|
US4873192A
(en)
|
1987-02-17 |
1989-10-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
Process for site specific mutagenesis without phenotypic selection
|
|
WO1993013120A1
(en)
|
1991-12-23 |
1993-07-08 |
Chiron Corporation |
Hbv amplifier probes for use in solution phase sandwich hybridization assays
|
|
EP1288296A3
(en)
*
|
1992-05-11 |
2003-03-12 |
Ribozyme Pharmaceuticals, Inc. |
Method and reagent for inhibiting HBV viral replication
|
|
US6015832A
(en)
|
1997-12-31 |
2000-01-18 |
The Regents Of The University Of Michigan |
Methods of inactivating bacteria including bacterial spores
|
|
US6559189B2
(en)
|
1999-04-28 |
2003-05-06 |
Regents Of The University Of Michigan |
Non-toxic antimicrobial compositions and methods of use
|
|
US6506803B1
(en)
|
1999-04-28 |
2003-01-14 |
Regents Of The University Of Michigan |
Methods of preventing and treating microbial infections
|
|
US6635676B2
(en)
|
1999-04-28 |
2003-10-21 |
Regents Of The University Of Michigan |
Non-toxic antimicrobial compositions and methods of use
|
|
US7767216B2
(en)
|
1999-04-28 |
2010-08-03 |
The Regents Of The University Of Michigan |
Antimicrobial compositions and methods of use
|
|
US6555674B2
(en)
|
2000-08-09 |
2003-04-29 |
Nsgene A/S |
JeT promoter
|
|
CN1204248C
(zh)
*
|
2002-02-05 |
2005-06-01 |
中国人民解放军第四军医大学 |
治疗乙肝病毒感染的靶向核糖核酸酶的制备工艺
|
|
US7074596B2
(en)
|
2002-03-25 |
2006-07-11 |
Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College |
Synthesis and use of anti-reverse mRNA cap analogues
|
|
US7404969B2
(en)
|
2005-02-14 |
2008-07-29 |
Sirna Therapeutics, Inc. |
Lipid nanoparticle based compositions and methods for the delivery of biologically active molecules
|
|
TWI382019B
(zh)
|
2005-08-19 |
2013-01-11 |
Array Biopharma Inc |
作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之胺基二氮雜呯
|
|
TW201402124A
(zh)
|
2005-08-19 |
2014-01-16 |
Array Biopharma Inc |
作為類鐸受體（ｔｏｌｌ-ｌｉｋｅ ｒｅｃｅｐｔｏｒ）調節劑之８-經取代苯并氮雜呯
|
|
EP4174179B1
(en)
|
2005-08-23 |
2025-05-07 |
The Trustees of the University of Pennsylvania |
Rna containing modified nucleosides and methods of use thereof
|
|
AU2006304668B2
(en)
|
2005-10-18 |
2013-03-07 |
Duke University |
Rationally-designed meganucleases with altered sequence specificity and DNA-binding affinity
|
|
JP4235837B2
(ja)
|
2006-04-04 |
2009-03-11 |
セイコーエプソン株式会社 |
粒状性の予測、プロファイルの作成および印刷装置
|
|
WO2008005555A1
(en)
|
2006-07-07 |
2008-01-10 |
Gilead Sciences, Inc. |
Modulators of toll-like receptor 7
|
|
WO2009001159A1
(en)
|
2007-06-25 |
2008-12-31 |
Cellectis |
Method for enhancing the cleavage activity of i-crei derived meganucleases
|
|
WO2008103380A2
(en)
*
|
2007-02-21 |
2008-08-28 |
Fox Chase Cancer Center |
Hepatitis b virus compositions and methods of use
|
|
MX2009013832A
(es)
|
2007-06-29 |
2010-03-10 |
Gilead Sciences Inc |
Derivados de purina y su uso como moduladores del receptor 7 similar a un puente.
|
|
WO2009059195A2
(en)
|
2007-10-31 |
2009-05-07 |
Precision Biosciences |
Rationally-designed single-chain meganucleases with non-palindromic recognition sequences
|
|
US20110117125A1
(en)
|
2008-01-02 |
2011-05-19 |
Tekmira Pharmaceuticals Corporation |
Compositions and methods for the delivery of nucleic acids
|
|
RS57132B1
(sr)
|
2008-07-08 |
2018-07-31 |
Incyte Holdings Corp |
1,2,5-oksadiazoli kao inhibitori indolamin 2,3-dioksigenaze
|
|
CA2732437C
(en)
|
2008-08-01 |
2017-11-21 |
Ventirx Pharmaceuticals, Inc. |
Toll-like receptor agonist formulations and their use
|
|
CA2745295C
(en)
|
2008-12-09 |
2017-01-10 |
Gilead Sciences, Inc. |
Modulators of toll-like receptors
|
|
WO2010136841A2
(en)
*
|
2009-05-26 |
2010-12-02 |
Cellectis |
Meganuclease variants cleaving the genome of a non-genomically integrating virus and uses thereof
|
|
EP2435560A2
(en)
|
2009-05-26 |
2012-04-04 |
Cellectis |
Meganuclease variants cleaving the genome of a pathogenic non-integrating virus and uses thereof
|
|
EP2467380B1
(en)
|
2009-08-18 |
2016-11-30 |
Ventirx Pharmaceuticals, Inc. |
Substituted benzoazepines as toll-like receptor modulators
|
|
HUE032626T2
(en)
|
2009-08-18 |
2017-10-30 |
Ventirx Pharmaceuticals Inc |
Toll receptor modulator substituted benzoazepines
|
|
SG10201406813RA
(en)
|
2009-10-22 |
2014-11-27 |
Gilead Sciences Inc |
Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections
|
|
WO2011106106A2
(en)
|
2010-02-24 |
2011-09-01 |
Oryzon Genomics, S.A. |
Lysine demethylase inhibitors for diseases and disorders associated with hepadnaviridae
|
|
TWI500617B
(zh)
|
2010-05-31 |
2015-09-21 |
Ono Pharmaceutical Co |
Purine ketone derivatives
|
|
US8907053B2
(en)
|
