JP2016506416A5 - - Google Patents
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- Publication number
- JP2016506416A5 JP2016506416A5 JP2015552058A JP2015552058A JP2016506416A5 JP 2016506416 A5 JP2016506416 A5 JP 2016506416A5 JP 2015552058 A JP2015552058 A JP 2015552058A JP 2015552058 A JP2015552058 A JP 2015552058A JP 2016506416 A5 JP2016506416 A5 JP 2016506416A5
- Authority
- JP
- Japan
- Prior art keywords
- epitope
- influenza
- derived
- immunogenic composition
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000427 antigen Substances 0.000 claims description 41
- 102000036639 antigens Human genes 0.000 claims description 41
- 108091007433 antigens Proteins 0.000 claims description 41
- 239000000203 mixture Substances 0.000 claims description 34
- 229920001184 polypeptide Polymers 0.000 claims description 30
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 30
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 30
- 230000002163 immunogen Effects 0.000 claims description 29
- 241000712461 unidentified influenza virus Species 0.000 claims description 13
- 239000000185 hemagglutinin Substances 0.000 claims description 8
- 206010022000 influenza Diseases 0.000 claims description 8
- 101710154606 Hemagglutinin Proteins 0.000 claims description 6
- 241000712431 Influenza A virus Species 0.000 claims description 6
- 241000713196 Influenza B virus Species 0.000 claims description 6
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 6
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 6
- 101710176177 Protein A56 Proteins 0.000 claims description 6
- 101900234398 Influenza B virus Hemagglutinin Proteins 0.000 claims description 5
- 101900159346 Influenza A virus Hemagglutinin Proteins 0.000 claims description 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims description 4
- 150000001413 amino acids Chemical class 0.000 claims description 4
- 241000710929 Alphavirus Species 0.000 claims description 2
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 2
- 229920002988 biodegradable polymer Polymers 0.000 claims description 2
- 239000004621 biodegradable polymer Substances 0.000 claims description 2
- 125000002091 cationic group Chemical group 0.000 claims description 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 2
- 239000002502 liposome Substances 0.000 claims description 2
- 239000011859 microparticle Substances 0.000 claims description 2
- 239000000839 emulsion Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 230000001988 toxicity Effects 0.000 claims 1
- 231100000419 toxicity Toxicity 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 229960005486 vaccine Drugs 0.000 description 4
- 229940124873 Influenza virus vaccine Drugs 0.000 description 3
- 239000007764 o/w emulsion Substances 0.000 description 2
- 210000002845 virion Anatomy 0.000 description 2
- 229940126581 whole-virion vaccine Drugs 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 1
- 108010029566 avian influenza A virus hemagglutinin Proteins 0.000 description 1
- 230000028993 immune response Effects 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 231100000252 nontoxic Toxicity 0.000 description 1
- 230000003000 nontoxic effect Effects 0.000 description 1
- 125000003729 nucleotide group Chemical group 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361751077P | 2013-01-10 | 2013-01-10 | |
| US61/751,077 | 2013-01-10 | ||
| PCT/EP2014/050414 WO2014108515A1 (en) | 2013-01-10 | 2014-01-10 | Influenza virus immunogenic compositions and uses thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017229215A Division JP2018035195A (ja) | 2013-01-10 | 2017-11-29 | インフルエンザウイルス免疫原性組成物およびその使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2016506416A JP2016506416A (ja) | 2016-03-03 |
| JP2016506416A5 true JP2016506416A5 (enExample) | 2017-02-16 |
Family
ID=49956176
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015552058A Pending JP2016506416A (ja) | 2013-01-10 | 2014-01-10 | インフルエンザウイルス免疫原性組成物およびその使用 |
| JP2017229215A Pending JP2018035195A (ja) | 2013-01-10 | 2017-11-29 | インフルエンザウイルス免疫原性組成物およびその使用 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017229215A Pending JP2018035195A (ja) | 2013-01-10 | 2017-11-29 | インフルエンザウイルス免疫原性組成物およびその使用 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20140193484A1 (enExample) |
