JP2019534242A5 - - Google Patents
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- Publication number
- JP2019534242A5 JP2019534242A5 JP2019511574A JP2019511574A JP2019534242A5 JP 2019534242 A5 JP2019534242 A5 JP 2019534242A5 JP 2019511574 A JP2019511574 A JP 2019511574A JP 2019511574 A JP2019511574 A JP 2019511574A JP 2019534242 A5 JP2019534242 A5 JP 2019534242A5
- Authority
- JP
- Japan
- Prior art keywords
- amino acid
- charged amino
- positively charged
- region
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 26
- 239000000203 mixture Substances 0.000 claims 21
- 150000001413 amino acids Chemical class 0.000 claims 20
- 229920001184 polypeptide Polymers 0.000 claims 12
- 102000004196 processed proteins & peptides Human genes 0.000 claims 12
- 108090000765 processed proteins & peptides Proteins 0.000 claims 12
- 229910052757 nitrogen Inorganic materials 0.000 claims 11
- 238000006467 substitution reaction Methods 0.000 claims 8
- 101710154606 Hemagglutinin Proteins 0.000 claims 6
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims 6
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims 6
- 101710176177 Protein A56 Proteins 0.000 claims 6
- 239000000185 hemagglutinin Substances 0.000 claims 6
- 208000037797 influenza A Diseases 0.000 claims 6
- 229910052698 phosphorus Inorganic materials 0.000 claims 5
- 230000002163 immunogen Effects 0.000 claims 4
- 239000002671 adjuvant Substances 0.000 claims 3
- 229960005486 vaccine Drugs 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 2
- 206010022000 influenza Diseases 0.000 claims 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims 2
- 241000712431 Influenza A virus Species 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 230000036755 cellular response Effects 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000012895 dilution Substances 0.000 claims 1
- 238000010790 dilution Methods 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 230000006698 induction Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 239000002245 particle Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127557 pharmaceutical product Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2022209044A JP7762643B2 (ja) | 2016-08-25 | 2022-12-26 | 免疫原性組成物 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1614485.9A GB201614485D0 (en) | 2016-08-25 | 2016-08-25 | Immunogenic composition |
| GB1614485.9 | 2016-08-25 | ||
| PCT/GB2017/052510 WO2018037246A1 (en) | 2016-08-25 | 2017-08-25 | Immunogenic composition |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022209044A Division JP7762643B2 (ja) | 2016-08-25 | 2022-12-26 | 免疫原性組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019534242A JP2019534242A (ja) | 2019-11-28 |
| JP2019534242A5 true JP2019534242A5 (enExample) | 2020-10-01 |
| JP7203015B2 JP7203015B2 (ja) | 2023-01-12 |
Family
ID=57119951
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019511574A Active JP7203015B2 (ja) | 2016-08-25 | 2017-08-25 | 免疫原性組成物 |
| JP2022209044A Active JP7762643B2 (ja) | 2016-08-25 | 2022-12-26 | 免疫原性組成物 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022209044A Active JP7762643B2 (ja) | 2016-08-25 | 2022-12-26 | 免疫原性組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US11123422B2 (enExample) |
| EP (1) | EP3504235A1 (enExample) |
| JP (2) | JP7203015B2 (enExample) |
| CN (1) | CN109923125B (enExample) |
| AU (2) | AU2017315238A1 (enExample) |
| CA (1) | CA3034328A1 (enExample) |
| GB (1) | GB201614485D0 (enExample) |
| WO (1) | WO2018037246A1 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB201614485D0 (en) * | 2016-08-25 | 2016-10-12 | Univ Oxford Innovation Ltd | Immunogenic composition |
| CN113423421A (zh) * | 2018-09-21 | 2021-09-21 | 内布拉斯加大学董事会 | 制备和使用通用中心化流感疫苗基因的方法 |
| GB2578163A (en) * | 2018-10-19 | 2020-04-22 | Univ Pretoria | Plant produced avian influenza antigens and their uses in diagnostic assays and devices |
| GB202204478D0 (en) * | 2022-03-29 | 2022-05-11 | Univ Oxford Innovation Ltd | Immunogenic compositions |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4235877A (en) | 1979-06-27 | 1980-11-25 | Merck & Co., Inc. | Liposome particle containing viral or bacterial antigenic subunit |
| CA2035576A1 (en) | 1990-02-07 | 1991-08-08 | Alexander R. Neurath | Conformational epitopes of human immunodeficiency virus envelope glycoprotein gp120 hiv-1 |
| BR9610262B1 (pt) * | 1995-09-01 | 2013-11-26 | Compostos e métodos para a imunoterapia e diagnose de tuberculose. | |
| US20040009939A1 (en) * | 2002-03-05 | 2004-01-15 | Board Of Regent, The University Of Texas System | Methods of enhancing immune induction involving MDA-7 |
| EP1877088B1 (en) * | 2005-04-11 | 2014-12-17 | THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES | Vaccine against pandemic strains of influenza viruses |
| EP2024393A2 (en) | 2006-05-15 | 2009-02-18 | Sea Lane Biotechnologies,llc. | Neutralizing antibodies to influenza viruses |
| AU2007286161B2 (en) * | 2006-08-09 | 2013-05-02 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| CA2730668C (en) | 2008-07-18 | 2020-04-28 | Medicago Inc. | New influenza virus immunizing epitope |
| MX340735B (es) * | 2010-04-09 | 2016-07-22 | Univ Utrecht Holding Bv | Proteinas multimericas recombinantes de la influenza. |
| JP2013540701A (ja) * | 2010-08-12 | 2013-11-07 | セラクローン サイエンシーズ， インコーポレイテッド | 抗赤血球凝集素抗体組成物およびその使用方法 |
| WO2012036993A1 (en) | 2010-09-14 | 2012-03-22 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Computationally optimized broadly reactive antigens for influenza |
| WO2012089231A1 (en) | 2010-12-30 | 2012-07-05 | Okairòs Ag | Paramyxovirus vaccines |
| CN104582714A (zh) * | 2012-05-23 | 2015-04-29 | 斯坦福大学托管董事会 | 流感疫苗构建体 |
| US8932598B2 (en) * | 2012-08-28 | 2015-01-13 | Vaxinnate Corporation | Fusion proteins and methods of use |
| WO2014153674A1 (en) | 2013-03-28 | 2014-10-02 | Medicago Inc. | Influenza virus-like particle production in plants |
| GB201614485D0 (en) * | 2016-08-25 | 2016-10-12 | Univ Oxford Innovation Ltd | Immunogenic composition |
-
2016
- 2016-08-25 GB GBGB1614485.9A patent/GB201614485D0/en not_active Ceased
-
2017
- 2017-08-25 EP EP17758932.2A patent/EP3504235A1/en active Pending
- 2017-08-25 JP JP2019511574A patent/JP7203015B2/ja active Active
- 2017-08-25 US US16/326,749 patent/US11123422B2/en active Active
- 2017-08-25 CN CN201780051719.XA patent/CN109923125B/zh active Active
- 2017-08-25 CA CA3034328A patent/CA3034328A1/en active Pending
- 2017-08-25 AU AU2017315238A patent/AU2017315238A1/en not_active Abandoned
- 2017-08-25 WO PCT/GB2017/052510 patent/WO2018037246A1/en not_active Ceased
-
2021
- 2021-08-27 US US17/458,712 patent/US12390518B2/en active Active
-
2022
- 2022-12-26 JP JP2022209044A patent/JP7762643B2/ja active Active
-
2024
- 2024-10-28 AU AU2024227680A patent/AU2024227680A1/en active Pending
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