2010-06-25 |
2014-12-09 |
Aurigene Discovery Technologies Limited |
Immunosuppression modulating compounds
|
|
US20120082658A1
(en)
|
2010-10-01 |
2012-04-05 |
Ventirx Pharmaceuticals, Inc. |
Methods for the Treatment of Allergic Diseases
|
|
JP5951615B2
(ja)
|
2010-10-01 |
2016-07-13 |
ベンティアールエックス ファーマシューティカルズ， インコーポレイテッドＶｅｎｔｉＲｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． |
Ｔｌｒアゴニストの治療用途および組み合わせ治療
|
|
UY33775A
(es)
|
2010-12-10 |
2012-07-31 |
Gilead Sciences Inc |
Inhibidores macrocíclicos de virus flaviviridae, composiciones farmacéuticas que los comprenden y sus usos
|
|
PT2663555T
(pt)
|
2011-01-12 |
2017-03-23 |
Array Biopharma Inc |
Benzoazepinas substituídas como moduladores de recetores tipo-toll
|
|
DK2663550T3
(en)
|
2011-01-12 |
2017-03-27 |
Ventirx Pharmaceuticals Inc |
SUBSTITUTED BENZOAZEPINS AS MODULATORS OF TOLL-LIKE RECEPTORS
|
|
AU2012214394B2
(en)
|
2011-02-12 |
2016-08-11 |
Globeimmune, Inc. |
Yeast-based therapeutic for chronic hepatitis B infection
|
|
PH12013502033A1
(en)
|
2011-04-08 |
2014-01-06 |
Janssen Sciences Ireland Uc |
Pyrimidine derivatives for the treatment of viral infections
|
|
US8916575B2
(en)
|
2011-05-18 |
2014-12-23 |
Janssen R&D Ireland |
Quinazoline derivatives for the treatment of viral infections and further diseases
|
|
ES2773891T3
(es)
|
2011-06-01 |
2020-07-15 |
Prec Biosciences Inc |
Procedimientos para la producción de líneas celulares de mamífero modificadas con transgenes amplificados
|
|
CN103732238A
(zh)
|
2011-06-08 |
2014-04-16 |
奥瑞基尼探索技术有限公司 |
用于免疫调节的治疗性化合物
|
|
KR102434346B1
(ko)
*
|
2011-06-30 |
2022-08-18 |
애로우헤드 파마슈티컬스 인코포레이티드 |
B형 간염 바이러스의 유전자 발현 저해용 조성물 및 방법
|
|
WO2013006841A1
(en)
*
|
2011-07-06 |
2013-01-10 |
Yale University |
Stimulation of arterial collateral growth and lymphogenesis
|
|
HUE031094T2
(en)
|
2011-11-29 |
2017-07-28 |
Ono Pharmaceutical Co |
Purinone derivative hydrochloride
|
|
CN106957282B
(zh)
|
2011-12-21 |
2019-08-30 |
诺维拉治疗公司 |
B型肝炎抗病毒剂
|
|
DK2812331T3
(en)
|
2012-02-08 |
2019-04-08 |
Janssen Sciences Ireland Unlimited Co |
PIPERIDINOPYRIMIDINE DERIVATIVES FOR TREATING VIRUS INFECTIONS
|
|
CN104159911A
(zh)
|
2012-03-07 |
2014-11-19 |
奥瑞基尼探索技术有限公司 |
作为免疫调节剂的模拟肽化合物
|
|
JP2015512910A
(ja)
|
2012-03-29 |
2015-04-30 |
オーリジーン ディスカバリー テクノロジーズ リミテッドＡｕｒｉｇｅｎｅ Ｄｉｓｃｏｖｅｒｙ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｉｍｉｔｅｄ |
ヒトｐｄ１のｂｃループに由来する免疫調節性環状化合物
|
|
US20130267517A1
(en)
|
2012-03-31 |
2013-10-10 |
Hoffmann-La Roche Inc. |
Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
|
|
CA2865259A1
(en)
|
2012-03-31 |
2013-10-03 |
F. Hoffmann-La Roche Ag |
Novel 4-methyl-dihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
|
|
WO2013159109A1
(en)
|
2012-04-20 |
2013-10-24 |
Isis Pharmaceuticals, Inc. |
Modulation of hepatitis b virus (hbv) expression
|
|
WO2013173223A1
(en)
|
2012-05-15 |
2013-11-21 |
Bristol-Myers Squibb Company |
Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
|
|
AR091279A1
(es)
|
2012-06-08 |
2015-01-21 |
Gilead Sciences Inc |
Inhibidores macrociclicos de virus flaviviridae
|
|
JP6209601B2
(ja)
|
2012-06-08 |
2017-10-04 |
ギリアード サイエンシーズ， インコーポレイテッド |
フラビウイルス科ウイルスの大環状阻害剤
|
|
CA2875718A1
(en)
|
2012-06-08 |
2013-12-12 |
Selcia Limited |
Macrocyclic inhibitors of flaviviridae viruses
|
|
MX369417B
(es)
|
2012-08-10 |
2019-11-07 |
Janssen Sciences Ireland Uc |
Derivados de alquilpirimidina para el tratamiento de infecciones víricas y otras enfermedades.
|
|
AR092270A1
(es)
|
2012-08-28 |
2015-04-08 |
Janssen R&D Ireland |
Sulfamoilarilamidas y su uso como medicamentos para el tratamiento de la hepatitis b
|
|
UA115069C2
(uk)
|
2012-08-28 |
2017-09-11 |
ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі |
Конденсовані біциклічні похідні сульфамоїлу та їх застосування як лікарських препаратів для лікування гепатиту b
|
|
EP2892893B2
(en)
|
2012-09-10 |
2019-10-16 |
F.Hoffmann-La Roche Ag |
6-amino acid heteroaryldihydropyrimidines for the treatment and prophylaxis of hepatitis b virus infection
|
|
PE20150998A1
(es)
|
2012-10-02 |
2015-06-29 |
Epitherapeutics Aps |
Inhibidores de histona demetilasas
|
|
US9499549B2
(en)
|
2012-10-10 |
2016-11-22 |
Janssen Sciences Ireland Uc |
Pyrrolo[3,2-]pyrimidine derivatives for the treatment of viral infections and other diseases
|
|
UA118341C2
(uk)
|
2012-11-16 |
2019-01-10 |
ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі |
Гетероциклічні заміщені похідні 2-амінохіназоліну для лікування вірусних інфекцій
|
|
MX2015007205A
(es)
|
2012-12-06 |
2016-03-31 |
Quanticel Pharmaceuticals Inc |
Inhibidores de la desmetilasa de histona.
