombinant avipox virus and method to induce an immune response |
| US4722848A (en) | 1982-12-08 | 1988-02-02 | Health Research, Incorporated | Method for immunizing animals with synthetically modified vaccinia virus |
| US4745051A (en) | 1983-05-27 | 1988-05-17 | The Texas A&M University System | Method for producing a recombinant baculovirus expression vector |
| US4552758A (en) * | 1983-12-20 | 1985-11-12 | St. Jude Children's Research Hospital | Human use of avian-human reassortants as vaccines for influenza A virus |
| US4945050A (en) | 1984-11-13 | 1990-07-31 | Cornell Research Foundation, Inc. | Method for transporting substances into living cells and tissues and apparatus therefor |
| IE872748L (en) | 1986-10-16 | 1988-04-16 | Arjomari Europ | Polypeptides derived from the evvelope gene of human¹immunodeficiency virus in recombinant baculovirus infected¹insect cells |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US6024983A (en) | 1986-10-24 | 2000-02-15 | Southern Research Institute | Composition for delivering bioactive agents for immune response and its preparation |
| GB8717430D0 (en) | 1987-07-23 | 1987-08-26 | Celltech Ltd | Recombinant dna product |
| EP0386185A1 (fr) | 1988-07-29 | 1990-09-12 | IntraCel Corporation | Procede d'expression genetique de proteines heterologues par des cellules transfectees in vivo |
| CA2003300A1 (en) | 1988-11-21 | 1990-05-21 | Franklin Volvovitz | Skin test and test kit for aids |
| ATE240401T1 (de) | 1989-03-21 | 2003-05-15 | Vical Inc | Expression von exogenen polynukleotidsequenzen in wirbeltieren |
| US5703055A (en) | 1989-03-21 | 1997-12-30 | Wisconsin Alumni Research Foundation | Generation of antibodies through lipid mediated DNA delivery |
| US5552143A (en) | 1989-03-24 | 1996-09-03 | The Wistar Institute Of Anatomy & Biology | Recombinant cytomegalovirus vaccine |
| US5591439A (en) | 1989-03-24 | 1997-01-07 | The Wistar Institute Of Anatomy And Biology | Recombinant cytomegalovirus vaccine |
| US5690938A (en) | 1989-07-07 | 1997-11-25 | Oravax, Inc. | Oral immunization with multiple particulate antigen delivery system |
| US5436146A (en) | 1989-09-07 | 1995-07-25 | The Trustees Of Princeton University | Helper-free stocks of recombinant adeno-associated virus vectors |
| GB9001766D0 (en) | 1990-01-25 | 1990-03-28 | Univ Court Of The University O | Vaccines |
| HK1004060A1 (en) | 1990-04-24 | 1998-11-13 | Flustat Pty Ltd | Oral vaccine comprising antigen surface-associated with red blood cells |
| JP3602530B2 (ja) | 1991-03-07 | 2004-12-15 | ヴァイロジェネティクス コーポレイション | 遺伝子操作したワクチン菌株 |
| US5997878A (en) | 1991-03-07 | 1999-12-07 | Connaught Laboratories | Recombinant poxvirus-cytomegalovirus, compositions and uses |
| ATE181108T1 (de) | 1991-08-26 | 1999-06-15 | Immuno Ag | Direkt molekuläre klonierung eines modifizierten genoms eines chordopocken-virus |
| US5643578A (en) | 1992-03-23 | 1997-07-01 | University Of Massachusetts Medical Center | Immunization by inoculation of DNA transcription unit |
| US5807722A (en) | 1992-10-30 | 1998-09-15 | Bioengineering Resources, Inc. | Biological production of acetic acid from waste gases with Clostridium ljungdahlii |
| US5801029A (en) | 1993-02-16 | 1998-09-01 | Onyx Pharmaceuticals, Inc. | Cytopathic viruses for therapy and prophylaxis of neoplasia |