| EP (1) | EP2943221A1 (enExample) |
| JP (2) | JP2016506416A (enExample) |
| CN (2) | CN109045294A (enExample) |
| AU (2) | AU2014204826A1 (enExample) |
| CA (1) | CA2897752A1 (enExample) |
| HK (1) | HK1214962A1 (enExample) |
| MX (1) | MX2015008847A (enExample) |
| RU (1) | RU2015132962A (enExample) |
| WO (1) | WO2014108515A1 (enExample) |
Families Citing this family (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9708373B2 (en) | 2010-03-30 | 2017-07-18 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccine and uses thereof |
| JP2013537518A (ja) | 2010-07-06 | 2013-10-03 | ノバルティス アーゲー | ＲＮＡ送達に有利なｐＫａ値を有する脂質を含むリポソーム |
| DK3243526T3 (da) | 2010-07-06 | 2020-02-17 | Glaxosmithkline Biologicals Sa | Levering af rna til at udløse flere immunsignalveje |
| CA2804492A1 (en) | 2010-07-06 | 2012-01-12 | Novartis Ag | Immunisation of large mammals with low doses of rna |
| EP3578205A1 (en) | 2010-08-06 | 2019-12-11 | ModernaTX, Inc. | A pharmaceutical formulation comprising engineered nucleic acids and medical use thereof |
| FI4066857T3 (fi) | 2010-08-31 | 2023-03-20 | Glaxosmithkline Biologicals Sa | Pegyloituja liposomeja immunogeeniä koodaavan rna:n kuljettamiseksi |
| EP4108671B1 (en) | 2010-10-01 | 2024-11-20 | ModernaTX, Inc. | Modified nucleosides, nucleotides, and nucleic acids, and uses thereof |
| RU2597974C2 (ru) | 2010-10-11 | 2016-09-20 | Новартис Аг | Платформы доставки антигенов |
| JP2014511687A (ja) | 2011-03-31 | 2014-05-19 | モデルナ セラピューティクス インコーポレイテッド | 工学操作された核酸の送達および製剤 |
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| WO2013043729A1 (en) | 2011-09-20 | 2013-03-28 | Mount Sinai School Of Medicine | Influenza virus vaccines and uses thereof |
| PL2791160T3 (pl) | 2011-12-16 | 2022-06-20 | Modernatx, Inc. | Kompozycje zmodyfikowanego mrna |
| WO2013151665A2 (en) | 2012-04-02 | 2013-10-10 | modeRNA Therapeutics | Modified polynucleotides for the production of proteins associated with human disease |
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| US9572897B2 (en) | 2012-04-02 | 2017-02-21 | Modernatx, Inc. | Modified polynucleotides for the production of cytoplasmic and cytoskeletal proteins |
| US9283287B2 (en) | 2012-04-02 | 2016-03-15 | Moderna Therapeutics, Inc. | Modified polynucleotides for the production of nuclear proteins |
| US9512456B2 (en) | 2012-08-14 | 2016-12-06 | Modernatx, Inc. | Enzymes and polymerases for the synthesis of RNA |
| RS63237B1 (sr) | 2012-11-26 | 2022-06-30 | Modernatx Inc | Terminalno modifikovana rnk |
| EP2934581B1 (en) | 2012-12-18 | 2022-09-14 | Icahn School of Medicine at Mount Sinai | Influenza virus vaccines and uses thereof |
| US20160024181A1 (en) | 2013-03-13 | 2016-01-28 | Moderna Therapeutics, Inc. | Long-lived polynucleotide molecules |
| WO2014152211A1 (en) | 2013-03-14 | 2014-09-25 | Moderna Therapeutics, Inc. | Formulation and delivery of modified nucleoside, nucleotide, and nucleic acid compositions |
| WO2014159960A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Antibodies against influenza virus hemagglutinin and uses thereof |
| WO2015048744A2 (en) | 2013-09-30 | 2015-04-02 | Moderna Therapeutics, Inc. | Polynucleotides encoding immune modulating polypeptides |
| JP2016538829A (ja) | 2013-10-03 | 2016-12-15 | モデルナ セラピューティクス インコーポレイテッドＭｏｄｅｒｎａ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． | 低密度リポタンパク質受容体をコードするポリヌクレオチド |
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| WO2016118937A1 (en) | 2015-01-23 | 2016-07-28 | Icahn School Of Medicine At Mount Sinai | Influenza virus vaccination regimens |
| RU2742993C2 (ru) | 2015-05-15 | 2021-02-12 | Куревак Аг | РЕЖИМЫ ПРАЙМ-БУСТ, ВКЛЮЧАЮЩИЕ ВВЕДЕНИЕ ПО МЕНЬШЕЙ МЕРЕ ОДНОЙ КОНСТРУКЦИИ мРНК |
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| RU2018118337A (ru) * | 2015-10-22 | 2019-11-25 | МОДЕРНАТиЭкс, ИНК. | Вакцина против вируса гриппа широкого спектра действия |
| CN108778365B (zh) | 2016-01-11 | 2021-05-25 | 沃达瑞公司 | 微针组合物及其使用方法 |
| CN105664149A (zh) * | 2016-02-24 | 2016-06-15 | 华东理工大学 | 一种多抗原流感通用疫苗及其制备方法 |