|
|
US9617242B2
(en)
|
2012-12-19 |
2017-04-11 |
Celgene Quanticel Research, Inc. |
Histone demethylase inhibitors
|
|
EA028774B1
(ru)
|
2012-12-21 |
2017-12-29 |
Квонтисел Фармасьютикалс, Инк. |
Ингибиторы гистондеметилазы
|
|
UA118751C2
(uk)
|
2013-02-21 |
2019-03-11 |
ЯНССЕН САЙЄНСІЗ АЙРЛЕНД ЮСі |
Похідні 2-амінопіримідину для лікування вірусних інфекцій
|
|
PL2961736T3
(pl)
|
2013-02-27 |
2018-08-31 |
Gilead Sciences, Inc. |
Inhibitory demetylaz histonowych
|
|
ES2628953T3
(es)
|
2013-02-28 |
2017-08-04 |
Janssen Sciences Ireland Uc |
Sulfamoilarilamidas y el uso de las mismas como medicamentos para el tratamiento de la hepatitis B
|
|
WO2014165128A2
(en)
|
2013-03-12 |
2014-10-09 |
Novira Therapeutics, Inc. |
Hepatitis b antiviral agents
|
|
US9738637B2
(en)
|
2013-03-12 |
2017-08-22 |
Celgene Quantical Research, Inc. |
Histone demethylase inhibitors
|
|
US10035801B2
(en)
|
2013-03-13 |
2018-07-31 |
Genentech, Inc. |
Pyrazolo compounds and uses thereof
|
|
CA2903081A1
(en)
|
2013-03-14 |
2014-09-25 |
Quanticel Pharmaceuticals, Inc. |
Histone demethylase inhibitors
|
|
US9308236B2
(en)
|
2013-03-15 |
2016-04-12 |
Bristol-Myers Squibb Company |
Macrocyclic inhibitors of the PD-1/PD-L1 and CD80(B7-1)/PD-L1 protein/protein interactions
|
|
HRP20171609T1
(hr)
|
2013-03-15 |
2017-12-15 |
Quanticel Pharmaceuticals Inc |
Inhibitori histon demetilaze
|
|
MX353412B
(es)
|
2013-04-03 |
2018-01-10 |
Janssen Sciences Ireland Uc |
Derivados de n-fenil-carboxamida y su uso como medicamentos para el tratamiento de la hepatitis b.
|
|
WO2014179760A1
(en)
|
2013-05-03 |
2014-11-06 |
The Regents Of The University Of California |
Cyclic di-nucleotide induction of type i interferon
|
|
MX2015015692A
(es)
|
2013-05-17 |
2016-03-04 |
Hoffmann La Roche |
Novedosas heteroarildihidropirimidinas, unidas por puentes en 6 para el tratamiento y la profilaxis de infeccion por el virus de hepatitis b.
|
|
JP6441315B2
(ja)
|
2013-05-17 |
2018-12-19 |
ヤンセン・サイエンシズ・アイルランド・ユーシー |
スルファモイルチオフェンアミド誘導体およびｂ型肝炎を治療するための医薬品としてのその使用
|
|
JO3603B1
(ar)
|
2013-05-17 |
2020-07-05 |
Janssen Sciences Ireland Uc |
مشتقات سلفامويل بيرولاميد واستخدامها كادوية لمعالجة التهاب الكبد نوع بي
|
|
PL3024819T3
(pl)
|
2013-07-25 |
2018-08-31 |
Janssen Sciences Ireland Uc |
Pochodne piroloamidowe podstawione glioksamidem i ich zastosowanie jako leków do leczenia wirusowego zapalenia wątroby typu B
|
|
CA2913691C
(en)
|
2013-07-30 |
2022-01-25 |
Janssen Sciences Ireland Uc |
Thieno[3,2-d]pyrimidines derivatives for the treatment of viral infections
|
|
JP2016527303A
(ja)
|
2013-08-05 |
2016-09-08 |
ケンブリッジ エンタープライズ リミテッド |
がん免疫療法におけるｃｘｃｒ４シグナル伝達の阻害
|
|
US10471139B2
(en)
|
2013-08-15 |
2019-11-12 |
The University Of Kansas |
Toll-like receptor agonists
|
|
WO2015034820A1
(en)
|
2013-09-04 |
2015-03-12 |
Bristol-Myers Squibb Company |
Compounds useful as immunomodulators
|
|
SG11201601685TA
(en)
|
2013-09-06 |
2016-04-28 |
Aurigene Discovery Tech Ltd |
Cyclic peptidomimetic compounds as immunomodulators
|
|
SG11201601679TA
(en)
|
2013-09-06 |
2016-04-28 |
Aurigene Discovery Tech Ltd |
1,3,4-oxadiazole and 1,3,4-thiadiazole derivatives as immunomodulators
|
|
ES2675027T3
(es)
|
2013-09-06 |
2018-07-05 |
Aurigene Discovery Technologies Limited |
Derivados de 1,2,4-oxadiazol como inmunomoduladores
|
|
WO2015036927A1
(en)
|
2013-09-10 |
2015-03-19 |
Aurigene Discovery Technologies Limited |
Immunomodulating peptidomimetic derivatives
|
|
MX377523B
(es)
|
2013-09-11 |
2025-03-10 |
Inst Nat Sante Rech Med |
Metodos y composiciones farmaceuticas para el tratamiento de la infeccion por el virus de la hepatitis b.
|
|
WO2015044900A1
(en)
|
2013-09-27 |
2015-04-02 |
Aurigene Discovery Technologies Limited |
Therapeutic immunomodulating compounds
|
|
BR112016008378B1
(pt)
|
2013-10-14 |
2022-11-08 |
Eisai R&D Management Co., Ltd |
Compostos de quinolina seletivamente substituídos ou sal dos mesmos, e composição farmacêutica contendo os ditos compostos
|
|
AU2014334554B2
(en)
|
2013-10-14 |
2018-12-06 |
Eisai R&D Management Co., Ltd. |
Selectively substituted quinoline compounds
|
|
SG11201602748XA
(en)
|
2013-10-23 |
2016-05-30 |
Janssen Sciences Ireland Uc |
Carboxamide derivatives and the use thereof as medicaments for the treatment of hepatitis b
|
|
US9115113B2
(en)
|
2013-11-14 |
2015-08-25 |
Novira Therapeutics, Inc. |
Azepane derivatives and methods of treating hepatitis B infections
|
|
SG10201804975PA
(en)
*
|
2013-12-12 |
2018-07-30 |
Broad Inst Inc |
Delivery, Use and Therapeutic Applications of the Crispr-Cas Systems and Compositions for HBV and Viral Diseases and Disorders
|
|
JP2016540013A
(ja)
|
2013-12-13 |
2016-12-22 |
武田薬品工業株式会社 |
Ｔｌｒ阻害剤としてのピロロ［３，２−ｃ］ピリジン誘導体