| IL108915A0 (en) | 1993-03-18 | 1994-06-24 | Merck & Co Inc | Polynucleotide vaccine against influenza virus |
| FR2711670B1 (fr) | 1993-10-22 | 1996-01-12 | Pasteur Institut | Vecteur nucléotidique, composition le contenant et vaccin pour l'immunisation à l'encontre d'une hépatite. |
| EP1170368B1 (en) | 1994-01-27 | 2010-07-28 | University Of Massachusetts Medical Center | Immunization by inoculation of dna transcription unit |
| ATE298370T1 (de) | 1994-04-29 | 2005-07-15 | Baxter Healthcare Sa | Rekombinante poxviren mit fremdenpolynukleotiden in wichtigen regionen |
| US5928913A (en) | 1995-03-23 | 1999-07-27 | Efstathiou; Stacey | Vectors for gene delivery |
| EP0979101B1 (en) | 1996-07-03 | 2010-10-27 | Merial, Inc. | Recombinant canine adenovirus 2 (cav2) containing exogenous dna |
| US6183752B1 (en) | 1997-02-05 | 2001-02-06 | Pasteur Merieux Serums Et Vaccins | Restenosis/atherosclerosis diagnosis, prophylaxis and therapy |
| US6204281B1 (en) * | 1998-07-10 | 2001-03-20 | Novartis Ag | Method of treatment and pharmaceutical composition |
| CN100489107C (zh) | 2000-04-28 | 2009-05-20 | 圣朱德儿童研究医院 | 用于产生感染性流感病毒的dna转染系统 |
| US20020095197A1 (en) | 2000-07-11 | 2002-07-18 | Lardo Albert C. | Application of photochemotherapy for the treatment of cardiac arrhythmias |
| JPWO2002062381A1 (ja) * | 2001-02-05 | 2004-06-03 | 久光製薬株式会社 | バキュロウイルスベクターワクチン |
| CA2456034A1 (en) * | 2001-08-03 | 2003-02-20 | Takeda Chemical Industries, Ltd. | Sustained-release medicines |
| JP2005539039A (ja) | 2002-08-27 | 2005-12-22 | ダウ アグロサイエンシィズ エルエルシー | 鳥類及び家禽類におけるアジュバントとしてのエシェリシア・コリ熱不安定性毒素の使用 |
| US7566458B2 (en) * | 2003-06-16 | 2009-07-28 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| WO2005004222A1 (en) | 2003-07-04 | 2005-01-13 | Koninklijke Philips Electronics N.V. | Precursor solution, method of preparation thereof and use thereof |
| DE202005022108U1 (de) | 2004-03-09 | 2013-11-12 | Novartis Vaccines And Diagnostics, Inc. | Influenza-Virus-Impfstoffe |
| EP1766059B1 (en) | 2004-05-25 | 2012-07-11 | MedImmune Vaccines, Inc. | Influenza hemagglutinin and neuraminidase variants |
| CN1748795A (zh) * | 2004-09-17 | 2006-03-22 | 金宁一 | 多价禽流感重组活载体疫苗 |
| RU2283139C1 (ru) * | 2005-03-21 | 2006-09-10 | Федеральное государственное унитарное предприятие "Научно-производственное объединение по медицинским иммунобиологическим препаратам "Микроген" Министерства здравоохранения Российской Федерации | Способ получения антигенов для вакцины против вирусов гриппа |
| EP1877088B1 (en) * | 2005-04-11 | 2014-12-17 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Vaccine against pandemic strains of influenza viruses |
| US7871626B2 (en) * | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
| TWI488968B (zh) | 2005-10-18 | 2015-06-21 | Novavax Inc | 功能性流行性感冒類病毒顆粒（ＶＬＰｓ） |
| CA2626866A1 (en) * | 2005-10-28 | 2007-05-10 | Boehringer Ingelheim Vetmedica, Inc. | Use of vaccines for the treatment/ prevention of the transmission of influenza pathogens between species |
| US20100150941A1 (en) | 2006-09-13 | 2010-06-17 | Dso National Laboratories | Hemagglutinin antibody and uses thereof |
| US8202967B2 (en) * | 2006-10-27 | 2012-06-19 | Boehringer Ingelheim Vetmedica, Inc. | H5 proteins, nucleic acid molecules and vectors encoding for those, and their medicinal use |