| US11266734B2 (en) | 2016-06-15 | 2022-03-08 | Icahn School Of Medicine At Mount Sinai | Influenza virus hemagglutinin proteins and uses thereof |
| US12491261B2 (en) | 2016-10-26 | 2025-12-09 | Acuitas Therapeutics, Inc. | Lipid nanoparticle formulations |
| EP3609534A4 (en) | 2017-03-15 | 2021-01-13 | ModernaTX, Inc. | WIDE SPECTRUM INFLUENZA VIRUS VACCINE |
| EP3606555A4 (en) | 2017-04-07 | 2021-08-04 | Icahn School of Medicine at Mount Sinai | INFLUENZA B VIRUS NEURAMINIDASE ANTIBODIES AND USES THEREOF |
| JP2020524143A (ja) * | 2017-06-15 | 2020-08-13 | インフェクシャス ディズィーズ リサーチ インスティチュート | ナノ構造脂質担体、安定エマルジョン、およびその使用 |
| EP3638215A4 (en) | 2017-06-15 | 2021-03-24 | Modernatx, Inc. | RNA FORMULATIONS |
| WO2019036008A1 (en) | 2017-08-16 | 2019-02-21 | Acuitas Therapeutics, Inc. | LIPIDS FOR USE IN LIPID NANOPARTICULAR FORMULATIONS |
| MX2020002348A (es) | 2017-08-31 | 2020-10-08 | Modernatx Inc | Métodos de elaboración de nanopartículas lipídicas. |
| AU2018357917B2 (en) | 2017-10-30 | 2024-08-01 | Takeda Pharmaceutical Company Limited | Environmentally compatible detergents for inactivation of lipid-enveloped viruses |
| WO2019246363A1 (en) | 2018-06-21 | 2019-12-26 | Icahn School Of Medicine At Mount Sinai | Mosaic influenza virus hemagglutinin polypeptides and uses thereof |
| JP2021534182A (ja) * | 2018-08-17 | 2021-12-09 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 免疫原性組成物及びその使用 |
| EP3852728B1 (en) | 2018-09-20 | 2024-09-18 | ModernaTX, Inc. | Preparation of lipid nanoparticles and methods of administration thereof |
| JP7513614B2 (ja) | 2018-12-20 | 2024-07-09 | インターベット インターナショナル ベー． フェー． | プライム－ブーストワクチン接種レジメン |
| US20230076515A1 (en) * | 2019-11-18 | 2023-03-09 | Children's Medical Center Corporation | Stimuli that hyperactivate resident dendritic cells for cancer immunotherapy |
| IL299787A (en) | 2020-07-16 | 2023-03-01 | Acuitas Therapeutics Inc | Cationic lipids for use in lipid nanoparticles |
| US12129223B2 (en) | 2021-12-16 | 2024-10-29 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| WO2024191777A2 (en) * | 2023-03-10 | 2024-09-19 | National Health Research Institutes | Influenza virus immunogenic composition and method using the same |
| WO2024231886A1 (en) * | 2023-05-10 | 2024-11-14 | Seqirus Inc. | Combination vaccine |
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| WO2013006838A1 (en) * | 2011-07-06 | 2013-01-10 | Novartis Ag | Immunogenic combination compositions and uses thereof |
| EP2729124B1 (en) | 2011-07-06 | 2018-10-24 | GlaxoSmithKline Biologicals SA | Cationic oil-in-water emulsions |
| EP4115875A1 (en) | 2011-07-06 | 2023-01-11 | GlaxoSmithKline Biologicals S.A. | Liposomes having useful n:p ratio for delivery of rna molecules |
| EP2750707B1 (en) | 2011-08-31 | 2018-10-24 | GlaxoSmithKline Biologicals SA | Pegylated liposomes for delivery of immunogen-encoding rna |
| CN104105504A (zh) * | 2011-10-11 | 2014-10-15 | 诺华股份有限公司 | 重组多顺反子核酸分子 |
| WO2013054199A2 (en) * | 2011-10-12 | 2013-04-18 | Novartis Ag | Cmv antigens and uses thereof |
| US9504747B2 (en) * | 2013-03-08 | 2016-11-29 | Novartis Ag | Lipids and lipid compositions for the delivery of active agents |
-
2014
- 2014-01-10 AU AU2014204826A patent/AU2014204826A1/en not_active Abandoned
- 2014-01-10 CA CA2897752A patent/CA2897752A1/en not_active Abandoned
- 2014-01-10 WO PCT/EP2014/050414 patent/WO2014108515A1/en not_active Ceased
- 2014-01-10 US US14/152,397 patent/US20140193484A1/en not_active Abandoned
- 2014-01-10 CN CN201811056155.1A patent/CN109045294A/zh active Pending
- 2014-01-10 MX MX2015008847A patent/MX2015008847A/es unknown
- 2014-01-10 RU RU2015132962A patent/RU2015132962A/ru not_active Application Discontinuation
- 2014-01-10 JP JP2015552058A patent/JP2016506416A/ja active Pending
- 2014-01-10 CN CN201480004387.6A patent/CN104902925A/zh active Pending
- 2014-01-10 EP EP14700356.0A patent/EP2943221A1/en not_active Withdrawn
- 2014-01-10 HK HK16102971.1A patent/HK1214962A1/zh unknown
-
2017
- 2017-11-29 JP JP2017229215A patent/JP2018035195A/ja active Pending
-
2018
- 2018-11-13 AU AU2018260983A patent/AU2018260983A1/en not_active Abandoned
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