|
|
WO2015095780A1
(en)
|
2013-12-20 |
2015-06-25 |
The University Of Kansas |
Toll-like receptor 8 agonists
|
|
US9181288B2
(en)
|
2014-01-16 |
2015-11-10 |
Novira Therapeutics, Inc. |
Azepane derivatives and methods of treating hepatitis B infections
|
|
US9169212B2
(en)
|
2014-01-16 |
2015-10-27 |
Novira Therapeutics, Inc. |
Azepane derivatives and methods of treating hepatitis B infections
|
|
WO2015113990A1
(en)
|
2014-01-30 |
2015-08-06 |
F. Hoffmann-La Roche Ag |
Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
|
|
KR20160108568A
(ko)
|
2014-02-04 |
2016-09-19 |
인사이트 코포레이션 |
암을 치료하기 위한 pd-1 길항제 및 ido1 억제제의 조합
|
|
ES2705401T3
(es)
|
2014-02-06 |
2019-03-25 |
Janssen Sciences Ireland Uc |
Derivados de sulfamoilpirrolamida y su uso como medicamentos para el tratamiento de la Hepatitis B
|
|
JP2017507155A
(ja)
|
2014-03-05 |
2017-03-16 |
ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ |
抗ｐｄ−１抗体と他の抗癌剤の組合せを使用する腎癌の処置
|
|
HUE041734T2
(hu)
|
2014-03-07 |
2019-05-28 |
Hoffmann La Roche |
Új, 6-tagú gyûrûvel kondenzált heteroarildihidropirimidinek hepatitisz B vírusfertõzés kezelésére és megelõzésére
|
|
US9400280B2
(en)
|
2014-03-27 |
2016-07-26 |
Novira Therapeutics, Inc. |
Piperidine derivatives and methods of treating hepatitis B infections
|
|
US9850225B2
(en)
|
2014-04-14 |
2017-12-26 |
Bristol-Myers Squibb Company |
Compounds useful as immunomodulators
|
|
PT3134402T
(pt)
|
2014-04-22 |
2020-07-02 |
Hoffmann La Roche |
Compostos de 4-amino-imidazoquinolina
|
|
EP3137468B1
(en)
|
2014-05-01 |
2021-10-06 |
Novartis AG |
Compounds and compositions as toll-like receptor 7 agonists
|
|
PL3137470T3
(pl)
|
2014-05-01 |
2021-10-11 |
Novartis Ag |
Związki i kompozycje jako agonisty receptora toll-like 7
|
|
CA2948080A1
(en)
|
2014-05-13 |
2015-11-19 |
F. Hoffmann-La Roche Ag |
Novel dihydroquinolizinones for the treatment and prophylaxis of hepatitis b virus infection
|
|
CN110354266A
(zh)
|
2014-05-23 |
2019-10-22 |
卫材 R&D 管理有限公司 |
用于治疗癌症的组合疗法
|
|
AU2015266776A1
(en)
|
2014-05-30 |
2016-12-08 |
The Board Of Trustees Of The Leland Stanford Junior University |
Compositions and methods of delivering treatments for latent viral infections
|
|
RU2016149812A
(ru)
|
2014-06-06 |
2018-07-17 |
Флексус Байосайенсиз, Инк. |
Иммунорегулирующие средства
|
|
WO2016012470A1
(en)
|
2014-07-25 |
2016-01-28 |
F. Hoffmann-La Roche Ag |
New amorphous and crystalline forms of (3s)-4-[[(4r)-4-(2-chloro-4-fluoro-phenyl)-5-methoxycarbonyl-2-thiazol-2-yl-1, 4-dihydropyrimidin-6-yl]methyl]morpholine-3-carboxylic acid
|
|
SG11201700700YA
(en)
|
2014-08-01 |
2017-02-27 |
3M Innovative Properties Co |
Methods and therapeutic combinations for treating tumors
|
|
KR101891933B1
(ko)
|
2014-08-14 |
2018-08-24 |
에프. 호프만-라 로슈 아게 |
B형 간염 바이러스 감염의 치료 또는 예방을 위한 신규한 피리다존 및 트라이아진온
|
|
AU2015303558B2
(en)
|
2014-08-15 |
2018-07-12 |
Chia Tai Tianqing Pharmaceutical Group Co., Ltd. |
Pyrrolopyrimidine compounds used as TLR7 agonist
|
|
WO2016029077A1
(en)
|
2014-08-22 |
2016-02-25 |
Janus Biotherapeutics, Inc. |
Novel n2, n4, n7, 6-tetrasubstituted pteridine-2,4,7-triamine and 2, 4, 6, 7-tetrasubstituted pteridine compounds and methods of synthesis and use thereof
|
|
MA40470A
(fr)
|
2014-08-27 |
2016-03-03 |
Gilead Sciences Inc |
Composés et procédés d'inhibition des histones déméthylases
|
|
US9884866B2
(en)
|
2014-09-08 |
2018-02-06 |
Regents Of The University Of Minnesota |
Immunomodulators and immunomodulator conjugates
|
|
MX380553B
(es)
|
2014-09-11 |
2025-03-12 |
Bristol Myers Squibb Co |
Inhibidores macrocíclicos de las interacciones proteína/proteína de muerte programada 1 (pd-1)/pd-l1 y cd80(b7-1)/pd-l1.
|
|
EP3204379B1
(en)
|
2014-10-10 |
2019-03-06 |
Genentech, Inc. |
Pyrrolidine amide compounds as histone demethylase inhibitors
|
|
US9732119B2
(en)
|
2014-10-10 |
2017-08-15 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
JP2017531655A
(ja)
|
2014-10-11 |
2017-10-26 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
感染性疾患の処置に使用するための化合物
|
|
US9637485B2
(en)
|
2014-11-03 |
2017-05-02 |
Hoffmann-La Roche Inc. |
6,7-dihydrobenzo[a]quinolizin-2-one derivatives for the treatment and prophylaxis of hepatitis B virus infection
|
|
MX2017005462A
(es)
|
2014-11-05 |
2017-07-28 |
Flexus Biosciences Inc |
Agentes inmunorreguladores.
|
|
UY36390A
(es)
|
2014-11-05 |
2016-06-01 |
Flexus Biosciences Inc |
Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
|
|
BR112017009648A2
(pt)
|
2014-11-13 |
2017-12-19 |
Glaxosmithkline Biologicals Sa |
composto, métodos para tratamento de doenças alérgicas ou outras condições inflamatórias ou prevenção de doença, de rinite alérgica ou asma, composição, e, uso de um composto.
