JP2016146837A5 - - Google Patents

Info

Publication number

JP2016146837A5

JP2016146837A5 JP2016041230A JP2016041230A JP2016146837A5 JP 2016146837 A5 JP2016146837 A5 JP 2016146837A5 JP 2016041230 A JP2016041230 A JP 2016041230A JP 2016041230 A JP2016041230 A JP 2016041230A JP 2016146837 A5 JP2016146837 A5 JP 2016146837A5

Authority

JP

Japan

Prior art keywords

seq

recombinant adenovirus

protein

recombinant

immunogenic epitope

Prior art date

2016-03-03

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 241000701161 unidentified adenovirus Species 0.000 claims 14
• 230000002163 immunogen Effects 0.000 claims 10
• 201000004792 malaria Diseases 0.000 claims 9
• 108090000623 proteins and genes Proteins 0.000 claims 9
• 210000003046 sporozoite Anatomy 0.000 claims 8
• NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 claims 7
• 239000002773 nucleotide Substances 0.000 claims 7
• 125000003729 nucleotide group Chemical group 0.000 claims 7
• 244000045947 parasite Species 0.000 claims 7
• 102000004169 proteins and genes Human genes 0.000 claims 7
• 108091007491 NSP3 Papain-like protease domains Proteins 0.000 claims 6
• 210000001744 T-lymphocyte Anatomy 0.000 claims 5
• KQPKMEYBZUPZGK-UHFFFAOYSA-N 4-[(4-azido-2-nitroanilino)methyl]-5-(hydroxymethyl)-2-methylpyridin-3-ol Chemical compound CC1=NC=C(CO)C(CNC=2C(=CC(=CC=2)N=[N+]=[N-])[N+]([O-])=O)=C1O KQPKMEYBZUPZGK-UHFFFAOYSA-N 0.000 claims 4
• 101001111984 Homo sapiens N-acylneuraminate-9-phosphatase Proteins 0.000 claims 4
• 102100023906 N-acylneuraminate-9-phosphatase Human genes 0.000 claims 4
• 108090000565 Capsid Proteins Proteins 0.000 claims 3
• 102100023321 Ceruloplasmin Human genes 0.000 claims 3
• 125000003275 alpha amino acid group Chemical group 0.000 claims 3
• 241000223960 Plasmodium falciparum Species 0.000 claims 2
• 101710143509 Pre-histone-like nucleoprotein Proteins 0.000 claims 2
• 239000000427 antigen Substances 0.000 claims 2
• 108091007433 antigens Proteins 0.000 claims 2
• 102000036639 antigens Human genes 0.000 claims 2
• 208000015181 infectious disease Diseases 0.000 claims 2
• 229960005486 vaccine Drugs 0.000 claims 2
• FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
• 101710132601 Capsid protein Proteins 0.000 claims 1
• 108020004705 Codon Proteins 0.000 claims 1
• 239000002671 adjuvant Substances 0.000 claims 1
• 210000003719 b-lymphocyte Anatomy 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1