| WO2011136738A1 (en) | 2010-04-30 | 2011-11-03 | Temasek Life Sciences Laboratory Limited | Universal vaccine against h5n1 lineages |
| AR088028A1 (es) | 2011-08-15 | 2014-05-07 | Boehringer Ingelheim Vetmed | Proteinas h5, de h5n1 para un uso medicinal |
| MX360137B (es) | 2013-02-21 | 2018-10-24 | Boehringer Ingelheim Vetmedica Gmbh | Proteínas h5 del virus de la influenza h5n1 para usarse como un medicamento. |
-
2007
- 2007-10-24 US US11/923,326 patent/US8202967B2/en active Active
- 2007-10-26 MX MX2009004243A patent/MX2009004243A/es active IP Right Grant
- 2007-10-26 WO PCT/US2007/082699 patent/WO2008052173A2/en not_active Ceased
- 2007-10-26 KR KR1020097010893A patent/KR101520307B1/ko active Active
- 2007-10-26 MY MYPI20091667A patent/MY150226A/en unknown
- 2007-10-26 RU RU2009119597/10A patent/RU2479589C2/ru active
- 2007-10-26 EP EP07863555.4A patent/EP2086576B8/en active Active
- 2007-10-26 SI SI200731036T patent/SI2086576T1/sl unknown
- 2007-10-26 ES ES07863555T patent/ES2391123T3/es active Active
- 2007-10-26 PL PL07863555T patent/PL2086576T3/pl unknown
- 2007-10-26 AU AU2007308869A patent/AU2007308869B2/en active Active
- 2007-10-26 KR KR20157008683A patent/KR20150041200A/ko not_active Withdrawn
- 2007-10-26 BR BRPI0718183A patent/BRPI0718183B8/pt active IP Right Grant
- 2007-10-26 SG SG2011077781A patent/SG176419A1/en unknown
- 2007-10-26 JP JP2009534896A patent/JP5442442B2/ja active Active
- 2007-10-26 PT PT07863555T patent/PT2086576E/pt unknown
- 2007-10-26 CA CA2664914A patent/CA2664914C/en active Active
- 2007-10-26 DK DK07863555.4T patent/DK2086576T3/da active
-
2009
- 2009-04-27 CO CO09042413A patent/CO6210831A2/es active IP Right Grant
-
2012
- 2012-05-21 US US13/476,405 patent/US8592558B2/en active Active
-
2013
- 2013-08-08 JP JP2013165132A patent/JP2014012008A/ja not_active Withdrawn
- 2013-10-23 US US14/061,249 patent/US9375469B2/en active Active
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2010508030A5 (enExample) | ||
| RU2609645C2 (ru) | Экспрессионные системы | |
| RU2009119597A (ru) | Новые белки н5, кодирующие их молекулы нуклеиновых кислот и векторы, и их применение в медицине | |
| JP2014527526A5 (enExample) | ||
| JP2011528222A5 (enExample) | ||
| JP2010500399A5 (enExample) | ||
| AR088028A1 (es) | Proteinas h5, de h5n1 para un uso medicinal | |
| EP2661442A1 (en) | Monomeric and multimeric immunogenic peptides | |
| CA2380833A1 (en) | Proteins derived from white spot syndrome virus and uses thereof | |
| CN104619718A (zh) | 源自病毒蛋白的肽用作免疫原和配药成分 | |
| CN101186637A (zh) | 抑制流感病毒感染的方法及其药物 | |
| JP7403733B2 (ja) | インフルエンザｈａスプリットワクチンの製造方法 | |
| TWI396741B (zh) | 非洲綠猴腎細胞培養之流感病毒及疫苗 | |
| JP2020509770A5 (enExample) | ||
| CN101879312B (zh) | 广谱型流感疫苗及其制备方法 | |
| JP2018533908A5 (enExample) | ||
| Li et al. | A recombinant protein containing highly conserved hemagglutinin residues 81-122 of influenza H5N1 induces strong humoral and mucosal immune responses | |
| ES2349153T3 (es) | Inhibidores del virus de la hepatitis c. | |
| CN107344969A (zh) | 一种纳米流感疫苗及构建方法和应用 | |
| JP2019534242A5 (enExample) | ||
| CN113069540B (zh) | 一种基于流感病毒载体的新型冠状病毒疫苗及其制备方法 | |
| TW202317600A (zh) | 預防多種病毒感染的多價疫苗 | |
| CN108348596A (zh) | 用牛免疫缺陷病毒Gag蛋白的重组病毒样颗粒 | |
| CN103316357A (zh) | 携带rsv基因的重组流感病毒嵌合疫苗及其制备方法 | |
| JPWO2002062381A1 (ja) | バキュロウイルスベクターワクチン |