|
|
US9856292B2
(en)
|
2014-11-14 |
2018-01-02 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
MA41134B1
(fr)
|
2014-12-08 |
2021-03-31 |
Hoffmann La Roche |
Composés substitués de 5-amino-6h-thiazolo[4,5-d]pyrimidine-2,7-dione pour le traitement et la prophylaxie des infections virales
|
|
US9861680B2
(en)
|
2014-12-18 |
2018-01-09 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
JP6644792B2
(ja)
|
2014-12-18 |
2020-02-12 |
エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト |
ベンザゼピンスルホンアミド化合物
|
|
US9944678B2
(en)
|
2014-12-19 |
2018-04-17 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
AR103222A1
(es)
|
2014-12-23 |
2017-04-26 |
Hoffmann La Roche |
Procedimiento para la preparación de análogos de 4-fenil-5-alcoxicarbonil-2-tiazol-2-il-1,4-dihidropirimidina
|
|
US9676793B2
(en)
|
2014-12-23 |
2017-06-13 |
Hoffmann-Laroche Inc. |
Co-crystals of 5-amino-2-oxothiazolo[4,5-d]pyrimidin-3(2H)-yl-5-hydroxymethyl tetrahydrofuran-3-yl acetate and methods for preparing and using the same
|
|
CN105732635A
(zh)
|
2014-12-29 |
2016-07-06 |
南京明德新药研发股份有限公司 |
一类Toll样受体7激动剂
|
|
US9550779B2
(en)
|
2014-12-30 |
2017-01-24 |
Novira Therapeutics, Inc. |
Derivatives and methods of treating hepatitis B infections
|
|
WO2016107832A1
(en)
|
2014-12-30 |
2016-07-07 |
F. Hoffmann-La Roche Ag |
Novel tetrahydropyridopyrimidines and tetrahydropyridopyridines for the treatment and prophylaxis of hepatitis b virus infection
|
|
CN107109497A
(zh)
|
2014-12-31 |
2017-08-29 |
豪夫迈·罗氏有限公司 |
通过实时PCR从细胞裂解物定量HBV cccDNA的高通量新方法
|
|
MA41338B1
(fr)
|
2015-01-16 |
2019-07-31 |
Hoffmann La Roche |
Composés de pyrazine pour le traitement de maladies infectieuses
|
|
EP3250685A1
(en)
|
2015-01-27 |
2017-12-06 |
F. Hoffmann-La Roche AG |
Recombinant hbv cccdna, the method to generate thereof and the use thereof
|
|
US20160222060A1
(en)
|
2015-02-04 |
2016-08-04 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
HK1244281B
(zh)
|
2015-02-11 |
2020-02-07 |
F. Hoffmann-La Roche Ag |
治疗和预防乙型肝炎病毒感染的2-氧代-6，7-二氢苯并[a]喹嗪-3-甲酸衍生物
|
|
SI3321265T1
(sl)
|
2015-03-04 |
2020-07-31 |
Gilead Sciences, Inc. |
Spojine 4,6-diamino-pirido(3,2-d)pirimidina in njihova uporaba kot modulatorji toličnih receptorjev
|
|
AU2016231289B2
(en)
|
2015-03-06 |
2020-07-16 |
F. Hoffmann-La Roche Ag |
Benzazepine dicarboxamide compounds
|
|
JP2018507885A
(ja)
|
2015-03-10 |
2018-03-22 |
オーリジーン ディスカバリー テクノロジーズ リミテッドＡｕｒｉｇｅｎｅ Ｄｉｓｃｏｖｅｒｙ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｌｉｍｉｔｅｄ |
免疫調節剤としての１，３，４−オキサジアゾールおよびチアジアゾール化合物
|
|
CA3220902A1
(en)
|
2015-03-10 |
2016-09-15 |
Aurigene Discovery Technologies Limited |
1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
|
|
SG11201706902SA
(en)
|
2015-03-10 |
2017-09-28 |
Aurigene Discovery Tech Ltd |
3-substituted-1,2,4-oxadiazole and thiadiazole compounds as immunomodulators
|
|
CU20170116A7
(es)
|
2015-03-10 |
2018-06-05 |
Aurigene Discovery Tech Ltd |
Compuestos cíclicos terapéuticos como inmunomoduladores
|
|
CU20170117A7
(es)
|
2015-03-10 |
2018-05-08 |
Aurigene Discovery Tech Ltd |
COMPUESTOS TIADIAZOL y 1,3,4-OXADIAZOL 3-SUSTITUIDOS COMO INMUNOMODULADORES
|
|
US9809625B2
(en)
|
2015-03-18 |
2017-11-07 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
WO2016161268A1
(en)
|
2015-04-01 |
2016-10-06 |
Enanta Pharmaceuticals, Inc. |
Hepatitis b antviral agents
|
|
US10273228B2
(en)
|
2015-04-17 |
2019-04-30 |
Indiana University Research And Technology Corporation |
Hepatitis B viral assembly effectors
|
|
JP6462155B2
(ja)
|
2015-05-04 |
2019-01-30 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
Ｂ型肝炎ウイルス感染症の治療用のＨＢｓＡｇ（ＨＢＶ表面抗原）及びＨＢＶ ＤＮＡ産生の阻害剤としてのテトラヒドロピリドピリミジン類及びテトラヒドロピリドピリジン類
|
|
EP4001283A1
(en)
|
2015-05-12 |
2022-05-25 |
F. Hoffmann-La Roche AG |
Substituted aminothiazolopyrimidinedione derivatives for the treatment and prophylaxis of virus infection
|
|
WO2016195982A2
(en)
|
2015-06-01 |
2016-12-08 |
The Penn State Research Foundation |
Hepatitis b virus capsid assembly
|
|
GB201511477D0
(en)
|
2015-06-30 |
2015-08-12 |
Redx Pharma Plc |
Antiviral compounds
|
|
EP3317289B1
(en)
|
2015-06-30 |
2021-10-27 |
F. Hoffmann-La Roche AG |
Novel substituted aminothiazolopyrimidinedione for the treatment and prophylaxis of virus infection
|
|
US10875876B2
(en)
|
2015-07-02 |
2020-12-29 |
Janssen Sciences Ireland Uc |
Cyclized sulfamoylarylamide derivatives and the use thereof as medicaments for the treatment of hepatitis B
|
|
WO2017007701A1
(en)
|
2015-07-07 |
2017-01-12 |
Merck Sharp & Dohme Corp. |
Antiviral phosphodiamide compounds
|
|
WO2017013046A1
(en)
|
2015-07-21 |
2017-01-26 |
F. Hoffmann-La Roche Ag |
Novel tricyclic 4-pyridone-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
|
|
WO2017016960A1
(en)
|
2015-07-24 |
2017-02-02 |
F. Hoffmann-La Roche Ag |
Process for the preparation of (6s)-6-alkyl-10-alkoxy-9-(substituted alkoxy)-2-oxo-6,7-dihydrobenzo[a]quinolizine-3-carboxylic acid analogues
|
|
WO2017017042A1
(en)
|
2015-07-27 |
2017-02-02 |
F. Hoffmann-La Roche Ag |
Novel tetracyclic 4-oxo-pyridine-3-carboxylic acid derivatives for the treatment and prophylaxis of hepatitis b virus infection
|
|
JP6559324B2
(ja)
|
2015-07-28 |
2019-08-14 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
Ｂ型肝炎ウイルス感染の治療及び予防用の新規６，７−ジヒドロピリド［２，１−ａ］フタラジン−２−オン類
|
|
US20180177872A1
(en)
|
2015-07-29 |
2018-06-28 |
Yong Jia |
Combination of PD-1 antagonist with an EGFR inhibitor
|
|
AU2016305941B2
(en)
|
2015-08-10 |
2018-11-15 |
Merck Sharp & Dohme Llc |
Antiviral beta-amino acid ester phosphodiamide compounds
|
|
GEP20207182B
(en)
|
2015-08-13 |
2020-11-25 |
Merck Sharp & Dohme |
Cyclic di-nucleotide compounds as sting agonists
|
|
WO2017034986A1
(en)
|
2015-08-21 |
2017-03-02 |
University Of Kansas |
Human tlr8-selective agonists
|
|
WO2017038909A1
(en)
|
2015-08-28 |
2017-03-09 |
Takeda Pharmaceutical Company Limited |
Heterocyclic compounds
|
|
WO2017040233A1
(en)
|
2015-08-31 |
2017-03-09 |
3M Innovative Properties Company |
GUANIDINE SUBSTITUTED IMIDAZO[4,5-c] RING COMPOUNDS
|
|
TWI730985B
(zh)
|
2015-09-15 |
2021-06-21 |
美商艾森伯利生物科學公司 |
B型肝炎核心蛋白質調節劑
|
|
JP6856900B2
(ja)
|
2015-09-17 |
2021-04-14 |
国立大学法人富山大学 |
トール様受容体７またはトール様受容体９の活性化阻害剤
|
|
CN108055842B
(zh)
|
2015-09-17 |
2021-06-29 |
豪夫迈·罗氏有限公司 |
亚磺酰基苯基或磺亚胺酰基苯基苯并氮杂䓬
|
|
JP6723254B2
(ja)
|
2015-10-05 |
2020-07-15 |
富士フイルム富山化学株式会社 |
抗ｂ型肝炎ウイルス剤
|
|
TWI718188B
(zh)
|
2015-10-07 |
2021-02-11 |
日商大日本住友製藥股份有限公司 |
嘧啶化合物
|
|
US10745382B2
(en)
|
2015-10-15 |
2020-08-18 |
Bristol-Myers Squibb Company |
Compounds useful as immunomodulators
|
|
MA52119A
(fr)
|
2015-10-19 |
2018-08-29 |
Ncyte Corp |
Composés hétérocycliques utilisés comme immunomodulateurs
|
|
UY36969A
(es)
|
2015-10-28 |
2017-05-31 |
Novartis Ag |
Composiciones y métodos para activar la señalización dependiente del estimulador del gen de interferon
|
|
MX2018005600A
(es)
|
2015-11-04 |
2018-11-09 |
Incyte Corp |
Composiciones farmaceuticas y metodos para la inhibicion de indolamina 2,3-dioxigenasa e indicaciones para ello.
|
|
SI3371316T1
(sl)
|
2015-11-04 |
2023-02-28 |
Hookipa Biotech Gmbh |
Cepivo proti virusu hepatitisa B
|
|
MX375353B
(es)
|
2015-11-05 |
2025-03-06 |
Chia Tai Tianqing Pharmaceutical Group Co Ltd |
Compuesto de 7-(tiazol-5-il)pirrolopirimidina como agonista de tlr7
|
|
MY199220A
(en)
|
2015-11-19 |
2023-10-20 |
Incyte Corp |
Heterocyclic compounds as immunomodulators
|
|
AU2016356780A1
(en)
|
2015-11-19 |
2018-06-28 |
Bristol-Myers Squibb Company |
Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof
|
|
MX363780B
(es)
|
2015-12-03 |
2019-04-03 |
Glaxosmithkline Ip Dev Ltd |
Dinucleótidos de purina cíclica como moduladores del estimulador de los genes de interferón.
|
|
WO2017100108A1
(en)
|
2015-12-10 |
2017-06-15 |
Merck Sharp & Dohme Corp. |
Antiviral phosphodiamide prodrugs of tenofovir
|
|
WO2017106740A1
(en)
|
2015-12-16 |
2017-06-22 |
Aduro Biotech, Inc. |
Methods for identifying inhibitors of "stimulator of interferon gene"-dependent interferon production
|
|
ES2916874T3
(es)
|
2015-12-17 |
2022-07-06 |
Incyte Corp |
Derivados de N-fenil-piridina-2-carboxamida y su uso como moduladores de la interacción proteína/proteína PD-1/PD-L1
|
|
NZ742476A
(en)
|
2015-12-17 |
2022-09-30 |
Merck Patent Gmbh |
Polycyclic tlr7/8 antagonists and use thereof in the treatment of immune disorders
|
|
JP6911031B2
(ja)
|
2015-12-22 |
2021-07-28 |
インサイト・コーポレイションＩｎｃｙｔｅ Ｃｏｒｐｏｒａｔｉｏｎ |
免疫調節剤としての複素環化合物
|
|
WO2017112859A1
(en)
*
|
2015-12-23 |
2017-06-29 |
Precision Biosciences, Inc. |
Engineered meganucleases with recognition sequences found in the human beta-2 microglobulin gene
|
|
US20200270265A1
(en)
|
2016-02-19 |
2020-08-27 |
Novartis Ag |
Tetracyclic pyridone compounds as antivirals
|
|
CN114751950B
(zh)
|
2016-03-18 |
2025-04-18 |
免疫传感器公司 |
环二核苷酸化合物及使用方法
|
|
EP3433249B1
(en)
|
2016-03-21 |
2022-11-09 |
Council Of Scientific & Industrial Research |
Blocking toll-like receptor 9 signaling with small molecule antagonist
|
|
US10358463B2
(en)
|
2016-04-05 |
2019-07-23 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
US10533007B2
(en)
|
2016-04-19 |
2020-01-14 |
Innate Tumor Immunity, Inc. |
NLRP3 modulators
|
|
EP3445761A1
(en)
|
2016-04-19 |
2019-02-27 |
Innate Tumor Immunity, Inc. |
Nlrp3 modulators
|
|
WO2017186711A1
(en)
|
2016-04-25 |
2017-11-02 |
Invivogen |
Novel complexes of immunostimulatory compounds, and uses thereof
|
|
EP3452583B1
(en)
|
2016-05-03 |
2021-10-27 |
Precision Biosciences, Inc. |
Engineered nucleases useful for treatment of hemophilia a
|
|
TW201808950A
(zh)
|
2016-05-06 |
2018-03-16 |
英塞特公司 |
作為免疫調節劑之雜環化合物
|
|
HUE057924T2
(hu)
|
2016-05-06 |
2022-06-28 |
Shanghai De Novo Pharmatech Co Ltd |
Benzazepin származék, elõállítási eljárása, gyógyászati készítmény és alkalmazása
|
|
EP3458455B1
(en)
|
2016-05-20 |
2021-06-16 |
F. Hoffmann-La Roche AG |
Novel pyrazine compounds with oxygen, sulfur and nitrogen linker for the treatment of infectious diseases
|
|
CN109311854B
(zh)
|
2016-05-23 |
2021-08-10 |
豪夫迈·罗氏有限公司 |
具有仲酰胺官能团的苯并氮杂卓二甲酰胺化合物
|
|
EP3464245B1
(en)
|
2016-05-23 |
2020-10-14 |
H. Hoffnabb-La Roche Ag |
Benzazepine dicarboxamide compounds with tertiary amide function
|
|
CN109311860B
(zh)
|
2016-05-26 |
2022-04-08 |
豪夫迈·罗氏有限公司 |
用于治疗或预防乙型肝炎病毒疾病的呫吨酮衍生物
|
|
US20170342060A1
(en)
|
2016-05-26 |
2017-11-30 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
|
WO2017211791A1
(en)
|
2016-06-07 |
2017-12-14 |
F. Hoffmann-La Roche Ag |
Combination therapy of an hbsag inhibitor and a tlr7 agonist
|
|
CA3028228A1
(en)
|
2016-06-10 |
2017-12-14 |
Enanta Pharmaceuticals, Inc. |
Hepatitis b antiviral agents
|
|
CN109311851B
(zh)
|
2016-06-12 |
2021-08-10 |
豪夫迈·罗氏有限公司 |
二氢嘧啶基苯并氮杂䓬甲酰胺化合物
|
|
WO2017216686A1
(en)
|
2016-06-16 |
2017-12-21 |
Novartis Ag |
8,9-fused 2-oxo-6,7-dihydropyrido-isoquinoline compounds as antivirals
|
|
WO2017216685A1
(en)
|
2016-06-16 |
2017-12-21 |
Novartis Ag |
Pentacyclic pyridone compounds as antivirals
|
|
MY197280A
(en)
|
2016-06-20 |
2023-06-09 |
Incyte Corp |
Heterocyclic compounds as immunomodulators
|
|
CN108290893B
(zh)
|
2016-06-22 |
2021-01-05 |
四川科伦博泰生物医药股份有限公司 |
二氢蝶啶酮类衍生物、其制备方法及其用途
|
|
AU2017286890B2
(en)
|
2016-06-29 |
2021-09-09 |
Novira Therapeutics, Inc. |
Oxadiazepinone derivatives and their use in the treatment of hepatitis B infections
|
|
US10071079B2
(en)
|
2016-06-29 |
2018-09-11 |
Bristol-Myers Squibb Company |
[1,2,4]triazolo[1,5-a]pyridinyl substituted indole compounds
|
|
WO2018001952A1
(en)
|
2016-06-29 |
2018-01-04 |
F. Hoffmann-La Roche Ag |
Novel tetrahydropyridopyrimidines for the treatment and prophylaxis of hbv infection
|
|
JP6935433B2
(ja)
|
2016-06-29 |
2021-09-15 |
ノヴィラ・セラピューティクス・インコーポレイテッド |
ジアゼピノン誘導体及びｂ型肝炎感染症の治療におけるその使用
|
|
JP6821716B2
(ja)
|
2016-06-29 |
2021-01-27 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
Ｂ型肝炎ウイルス感染の処置および予防のための新規のジヒドロピロロピリミジン
|
|
KR102468272B1
(ko)
|
2016-06-30 |
2022-11-18 |
삼성전자주식회사 |
음향 출력 장치 및 그 제어 방법
|
|
CN109476675B
(zh)
|
2016-07-01 |
2022-12-09 |
爱尔兰詹森科学公司 |
用于治疗病毒性感染的二氢吡喃并嘧啶衍生物
|
|
US11098077B2
(en)
|
2016-07-05 |
2021-08-24 |
Chinook Therapeutics, Inc. |
Locked nucleic acid cyclic dinucleotide compounds and uses thereof
|
|
BR112019000247A2
(pt)
|
2016-07-08 |
2019-04-16 |
Bristol-Myers Squibb Company |
derivados de 1,3-di-hidróxi-fenila úteis como imunomoduladores
|
|
EP3484866B1
(en)
|
2016-07-14 |
2022-09-07 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
|
EP3484883B1
(en)
|
2016-07-14 |
2020-04-15 |
H. Hoffnabb-La Roche Ag |
Novel tetrahydropyrazolopyridine compounds for the treatment of infectious diseases
|
|
WO2018011160A1
(en)
|
2016-07-14 |
2018-01-18 |
F. Hoffmann-La Roche Ag |
6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases
|
|
WO2018011163A1
(en)
|
2016-07-14 |
2018-01-18 |
F. Hoffmann-La Roche Ag |
6,7-dihydro-4h-pyrazolo[1,5-a]pyrazine and 6,7-dihydro-4h-triazolo[1,5-a]pyrazine compounds for the treatment of infectious diseases
|
|
JP7034133B2
(ja)
|
2016-07-14 |
2022-03-11 |
エフ．ホフマン－ラ ロシュ アーゲー |
感染性疾患の処置のためのカルボキシ ６，７－ジヒドロ－４Ｈ－ピラゾロ［１，５－ａ］ピラジン化合物
|
|
EP3490987B1
(en)
|
2016-07-29 |
2022-09-21 |
Guangzhou Lupeng Pharmaceutical Company Ltd. |
Novel therapeutic agents for the treatment of hbv infection
|
|
WO2018019297A1
(zh)
|
2016-07-29 |
2018-02-01 |
银杏树药业(苏州)有限公司 |
异喹啉酮类化合物及其制备抗病毒药物的应用
|
|
EP3490983B1
(en)
|
2016-07-30 |
2021-02-17 |
Bristol-Myers Squibb Company |
Dimethoxyphenyl substituted indole compounds as tlr7, tlr8 or tlr9 inhibitors
|
|
JP2019530732A
(ja)
|
2016-08-03 |
2019-10-24 |
アライジング・インターナショナル・インコーポレイテッドＡｒｉｓｉｎｇ Ｉｎｔｅｒｎａｔｉｏｎａｌ， Ｉｎｃ． |
免疫モジュレータとして有用な対称または半対称化合物
|
|
RU2758686C2
(ru)
|
2016-08-08 |
2021-11-01 |
Мерк Патент Гмбх |
Антагонисты tlr7/8 и их применение
|
|
JP2019526562A
(ja)
|
2016-08-24 |
2019-09-19 |
エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ |
Ｈｂｖキャプシドアセンブリ阻害剤とヌクレオシ（チ）ド類似体の併用療法
|
|
EP3504215B1
(en)
|
2016-08-26 |
2022-04-06 |
3M Innovative Properties Company |
Fused [1,2]imidazo[4,5-c]ring compounds substituted with guanidino groups
|
|
MA46045A
(fr)
|
2016-08-29 |
2021-04-28 |
Incyte Corp |
Composés hétérocycliques utilisés comme immunomodulateurs
|
|
US10144706B2
(en)
|
2016-09-01 |
2018-12-04 |
Bristol-Myers Squibb Company |
Compounds useful as immunomodulators
|
|
ES2826748T3
(es)
|
2016-09-02 |
2021-05-19 |
Gilead Sciences Inc |
Derivados de 4,6-diamino-pirido[3,2-d]pirimidina como moduladores de receptores de tipo Toll
|
|
JP6746776B2
(ja)
|
2016-09-02 |
2020-08-26 |
ギリアード サイエンシーズ， インコーポレイテッド |
Ｔｏｌｌ様受容体調節剤化合物
|
|
WO2018043747A1
(ja)
|
2016-09-05 |
2018-03-08 |
国立大学法人京都大学 |
抗ｂ型肝炎ウイルス剤
|
|
WO2018046460A1
(en)
|
2016-09-07 |
2018-03-15 |
Glaxosmithkline Biologicals S.A. |
Imidazoquinoline derivatives and their use in therapy
|
|
PL3510033T3
(pl)
|
2016-09-09 |
2022-03-07 |
Novartis Ag |
Związki i kompozycje jako inhibitory endosomalnych receptorów toll- podobnych
|
|
KR102519535B1
(ko)
|
2016-09-09 |
2023-04-06 |
브리스톨-마이어스 스큅 컴퍼니 |
피리딜 치환된 인돌 화합물
|
|
CN109803967B
(zh)
|
2016-09-09 |
2022-05-24 |
浙江海正药业股份有限公司 |
二氢嘧啶类化合物及其制备方法和用途
|
|
WO2018051255A1
(en)
|
2016-09-14 |
2018-03-22 |
Aurigene Discovery Technologies Limited |
Cyclic substituted-1,3,4-oxadiazole and thiadiazole compounds as immunomodulators
|
|
WO2018051254A1
(en)
|
2016-09-14 |
2018-03-22 |
Aurigene Discovery Technologies Limited |
Cyclic substituted-1,2,4-oxadiazole compounds as immunomodulators
|
|
US10537590B2
(en)
|
2016-09-30 |
2020-01-21 |
Boehringer Ingelheim International Gmbh |
Cyclic dinucleotide compounds
|
|
TN2020000158A1
(en)
|
2016-10-04 |
2022-04-04 |
Merck Sharp & Dohme |
BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS
|
|
WO2018065360A1
(de)
|
2016-10-07 |
2018-04-12 |
Biolog Life Science Institute Forschungslabor Und Biochemica-Vertrieb Gmbh |
Benzimidazolhaltige cyclische dinukleotide, verfahren zu deren herstellung und ihre verwendung zur aktivierung von stimulator von interferongenen (sting)-abhängigen signalwegen
|
|
IL308894A
(en)
|
2016-10-14 |
2024-01-01 |
Prec Biosciences Inc |
Engineered meganucleases specific for recognition sequences in the hepatitis b virus genome
|
|
KR20190067235A
(ko)
|
2016-10-20 |
2019-06-14 |
오리진 디스커버리 테크놀로지스 리미티드 |
Vista 및 pd-1 경로의 이중 억제제
|
|
US10736908B2
(en)
|
2016-10-26 |
2020-08-11 |
Merck Sharp & Dohme Corp. |
Antiviral aryl-amide phosphodiamide compounds
|
|
WO2018078149A1
(en)
|
2016-10-31 |
2018-05-03 |
F. Hoffmann-La Roche Ag |
Novel cyclicsulfonimidoylpurinone compounds and derivatives for the treatment and prophylaxis of virus infection
|
|
WO2018085750A2
(en)
|
2016-11-07 |
2018-05-11 |
Bristol-Myers Squibb Company |
Immunomodulators
|
|
EP3538513A1
(en)
|
2016-11-11 |
2019-09-18 |
Dynavax Technologies Corporation |
Toll-like receptor antagonist compounds and methods of use
|
|
CN108069969B
(zh)
|
2016-11-11 |
2020-09-18 |
南京海璞医药科技有限公司 |
含氮杂环化合物、制备方法、中间体、药物组合物和应用
|
|
JOP20170188A1
(ar)
|
2016-11-25 |
2019-01-30 |
Janssen Biotech Inc |
ثنائي النوكليوتيدات الحلقية كمنبهات ستينغ (sting)
|
|
PT3546457T
(pt)
|
2016-11-28 |
2021-08-06 |
Jiangsu Hengrui Medicine Co |
Derivado de pirazolo-heteroarílico, método de preparação e a utilização médica do mesmo
|
|
JOP20170192A1
(ar)
|
2016-12-01 |
2019-01-30 |
Takeda Pharmaceuticals Co |
داي نوكليوتيد حلقي
|
|
AU2017378782A1
(en)
|
2016-12-20 |
2019-07-04 |
Merck Sharp & Dohme Corp. |
Combinations of PD-1 antagonists and cyclic dinucleotide sting agonists for cancer treatment
|
|
AU2017378783A1
(en)
|
2016-12-20 |
2019-07-04 |
Merck Sharp & Dohme Corp. |
Cyclic dinucleotide sting agonists for cancer treatment
|
|
EP3558970B1
(en)
|
2016-12-20 |
2021-09-01 |
Bristol-Myers Squibb Company |
Compounds useful as immunomodulators
|
|
WO2018119263A1
(en)
|
2016-12-22 |
2018-06-28 |
Incyte Corporation |
Heterocyclic compounds derivatives as pd-l1 internalization inducers
|
|
BR112019012511A2
(pt)
|
2016-12-22 |
2019-11-19 |
Idenix Pharmaceuticals Llc |
compostos antivirais de benzil-amina fosfodiamida, composição farmacêutica e uso do composto
|
|
ES2899402T3
(es)
|
2016-12-22 |
2022-03-11 |
Incyte Corp |
Derivados de piridina como inmunomoduladores
|
|
BR112019012993A2
(pt)
|
2016-12-22 |
2019-12-03 |
Incyte Corporation |
derivados de benzo-oxazol como imunomoduladores
|
|
US20180179201A1
(en)
|
2016-12-22 |
2018-06-28 |
Incyte Corporation |
Heterocyclic compounds as immunomodulators
|
|
MA47099A
(fr)
|
2016-12-22 |
2021-05-12 |
Incyte Corp |
Composés hétéroaromatiques bicycliques utilisés en tant qu'immunomodulateurs
|
|
CA3047573A1
(en)
|
2016-12-22 |
2018-06-28 |
Merck Sharp & Dohme Corp. |
Antiviral aliphatic ester prodrugs of tenofovir
|
|
JPWO2018199338A1
(ja)
|
2017-04-27 |
2020-03-12 |
国立大学法人広島大学 |
Ｂ型肝炎治療用核酸分子
|
|
TW201945388A
(zh)
|
2018-04-12 |
2019-12-01 |
美商精密生物科學公司 |
對b型肝炎病毒基因體中之識別序列具有特異性之最佳化之經工程化巨核酸酶
|